Putative Qb-SNARE protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Qb-SNARE protein, putative

Species:

Leishmania major

UniProt:

Q4QIZ5_LEIMA

TriTrypDb:

LmjF.06.0820 , LMJLV39_060014700 , LMJSD75_060014600

Length:

397

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0012505	endomembrane system	2	2
GO:0016020	membrane	2	10
GO:0031201	SNARE complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0098796	membrane protein complex	2	2
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4QIZ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIZ5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0006906	vesicle fusion	6	2
GO:0006996	organelle organization	4	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016043	cellular component organization	3	2
GO:0016050	vesicle organization	5	2
GO:0022406	membrane docking	2	2
GO:0033036	macromolecule localization	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0048278	vesicle docking	4	2
GO:0048284	organelle fusion	5	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051640	organelle localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0061024	membrane organization	4	2
GO:0061025	membrane fusion	5	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090174	organelle membrane fusion	6	2
GO:0140056	organelle localization by membrane tethering	3	2

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	2
GO:0005484	SNAP receptor activity	3	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0030674	protein-macromolecule adaptor activity	2	2
GO:0060090	molecular adaptor activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	178	182	PF00656	0.629
CLV_C14_Caspase3-7	308	312	PF00656	0.587
CLV_C14_Caspase3-7	97	101	PF00656	0.714
CLV_NRD_NRD_1	114	116	PF00675	0.561
CLV_NRD_NRD_1	143	145	PF00675	0.414
CLV_NRD_NRD_1	36	38	PF00675	0.457
CLV_NRD_NRD_1	361	363	PF00675	0.386
CLV_NRD_NRD_1	83	85	PF00675	0.447
CLV_PCSK_KEX2_1	114	116	PF00082	0.561
CLV_PCSK_KEX2_1	143	145	PF00082	0.417
CLV_PCSK_KEX2_1	2	4	PF00082	0.523
CLV_PCSK_KEX2_1	36	38	PF00082	0.456
CLV_PCSK_KEX2_1	361	363	PF00082	0.395
CLV_PCSK_KEX2_1	45	47	PF00082	0.380
CLV_PCSK_KEX2_1	83	85	PF00082	0.447
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.523
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.439
CLV_PCSK_PC7_1	139	145	PF00082	0.436
CLV_PCSK_SKI1_1	209	213	PF00082	0.462
CLV_PCSK_SKI1_1	297	301	PF00082	0.472
CLV_PCSK_SKI1_1	46	50	PF00082	0.494
CLV_PCSK_SKI1_1	68	72	PF00082	0.393
DEG_APCC_DBOX_1	67	75	PF00400	0.574
DEG_Nend_UBRbox_1	1	4	PF02207	0.732
DEG_SPOP_SBC_1	169	173	PF00917	0.734
DOC_CYCLIN_yCln2_LP_2	227	233	PF00134	0.793
DOC_USP7_MATH_1	169	173	PF00917	0.708
DOC_USP7_MATH_1	175	179	PF00917	0.739
DOC_USP7_MATH_1	233	237	PF00917	0.735
DOC_USP7_MATH_1	249	253	PF00917	0.759
DOC_USP7_MATH_1	258	262	PF00917	0.786
DOC_USP7_MATH_1	268	272	PF00917	0.663
DOC_WW_Pin1_4	260	265	PF00397	0.742
DOC_WW_Pin1_4	279	284	PF00397	0.736
DOC_WW_Pin1_4	48	53	PF00397	0.640
LIG_14-3-3_CanoR_1	215	221	PF00244	0.661
LIG_14-3-3_CanoR_1	28	34	PF00244	0.725
LIG_14-3-3_CanoR_1	3	9	PF00244	0.665
LIG_14-3-3_CanoR_1	316	324	PF00244	0.597
