PPM-type phosphatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein phosphatase 2C, putative

Species:

Leishmania major

UniProt:

Q4QIY7_LEIMA

TriTrypDb:

LmjF.06.0900 , LMJLV39_060015300 , LMJSD75_060015400

Length:

1857

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QIY7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016311	dephosphorylation	5	6
GO:0019538	protein metabolic process	3	6
GO:0036211	protein modification process	4	6
GO:0043170	macromolecule metabolic process	3	6

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0004721	phosphoprotein phosphatase activity	3	6
GO:0004722	protein serine/threonine phosphatase activity	4	6
GO:0016787	hydrolase activity	2	6
GO:0016788	hydrolase activity, acting on ester bonds	3	6
GO:0016791	phosphatase activity	5	6
GO:0042578	phosphoric ester hydrolase activity	4	6
GO:0140096	catalytic activity, acting on a protein	2	6

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1156	1160	PF00656	0.728
CLV_C14_Caspase3-7	15	19	PF00656	0.540
CLV_C14_Caspase3-7	1729	1733	PF00656	0.544
CLV_C14_Caspase3-7	1810	1814	PF00656	0.670
CLV_C14_Caspase3-7	1844	1848	PF00656	0.587
CLV_C14_Caspase3-7	187	191	PF00656	0.599
CLV_C14_Caspase3-7	254	258	PF00656	0.671
CLV_C14_Caspase3-7	550	554	PF00656	0.669
CLV_C14_Caspase3-7	616	620	PF00656	0.617
CLV_C14_Caspase3-7	727	731	PF00656	0.443

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H5T2	Leishmania donovani	83%	100%
A4H4Q3	Leishmania braziliensis	53%	88%
A4HSY2	Leishmania infantum	83%	100%
E9AKW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%

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