Putative arginine N-methyltransferase, type III

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein arginine n-methyltransferase 7

Species:

Leishmania major

UniProt:

Q4QIZ0_LEIMA

TriTrypDb:

LmjF.06.0870 , LMJSD75_060015100

Length:

438

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QIZ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIZ0

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008213	protein alkylation	5	12
GO:0009987	cellular process	1	12
GO:0016570	histone modification	5	2
GO:0016571	histone methylation	5	2
GO:0018193	peptidyl-amino acid modification	5	12
GO:0018195	peptidyl-arginine modification	6	12
GO:0018216	peptidyl-arginine methylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0032259	methylation	2	12
GO:0034969	histone arginine methylation	6	2
GO:0035246	peptidyl-arginine N-methylation	6	2
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043414	macromolecule methylation	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008168	methyltransferase activity	4	12
GO:0008170	N-methyltransferase activity	5	12
GO:0008276	protein methyltransferase activity	3	12
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	12
GO:0016273	arginine N-methyltransferase activity	6	12
GO:0016274	protein-arginine N-methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0035241	protein-arginine omega-N monomethyltransferase activity	5	2
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	290	292	PF00675	0.360
CLV_NRD_NRD_1	424	426	PF00675	0.607
CLV_NRD_NRD_1	87	89	PF00675	0.533
CLV_PCSK_FUR_1	85	89	PF00082	0.492
CLV_PCSK_KEX2_1	290	292	PF00082	0.327
CLV_PCSK_KEX2_1	307	309	PF00082	0.409
CLV_PCSK_KEX2_1	423	425	PF00082	0.606
CLV_PCSK_KEX2_1	87	89	PF00082	0.498
CLV_PCSK_PC1ET2_1	307	309	PF00082	0.540
CLV_PCSK_PC1ET2_1	423	425	PF00082	0.606
CLV_PCSK_SKI1_1	227	231	PF00082	0.415
CLV_PCSK_SKI1_1	312	316	PF00082	0.510
DOC_CYCLIN_yCln2_LP_2	292	298	PF00134	0.348
DOC_MAPK_DCC_7	291	301	PF00069	0.470
DOC_MAPK_gen_1	290	298	PF00069	0.328
DOC_MAPK_gen_1	312	319	PF00069	0.456
DOC_PP2B_PxIxI_1	195	201	PF00149	0.396
DOC_PP4_FxxP_1	34	37	PF00568	0.558
DOC_PP4_FxxP_1	81	84	PF00568	0.415
DOC_USP7_MATH_1	124	128	PF00917	0.535
DOC_USP7_MATH_1	253	257	PF00917	0.509
DOC_USP7_MATH_1	321	325	PF00917	0.370
DOC_USP7_MATH_1	392	396	PF00917	0.480
DOC_USP7_MATH_1	43	47	PF00917	0.658
DOC_USP7_UBL2_3	145	149	PF12436	0.510
DOC_WW_Pin1_4	372	377	PF00397	0.475
LIG_14-3-3_CanoR_1	283	288	PF00244	0.377
LIG_14-3-3_CanoR_1	308	312	PF00244	0.510
LIG_14-3-3_CanoR_1	397	403	PF00244	0.420
LIG_14-3-3_CanoR_1	55	61	PF00244	0.653
LIG_Actin_WH2_2	73	89	PF00022	0.448
LIG_BRCT_BRCA1_1	200	204	PF00533	0.339
LIG_BRCT_BRCA1_1	272	276	PF00533	0.364
LIG_BRCT_BRCA1_1	285	289	PF00533	0.372
LIG_BRCT_BRCA1_2	272	278	PF00533	0.361
LIG_EVH1_1	192	196	PF00568	0.461
LIG_FHA_1	168	174	PF00498	0.519
LIG_FHA_1	204	210	PF00498	0.318
LIG_FHA_1	226	232	PF00498	0.368
LIG_FHA_1	269	275	PF00498	0.380
LIG_FHA_2	335	341	PF00498	0.426
LIG_FHA_2	343	349	PF00498	0.406
LIG_FHA_2	425	431	PF00498	0.608
LIG_GBD_Chelix_1	199	207	PF00786	0.378
LIG_LIR_Apic_2	31	37	PF02991	0.576
LIG_LIR_Apic_2	430	436	PF02991	0.490
LIG_LIR_Gen_1	112	123	PF02991	0.425
LIG_LIR_Gen_1	99	109	PF02991	0.367
LIG_LIR_Nem_3	112	118	PF02991	0.416
LIG_LIR_Nem_3	201	207	PF02991	0.384
LIG_LIR_Nem_3	255	260	PF02991	0.398
