Putative serine-threonine dehydratase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine-threonine dehydratase, putative

Species:

Leishmania major

UniProt:

Q4QJ04_LEIMA

TriTrypDb:

LmjF.06.0730 , LMJLV39_060013500 , LMJSD75_060013400

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QJ04

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ04

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006090	pyruvate metabolic process	7	2
GO:0006520	amino acid metabolic process	3	2
GO:0006563	L-serine metabolic process	6	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008652	amino acid biosynthetic process	4	2
GO:0009058	biosynthetic process	2	2
GO:0009069	serine family amino acid metabolic process	5	2
GO:0009070	serine family amino acid biosynthetic process	6	2
GO:0009987	cellular process	1	2
GO:0016053	organic acid biosynthetic process	4	2
GO:0019752	carboxylic acid metabolic process	5	2
GO:0032787	monocarboxylic acid metabolic process	6	2
GO:0042866	pyruvate biosynthetic process	7	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0044283	small molecule biosynthetic process	3	2
GO:0046394	carboxylic acid biosynthetic process	5	2
GO:0046416	D-amino acid metabolic process	5	2
GO:0046437	D-amino acid biosynthetic process	6	2
GO:0070178	D-serine metabolic process	6	2
GO:0070179	D-serine biosynthetic process	7	2
GO:0071704	organic substance metabolic process	2	2
GO:0072330	monocarboxylic acid biosynthetic process	6	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901566	organonitrogen compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2
GO:1901605	alpha-amino acid metabolic process	4	2
GO:1901607	alpha-amino acid biosynthetic process	5	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0000287	magnesium ion binding	5	2
GO:0003824	catalytic activity	1	7
GO:0003941	L-serine ammonia-lyase activity	5	3
GO:0004794	L-threonine ammonia-lyase activity	5	6
GO:0005488	binding	1	2
GO:0005524	ATP binding	5	2
GO:0016829	lyase activity	2	7
GO:0016840	carbon-nitrogen lyase activity	3	7
GO:0016841	ammonia-lyase activity	4	7
GO:0016853	isomerase activity	2	3
GO:0016854	racemase and epimerase activity	3	3
GO:0016855	racemase and epimerase activity, acting on amino acids and derivatives	4	3
GO:0017076	purine nucleotide binding	4	2
GO:0018114	threonine racemase activity	7	2
GO:0019842	vitamin binding	3	2
GO:0030170	pyridoxal phosphate binding	4	2
GO:0030378	serine racemase activity	7	3
GO:0030554	adenyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032559	adenyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0036361	racemase activity, acting on amino acids and derivatives	5	3
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2
GO:0047661	amino-acid racemase activity	6	3
GO:0070279	vitamin B6 binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.487
CLV_NRD_NRD_1	233	235	PF00675	0.428
CLV_NRD_NRD_1	314	316	PF00675	0.365
CLV_PCSK_KEX2_1	147	149	PF00082	0.408
CLV_PCSK_KEX2_1	226	228	PF00082	0.391
CLV_PCSK_KEX2_1	241	243	PF00082	0.435
CLV_PCSK_KEX2_1	314	316	PF00082	0.377
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.408
