Aminoacyl-tRNA hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peptidyl-tRNA hydrolase, putative

Species:

Leishmania major

UniProt:

Q4QIY6_LEIMA

TriTrypDb:

LmjF.06.0910 , LMJLV39_060015400 , LMJSD75_060015500

Length:

221

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	3
GO:0005829	cytosol	2	3
GO:0016020	membrane	2	10
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4QIY6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIY6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	17
GO:0004045	aminoacyl-tRNA hydrolase activity	5	17
GO:0016787	hydrolase activity	2	17
GO:0016788	hydrolase activity, acting on ester bonds	3	17
GO:0052689	carboxylic ester hydrolase activity	4	17
GO:0140098	catalytic activity, acting on RNA	3	17
GO:0140101	catalytic activity, acting on a tRNA	4	17
GO:0140640	catalytic activity, acting on a nucleic acid	2	17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	38	40	PF00675	0.665
CLV_NRD_NRD_1	70	72	PF00675	0.435
CLV_NRD_NRD_1	95	97	PF00675	0.265
CLV_PCSK_KEX2_1	70	72	PF00082	0.459
CLV_PCSK_SKI1_1	157	161	PF00082	0.265
CLV_PCSK_SKI1_1	90	94	PF00082	0.308
CLV_PCSK_SKI1_1	97	101	PF00082	0.265
CLV_Separin_Metazoa	36	40	PF03568	0.358
DEG_APCC_DBOX_1	132	140	PF00400	0.416
DEG_Nend_UBRbox_2	1	3	PF02207	0.419
DOC_PP4_FxxP_1	69	72	PF00568	0.601
DOC_USP7_MATH_1	123	127	PF00917	0.561
DOC_USP7_MATH_1	31	35	PF00917	0.396
DOC_WW_Pin1_4	128	133	PF00397	0.600
DOC_WW_Pin1_4	9	14	PF00397	0.493
LIG_14-3-3_CanoR_1	77	83	PF00244	0.679
LIG_14-3-3_CanoR_1	9	13	PF00244	0.405
LIG_Actin_WH2_2	85	102	PF00022	0.443
LIG_BRCT_BRCA1_1	11	15	PF00533	0.336
LIG_BRCT_BRCA1_1	46	50	PF00533	0.464
LIG_FHA_1	213	219	PF00498	0.518
LIG_FHA_1	55	61	PF00498	0.323
LIG_FHA_2	31	37	PF00498	0.366
LIG_LIR_Apic_2	67	72	PF02991	0.593
LIG_LIR_Gen_1	14	23	PF02991	0.399
LIG_LIR_Nem_3	12	18	PF02991	0.388
LIG_OCRL_FandH_1	15	27	PF00620	0.374
LIG_Pex14_1	143	147	PF04695	0.494
LIG_Pex14_2	42	46	PF04695	0.267
LIG_SH2_STAP1	3	7	PF00017	0.432
LIG_SH2_STAT5	183	186	PF00017	0.556
LIG_SH3_3	175	181	PF00018	0.479
LIG_SH3_3	35	41	PF00018	0.419
LIG_SUMO_SIM_anti_2	57	62	PF11976	0.262
LIG_UBA3_1	168	173	PF00899	0.520
MOD_CDK_SPK_2	128	133	PF00069	0.442
MOD_CK1_1	11	17	PF00069	0.498
MOD_CK1_1	126	132	PF00069	0.489
MOD_CK1_1	153	159	PF00069	0.520
MOD_CK2_1	30	36	PF00069	0.412
MOD_CMANNOS	143	146	PF00535	0.286
MOD_GlcNHglycan	133	136	PF01048	0.378
MOD_GlcNHglycan	139	142	PF01048	0.351
MOD_GlcNHglycan	152	155	PF01048	0.243
MOD_GlcNHglycan	33	36	PF01048	0.687
MOD_GSK3_1	124	131	PF00069	0.515
MOD_GSK3_1	50	57	PF00069	0.317
MOD_GSK3_1	78	85	PF00069	0.646
MOD_NEK2_1	124	129	PF00069	0.511
MOD_NEK2_1	50	55	PF00069	0.323
MOD_NEK2_1	64	69	PF00069	0.594
MOD_NEK2_1	99	104	PF00069	0.553
MOD_PIKK_1	188	194	PF00454	0.455
MOD_PKA_2	150	156	PF00069	0.399
MOD_PKA_2	8	14	PF00069	0.402
MOD_Plk_4	11	17	PF00069	0.504
MOD_Plk_4	196	202	PF00069	0.458
MOD_Plk_4	206	212	PF00069	0.476
MOD_Plk_4	50	56	PF00069	0.392
MOD_Plk_4	64	70	PF00069	0.602
MOD_ProDKin_1	128	134	PF00069	0.600
MOD_ProDKin_1	9	15	PF00069	0.493
TRG_ER_diArg_1	69	71	PF00400	0.662

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P574	Leptomonas seymouri	61%	100%
A0A0N1IHT0	Leptomonas seymouri	33%	92%
A0A1X0NKN2	Trypanosomatidae	47%	100%
A0A1X0P1N6	Trypanosomatidae	29%	85%
A0A3Q8IED2	Leishmania donovani	31%	100%
A0A3R7N0D9	Trypanosoma rangeli	49%	100%
A0A3S7WPI5	Leishmania donovani	90%	100%
A4H4Q4	Leishmania braziliensis	76%	100%
A4HIH3	Leishmania braziliensis	30%	100%
A4I5S0	Leishmania infantum	31%	100%
C9ZR39	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	86%
C9ZTL2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AKW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
E9B115	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
Q4Q751	Leishmania major	30%	100%