LIG_LIR_Nem_3	286	292	PF02991	0.366
LIG_LIR_Nem_3	309	314	PF02991	0.542
LIG_LIR_Nem_3	385	389	PF02991	0.255
LIG_Pex14_2	311	315	PF04695	0.460
LIG_Pex14_2	72	76	PF04695	0.448
LIG_SH2_CRK	115	119	PF00017	0.492
LIG_SH2_CRK	239	243	PF00017	0.327
LIG_SH2_GRB2like	114	117	PF00017	0.482
LIG_SH2_STAT3	60	63	PF00017	0.650
LIG_SH2_STAT5	216	219	PF00017	0.345
LIG_SH2_STAT5	404	407	PF00017	0.507
LIG_SH3_3	190	196	PF00018	0.383
LIG_SH3_3	314	320	PF00018	0.408
LIG_SUMO_SIM_par_1	150	155	PF11976	0.449
LIG_SUMO_SIM_par_1	205	212	PF11976	0.389
LIG_UBA3_1	138	145	PF00899	0.510
LIG_WW_3	82	86	PF00397	0.487
MOD_CK2_1	334	340	PF00069	0.428
MOD_CK2_1	342	348	PF00069	0.453
MOD_CK2_1	379	385	PF00069	0.481
MOD_CK2_1	424	430	PF00069	0.610
MOD_GlcNHglycan	126	129	PF01048	0.265
MOD_GlcNHglycan	135	138	PF01048	0.213
MOD_GlcNHglycan	211	214	PF01048	0.337
MOD_GlcNHglycan	323	326	PF01048	0.365
MOD_GlcNHglycan	381	384	PF01048	0.525
MOD_GlcNHglycan	408	411	PF01048	0.581
MOD_GlcNHglycan	56	59	PF01048	0.751
MOD_GlcNHglycan	6	9	PF01048	0.767
MOD_GSK3_1	13	20	PF00069	0.795
MOD_GSK3_1	133	140	PF00069	0.449
MOD_GSK3_1	155	162	PF00069	0.541
MOD_GSK3_1	163	170	PF00069	0.491
MOD_GSK3_1	194	201	PF00069	0.392
MOD_GSK3_1	270	277	PF00069	0.439
MOD_GSK3_1	303	310	PF00069	0.513
MOD_GSK3_1	319	326	PF00069	0.265
MOD_GSK3_1	368	375	PF00069	0.547
MOD_GSK3_1	398	405	PF00069	0.438
MOD_N-GLC_1	352	357	PF02516	0.508
MOD_NEK2_1	163	168	PF00069	0.517
MOD_NEK2_1	209	214	PF00069	0.336
MOD_NEK2_1	268	273	PF00069	0.408
MOD_NEK2_1	282	287	PF00069	0.326
MOD_NEK2_1	303	308	PF00069	0.394
MOD_NEK2_1	379	384	PF00069	0.487
MOD_NEK2_1	402	407	PF00069	0.459
MOD_NEK2_2	347	352	PF00069	0.480
MOD_PK_1	283	289	PF00069	0.360
MOD_PKA_1	12	18	PF00069	0.696
MOD_PKA_1	307	313	PF00069	0.518
MOD_PKA_1	424	430	PF00069	0.616
MOD_PKA_2	282	288	PF00069	0.342
MOD_PKA_2	307	313	PF00069	0.505
MOD_PKA_2	424	430	PF00069	0.668
MOD_PKA_2	54	60	PF00069	0.693
MOD_Plk_1	260	266	PF00069	0.419
MOD_Plk_1	269	275	PF00069	0.380
MOD_Plk_1	347	353	PF00069	0.530
MOD_Plk_1	43	49	PF00069	0.631
MOD_Plk_4	137	143	PF00069	0.449
MOD_Plk_4	194	200	PF00069	0.426
MOD_Plk_4	203	209	PF00069	0.273
MOD_Plk_4	270	276	PF00069	0.380
MOD_ProDKin_1	372	378	PF00069	0.471
MOD_SUMO_rev_2	184	189	PF00179	0.489
TRG_DiLeu_BaEn_2	76	82	PF01217	0.539
TRG_DiLeu_BaLyEn_6	220	225	PF01217	0.391
TRG_DiLeu_BaLyEn_6	294	299	PF01217	0.502
TRG_ENDOCYTIC_2	102	105	PF00928	0.392
TRG_ENDOCYTIC_2	114	117	PF00928	0.361
TRG_ER_diArg_1	221	224	PF00400	0.453
TRG_ER_diArg_1	289	291	PF00400	0.374
TRG_ER_diArg_1	84	87	PF00400	0.493
TRG_Pf-PMV_PEXEL_1	290	294	PF00026	0.324

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDL4	Leptomonas seymouri	75%	100%
A0A0S4IRB2	Bodo saltans	58%	98%
A0A1X0NKR3	Trypanosomatidae	57%	91%
A0A3S7WPK3	Leishmania donovani	96%	100%
A0A422NZF0	Trypanosoma rangeli	58%	100%
A2YPT7	Oryza sativa subsp. indica	28%	83%
A4H4P9	Leishmania braziliensis	82%	100%
A4HSX9	Leishmania infantum	96%	100%
C9ZTK9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AKW5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4AE70	Rattus norvegicus	27%	67%
Q582G4	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	52%	100%
Q7XI75	Oryza sativa subsp. japonica	28%	83%
Q86X55	Homo sapiens	27%	72%
Q9WVG6	Mus musculus	27%	72%
V5BT47	Trypanosoma cruzi	57%	100%