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.391
CLV_PCSK_PC1ET2_1	241	243	PF00082	0.435
CLV_PCSK_SKI1_1	11	15	PF00082	0.496
CLV_PCSK_SKI1_1	202	206	PF00082	0.311
CLV_PCSK_SKI1_1	234	238	PF00082	0.384
CLV_PCSK_SKI1_1	332	336	PF00082	0.528
CLV_PCSK_SKI1_1	54	58	PF00082	0.420
DEG_APCC_DBOX_1	250	258	PF00400	0.420
DEG_SCF_FBW7_2	18	25	PF00400	0.462
DOC_CKS1_1	19	24	PF01111	0.420
DOC_MAPK_gen_1	146	154	PF00069	0.420
DOC_MAPK_gen_1	202	210	PF00069	0.321
DOC_MAPK_gen_1	314	320	PF00069	0.351
DOC_MAPK_gen_1	32	40	PF00069	0.420
DOC_MAPK_gen_1	62	70	PF00069	0.345
DOC_MAPK_MEF2A_6	202	210	PF00069	0.321
DOC_PP2B_LxvP_1	215	218	PF13499	0.420
DOC_USP7_UBL2_3	123	127	PF12436	0.414
DOC_USP7_UBL2_3	142	146	PF12436	0.461
DOC_USP7_UBL2_3	237	241	PF12436	0.439
DOC_WW_Pin1_4	18	23	PF00397	0.321
LIG_14-3-3_CanoR_1	135	143	PF00244	0.228
LIG_14-3-3_CanoR_1	54	59	PF00244	0.420
LIG_APCC_ABBA_1	154	159	PF00400	0.420
LIG_eIF4E_1	285	291	PF01652	0.321
LIG_FHA_1	102	108	PF00498	0.291
LIG_FHA_1	166	172	PF00498	0.321
LIG_FHA_1	19	25	PF00498	0.321
LIG_FHA_1	55	61	PF00498	0.420
LIG_FHA_1	93	99	PF00498	0.383
LIG_FHA_2	1	7	PF00498	0.437
LIG_FHA_2	167	173	PF00498	0.420
LIG_FHA_2	31	37	PF00498	0.381
LIG_IBAR_NPY_1	155	157	PF08397	0.420
LIG_LIR_Gen_1	138	144	PF02991	0.376
LIG_LIR_Gen_1	220	230	PF02991	0.462
LIG_LIR_Gen_1	3	10	PF02991	0.422
LIG_LIR_Nem_3	138	143	PF02991	0.376
LIG_LIR_Nem_3	220	225	PF02991	0.464
LIG_LIR_Nem_3	3	7	PF02991	0.428
LIG_LIR_Nem_3	311	316	PF02991	0.377
LIG_LIR_Nem_3	57	61	PF02991	0.420
LIG_SH2_CRK	313	317	PF00017	0.377
LIG_SH2_CRK	58	62	PF00017	0.420
LIG_SH2_SRC	265	268	PF00017	0.420
LIG_SH2_STAP1	157	161	PF00017	0.478
LIG_SH2_STAP1	279	283	PF00017	0.377
LIG_SH2_STAT5	121	124	PF00017	0.420
LIG_SH2_STAT5	17	20	PF00017	0.321
LIG_SH2_STAT5	222	225	PF00017	0.420
LIG_SH2_STAT5	261	264	PF00017	0.418
LIG_SH2_STAT5	265	268	PF00017	0.420
LIG_SH2_STAT5	283	286	PF00017	0.420
LIG_SH3_3	181	187	PF00018	0.321
LIG_SH3_3	95	101	PF00018	0.379
LIG_SH3_4	123	130	PF00018	0.420
LIG_SUMO_SIM_anti_2	168	175	PF11976	0.420
LIG_TRAF2_1	273	276	PF00917	0.420
LIG_TRAF2_1	63	66	PF00917	0.462
LIG_WRC_WIRS_1	1	6	PF05994	0.448
MOD_CK2_1	125	131	PF00069	0.343
MOD_CK2_1	166	172	PF00069	0.420
MOD_CK2_1	270	276	PF00069	0.420
MOD_CK2_1	30	36	PF00069	0.321
MOD_Cter_Amidation	144	147	PF01082	0.406
MOD_GlcNHglycan	320	323	PF01048	0.345
MOD_GlcNHglycan	77	80	PF01048	0.387
MOD_GSK3_1	30	37	PF00069	0.359
MOD_GSK3_1	87	94	PF00069	0.391
MOD_LATS_1	52	58	PF00433	0.420
MOD_N-GLC_2	149	151	PF02516	0.357
MOD_NEK2_1	257	262	PF00069	0.397
MOD_NEK2_1	45	50	PF00069	0.345
MOD_NEK2_1	92	97	PF00069	0.352
MOD_PK_1	34	40	PF00069	0.420
MOD_Plk_1	177	183	PF00069	0.462
MOD_Plk_4	220	226	PF00069	0.462
MOD_Plk_4	257	263	PF00069	0.462
MOD_Plk_4	34	40	PF00069	0.420
MOD_ProDKin_1	18	24	PF00069	0.321
MOD_SUMO_for_1	40	43	PF00179	0.321
MOD_SUMO_for_1	63	66	PF00179	0.462
TRG_DiLeu_BaEn_1	286	291	PF01217	0.321
TRG_ENDOCYTIC_2	222	225	PF00928	0.399
TRG_ENDOCYTIC_2	313	316	PF00928	0.321
TRG_ENDOCYTIC_2	58	61	PF00928	0.420
TRG_ER_diArg_1	313	315	PF00400	0.377
TRG_NLS_MonoExtC_3	233	239	PF00514	0.423
TRG_Pf-PMV_PEXEL_1	234	239	PF00026	0.384
TRG_PTS1	335	338	PF00515	0.464

