Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIY8_LEIMA

TriTrypDb:

LmjF.06.0890 , LMJLV39_060015200 , LMJSD75_060015300

Length:

779

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QIY8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIY8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	220	222	PF00675	0.532
CLV_NRD_NRD_1	236	238	PF00675	0.550
CLV_NRD_NRD_1	305	307	PF00675	0.779
CLV_NRD_NRD_1	402	404	PF00675	0.753
CLV_NRD_NRD_1	440	442	PF00675	0.712
CLV_NRD_NRD_1	516	518	PF00675	0.690
CLV_NRD_NRD_1	530	532	PF00675	0.499
CLV_NRD_NRD_1	56	58	PF00675	0.666
CLV_PCSK_KEX2_1	220	222	PF00082	0.532
CLV_PCSK_KEX2_1	236	238	PF00082	0.550
CLV_PCSK_KEX2_1	305	307	PF00082	0.713
CLV_PCSK_KEX2_1	402	404	PF00082	0.753
CLV_PCSK_KEX2_1	440	442	PF00082	0.712
CLV_PCSK_KEX2_1	515	517	PF00082	0.565
CLV_PCSK_KEX2_1	530	532	PF00082	0.586
CLV_PCSK_KEX2_1	713	715	PF00082	0.753
CLV_PCSK_PC1ET2_1	713	715	PF00082	0.753
CLV_PCSK_PC7_1	398	404	PF00082	0.749
CLV_PCSK_SKI1_1	205	209	PF00082	0.475
CLV_PCSK_SKI1_1	223	227	PF00082	0.688
CLV_PCSK_SKI1_1	247	251	PF00082	0.577
CLV_PCSK_SKI1_1	306	310	PF00082	0.712
CLV_PCSK_SKI1_1	516	520	PF00082	0.555
CLV_PCSK_SKI1_1	531	535	PF00082	0.596
CLV_PCSK_SKI1_1	545	549	PF00082	0.552
DEG_APCC_DBOX_1	239	247	PF00400	0.535
DEG_Nend_UBRbox_2	1	3	PF02207	0.621
DEG_SCF_TRCP1_1	589	594	PF00400	0.738
DEG_SCF_TRCP1_1	674	679	PF00400	0.698
DOC_CDC14_PxL_1	765	773	PF14671	0.578
DOC_CKS1_1	334	339	PF01111	0.613
DOC_CKS1_1	353	358	PF01111	0.499
DOC_CKS1_1	549	554	PF01111	0.568
DOC_CYCLIN_yCln2_LP_2	368	374	PF00134	0.649
DOC_CYCLIN_yCln2_LP_2	766	772	PF00134	0.510
DOC_MAPK_gen_1	236	245	PF00069	0.613
DOC_MAPK_gen_1	402	408	PF00069	0.727
DOC_PP1_RVXF_1	344	350	PF00149	0.526
DOC_PP2B_LxvP_1	104	107	PF13499	0.578
DOC_PP2B_LxvP_1	149	152	PF13499	0.628
DOC_PP2B_LxvP_1	179	182	PF13499	0.516
DOC_PP2B_LxvP_1	368	371	PF13499	0.673
DOC_PP2B_LxvP_1	766	769	PF13499	0.506
DOC_PP4_FxxP_1	14	17	PF00568	0.585
DOC_PP4_FxxP_1	74	77	PF00568	0.585
DOC_USP7_MATH_1	105	109	PF00917	0.606
DOC_USP7_MATH_1	29	33	PF00917	0.762
DOC_USP7_MATH_1	298	302	PF00917	0.729
DOC_USP7_MATH_1	308	312	PF00917	0.613
DOC_USP7_MATH_1	397	401	PF00917	0.722
DOC_USP7_MATH_1	450	454	PF00917	0.806
DOC_USP7_MATH_1	46	50	PF00917	0.511
