C2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

C2 domain/Ankyrin repeats (3 copies), putative

Species:

Leishmania major

UniProt:

Q4QJ07_LEIMA

TriTrypDb:

LmjF.06.0700 , LMJLV39_060012900 , LMJSD75_060012800

Length:

737

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QJ07

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ07

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	342	346	PF00656	0.667
CLV_NRD_NRD_1	573	575	PF00675	0.717
CLV_NRD_NRD_1	616	618	PF00675	0.324
CLV_PCSK_KEX2_1	572	574	PF00082	0.722
CLV_PCSK_KEX2_1	616	618	PF00082	0.364
CLV_PCSK_SKI1_1	638	642	PF00082	0.400
CLV_PCSK_SKI1_1	714	718	PF00082	0.420
DEG_SPOP_SBC_1	318	322	PF00917	0.645
DEG_SPOP_SBC_1	95	99	PF00917	0.519
DOC_CKS1_1	247	252	PF01111	0.649
DOC_CKS1_1	38	43	PF01111	0.418
DOC_CYCLIN_yCln2_LP_2	159	165	PF00134	0.564
DOC_PP1_RVXF_1	71	77	PF00149	0.391
DOC_PP2B_LxvP_1	159	162	PF13499	0.566
DOC_PP2B_LxvP_1	248	251	PF13499	0.658
DOC_PP2B_LxvP_1	301	304	PF13499	0.674
DOC_PP2B_LxvP_1	409	412	PF13499	0.617
DOC_PP2B_LxvP_1	733	736	PF13499	0.479
DOC_USP7_MATH_1	176	180	PF00917	0.651
DOC_USP7_MATH_1	181	185	PF00917	0.598
DOC_USP7_MATH_1	231	235	PF00917	0.667
DOC_USP7_MATH_1	319	323	PF00917	0.646
DOC_USP7_MATH_1	387	391	PF00917	0.649
DOC_USP7_MATH_1	401	405	PF00917	0.707
DOC_USP7_MATH_1	491	495	PF00917	0.733
DOC_USP7_MATH_1	541	545	PF00917	0.705
DOC_USP7_MATH_1	548	552	PF00917	0.720
DOC_USP7_MATH_1	560	564	PF00917	0.599
DOC_USP7_MATH_1	584	588	PF00917	0.769
DOC_USP7_MATH_1	673	677	PF00917	0.333
DOC_USP7_MATH_1	95	99	PF00917	0.411
DOC_WW_Pin1_4	238	243	PF00397	0.699
DOC_WW_Pin1_4	246	251	PF00397	0.634
DOC_WW_Pin1_4	272	277	PF00397	0.692
DOC_WW_Pin1_4	37	42	PF00397	0.418
DOC_WW_Pin1_4	417	422	PF00397	0.625
DOC_WW_Pin1_4	472	477	PF00397	0.754
DOC_WW_Pin1_4	486	491	PF00397	0.593
DOC_WW_Pin1_4	504	509	PF00397	0.624
DOC_WW_Pin1_4	567	572	PF00397	0.662
LIG_14-3-3_CanoR_1	366	371	PF00244	0.645
LIG_14-3-3_CanoR_1	497	503	PF00244	0.718
LIG_14-3-3_CanoR_1	574	582	PF00244	0.743
LIG_14-3-3_CanoR_1	697	701	PF00244	0.465
LIG_14-3-3_CanoR_1	711	717	PF00244	0.435
LIG_BRCT_BRCA1_1	24	28	PF00533	0.418
LIG_BRCT_BRCA1_1	363	367	PF00533	0.686
LIG_BRCT_BRCA1_1	450	454	PF00533	0.637
LIG_CtBP_PxDLS_1	250	254	PF00389	0.696