LIG_14-3-3_CanoR_1	46	51	PF00244	0.662
LIG_14-3-3_CanoR_1	83	89	PF00244	0.665
LIG_14-3-3_CterR_2	394	397	PF00244	0.408
LIG_Actin_WH2_2	378	396	PF00022	0.402
LIG_Actin_WH2_2	57	74	PF00022	0.580
LIG_CaM_IQ_9	354	370	PF13499	0.667
LIG_Clathr_ClatBox_1	284	288	PF01394	0.738
LIG_EH1_1	377	385	PF00400	0.447
LIG_eIF4E_1	378	384	PF01652	0.447
LIG_FHA_1	126	132	PF00498	0.695
LIG_FHA_2	29	35	PF00498	0.689
LIG_GBD_Chelix_1	379	387	PF00786	0.480
LIG_LIR_Gen_1	298	305	PF02991	0.585
LIG_LIR_LC3C_4	333	337	PF02991	0.496
LIG_LIR_Nem_3	293	299	PF02991	0.563
LIG_LIR_Nem_3	57	61	PF02991	0.570
LIG_MAD2	215	223	PF02301	0.665
LIG_NRBOX	381	387	PF00104	0.447
LIG_NRBOX	388	394	PF00104	0.447
LIG_Pex14_2	296	300	PF04695	0.622
LIG_SH2_CRK	208	212	PF00017	0.516
LIG_SH2_STAT5	378	381	PF00017	0.378
LIG_SH3_3	227	233	PF00018	0.793
LIG_SUMO_SIM_par_1	282	289	PF11976	0.675
LIG_Vh1_VBS_1	377	395	PF01044	0.441
MOD_CDK_SPxK_1	48	54	PF00069	0.596
MOD_CK1_1	122	128	PF00069	0.652
MOD_CK1_1	183	189	PF00069	0.608
MOD_CK1_1	236	242	PF00069	0.783
MOD_CK1_1	252	258	PF00069	0.685
MOD_CK1_1	26	32	PF00069	0.731
MOD_CK1_1	262	268	PF00069	0.664
MOD_CK1_1	4	10	PF00069	0.570
MOD_CK2_1	121	127	PF00069	0.602
MOD_CK2_1	28	34	PF00069	0.669
MOD_CK2_1	286	292	PF00069	0.544
MOD_Cter_Amidation	81	84	PF01082	0.539
MOD_GlcNHglycan	172	175	PF01048	0.703
MOD_GlcNHglycan	181	185	PF01048	0.691
MOD_GlcNHglycan	235	238	PF01048	0.684
MOD_GlcNHglycan	25	28	PF01048	0.620
MOD_GlcNHglycan	264	267	PF01048	0.752
MOD_GlcNHglycan	288	291	PF01048	0.617
MOD_GlcNHglycan	346	350	PF01048	0.447
MOD_GlcNHglycan	85	88	PF01048	0.591
MOD_GSK3_1	119	126	PF00069	0.644
MOD_GSK3_1	14	21	PF00069	0.665
MOD_GSK3_1	258	265	PF00069	0.654
MOD_GSK3_1	357	364	PF00069	0.462
MOD_NEK2_1	1	6	PF00069	0.607
MOD_NEK2_1	135	140	PF00069	0.535
MOD_NEK2_1	286	291	PF00069	0.548
MOD_NEK2_1	299	304	PF00069	0.501
MOD_NEK2_1	370	375	PF00069	0.550
MOD_PIKK_1	354	360	PF00454	0.522
MOD_PKA_1	361	367	PF00069	0.358
MOD_PKA_1	83	89	PF00069	0.591
MOD_PKA_2	268	274	PF00069	0.746
MOD_PKA_2	315	321	PF00069	0.481
MOD_PKA_2	35	41	PF00069	0.561
MOD_PKA_2	361	367	PF00069	0.550
MOD_PKA_2	82	88	PF00069	0.638
MOD_Plk_1	106	112	PF00069	0.568
MOD_Plk_1	370	376	PF00069	0.509
MOD_ProDKin_1	260	266	PF00069	0.698
MOD_ProDKin_1	279	285	PF00069	0.690
MOD_ProDKin_1	48	54	PF00069	0.552
TRG_DiLeu_BaEn_1	108	113	PF01217	0.678
TRG_DiLeu_BaLyEn_6	280	285	PF01217	0.681
TRG_DiLeu_BaLyEn_6	320	325	PF01217	0.563
TRG_DiLeu_LyEn_5	108	113	PF01217	0.633
TRG_ENDOCYTIC_2	208	211	PF00928	0.616
TRG_ENDOCYTIC_2	58	61	PF00928	0.453
TRG_ER_diArg_1	113	115	PF00400	0.654
TRG_ER_diArg_1	13	16	PF00400	0.442
TRG_ER_diArg_1	361	363	PF00400	0.510
TRG_Pf-PMV_PEXEL_1	111	116	PF00026	0.608
TRG_Pf-PMV_PEXEL_1	329	333	PF00026	0.442
TRG_Pf-PMV_PEXEL_1	365	369	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P557	Leptomonas seymouri	46%	88%
A0A0S4JA95	Bodo saltans	27%	100%
A0A1X0NMF9	Trypanosomatidae	27%	100%
A0A3S7WPJ4	Leishmania donovani	87%	96%
A0A422NZG0	Trypanosoma rangeli	29%	100%
A4H4P4	Leishmania braziliensis	72%	97%
A4HSX4	Leishmania infantum	87%	96%
E9AKW0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%
V5BT43	Trypanosoma cruzi	30%	90%