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5H6	Leptomonas seymouri	28%	73%
A0A0N1PDR0	Leptomonas seymouri	77%	99%
A0A0S4IP22	Bodo saltans	28%	73%
A0A1X0NKY6	Trypanosomatidae	42%	95%
A0A3R7NHK6	Trypanosoma rangeli	46%	98%
A0A3S5H5S2	Leishmania donovani	100%	100%
A0JNI4	Bos taurus	34%	100%
A1B8Z2	Paracoccus denitrificans (strain Pd 1222)	30%	100%
A2XWA9	Oryza sativa subsp. indica	29%	100%
A4F2N8	Pseudomonas sp.	26%	100%
A4H4N7	Leishmania braziliensis	93%	100%
A4HSW5	Leishmania infantum	100%	100%
E9AKV2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
O59791	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
P0AGF6	Escherichia coli (strain K12)	30%	100%
P0AGF7	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	30%	100%
P0AGF8	Escherichia coli O157:H7	30%	100%
P0AGF9	Shigella flexneri	30%	100%
P11954	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	29%	100%
P36007	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
P37946	Bacillus subtilis (strain 168)	24%	80%
P53607	Burkholderia multivorans (strain ATCC 17616 / 249)	26%	67%
P55664	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	26%	100%
Q02145	Lactococcus lactis subsp. lactis (strain IL1403)	24%	81%
Q10725	Ralstonia pickettii	24%	100%
Q2FH01	Staphylococcus aureus (strain USA300)	28%	98%
Q2FYJ3	Staphylococcus aureus (strain NCTC 8325 / PS 47)	28%	98%
Q2PGG3	Arabidopsis thaliana	32%	100%
Q2YY67	Staphylococcus aureus (strain bovine RF122 / ET3-1)	28%	98%
Q49Z16	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	26%	80%
Q54HH2	Dictyostelium discoideum	34%	100%
Q5HFY5	Staphylococcus aureus (strain COL)	28%	98%
Q5HMF5	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	26%	80%
Q6G9C4	Staphylococcus aureus (strain MSSA476)	28%	98%
Q6GGX0	Staphylococcus aureus (strain MRSA252)	28%	98%
Q74FW6	Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)	29%	84%
Q76EQ0	Rattus norvegicus	34%	100%
Q7A5L8	Staphylococcus aureus (strain N315)	28%	98%
Q7XSN8	Oryza sativa subsp. japonica	29%	100%
Q8CNK9	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	26%	80%
Q8NWQ4	Staphylococcus aureus (strain MW2)	28%	98%
Q99U50	Staphylococcus aureus (strain Mu50 / ATCC 700699)	28%	98%
Q9GZT4	Homo sapiens	34%	99%
Q9KC63	Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)	24%	81%
Q9QZX7	Mus musculus	34%	100%
V5BT28	Trypanosoma cruzi	48%	99%
V5Y0V0	Alternaria alternata	25%	83%