Exosome-associated protein 3

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIZ3_LEIMA

TriTrypDb:

LmjF.06.0840 , LMJLV39_060014900 , LMJSD75_060014800

Length:

233

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QIZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIZ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.603
CLV_NRD_NRD_1	123	125	PF00675	0.566
CLV_NRD_NRD_1	16	18	PF00675	0.336
CLV_NRD_NRD_1	30	32	PF00675	0.499
CLV_PCSK_FUR_1	120	124	PF00082	0.466
CLV_PCSK_KEX2_1	122	124	PF00082	0.478
CLV_PCSK_KEX2_1	148	150	PF00082	0.587
CLV_PCSK_KEX2_1	16	18	PF00082	0.536
CLV_PCSK_KEX2_1	30	32	PF00082	0.499
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.608
CLV_PCSK_PC7_1	12	18	PF00082	0.515
CLV_PCSK_SKI1_1	124	128	PF00082	0.508
CLV_PCSK_SKI1_1	215	219	PF00082	0.537
DEG_Nend_UBRbox_2	1	3	PF02207	0.537
DEG_SPOP_SBC_1	220	224	PF00917	0.421
DOC_MAPK_gen_1	110	118	PF00069	0.516
DOC_USP7_MATH_1	128	132	PF00917	0.541
DOC_USP7_MATH_1	133	137	PF00917	0.566
DOC_USP7_MATH_1	147	151	PF00917	0.712
DOC_USP7_MATH_1	220	224	PF00917	0.677
DOC_USP7_MATH_1	78	82	PF00917	0.726
DOC_USP7_MATH_1	85	89	PF00917	0.656
DOC_WW_Pin1_4	83	88	PF00397	0.543
LIG_14-3-3_CanoR_1	104	112	PF00244	0.426
LIG_14-3-3_CanoR_1	151	161	PF00244	0.524
LIG_14-3-3_CanoR_1	48	57	PF00244	0.411
LIG_BIR_III_4	191	195	PF00653	0.484
LIG_BRCT_BRCA1_1	51	55	PF00533	0.490
LIG_Clathr_ClatBox_1	115	119	PF01394	0.435
LIG_FHA_1	104	110	PF00498	0.483
LIG_FHA_1	135	141	PF00498	0.530
LIG_FHA_1	156	162	PF00498	0.560
LIG_FHA_1	207	213	PF00498	0.539
LIG_FHA_1	56	62	PF00498	0.460
LIG_FHA_2	162	168	PF00498	0.725
LIG_SH2_STAT5	108	111	PF00017	0.384
LIG_SH2_STAT5	50	53	PF00017	0.459
LIG_SUMO_SIM_par_1	114	119	PF11976	0.365
LIG_SUMO_SIM_par_1	57	63	PF11976	0.394
LIG_Vh1_VBS_1	198	216	PF01044	0.538
MOD_CK1_1	150	156	PF00069	0.697
MOD_CK1_1	180	186	PF00069	0.646
MOD_CK1_1	200	206	PF00069	0.609
MOD_CK1_1	222	228	PF00069	0.494
MOD_CK1_1	39	45	PF00069	0.501
MOD_CK1_1	60	66	PF00069	0.464
MOD_CK1_1	88	94	PF00069	0.578
MOD_CK2_1	161	167	PF00069	0.642
MOD_CK2_1	2	8	PF00069	0.546
MOD_CK2_1	227	233	PF00069	0.623
MOD_CK2_1	39	45	PF00069	0.513
MOD_GlcNHglycan	130	133	PF01048	0.541
MOD_GlcNHglycan	152	155	PF01048	0.602
MOD_GlcNHglycan	224	227	PF01048	0.661
MOD_GlcNHglycan	51	54	PF01048	0.476
MOD_GlcNHglycan	73	76	PF01048	0.548
MOD_GlcNHglycan	90	93	PF01048	0.650
MOD_GSK3_1	124	131	PF00069	0.506
MOD_GSK3_1	157	164	PF00069	0.614
MOD_GSK3_1	83	90	PF00069	0.671
MOD_NEK2_1	227	232	PF00069	0.728
MOD_NEK2_1	49	54	PF00069	0.478
MOD_NEK2_1	55	60	PF00069	0.503
MOD_PIKK_1	93	99	PF00454	0.580
MOD_PKA_2	103	109	PF00069	0.382
MOD_PKA_2	150	156	PF00069	0.617
MOD_PKB_1	122	130	PF00069	0.384
MOD_Plk_1	33	39	PF00069	0.489
MOD_Plk_2-3	114	120	PF00069	0.434
MOD_Plk_2-3	2	8	PF00069	0.567
MOD_Plk_4	208	214	PF00069	0.554
MOD_Plk_4	33	39	PF00069	0.558
MOD_Plk_4	57	63	PF00069	0.513
MOD_Plk_4	78	84	PF00069	0.470
MOD_ProDKin_1	83	89	PF00069	0.540
MOD_SUMO_for_1	100	103	PF00179	0.443
TRG_DiLeu_BaEn_1	208	213	PF01217	0.586
TRG_DiLeu_LyEn_5	6	11	PF01217	0.507
TRG_ER_diArg_1	120	123	PF00400	0.463
TRG_ER_diArg_1	16	18	PF00400	0.452
TRG_ER_diArg_1	29	31	PF00400	0.459
TRG_NES_CRM1_1	107	119	PF08389	0.425
TRG_NES_CRM1_1	8	24	PF08389	0.436
TRG_NLS_MonoExtC_3	170	176	PF00514	0.695
TRG_NLS_MonoExtN_4	145	152	PF00514	0.783
TRG_NLS_MonoExtN_4	169	175	PF00514	0.689
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.563

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3M9	Leptomonas seymouri	59%	97%
A0A1X0NKL8	Trypanosomatidae	25%	100%
A0A3R7KNC7	Trypanosoma rangeli	31%	100%
A0A3S5H5S8	Leishmania donovani	91%	100%
A4H4P6	Leishmania braziliensis	67%	98%
A4HSX6	Leishmania infantum	91%	100%
C9ZTK5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AKW2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	95%
V5BNH6	Trypanosoma cruzi	30%	100%