Vesicle-fusing ATPase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIY5_LEIMA

TriTrypDb:

LmjF.06.0920 , LMJLV39_060015500 , LMJSD75_060015600

Length:

449

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 6

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QIY5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIY5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	298	302	PF00656	0.812
CLV_NRD_NRD_1	103	105	PF00675	0.527
CLV_NRD_NRD_1	141	143	PF00675	0.585
CLV_NRD_NRD_1	204	206	PF00675	0.456
CLV_PCSK_SKI1_1	4	8	PF00082	0.490
DEG_APCC_DBOX_1	403	411	PF00400	0.704
DEG_COP1_1	383	393	PF00400	0.732
DOC_CYCLIN_RxL_1	1	9	PF00134	0.542
DOC_CYCLIN_yCln2_LP_2	370	376	PF00134	0.723
DOC_MAPK_gen_1	104	111	PF00069	0.483
DOC_MAPK_MEF2A_6	104	113	PF00069	0.477
DOC_MAPK_MEF2A_6	226	234	PF00069	0.457
DOC_PP2B_LxvP_1	170	173	PF13499	0.631
DOC_PP2B_LxvP_1	370	373	PF13499	0.708
DOC_PP2B_PxIxI_1	417	423	PF00149	0.726
DOC_USP7_MATH_1	211	215	PF00917	0.410
DOC_USP7_MATH_1	295	299	PF00917	0.791
DOC_USP7_MATH_1	334	338	PF00917	0.759
DOC_USP7_MATH_1	346	350	PF00917	0.764
DOC_USP7_MATH_1	351	355	PF00917	0.726
DOC_USP7_MATH_1	416	420	PF00917	0.703
DOC_USP7_UBL2_3	145	149	PF12436	0.561
DOC_WW_Pin1_4	255	260	PF00397	0.837
DOC_WW_Pin1_4	270	275	PF00397	0.707
DOC_WW_Pin1_4	290	295	PF00397	0.686
LIG_14-3-3_CanoR_1	104	112	PF00244	0.610
LIG_14-3-3_CanoR_1	30	37	PF00244	0.587
LIG_14-3-3_CanoR_1	43	49	PF00244	0.552
LIG_AP2alpha_2	362	364	PF02296	0.759
LIG_BIR_III_2	415	419	PF00653	0.695
LIG_CaM_IQ_9	213	228	PF13499	0.584
LIG_Clathr_ClatBox_1	110	114	PF01394	0.477
LIG_FHA_1	104	110	PF00498	0.578
LIG_FHA_1	127	133	PF00498	0.542
LIG_FHA_1	135	141	PF00498	0.540
LIG_FHA_1	155	161	PF00498	0.270
LIG_FHA_1	213	219	PF00498	0.496
LIG_FHA_1	71	77	PF00498	0.457
LIG_FHA_2	338	344	PF00498	0.636
LIG_LIR_Gen_1	266	275	PF02991	0.618
LIG_LIR_Gen_1	361	372	PF02991	0.759
LIG_LIR_Gen_1	47	56	PF02991	0.557
LIG_LIR_LC3C_4	176	181	PF02991	0.547
LIG_LIR_Nem_3	219	225	PF02991	0.596
LIG_LIR_Nem_3	266	270	PF02991	0.618
LIG_LIR_Nem_3	361	367	PF02991	0.720
LIG_LIR_Nem_3	415	420	PF02991	0.731
LIG_LIR_Nem_3	47	51	PF02991	0.475
LIG_MYND_1	255	259	PF01753	0.849
LIG_NRBOX	40	46	PF00104	0.578
LIG_PDZ_Class_2	444	449	PF00595	0.782
LIG_SH2_CRK	222	226	PF00017	0.649
LIG_SH2_CRK	267	271	PF00017	0.621
LIG_SH2_CRK	331	335	PF00017	0.785
LIG_SH2_CRK	48	52	PF00017	0.464
LIG_SH2_NCK_1	168	172	PF00017	0.571