LIG_DLG_GKlike_1	366	374	PF00625	0.624
LIG_DLG_GKlike_1	474	482	PF00625	0.588
LIG_EH_1	25	29	PF12763	0.418
LIG_eIF4E_1	635	641	PF01652	0.333
LIG_EVH1_1	301	305	PF00568	0.650
LIG_FHA_1	124	130	PF00498	0.460
LIG_FHA_1	168	174	PF00498	0.586
LIG_FHA_1	212	218	PF00498	0.675
LIG_FHA_1	261	267	PF00498	0.645
LIG_FHA_1	28	34	PF00498	0.344
LIG_FHA_1	37	43	PF00498	0.344
LIG_FHA_1	418	424	PF00498	0.561
LIG_FHA_1	481	487	PF00498	0.806
LIG_FHA_1	5	11	PF00498	0.362
LIG_FHA_1	83	89	PF00498	0.344
LIG_FHA_1	97	103	PF00498	0.457
LIG_FHA_2	319	325	PF00498	0.658
LIG_FHA_2	606	612	PF00498	0.391
LIG_FHA_2	715	721	PF00498	0.428
LIG_FHA_2	87	93	PF00498	0.344
LIG_LIR_Apic_2	263	267	PF02991	0.640
LIG_LIR_Apic_2	56	61	PF02991	0.404
LIG_LIR_Gen_1	364	372	PF02991	0.675
LIG_LIR_Nem_3	234	238	PF02991	0.698
LIG_LIR_Nem_3	288	294	PF02991	0.689
LIG_LIR_Nem_3	364	370	PF02991	0.675
LIG_LIR_Nem_3	53	58	PF02991	0.391
LIG_LIR_Nem_3	613	618	PF02991	0.337
LIG_LIR_Nem_3	724	730	PF02991	0.426
LIG_MAD2	651	659	PF02301	0.333
LIG_MYND_1	251	255	PF01753	0.646
LIG_NRBOX	652	658	PF00104	0.333
LIG_PCNA_yPIPBox_3	689	697	PF02747	0.333
LIG_Pex14_2	51	55	PF04695	0.344
LIG_PTB_Apo_2	23	30	PF02174	0.418
LIG_PTB_Apo_2	45	52	PF02174	0.344
LIG_SH2_CRK	58	62	PF00017	0.391
LIG_SH2_GRB2like	327	330	PF00017	0.651
LIG_SH2_NCK_1	127	131	PF00017	0.509
LIG_SH2_NCK_1	393	397	PF00017	0.638
LIG_SH2_NCK_1	559	563	PF00017	0.677
LIG_SH2_NCK_1	698	702	PF00017	0.483
LIG_SH2_STAP1	291	295	PF00017	0.646
LIG_SH2_STAP1	393	397	PF00017	0.638
LIG_SH2_STAT3	294	297	PF00017	0.707
LIG_SH2_STAT5	264	267	PF00017	0.684
LIG_SH2_STAT5	393	396	PF00017	0.641
LIG_SH2_STAT5	601	604	PF00017	0.476
LIG_SH3_1	300	306	PF00018	0.789
LIG_SH3_3	170	176	PF00018	0.635
LIG_SH3_3	230	236	PF00018	0.579
LIG_SH3_3	252	258	PF00018	0.656
LIG_SH3_3	266	272	PF00018	0.661
LIG_SH3_3	299	305	PF00018	0.691
LIG_SH3_3	35	41	PF00018	0.422
LIG_SH3_3	353	359	PF00018	0.601
LIG_SH3_3	407	413	PF00018	0.612
LIG_SH3_3	455	461	PF00018	0.599
LIG_SH3_3	470	476	PF00018	0.636
LIG_SH3_3	512	518	PF00018	0.633
LIG_SH3_3	658	664	PF00018	0.369
LIG_SUMO_SIM_anti_2	7	12	PF11976	0.391
LIG_SUMO_SIM_par_1	4	9	PF11976	0.418
LIG_SUMO_SIM_par_1	663	670	PF11976	0.350
LIG_SUMO_SIM_par_1	704	709	PF11976	0.476