DOC_USP7_MATH_1	483	487	PF00917	0.760
DOC_USP7_MATH_1	665	669	PF00917	0.703
DOC_USP7_MATH_1	721	725	PF00917	0.688
DOC_USP7_MATH_1	91	95	PF00917	0.672
DOC_USP7_MATH_1	98	102	PF00917	0.643
DOC_USP7_MATH_2	631	637	PF00917	0.569
DOC_WW_Pin1_4	106	111	PF00397	0.690
DOC_WW_Pin1_4	30	35	PF00397	0.699
DOC_WW_Pin1_4	333	338	PF00397	0.651
DOC_WW_Pin1_4	352	357	PF00397	0.415
DOC_WW_Pin1_4	499	504	PF00397	0.608
DOC_WW_Pin1_4	545	550	PF00397	0.787
DOC_WW_Pin1_4	56	61	PF00397	0.675
DOC_WW_Pin1_4	589	594	PF00397	0.733
DOC_WW_Pin1_4	76	81	PF00397	0.651
LIG_14-3-3_CanoR_1	11	17	PF00244	0.676
LIG_14-3-3_CanoR_1	123	129	PF00244	0.730
LIG_14-3-3_CanoR_1	144	150	PF00244	0.612
LIG_14-3-3_CanoR_1	205	212	PF00244	0.600
LIG_14-3-3_CanoR_1	365	369	PF00244	0.662
LIG_14-3-3_CanoR_1	398	402	PF00244	0.670
LIG_14-3-3_CanoR_1	403	407	PF00244	0.601
LIG_14-3-3_CanoR_1	530	540	PF00244	0.581
LIG_14-3-3_CanoR_1	643	652	PF00244	0.744
LIG_14-3-3_CanoR_1	748	757	PF00244	0.716
LIG_BIR_III_2	500	504	PF00653	0.730
LIG_BIR_III_4	392	396	PF00653	0.721
LIG_CtBP_PxDLS_1	652	656	PF00389	0.574
LIG_deltaCOP1_diTrp_1	415	419	PF00928	0.725
LIG_FHA_1	11	17	PF00498	0.504
LIG_FHA_1	213	219	PF00498	0.517
LIG_FHA_1	271	277	PF00498	0.595
LIG_FHA_1	334	340	PF00498	0.613
LIG_FHA_1	590	596	PF00498	0.704
LIG_FHA_1	738	744	PF00498	0.572
LIG_FHA_1	772	778	PF00498	0.667
LIG_FHA_1	79	85	PF00498	0.693
LIG_FHA_2	49	55	PF00498	0.637
LIG_Integrin_RGD_1	120	122	PF01839	0.698
LIG_Integrin_RGD_1	409	411	PF01839	0.605
LIG_LIR_Apic_2	13	17	PF02991	0.495
LIG_LIR_Apic_2	188	194	PF02991	0.536
LIG_LIR_Gen_1	355	366	PF02991	0.733
LIG_LIR_Gen_1	508	513	PF02991	0.553
LIG_LIR_Gen_1	87	98	PF02991	0.612
LIG_LIR_Nem_3	355	361	PF02991	0.587
LIG_LIR_Nem_3	415	420	PF02991	0.726
LIG_LIR_Nem_3	508	512	PF02991	0.558
LIG_LIR_Nem_3	87	93	PF02991	0.611
LIG_NRBOX	537	543	PF00104	0.720
LIG_PDZ_Class_2	774	779	PF00595	0.705
LIG_Pex14_1	416	420	PF04695	0.588
LIG_Rb_pABgroove_1	14	22	PF01858	0.623
LIG_SH2_CRK	191	195	PF00017	0.630
LIG_SH2_CRK	90	94	PF00017	0.605
LIG_SH2_NCK_1	498	502	PF00017	0.743
LIG_SH2_SRC	20	23	PF00017	0.748
LIG_SH2_SRC	498	501	PF00017	0.651
LIG_SH2_STAP1	27	31	PF00017	0.623
LIG_SH2_STAT5	197	200	PF00017	0.477
LIG_SH2_STAT5	420	423	PF00017	0.588
LIG_SH3_2	596	601	PF14604	0.703
