Haemolysin-III_related_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Haemolysin-III related, putative

Species:

Leishmania major

UniProt:

Q4QJ02_LEIMA

TriTrypDb:

LmjF.06.0750 , LMJLV39_060013700 , LMJSD75_060013600

Length:

669

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4QJ02

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ02

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0038023	signaling receptor activity	2	2
GO:0060089	molecular transducer activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.647
CLV_C14_Caspase3-7	121	125	PF00656	0.229
CLV_C14_Caspase3-7	186	190	PF00656	0.470
CLV_MEL_PAP_1	27	33	PF00089	0.372
CLV_NRD_NRD_1	291	293	PF00675	0.464
CLV_NRD_NRD_1	39	41	PF00675	0.416
CLV_NRD_NRD_1	530	532	PF00675	0.364
CLV_NRD_NRD_1	537	539	PF00675	0.388
CLV_NRD_NRD_1	59	61	PF00675	0.329
CLV_NRD_NRD_1	67	69	PF00675	0.340
CLV_PCSK_FUR_1	289	293	PF00082	0.464
CLV_PCSK_KEX2_1	291	293	PF00082	0.464
CLV_PCSK_KEX2_1	39	41	PF00082	0.416
CLV_PCSK_KEX2_1	530	532	PF00082	0.364
CLV_PCSK_KEX2_1	537	539	PF00082	0.398
CLV_PCSK_KEX2_1	59	61	PF00082	0.329
CLV_PCSK_KEX2_1	69	71	PF00082	0.339
CLV_PCSK_PC1ET2_1	69	71	PF00082	0.339
CLV_PCSK_PC7_1	65	71	PF00082	0.341
CLV_PCSK_SKI1_1	205	209	PF00082	0.268
CLV_PCSK_SKI1_1	70	74	PF00082	0.376
DEG_APCC_DBOX_1	69	77	PF00400	0.581
DEG_Nend_UBRbox_3	1	3	PF02207	0.671
DEG_SPOP_SBC_1	568	572	PF00917	0.704
DOC_MAPK_DCC_7	259	269	PF00069	0.531
DOC_MAPK_DCC_7	614	622	PF00069	0.653
DOC_MAPK_gen_1	39	45	PF00069	0.546
DOC_MAPK_MEF2A_6	614	622	PF00069	0.653
DOC_PP2B_LxvP_1	102	105	PF13499	0.313
DOC_PP2B_LxvP_1	249	252	PF13499	0.479
DOC_PP2B_LxvP_1	615	618	PF13499	0.652
DOC_USP7_MATH_1	109	113	PF00917	0.258
DOC_USP7_MATH_1	132	136	PF00917	0.354
DOC_USP7_MATH_1	176	180	PF00917	0.503
DOC_USP7_MATH_1	215	219	PF00917	0.487
DOC_USP7_MATH_1	233	237	PF00917	0.512
DOC_USP7_MATH_1	386	390	PF00917	0.583
DOC_USP7_MATH_1	415	419	PF00917	0.614
DOC_USP7_MATH_1	567	571	PF00917	0.700
DOC_USP7_MATH_1	72	76	PF00917	0.510
DOC_WW_Pin1_4	14	19	PF00397	0.749
DOC_WW_Pin1_4	200	205	PF00397	0.467
DOC_WW_Pin1_4	216	221	PF00397	0.544
DOC_WW_Pin1_4	234	239	PF00397	0.476
DOC_WW_Pin1_4	262	267	PF00397	0.337
DOC_WW_Pin1_4	408	413	PF00397	0.701
DOC_WW_Pin1_4	580	585	PF00397	0.691
DOC_WW_Pin1_4	600	605	PF00397	0.617
LIG_14-3-3_CanoR_1	156	166	PF00244	0.467
LIG_14-3-3_CanoR_1	223	229	PF00244	0.489
LIG_14-3-3_CanoR_1	259	265	PF00244	0.500
LIG_14-3-3_CanoR_1	431	441	PF00244	0.749
LIG_14-3-3_CanoR_1	465	469	PF00244	0.509
LIG_APCC_ABBA_1	654	659	PF00400	0.499
LIG_BIR_III_4	562	566	PF00653	0.618
LIG_BRCT_BRCA1_1	218	222	PF00533	0.531
LIG_CSL_BTD_1	102	105	PF09270	0.313
LIG_deltaCOP1_diTrp_1	49	54	PF00928	0.524
LIG_EVH1_1	249	253	PF00568	0.531
LIG_FHA_1	263	269	PF00498	0.351
LIG_FHA_1	272	278	PF00498	0.284
LIG_FHA_1	330	336	PF00498	0.306
LIG_FHA_1	40	46	PF00498	0.537
LIG_FHA_1	534	540	PF00498	0.618
