Protein kinase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Protein kinase

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QJ03_LEIMA

TriTrypDb:

LmjF.06.0740 , LMJLV39_060013600 , LMJSD75_060013500

Length:

1066

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QJ03

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ03

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	509	513	PF00656	0.647
CLV_C14_Caspase3-7	578	582	PF00656	0.633
CLV_C14_Caspase3-7	637	641	PF00656	0.592
CLV_C14_Caspase3-7	762	766	PF00656	0.512
CLV_C14_Caspase3-7	814	818	PF00656	0.495
CLV_NRD_NRD_1	251	253	PF00675	0.622
CLV_NRD_NRD_1	321	323	PF00675	0.775
CLV_NRD_NRD_1	346	348	PF00675	0.633
CLV_NRD_NRD_1	430	432	PF00675	0.564
CLV_NRD_NRD_1	5	7	PF00675	0.435
CLV_NRD_NRD_1	558	560	PF00675	0.619
CLV_NRD_NRD_1	597	599	PF00675	0.655
CLV_NRD_NRD_1	616	618	PF00675	0.480
CLV_NRD_NRD_1	657	659	PF00675	0.566
CLV_NRD_NRD_1	742	744	PF00675	0.474
CLV_NRD_NRD_1	76	78	PF00675	0.462
CLV_NRD_NRD_1	815	817	PF00675	0.467
CLV_NRD_NRD_1	839	841	PF00675	0.453
CLV_NRD_NRD_1	891	893	PF00675	0.476
CLV_PCSK_KEX2_1	251	253	PF00082	0.622
CLV_PCSK_KEX2_1	321	323	PF00082	0.775
CLV_PCSK_KEX2_1	345	347	PF00082	0.626
CLV_PCSK_KEX2_1	354	356	PF00082	0.712
CLV_PCSK_KEX2_1	430	432	PF00082	0.571
CLV_PCSK_KEX2_1	5	7	PF00082	0.435
CLV_PCSK_KEX2_1	558	560	PF00082	0.619
CLV_PCSK_KEX2_1	579	581	PF00082	0.604
CLV_PCSK_KEX2_1	597	599	PF00082	0.655
CLV_PCSK_KEX2_1	616	618	PF00082	0.480
CLV_PCSK_KEX2_1	656	658	PF00082	0.566
CLV_PCSK_KEX2_1	742	744	PF00082	0.508
CLV_PCSK_KEX2_1	76	78	PF00082	0.462
CLV_PCSK_KEX2_1	815	817	PF00082	0.467
CLV_PCSK_KEX2_1	838	840	PF00082	0.463
CLV_PCSK_KEX2_1	891	893	PF00082	0.476
CLV_PCSK_PC1ET2_1	354	356	PF00082	0.605
CLV_PCSK_PC1ET2_1	579	581	PF00082	0.633
CLV_PCSK_SKI1_1	840	844	PF00082	0.437
DEG_APCC_DBOX_1	826	834	PF00400	0.568
DEG_APCC_DBOX_1	890	898	PF00400	0.368
DEG_APCC_DBOX_1	924	932	PF00400	0.485
DEG_SCF_TRCP1_1	300	305	PF00400	0.640
DEG_SPOP_SBC_1	1015	1019	PF00917	0.667
DOC_ANK_TNKS_1	251	258	PF00023	0.584
DOC_CYCLIN_RxL_1	110	123	PF00134	0.480
DOC_CYCLIN_yCln2_LP_2	149	155	PF00134	0.649
DOC_MAPK_DCC_7	559	569	PF00069	0.605
DOC_MAPK_gen_1	594	602	PF00069	0.457
DOC_MAPK_gen_1	923	930	PF00069	0.488
DOC_MAPK_MEF2A_6	116	124	PF00069	0.490
DOC_PP2B_LxvP_1	569	572	PF13499	0.676
