Haemolysin-III_related_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Haemolysin-III related, putative

Species:

Leishmania major

UniProt:

Q4QJ02_LEIMA

TriTrypDb:

LmjF.06.0750 , LMJLV39_060013700 , LMJSD75_060013600

Length:

669

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

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Expansion

Sequence features

Q4QJ02

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QJ02

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0038023	signaling receptor activity	2	2
GO:0060089	molecular transducer activity	1	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.647
CLV_C14_Caspase3-7	121	125	PF00656	0.229
CLV_C14_Caspase3-7	186	190	PF00656	0.470
CLV_MEL_PAP_1	27	33	PF00089	0.372
CLV_NRD_NRD_1	291	293	PF00675	0.464
CLV_NRD_NRD_1	39	41	PF00675	0.416
CLV_NRD_NRD_1	530	532	PF00675	0.364
CLV_NRD_NRD_1	537	539	PF00675	0.388
CLV_NRD_NRD_1	59	61	PF00675	0.329
CLV_NRD_NRD_1	67	69	PF00675	0.340

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4X6	Leptomonas seymouri	44%	87%
A0A3S5H5S3	Leishmania donovani	90%	100%
A4H4N9	Leishmania braziliensis	73%	99%
A4HSW7	Leishmania infantum	90%	100%
E9AKV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%

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