LIG_FHA_1	621	627	PF00498	0.605
LIG_FHA_1	82	88	PF00498	0.531
LIG_FHA_2	184	190	PF00498	0.474
LIG_FHA_2	451	457	PF00498	0.686
LIG_FHA_2	608	614	PF00498	0.659
LIG_GBD_Chelix_1	241	249	PF00786	0.285
LIG_GBD_Chelix_1	256	264	PF00786	0.264
LIG_GBD_Chelix_1	375	383	PF00786	0.390
LIG_IBAR_NPY_1	55	57	PF08397	0.574
LIG_LIR_Gen_1	26	36	PF02991	0.595
LIG_LIR_Gen_1	278	286	PF02991	0.313
LIG_LIR_Gen_1	312	322	PF02991	0.390
LIG_LIR_Gen_1	49	58	PF02991	0.519
LIG_LIR_Gen_1	505	515	PF02991	0.272
LIG_LIR_Gen_1	610	620	PF02991	0.655
LIG_LIR_Gen_1	83	93	PF02991	0.507
LIG_LIR_Nem_3	124	130	PF02991	0.265
LIG_LIR_Nem_3	219	225	PF02991	0.512
LIG_LIR_Nem_3	26	31	PF02991	0.595
LIG_LIR_Nem_3	278	284	PF02991	0.313
LIG_LIR_Nem_3	312	317	PF02991	0.390
LIG_LIR_Nem_3	49	54	PF02991	0.545
LIG_LIR_Nem_3	505	511	PF02991	0.272
LIG_LIR_Nem_3	610	615	PF02991	0.605
LIG_LIR_Nem_3	662	666	PF02991	0.524
LIG_LIR_Nem_3	83	88	PF02991	0.507
LIG_NRBOX	95	101	PF00104	0.332
LIG_PCNA_yPIPBox_3	292	306	PF02747	0.276
LIG_Pex14_2	62	66	PF04695	0.554
LIG_PTAP_UEV_1	387	392	PF05743	0.594
LIG_PTB_Apo_2	500	507	PF02174	0.318
LIG_PTB_Apo_2	79	86	PF02174	0.476
LIG_PTB_Phospho_1	500	506	PF10480	0.314
LIG_RPA_C_Fungi	426	438	PF08784	0.412
LIG_SH2_CRK	294	298	PF00017	0.313
LIG_SH2_CRK	472	476	PF00017	0.313
LIG_SH2_CRK	663	667	PF00017	0.398
LIG_SH2_GRB2like	501	504	PF00017	0.364
LIG_SH2_NCK_1	130	134	PF00017	0.351
LIG_SH2_NCK_1	663	667	PF00017	0.475
LIG_SH2_PTP2	345	348	PF00017	0.390
LIG_SH2_PTP2	480	483	PF00017	0.318
LIG_SH2_PTP2	506	509	PF00017	0.351
LIG_SH2_SRC	194	197	PF00017	0.263
LIG_SH2_STAP1	130	134	PF00017	0.351
LIG_SH2_STAT5	130	133	PF00017	0.351
LIG_SH2_STAT5	194	197	PF00017	0.263
LIG_SH2_STAT5	316	319	PF00017	0.313
LIG_SH2_STAT5	327	330	PF00017	0.313
LIG_SH2_STAT5	345	348	PF00017	0.262
LIG_SH2_STAT5	472	475	PF00017	0.313
LIG_SH2_STAT5	480	483	PF00017	0.313
LIG_SH2_STAT5	506	509	PF00017	0.297
LIG_SH2_STAT5	57	60	PF00017	0.459
LIG_SH2_STAT5	624	627	PF00017	0.468
LIG_SH2_STAT5	633	636	PF00017	0.383
LIG_SH2_STAT5	79	82	PF00017	0.313
LIG_SH3_3	232	238	PF00018	0.390
LIG_SH3_3	247	253	PF00018	0.507
LIG_SH3_3	345	351	PF00018	0.313
LIG_SH3_3	385	391	PF00018	0.486
LIG_SH3_3	407	413	PF00018	0.680
LIG_SUMO_SIM_par_1	41	47	PF11976	0.388
LIG_WRC_WIRS_1	272	277	PF05994	0.313
LIG_WRC_WIRS_1	281	286	PF05994	0.313
LIG_WW_3	103	107	PF00397	0.390
MOD_CDK_SPK_2	200	205	PF00069	0.281
MOD_CDK_SPxxK_3	216	223	PF00069	0.351
MOD_CK1_1	179	185	PF00069	0.314
MOD_CK1_1	218	224	PF00069	0.351
MOD_CK1_1	229	235	PF00069	0.258
MOD_CK1_1	23	29	PF00069	0.641
MOD_CK1_1	570	576	PF00069	0.633
MOD_CK1_1	627	633	PF00069	0.400
MOD_CK1_1	648	654	PF00069	0.355
MOD_CK1_1	8	14	PF00069	0.726
MOD_CK2_1	194	200	PF00069	0.306
MOD_CK2_1	397	403	PF00069	0.573
MOD_CK2_1	41	47	PF00069	0.465
MOD_GlcNHglycan	111	114	PF01048	0.346
MOD_GlcNHglycan	134	137	PF01048	0.319
MOD_GlcNHglycan	178	181	PF01048	0.351
MOD_GlcNHglycan	22	25	PF01048	0.682