DOC_PP2B_LxvP_1	953	956	PF13499	0.540
DOC_PP4_FxxP_1	27	30	PF00568	0.439
DOC_SPAK_OSR1_1	701	705	PF12202	0.474
DOC_USP7_MATH_1	1015	1019	PF00917	0.667
DOC_USP7_MATH_1	36	40	PF00917	0.453
DOC_USP7_MATH_1	389	393	PF00917	0.586
DOC_USP7_MATH_1	42	46	PF00917	0.453
DOC_USP7_MATH_1	572	576	PF00917	0.722
DOC_USP7_MATH_1	607	611	PF00917	0.694
DOC_USP7_MATH_1	647	651	PF00917	0.571
DOC_USP7_MATH_1	666	670	PF00917	0.574
DOC_USP7_MATH_1	70	74	PF00917	0.445
DOC_USP7_MATH_1	754	758	PF00917	0.622
DOC_USP7_MATH_1	763	767	PF00917	0.652
DOC_USP7_MATH_1	909	913	PF00917	0.527
DOC_USP7_UBL2_3	923	927	PF12436	0.480
DOC_WW_Pin1_4	151	156	PF00397	0.657
DOC_WW_Pin1_4	227	232	PF00397	0.652
DOC_WW_Pin1_4	26	31	PF00397	0.442
DOC_WW_Pin1_4	371	376	PF00397	0.593
DOC_WW_Pin1_4	455	460	PF00397	0.808
DOC_WW_Pin1_4	51	56	PF00397	0.448
DOC_WW_Pin1_4	58	63	PF00397	0.439
DOC_WW_Pin1_4	750	755	PF00397	0.583
DOC_WW_Pin1_4	764	769	PF00397	0.534
DOC_WW_Pin1_4	770	775	PF00397	0.508
DOC_WW_Pin1_4	84	89	PF00397	0.472
LIG_14-3-3_CanoR_1	116	121	PF00244	0.475
LIG_14-3-3_CanoR_1	303	311	PF00244	0.669
LIG_14-3-3_CanoR_1	321	327	PF00244	0.511
LIG_14-3-3_CanoR_1	41	50	PF00244	0.450
LIG_14-3-3_CanoR_1	56	61	PF00244	0.457
LIG_14-3-3_CanoR_1	750	754	PF00244	0.513
LIG_14-3-3_CanoR_1	77	86	PF00244	0.476
LIG_14-3-3_CanoR_1	860	866	PF00244	0.495
LIG_APCC_ABBA_1	293	298	PF00400	0.577
LIG_APCC_ABBA_1	709	714	PF00400	0.460
LIG_BIR_III_4	611	615	PF00653	0.648
LIG_BRCT_BRCA1_1	373	377	PF00533	0.587
LIG_BRCT_BRCA1_1	402	406	PF00533	0.536
LIG_Clathr_ClatBox_1	808	812	PF01394	0.495
LIG_CSL_BTD_1	145	148	PF09270	0.548
LIG_DLG_GKlike_1	116	124	PF00625	0.465
LIG_DLG_GKlike_1	322	330	PF00625	0.558
LIG_FHA_1	336	342	PF00498	0.566
LIG_FHA_1	455	461	PF00498	0.693
LIG_FHA_1	52	58	PF00498	0.455
LIG_FHA_1	529	535	PF00498	0.526
LIG_FHA_1	637	643	PF00498	0.657
LIG_FHA_1	646	652	PF00498	0.534
LIG_FHA_1	677	683	PF00498	0.611
LIG_FHA_1	787	793	PF00498	0.578
LIG_FHA_1	955	961	PF00498	0.562
LIG_FHA_2	315	321	PF00498	0.595
LIG_FHA_2	449	455	PF00498	0.525
LIG_FHA_2	576	582	PF00498	0.543
LIG_FHA_2	588	594	PF00498	0.469
LIG_FHA_2	635	641	PF00498	0.589
LIG_FHA_2	818	824	PF00498	0.458
LIG_FHA_2	957	963	PF00498	0.606
LIG_Integrin_RGD_1	992	994	PF01839	0.635
LIG_LIR_Apic_2	142	148	PF02991	0.620
LIG_LIR_Apic_2	26	30	PF02991	0.441
LIG_LIR_Gen_1	119	128	PF02991	0.454