LIG_SUMO_SIM_par_1	85	92	PF11976	0.344
LIG_TRAF2_1	133	136	PF00917	0.756
LIG_TRAF2_1	369	372	PF00917	0.625
LIG_UBA3_1	65	73	PF00899	0.364
MOD_CDC14_SPxK_1	570	573	PF00782	0.673
MOD_CDK_SPK_2	567	572	PF00069	0.662
MOD_CDK_SPxK_1	567	573	PF00069	0.664
MOD_CDK_SPxxK_3	238	245	PF00069	0.679
MOD_CDK_SPxxK_3	567	574	PF00069	0.666
MOD_CK1_1	146	152	PF00069	0.735
MOD_CK1_1	203	209	PF00069	0.796
MOD_CK1_1	246	252	PF00069	0.769
MOD_CK1_1	275	281	PF00069	0.806
MOD_CK1_1	282	288	PF00069	0.719
MOD_CK1_1	322	328	PF00069	0.721
MOD_CK1_1	37	43	PF00069	0.333
MOD_CK1_1	379	385	PF00069	0.724
MOD_CK1_1	388	394	PF00069	0.645
MOD_CK1_1	417	423	PF00069	0.687
MOD_CK1_1	427	433	PF00069	0.794
MOD_CK1_1	477	483	PF00069	0.696
MOD_CK1_1	520	526	PF00069	0.693
MOD_CK1_1	563	569	PF00069	0.685
MOD_CK1_1	575	581	PF00069	0.639
MOD_CK1_1	587	593	PF00069	0.497
MOD_CK1_1	636	642	PF00069	0.391
MOD_CK1_1	676	682	PF00069	0.376
MOD_CK1_1	699	705	PF00069	0.472
MOD_CK2_1	318	324	PF00069	0.654
MOD_CK2_1	366	372	PF00069	0.653
MOD_CK2_1	427	433	PF00069	0.626
MOD_CK2_1	575	581	PF00069	0.744
MOD_CK2_1	588	594	PF00069	0.453
MOD_CK2_1	714	720	PF00069	0.438
MOD_GlcNHglycan	142	146	PF01048	0.650
MOD_GlcNHglycan	183	186	PF01048	0.747
MOD_GlcNHglycan	204	208	PF01048	0.846
MOD_GlcNHglycan	321	324	PF01048	0.700
MOD_GlcNHglycan	335	338	PF01048	0.631
MOD_GlcNHglycan	341	344	PF01048	0.615
MOD_GlcNHglycan	374	377	PF01048	0.767
MOD_GlcNHglycan	387	390	PF01048	0.641
MOD_GlcNHglycan	394	397	PF01048	0.648
MOD_GlcNHglycan	416	419	PF01048	0.609
MOD_GlcNHglycan	438	441	PF01048	0.742
MOD_GlcNHglycan	493	496	PF01048	0.700
MOD_GlcNHglycan	519	522	PF01048	0.820
MOD_GlcNHglycan	535	538	PF01048	0.635
MOD_GlcNHglycan	543	546	PF01048	0.735
MOD_GlcNHglycan	550	553	PF01048	0.586
MOD_GlcNHglycan	560	563	PF01048	0.535
MOD_GlcNHglycan	565	568	PF01048	0.661
MOD_GlcNHglycan	585	589	PF01048	0.495
MOD_GlcNHglycan	590	593	PF01048	0.472
MOD_GlcNHglycan	634	638	PF01048	0.333
MOD_GlcNHglycan	675	678	PF01048	0.333
MOD_GSK3_1	121	128	PF00069	0.472
MOD_GSK3_1	137	144	PF00069	0.692
MOD_GSK3_1	146	153	PF00069	0.694
MOD_GSK3_1	167	174	PF00069	0.624
MOD_GSK3_1	181	188	PF00069	0.723
MOD_GSK3_1	190	197	PF00069	0.746
MOD_GSK3_1	271	278	PF00069	0.742
MOD_GSK3_1	318	325	PF00069	0.795