MOD_GlcNHglycan	228	231	PF01048	0.448
MOD_GlcNHglycan	242	245	PF01048	0.325
MOD_GlcNHglycan	309	312	PF01048	0.351
MOD_GlcNHglycan	388	391	PF01048	0.551
MOD_GlcNHglycan	399	402	PF01048	0.534
MOD_GlcNHglycan	434	437	PF01048	0.489
MOD_GlcNHglycan	460	463	PF01048	0.433
MOD_GlcNHglycan	575	578	PF01048	0.680
MOD_GlcNHglycan	626	629	PF01048	0.428
MOD_GlcNHglycan	647	650	PF01048	0.349
MOD_GSK3_1	104	111	PF00069	0.482
MOD_GSK3_1	128	135	PF00069	0.420
MOD_GSK3_1	179	186	PF00069	0.292
MOD_GSK3_1	19	26	PF00069	0.526
MOD_GSK3_1	229	236	PF00069	0.329
MOD_GSK3_1	240	247	PF00069	0.301
MOD_GSK3_1	258	265	PF00069	0.361
MOD_GSK3_1	267	274	PF00069	0.287
MOD_GSK3_1	440	447	PF00069	0.586
MOD_GSK3_1	5	12	PF00069	0.695
MOD_GSK3_1	569	576	PF00069	0.729
MOD_GSK3_1	594	601	PF00069	0.620
MOD_GSK3_1	620	627	PF00069	0.526
MOD_N-GLC_1	502	507	PF02516	0.384
MOD_N-GLC_1	81	86	PF02516	0.313
MOD_NEK2_1	260	265	PF00069	0.313
MOD_NEK2_1	267	272	PF00069	0.314
MOD_NEK2_1	275	280	PF00069	0.345
MOD_NEK2_1	397	402	PF00069	0.570
MOD_NEK2_1	526	531	PF00069	0.419
MOD_NEK2_1	599	604	PF00069	0.592
MOD_NEK2_1	620	625	PF00069	0.640
MOD_NEK2_2	41	46	PF00069	0.385
MOD_PIKK_1	493	499	PF00454	0.472
MOD_PKA_1	39	45	PF00069	0.411
MOD_PKA_2	105	111	PF00069	0.429
MOD_PKA_2	258	264	PF00069	0.360
MOD_PKA_2	39	45	PF00069	0.603
MOD_PKA_2	464	470	PF00069	0.325
MOD_PKA_2	533	539	PF00069	0.504
MOD_PKA_2	573	579	PF00069	0.637
MOD_Plk_1	502	508	PF00069	0.386
MOD_Plk_1	81	87	PF00069	0.313
MOD_Plk_4	164	170	PF00069	0.313
MOD_Plk_4	23	29	PF00069	0.503
MOD_Plk_4	271	277	PF00069	0.298
MOD_Plk_4	280	286	PF00069	0.304
MOD_Plk_4	337	343	PF00069	0.313
MOD_Plk_4	464	470	PF00069	0.349
MOD_Plk_4	502	508	PF00069	0.353
MOD_Plk_4	594	600	PF00069	0.621
MOD_Plk_4	607	613	PF00069	0.451
MOD_Plk_4	620	626	PF00069	0.480
MOD_Plk_4	72	78	PF00069	0.379
MOD_ProDKin_1	14	20	PF00069	0.695
MOD_ProDKin_1	200	206	PF00069	0.300
MOD_ProDKin_1	216	222	PF00069	0.409
MOD_ProDKin_1	234	240	PF00069	0.313
MOD_ProDKin_1	262	268	PF00069	0.337
MOD_ProDKin_1	408	414	PF00069	0.627
MOD_ProDKin_1	580	586	PF00069	0.613
MOD_ProDKin_1	600	606	PF00069	0.509
TRG_ENDOCYTIC_2	281	284	PF00928	0.313
TRG_ENDOCYTIC_2	294	297	PF00928	0.313
TRG_ENDOCYTIC_2	314	317	PF00928	0.390
TRG_ENDOCYTIC_2	345	348	PF00928	0.313
TRG_ENDOCYTIC_2	472	475	PF00928	0.313
TRG_ENDOCYTIC_2	480	483	PF00928	0.313
TRG_ENDOCYTIC_2	506	509	PF00928	0.313
TRG_ENDOCYTIC_2	663	666	PF00928	0.397
TRG_ER_diArg_1	289	292	PF00400	0.297
TRG_ER_diArg_1	38	40	PF00400	0.510
TRG_ER_diArg_1	537	539	PF00400	0.449
TRG_ER_diArg_1	58	60	PF00400	0.384
TRG_ER_diArg_1	62	65	PF00400	0.374
TRG_ER_diArg_1	67	70	PF00400	0.410

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4X6	Leptomonas seymouri	44%	87%
A0A3S5H5S3	Leishmania donovani	90%	100%
A4H4N9	Leishmania braziliensis	73%	99%
A4HSW7	Leishmania infantum	90%	100%
E9AKV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%