LIG_LIR_Gen_1	64	72	PF02991	0.448
LIG_LIR_Nem_3	119	124	PF02991	0.462
LIG_LIR_Nem_3	64	68	PF02991	0.431
LIG_LIR_Nem_3	87	93	PF02991	0.476
LIG_MYND_1	84	88	PF01753	0.453
LIG_REV1ctd_RIR_1	484	490	PF16727	0.512
LIG_SH2_CRK	981	985	PF00017	0.562
LIG_SH2_NCK_1	981	985	PF00017	0.607
LIG_SH2_STAT5	121	124	PF00017	0.461
LIG_SH2_STAT5	601	604	PF00017	0.515
LIG_SH2_STAT5	63	66	PF00017	0.419
LIG_SH2_STAT5	712	715	PF00017	0.481
LIG_SH3_1	13	19	PF00018	0.422
LIG_SH3_1	354	360	PF00018	0.662
LIG_SH3_2	774	779	PF14604	0.653
LIG_SH3_3	13	19	PF00018	0.435
LIG_SH3_3	149	155	PF00018	0.677
LIG_SH3_3	177	183	PF00018	0.667
LIG_SH3_3	191	197	PF00018	0.837
LIG_SH3_3	232	238	PF00018	0.648
LIG_SH3_3	354	360	PF00018	0.662
LIG_SH3_3	369	375	PF00018	0.511
LIG_SH3_3	675	681	PF00018	0.478
LIG_SH3_3	771	777	PF00018	0.770
LIG_SH3_3	831	837	PF00018	0.475
LIG_SH3_3	90	96	PF00018	0.449
LIG_SUMO_SIM_anti_2	789	794	PF11976	0.564
LIG_SUMO_SIM_anti_2	926	932	PF11976	0.485
LIG_SUMO_SIM_anti_2	957	962	PF11976	0.637
LIG_SUMO_SIM_par_1	786	794	PF11976	0.540
LIG_SUMO_SIM_par_1	807	812	PF11976	0.383
LIG_SUMO_SIM_par_1	956	962	PF11976	0.560
LIG_TRAF2_1	1051	1054	PF00917	0.533
LIG_TRAF2_1	204	207	PF00917	0.631
LIG_TRAF2_1	463	466	PF00917	0.635
LIG_TRAF2_1	660	663	PF00917	0.530
LIG_TRAF2_1	879	882	PF00917	0.397
LIG_TRAF2_2	491	496	PF00917	0.530
LIG_WW_2	183	186	PF00397	0.646
MOD_CDK_SPK_2	51	56	PF00069	0.448
MOD_CDK_SPxxK_3	455	462	PF00069	0.634
MOD_CK1_1	1018	1024	PF00069	0.645
MOD_CK1_1	136	142	PF00069	0.578
MOD_CK1_1	217	223	PF00069	0.604
MOD_CK1_1	276	282	PF00069	0.690
MOD_CK1_1	288	294	PF00069	0.559
MOD_CK1_1	301	307	PF00069	0.694
MOD_CK1_1	316	322	PF00069	0.595
MOD_CK1_1	331	337	PF00069	0.526
MOD_CK1_1	376	382	PF00069	0.580
MOD_CK1_1	392	398	PF00069	0.530
MOD_CK1_1	449	455	PF00069	0.698
MOD_CK1_1	505	511	PF00069	0.772
MOD_CK1_1	51	57	PF00069	0.460
MOD_CK1_1	575	581	PF00069	0.621
MOD_CK1_1	61	67	PF00069	0.416
MOD_CK1_1	636	642	PF00069	0.624
MOD_CK1_1	78	84	PF00069	0.425
MOD_CK1_1	786	792	PF00069	0.661
MOD_CK1_1	864	870	PF00069	0.448
MOD_CK1_1	926	932	PF00069	0.517
MOD_CK1_1	964	970	PF00069	0.590
MOD_CK2_1	25	31	PF00069	0.443
MOD_CK2_1	314	320	PF00069	0.599
MOD_CK2_1	448	454	PF00069	0.574
MOD_CK2_1	460	466	PF00069	0.611
MOD_CK2_1	587	593	PF00069	0.524
MOD_CK2_1	817	823	PF00069	0.421
MOD_CK2_1	926	932	PF00069	0.517
