Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QJ09_LEIMA

TriTrypDb:

LmjF.06.0685 , LMJLV39_060012700 , LMJSD75_060012600

Length:

404

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0031390	Ctf18 RFC-like complex	3	6
GO:0032991	protein-containing complex	1	6
GO:0140513	nuclear protein-containing complex	2	6

Expansion

Sequence features

Q4QJ09

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ09

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	6
GO:0007062	sister chromatid cohesion	3	6
GO:0007064	mitotic sister chromatid cohesion	4	6
GO:0009987	cellular process	1	6
GO:0016043	cellular component organization	3	6
GO:0022402	cell cycle process	2	6
GO:0051276	chromosome organization	5	6
GO:0071840	cellular component organization or biogenesis	2	6
GO:1903047	mitotic cell cycle process	3	6

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	158	160	PF00675	0.644
CLV_NRD_NRD_1	222	224	PF00675	0.511
CLV_NRD_NRD_1	226	228	PF00675	0.317
CLV_NRD_NRD_1	311	313	PF00675	0.607
CLV_NRD_NRD_1	337	339	PF00675	0.612
CLV_NRD_NRD_1	39	41	PF00675	0.536
CLV_NRD_NRD_1	43	45	PF00675	0.552
CLV_NRD_NRD_1	48	50	PF00675	0.590
CLV_PCSK_FUR_1	44	48	PF00082	0.600
CLV_PCSK_KEX2_1	158	160	PF00082	0.644
CLV_PCSK_KEX2_1	189	191	PF00082	0.334
CLV_PCSK_KEX2_1	208	210	PF00082	0.276
CLV_PCSK_KEX2_1	226	228	PF00082	0.264
CLV_PCSK_KEX2_1	311	313	PF00082	0.607
CLV_PCSK_KEX2_1	339	341	PF00082	0.756
CLV_PCSK_KEX2_1	38	40	PF00082	0.541
CLV_PCSK_KEX2_1	43	45	PF00082	0.545
CLV_PCSK_KEX2_1	46	48	PF00082	0.583
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.359
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.271
CLV_PCSK_PC1ET2_1	339	341	PF00082	0.756
CLV_PCSK_PC7_1	185	191	PF00082	0.402
CLV_PCSK_PC7_1	204	210	PF00082	0.229
CLV_PCSK_PC7_1	39	45	PF00082	0.643
CLV_PCSK_SKI1_1	236	240	PF00082	0.739
CLV_PCSK_SKI1_1	242	246	PF00082	0.735
CLV_PCSK_SKI1_1	33	37	PF00082	0.498
DEG_Nend_Nbox_1	1	3	PF02207	0.505
DEG_SPOP_SBC_1	133	137	PF00917	0.715
DEG_SPOP_SBC_1	75	79	PF00917	0.677
DOC_MAPK_gen_1	189	195	PF00069	0.262
DOC_MAPK_gen_1	208	214	PF00069	0.271
DOC_MAPK_MEF2A_6	169	178	PF00069	0.453
DOC_MAPK_RevD_3	176	190	PF00069	0.358
DOC_PP4_FxxP_1	207	210	PF00568	0.453
DOC_USP7_MATH_1	132	136	PF00917	0.796
DOC_USP7_MATH_1	165	169	PF00917	0.445
DOC_USP7_MATH_1	322	326	PF00917	0.646
DOC_USP7_MATH_1	51	55	PF00917	0.713
DOC_USP7_MATH_1	71	75	PF00917	0.780
DOC_USP7_MATH_1	76	80	PF00917	0.690
DOC_USP7_MATH_1	81	85	PF00917	0.615
DOC_WW_Pin1_4	145	150	PF00397	0.706
DOC_WW_Pin1_4	153	158	PF00397	0.665
DOC_WW_Pin1_4	161	166	PF00397	0.567
DOC_WW_Pin1_4	215	220	PF00397	0.335
DOC_WW_Pin1_4	267	272	PF00397	0.669
DOC_WW_Pin1_4	355	360	PF00397	0.637
LIG_14-3-3_CanoR_1	105	113	PF00244	0.593
LIG_14-3-3_CanoR_1	144	149	PF00244	0.716
LIG_14-3-3_CanoR_1	190	194	PF00244	0.340
LIG_14-3-3_CanoR_1	204	208	PF00244	0.387
LIG_14-3-3_CanoR_1	376	383	PF00244	0.454
LIG_Actin_WH2_2	15	32	PF00022	0.552
LIG_AP2alpha_1	296	300	PF02296	0.702
LIG_BIR_III_4	61	65	PF00653	0.581
LIG_BRCT_BRCA1_1	391	395	PF00533	0.382
LIG_eIF4E_1	380	386	PF01652	0.410
LIG_FHA_1	190	196	PF00498	0.335
LIG_FHA_1	273	279	PF00498	0.554
LIG_FHA_2	312	318	PF00498	0.583
LIG_FHA_2	63	69	PF00498	0.674
LIG_FHA_2	92	98	PF00498	0.740
LIG_LIR_Apic_2	205	210	PF02991	0.334
LIG_LIR_Gen_1	382	389	PF02991	0.387
LIG_LIR_Nem_3	378	383	PF02991	0.497
LIG_Pex14_2	207	211	PF04695	0.453
LIG_Pex14_2	296	300	PF04695	0.702
LIG_SH2_NCK_1	383	387	PF00017	0.411