LIG_SH3_3	104	110	PF00018	0.599
LIG_SH3_3	125	131	PF00018	0.744
LIG_SH3_3	28	34	PF00018	0.691
LIG_SH3_3	331	337	PF00018	0.800
LIG_SH3_3	350	356	PF00018	0.442
LIG_SH3_3	546	552	PF00018	0.615
LIG_SH3_3	574	580	PF00018	0.642
LIG_SH3_3	590	596	PF00018	0.699
LIG_SH3_3	634	640	PF00018	0.729
LIG_SH3_3	646	652	PF00018	0.781
LIG_SH3_3	659	665	PF00018	0.604
LIG_SH3_3	74	80	PF00018	0.786
LIG_SUMO_SIM_anti_2	241	247	PF11976	0.634
LIG_TRAF2_1	239	242	PF00917	0.542
LIG_TRAF2_1	38	41	PF00917	0.628
LIG_WRC_WIRS_1	524	529	PF05994	0.590
MOD_CDK_SPK_2	352	357	PF00069	0.562
MOD_CDK_SPK_2	56	61	PF00069	0.600
MOD_CDK_SPxxK_3	76	83	PF00069	0.722
MOD_CK1_1	10	16	PF00069	0.497
MOD_CK1_1	100	106	PF00069	0.741
MOD_CK1_1	285	291	PF00069	0.594
MOD_CK1_1	335	341	PF00069	0.580
MOD_CK1_1	378	384	PF00069	0.674
MOD_CK1_1	469	475	PF00069	0.707
MOD_CK1_1	486	492	PF00069	0.675
MOD_CK1_1	605	611	PF00069	0.576
MOD_CK1_1	697	703	PF00069	0.746
MOD_CK2_1	76	82	PF00069	0.708
MOD_CMANNOS	416	419	PF00535	0.586
MOD_Cter_Amidation	303	306	PF01082	0.711
MOD_GlcNHglycan	100	103	PF01048	0.658
MOD_GlcNHglycan	200	203	PF01048	0.540
MOD_GlcNHglycan	284	287	PF01048	0.675
MOD_GlcNHglycan	311	314	PF01048	0.587
MOD_GlcNHglycan	340	343	PF01048	0.697
MOD_GlcNHglycan	372	375	PF01048	0.777
MOD_GlcNHglycan	379	383	PF01048	0.723
MOD_GlcNHglycan	434	438	PF01048	0.800
MOD_GlcNHglycan	446	449	PF01048	0.659
MOD_GlcNHglycan	460	464	PF01048	0.605
MOD_GlcNHglycan	471	474	PF01048	0.568
MOD_GlcNHglycan	48	51	PF01048	0.777
MOD_GlcNHglycan	559	562	PF01048	0.770
MOD_GlcNHglycan	589	592	PF01048	0.653
MOD_GlcNHglycan	604	607	PF01048	0.705
MOD_GlcNHglycan	612	616	PF01048	0.720
MOD_GlcNHglycan	627	630	PF01048	0.518
MOD_GlcNHglycan	645	648	PF01048	0.642
MOD_GlcNHglycan	674	677	PF01048	0.671
MOD_GlcNHglycan	680	683	PF01048	0.691
MOD_GlcNHglycan	723	726	PF01048	0.739
MOD_GlcNHglycan	732	735	PF01048	0.627
MOD_GSK3_1	168	175	PF00069	0.682
MOD_GSK3_1	208	215	PF00069	0.516
MOD_GSK3_1	281	288	PF00069	0.600
MOD_GSK3_1	294	301	PF00069	0.619
MOD_GSK3_1	329	336	PF00069	0.724
MOD_GSK3_1	469	476	PF00069	0.727
MOD_GSK3_1	482	489	PF00069	0.716
MOD_GSK3_1	56	63	PF00069	0.781
MOD_GSK3_1	587	594	PF00069	0.776
MOD_GSK3_1	638	645	PF00069	0.781
MOD_GSK3_1	672	679	PF00069	0.562