MOD_DYRK1A_RPxSP_1	151	155	PF00069	0.652
MOD_DYRK1A_RPxSP_1	750	754	PF00069	0.537
MOD_GlcNHglycan	1020	1023	PF01048	0.762
MOD_GlcNHglycan	130	133	PF01048	0.568
MOD_GlcNHglycan	222	225	PF01048	0.749
MOD_GlcNHglycan	258	261	PF01048	0.724
MOD_GlcNHglycan	263	266	PF01048	0.777
MOD_GlcNHglycan	275	278	PF01048	0.534
MOD_GlcNHglycan	298	303	PF01048	0.804
MOD_GlcNHglycan	368	371	PF01048	0.640
MOD_GlcNHglycan	425	428	PF01048	0.653
MOD_GlcNHglycan	512	515	PF01048	0.672
MOD_GlcNHglycan	574	577	PF01048	0.742
MOD_GlcNHglycan	581	584	PF01048	0.684
MOD_GlcNHglycan	603	606	PF01048	0.674
MOD_GlcNHglycan	756	759	PF01048	0.628
MOD_GlcNHglycan	885	890	PF01048	0.361
MOD_GlcNHglycan	962	966	PF01048	0.651
MOD_GSK3_1	1014	1021	PF00069	0.637
MOD_GSK3_1	106	113	PF00069	0.523
MOD_GSK3_1	116	123	PF00069	0.583
MOD_GSK3_1	133	140	PF00069	0.556
MOD_GSK3_1	214	221	PF00069	0.650
MOD_GSK3_1	256	263	PF00069	0.684
MOD_GSK3_1	272	279	PF00069	0.632
MOD_GSK3_1	285	292	PF00069	0.536
MOD_GSK3_1	298	305	PF00069	0.684
MOD_GSK3_1	309	316	PF00069	0.663
MOD_GSK3_1	328	335	PF00069	0.498
MOD_GSK3_1	371	378	PF00069	0.597
MOD_GSK3_1	44	51	PF00069	0.443
MOD_GSK3_1	446	453	PF00069	0.657
MOD_GSK3_1	461	468	PF00069	0.609
MOD_GSK3_1	497	504	PF00069	0.694
MOD_GSK3_1	506	513	PF00069	0.597
MOD_GSK3_1	567	574	PF00069	0.761
MOD_GSK3_1	575	582	PF00069	0.692
MOD_GSK3_1	645	652	PF00069	0.630
MOD_GSK3_1	75	82	PF00069	0.473
MOD_GSK3_1	750	757	PF00069	0.521
MOD_GSK3_1	791	798	PF00069	0.523
MOD_GSK3_1	817	824	PF00069	0.407
MOD_GSK3_1	98	105	PF00069	0.489
MOD_LATS_1	114	120	PF00433	0.474
MOD_NEK2_1	1056	1061	PF00069	0.598
MOD_NEK2_1	120	125	PF00069	0.602
MOD_NEK2_1	128	133	PF00069	0.561
MOD_NEK2_1	134	139	PF00069	0.553
MOD_NEK2_1	311	316	PF00069	0.703
MOD_NEK2_1	377	382	PF00069	0.570
MOD_NEK2_1	471	476	PF00069	0.688
MOD_NEK2_1	501	506	PF00069	0.707
MOD_NEK2_1	567	572	PF00069	0.672
MOD_NEK2_1	98	103	PF00069	0.473
MOD_NEK2_2	497	502	PF00069	0.761
MOD_NEK2_2	89	94	PF00069	0.440
MOD_PIKK_1	502	508	PF00454	0.644
MOD_PIKK_1	587	593	PF00454	0.489
MOD_PIKK_1	634	640	PF00454	0.579
MOD_PIKK_1	704	710	PF00454	0.436
MOD_PIKK_1	780	786	PF00454	0.598
MOD_PIKK_1	817	823	PF00454	0.432
MOD_PIKK_1	909	915	PF00454	0.528
MOD_PKA_1	558	564	PF00069	0.534
MOD_PKA_1	579	585	PF00069	0.623
MOD_PKA_2	1056	1062	PF00069	0.601
MOD_PKA_2	302	308	PF00069	0.667