LIG_SH2_STAT5	121	124	PF00017	0.598
LIG_SH3_1	159	165	PF00018	0.683
LIG_SH3_2	154	159	PF14604	0.660
LIG_SH3_3	113	119	PF00018	0.571
LIG_SH3_3	146	152	PF00018	0.744
LIG_SH3_3	154	160	PF00018	0.760
LIG_SH3_3	171	177	PF00018	0.211
LIG_SH3_3	257	263	PF00018	0.655
LIG_SH3_3	353	359	PF00018	0.789
LIG_SUMO_SIM_anti_2	112	118	PF11976	0.559
LIG_UBA3_1	15	21	PF00899	0.633
MOD_CDC14_SPxK_1	156	159	PF00782	0.662
MOD_CDK_SPK_2	153	158	PF00069	0.662
MOD_CDK_SPxK_1	153	159	PF00069	0.662
MOD_CDK_SPxK_1	215	221	PF00069	0.335
MOD_CK1_1	123	129	PF00069	0.598
MOD_CK1_1	135	141	PF00069	0.644
MOD_CK1_1	153	159	PF00069	0.685
MOD_CK1_1	203	209	PF00069	0.453
MOD_CK1_1	232	238	PF00069	0.278
MOD_CK1_1	269	275	PF00069	0.616
MOD_CK1_1	291	297	PF00069	0.704
MOD_CK1_1	325	331	PF00069	0.794
MOD_CK1_1	74	80	PF00069	0.786
MOD_CK1_1	83	89	PF00069	0.653
MOD_CK1_1	90	96	PF00069	0.559
MOD_CK2_1	39	45	PF00069	0.611
MOD_DYRK1A_RPxSP_1	161	165	PF00069	0.679
MOD_GlcNHglycan	125	128	PF01048	0.646
MOD_GlcNHglycan	140	143	PF01048	0.603
MOD_GlcNHglycan	324	327	PF01048	0.668
MOD_GlcNHglycan	330	333	PF01048	0.718
MOD_GlcNHglycan	363	366	PF01048	0.718
MOD_GlcNHglycan	369	372	PF01048	0.634
MOD_GlcNHglycan	60	65	PF01048	0.664
MOD_GlcNHglycan	73	76	PF01048	0.632
MOD_GSK3_1	119	126	PF00069	0.628
MOD_GSK3_1	134	141	PF00069	0.680
MOD_GSK3_1	161	168	PF00069	0.324
MOD_GSK3_1	232	239	PF00069	0.294
MOD_GSK3_1	265	272	PF00069	0.649
MOD_GSK3_1	273	280	PF00069	0.671
MOD_GSK3_1	307	314	PF00069	0.580
MOD_GSK3_1	324	331	PF00069	0.693
MOD_GSK3_1	363	370	PF00069	0.653
MOD_GSK3_1	371	378	PF00069	0.630
MOD_GSK3_1	70	77	PF00069	0.634
MOD_GSK3_1	79	86	PF00069	0.650
MOD_GSK3_1	87	94	PF00069	0.740
MOD_N-GLC_1	91	96	PF02516	0.590
MOD_NEK2_1	143	148	PF00069	0.560
MOD_NEK2_1	229	234	PF00069	0.342
MOD_NEK2_1	394	399	PF00069	0.460
MOD_NEK2_2	194	199	PF00069	0.335
MOD_PIKK_1	229	235	PF00454	0.326
MOD_PKA_1	189	195	PF00069	0.402
MOD_PKA_1	311	317	PF00069	0.563
MOD_PKA_1	39	45	PF00069	0.627
MOD_PKA_2	104	110	PF00069	0.526
MOD_PKA_2	143	149	PF00069	0.684
MOD_PKA_2	189	195	PF00069	0.304
MOD_PKA_2	203	209	PF00069	0.356
MOD_PKA_2	311	317	PF00069	0.605
MOD_PKA_2	375	381	PF00069	0.488
MOD_PKA_2	389	395	PF00069	0.389
MOD_PKA_2	39	45	PF00069	0.652
MOD_PKA_2	88	94	PF00069	0.707
MOD_Plk_1	273	279	PF00069	0.689
MOD_Plk_4	273	279	PF00069	0.580
MOD_Plk_4	291	297	PF00069	0.530
MOD_Plk_4	347	353	PF00069	0.584
MOD_Plk_4	389	395	PF00069	0.390
MOD_ProDKin_1	145	151	PF00069	0.708
MOD_ProDKin_1	153	159	PF00069	0.665
MOD_ProDKin_1	161	167	PF00069	0.278
MOD_ProDKin_1	215	221	PF00069	0.335
MOD_ProDKin_1	267	273	PF00069	0.664
MOD_ProDKin_1	355	361	PF00069	0.640
TRG_DiLeu_BaEn_1	240	245	PF01217	0.669
TRG_ENDOCYTIC_2	383	386	PF00928	0.416
TRG_ER_diArg_1	157	159	PF00400	0.627
TRG_ER_diArg_1	225	227	PF00400	0.335
TRG_ER_diArg_1	311	313	PF00400	0.562
TRG_ER_diArg_1	338	341	PF00400	0.599
TRG_ER_diArg_1	38	40	PF00400	0.672
TRG_ER_diArg_1	46	49	PF00400	0.598
TRG_NLS_Bipartite_1	208	227	PF00514	0.389
TRG_NLS_MonoExtC_3	222	227	PF00514	0.453
TRG_NLS_MonoExtC_3	337	342	PF00514	0.601
TRG_NLS_MonoExtN_4	221	227	PF00514	0.453
TRG_Pf-PMV_PEXEL_1	223	228	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	236	240	PF00026	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I714	Leptomonas seymouri	41%	100%
A0A3S7WPI0	Leishmania donovani	88%	99%
A4H4N4	Leishmania braziliensis	62%	100%
A4HSW0	Leishmania infantum	89%	100%
E9AKU8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%