MOD_GSK3_1	362	369	PF00069	0.646
MOD_GSK3_1	372	379	PF00069	0.614
MOD_GSK3_1	383	390	PF00069	0.715
MOD_GSK3_1	413	420	PF00069	0.702
MOD_GSK3_1	424	431	PF00069	0.631
MOD_GSK3_1	432	439	PF00069	0.590
MOD_GSK3_1	444	451	PF00069	0.679
MOD_GSK3_1	468	475	PF00069	0.693
MOD_GSK3_1	476	483	PF00069	0.672
MOD_GSK3_1	500	507	PF00069	0.798
MOD_GSK3_1	563	570	PF00069	0.760
MOD_GSK3_1	584	591	PF00069	0.638
MOD_GSK3_1	82	89	PF00069	0.348
MOD_N-GLC_1	328	333	PF02516	0.639
MOD_N-GLC_1	51	56	PF02516	0.383
MOD_N-GLC_2	118	120	PF02516	0.451
MOD_NEK2_1	279	284	PF00069	0.649
MOD_NEK2_1	29	34	PF00069	0.418
MOD_NEK2_1	370	375	PF00069	0.621
MOD_NEK2_1	392	397	PF00069	0.679
MOD_NEK2_1	424	429	PF00069	0.823
MOD_NEK2_1	432	437	PF00069	0.693
MOD_NEK2_1	478	483	PF00069	0.685
MOD_NEK2_1	51	56	PF00069	0.344
MOD_NEK2_1	633	638	PF00069	0.391
MOD_NEK2_1	696	701	PF00069	0.453
MOD_NEK2_1	706	711	PF00069	0.454
MOD_NEK2_2	525	530	PF00069	0.571
MOD_NEK2_2	64	69	PF00069	0.418
MOD_NEK2_2	86	91	PF00069	0.347
MOD_PIKK_1	243	249	PF00454	0.667
MOD_PIKK_1	379	385	PF00454	0.682
MOD_PIKK_1	401	407	PF00454	0.698
MOD_PIKK_1	424	430	PF00454	0.687
MOD_PKA_2	181	187	PF00069	0.576
MOD_PKA_2	696	702	PF00069	0.462
MOD_Plk_1	51	57	PF00069	0.383
MOD_Plk_1	584	590	PF00069	0.668
MOD_Plk_4	260	266	PF00069	0.633
MOD_Plk_4	322	328	PF00069	0.693
MOD_Plk_4	388	394	PF00069	0.640
MOD_Plk_4	419	425	PF00069	0.740
MOD_Plk_4	6	12	PF00069	0.356
MOD_Plk_4	676	682	PF00069	0.367
MOD_Plk_4	86	92	PF00069	0.344
MOD_ProDKin_1	238	244	PF00069	0.700
MOD_ProDKin_1	246	252	PF00069	0.634
MOD_ProDKin_1	272	278	PF00069	0.697
MOD_ProDKin_1	37	43	PF00069	0.418
MOD_ProDKin_1	417	423	PF00069	0.627
MOD_ProDKin_1	472	478	PF00069	0.758
MOD_ProDKin_1	486	492	PF00069	0.593
MOD_ProDKin_1	504	510	PF00069	0.618
MOD_ProDKin_1	567	573	PF00069	0.664
MOD_SUMO_for_1	11	14	PF00179	0.333
TRG_DiLeu_BaLyEn_6	702	707	PF01217	0.462
TRG_DiLeu_BaLyEn_6	729	734	PF01217	0.406
TRG_ER_diArg_1	571	574	PF00400	0.716
TRG_ER_diArg_1	615	617	PF00400	0.376

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5C1	Leptomonas seymouri	55%	98%
A0A3S7WPJ8	Leishmania donovani	93%	100%
A4H4U3	Leishmania braziliensis	70%	100%
A4HSW2	Leishmania infantum	93%	100%
E9AKV0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%