MOD_PKA_2	461	467	PF00069	0.556
MOD_PKA_2	55	61	PF00069	0.460
MOD_PKA_2	558	564	PF00069	0.662
MOD_PKA_2	567	573	PF00069	0.712
MOD_PKA_2	579	585	PF00069	0.622
MOD_PKA_2	631	637	PF00069	0.569
MOD_PKA_2	749	755	PF00069	0.517
MOD_PKA_2	75	81	PF00069	0.450
MOD_PKA_2	861	867	PF00069	0.449
MOD_PKB_1	415	423	PF00069	0.652
MOD_PKB_1	77	85	PF00069	0.450
MOD_Plk_1	289	295	PF00069	0.580
MOD_Plk_1	335	341	PF00069	0.657
MOD_Plk_1	435	441	PF00069	0.532
MOD_Plk_1	443	449	PF00069	0.526
MOD_Plk_1	497	503	PF00069	0.818
MOD_Plk_1	517	523	PF00069	0.465
MOD_Plk_1	620	626	PF00069	0.533
MOD_Plk_1	676	682	PF00069	0.420
MOD_Plk_1	885	891	PF00069	0.501
MOD_Plk_2-3	465	471	PF00069	0.548
MOD_Plk_4	116	122	PF00069	0.476
MOD_Plk_4	171	177	PF00069	0.702
MOD_Plk_4	289	295	PF00069	0.580
MOD_Plk_4	791	797	PF00069	0.520
MOD_Plk_4	799	805	PF00069	0.400
MOD_Plk_4	861	867	PF00069	0.352
MOD_Plk_4	926	932	PF00069	0.496
MOD_Plk_4	956	962	PF00069	0.685
MOD_ProDKin_1	151	157	PF00069	0.660
MOD_ProDKin_1	227	233	PF00069	0.654
MOD_ProDKin_1	26	32	PF00069	0.441
MOD_ProDKin_1	371	377	PF00069	0.593
MOD_ProDKin_1	455	461	PF00069	0.809
MOD_ProDKin_1	51	57	PF00069	0.450
MOD_ProDKin_1	58	64	PF00069	0.434
MOD_ProDKin_1	750	756	PF00069	0.587
MOD_ProDKin_1	764	770	PF00069	0.538
MOD_ProDKin_1	84	90	PF00069	0.473
MOD_SUMO_for_1	986	989	PF00179	0.535
TRG_DiLeu_BaLyEn_6	562	567	PF01217	0.657
TRG_DiLeu_BaLyEn_6	678	683	PF01217	0.533
TRG_DiLeu_BaLyEn_6	826	831	PF01217	0.569
TRG_ENDOCYTIC_2	121	124	PF00928	0.461
TRG_ER_diArg_1	251	253	PF00400	0.621
TRG_ER_diArg_1	321	323	PF00400	0.775
TRG_ER_diArg_1	344	347	PF00400	0.619
TRG_ER_diArg_1	4	6	PF00400	0.432
TRG_ER_diArg_1	409	412	PF00400	0.659
TRG_ER_diArg_1	414	417	PF00400	0.647
TRG_ER_diArg_1	421	424	PF00400	0.576
TRG_ER_diArg_1	597	599	PF00400	0.537
TRG_ER_diArg_1	656	658	PF00400	0.551
TRG_ER_diArg_1	716	719	PF00400	0.506
TRG_ER_diArg_1	75	77	PF00400	0.458
TRG_ER_diArg_1	837	840	PF00400	0.441
TRG_ER_diArg_1	859	862	PF00400	0.615
TRG_ER_diArg_1	890	892	PF00400	0.376
TRG_NES_CRM1_1	919	934	PF08389	0.619
TRG_Pf-PMV_PEXEL_1	892	896	PF00026	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2K9	Leptomonas seymouri	32%	100%
A0A3S7WPI2	Leishmania donovani	80%	100%
A4H4N8	Leishmania braziliensis	61%	100%
A4HSW6	Leishmania infantum	85%	100%
E9AKV3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%