MOD_GSK3_1	684	691	PF00069	0.590
MOD_N-GLC_1	123	128	PF02516	0.691
MOD_N-GLC_1	486	491	PF02516	0.702
MOD_N-GLC_1	602	607	PF02516	0.571
MOD_NEK2_1	12	17	PF00069	0.642
MOD_NEK2_1	186	191	PF00069	0.509
MOD_NEK2_1	250	255	PF00069	0.642
MOD_NEK2_1	309	314	PF00069	0.731
MOD_NEK2_1	364	369	PF00069	0.594
MOD_NEK2_1	466	471	PF00069	0.566
MOD_NEK2_1	619	624	PF00069	0.577
MOD_NEK2_1	84	89	PF00069	0.720
MOD_NEK2_2	145	150	PF00069	0.538
MOD_NEK2_2	397	402	PF00069	0.716
MOD_PIKK_1	298	304	PF00454	0.594
MOD_PIKK_1	531	537	PF00454	0.583
MOD_PIKK_1	60	66	PF00454	0.736
MOD_PK_1	402	408	PF00069	0.762
MOD_PKA_1	402	408	PF00069	0.727
MOD_PKA_2	10	16	PF00069	0.527
MOD_PKA_2	364	370	PF00069	0.661
MOD_PKA_2	397	403	PF00069	0.669
MOD_PKA_2	483	489	PF00069	0.683
MOD_PKA_2	642	648	PF00069	0.738
MOD_Plk_1	123	129	PF00069	0.693
MOD_Plk_1	250	256	PF00069	0.600
MOD_Plk_1	27	33	PF00069	0.587
MOD_Plk_1	620	626	PF00069	0.612
MOD_Plk_2-3	36	42	PF00069	0.674
MOD_Plk_4	15	21	PF00069	0.593
MOD_Plk_4	186	192	PF00069	0.512
MOD_Plk_4	329	335	PF00069	0.669
MOD_Plk_4	364	370	PF00069	0.661
MOD_Plk_4	4	10	PF00069	0.552
MOD_Plk_4	466	472	PF00069	0.567
MOD_Plk_4	505	511	PF00069	0.499
MOD_Plk_4	605	611	PF00069	0.686
MOD_Plk_4	620	626	PF00069	0.539
MOD_Plk_4	688	694	PF00069	0.632
MOD_ProDKin_1	106	112	PF00069	0.689
MOD_ProDKin_1	30	36	PF00069	0.699
MOD_ProDKin_1	333	339	PF00069	0.649
MOD_ProDKin_1	352	358	PF00069	0.420
MOD_ProDKin_1	499	505	PF00069	0.606
MOD_ProDKin_1	545	551	PF00069	0.792
MOD_ProDKin_1	56	62	PF00069	0.674
MOD_ProDKin_1	589	595	PF00069	0.734
MOD_ProDKin_1	76	82	PF00069	0.650
MOD_SUMO_for_1	276	279	PF00179	0.668
TRG_DiLeu_BaEn_1	241	246	PF01217	0.546
TRG_DiLeu_BaLyEn_6	109	114	PF01217	0.576
TRG_DiLeu_BaLyEn_6	462	467	PF01217	0.580
TRG_ENDOCYTIC_2	420	423	PF00928	0.725
TRG_ENDOCYTIC_2	90	93	PF00928	0.605
TRG_ER_diArg_1	220	223	PF00400	0.529
TRG_ER_diArg_1	235	237	PF00400	0.555
TRG_ER_diArg_1	401	403	PF00400	0.748
TRG_ER_diArg_1	515	517	PF00400	0.697
TRG_ER_diArg_1	529	531	PF00400	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4D6	Leptomonas seymouri	34%	100%
A0A3S7WPJ7	Leishmania donovani	87%	100%
A4H4Q1	Leishmania braziliensis	60%	100%
A4HSY1	Leishmania infantum	87%	100%
E9AKW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%