LIG_SH2_NCK_1	331	335	PF00017	0.785
LIG_SH2_NCK_1	48	52	PF00017	0.521
LIG_SH2_STAP1	168	172	PF00017	0.603
LIG_SH2_STAP1	48	52	PF00017	0.528
LIG_SH2_STAP1	80	84	PF00017	0.590
LIG_SH2_STAT5	124	127	PF00017	0.599
LIG_SH2_STAT5	131	134	PF00017	0.587
LIG_SH2_STAT5	158	161	PF00017	0.441
LIG_SH2_STAT5	168	171	PF00017	0.551
LIG_SH2_STAT5	37	40	PF00017	0.425
LIG_SH2_STAT5	55	58	PF00017	0.458
LIG_SH2_STAT5	64	67	PF00017	0.441
LIG_SH3_2	339	344	PF14604	0.678
LIG_SH3_3	177	183	PF00018	0.524
LIG_SH3_3	247	253	PF00018	0.722
LIG_SH3_3	315	321	PF00018	0.751
LIG_SH3_3	336	342	PF00018	0.765
LIG_SH3_3	370	376	PF00018	0.771
LIG_SH3_3	387	393	PF00018	0.629
LIG_SH3_3	425	431	PF00018	0.739
LIG_SUMO_SIM_anti_2	114	120	PF11976	0.605
LIG_SUMO_SIM_anti_2	176	181	PF11976	0.477
LIG_SUMO_SIM_anti_2	9	15	PF11976	0.474
LIG_TYR_ITIM	220	225	PF00017	0.639
MOD_CDK_SPxxK_3	270	277	PF00069	0.624
MOD_CK1_1	288	294	PF00069	0.843
MOD_CK1_1	337	343	PF00069	0.764
MOD_CK1_1	383	389	PF00069	0.758
MOD_CK1_1	47	53	PF00069	0.549
MOD_CK2_1	138	144	PF00069	0.540
MOD_CK2_1	184	190	PF00069	0.663
MOD_CK2_1	355	361	PF00069	0.781
MOD_GlcNHglycan	186	189	PF01048	0.617
MOD_GlcNHglycan	222	225	PF01048	0.581
MOD_GlcNHglycan	245	248	PF01048	0.713
MOD_GlcNHglycan	259	262	PF01048	0.668
MOD_GlcNHglycan	279	282	PF01048	0.785
MOD_GlcNHglycan	297	300	PF01048	0.878
MOD_GlcNHglycan	334	337	PF01048	0.822
MOD_GlcNHglycan	347	351	PF01048	0.796
MOD_GlcNHglycan	353	356	PF01048	0.845
MOD_GlcNHglycan	358	361	PF01048	0.813
MOD_GlcNHglycan	382	385	PF01048	0.778
MOD_GSK3_1	134	141	PF00069	0.556
MOD_GSK3_1	154	161	PF00069	0.276
MOD_GSK3_1	266	273	PF00069	0.793
MOD_GSK3_1	346	353	PF00069	0.791
MOD_GSK3_1	90	97	PF00069	0.631
MOD_LATS_1	34	40	PF00433	0.443
MOD_N-GLC_1	82	87	PF02516	0.586
MOD_NEK2_1	151	156	PF00069	0.613
MOD_NEK2_1	29	34	PF00069	0.665
MOD_NEK2_1	70	75	PF00069	0.605
MOD_NEK2_2	126	131	PF00069	0.623
MOD_NEK2_2	158	163	PF00069	0.519
MOD_NEK2_2	399	404	PF00069	0.676
MOD_PKA_2	184	190	PF00069	0.663
MOD_PKA_2	220	226	PF00069	0.522
MOD_PKA_2	29	35	PF00069	0.615
MOD_PKA_2	65	71	PF00069	0.514
MOD_PKA_2	97	103	PF00069	0.633
MOD_Plk_1	126	132	PF00069	0.598
MOD_Plk_1	166	172	PF00069	0.591
MOD_Plk_1	211	217	PF00069	0.560
MOD_Plk_4	126	132	PF00069	0.599
MOD_Plk_4	154	160	PF00069	0.467
MOD_Plk_4	383	389	PF00069	0.813
MOD_Plk_4	47	53	PF00069	0.503
MOD_ProDKin_1	255	261	PF00069	0.835
MOD_ProDKin_1	270	276	PF00069	0.708
MOD_ProDKin_1	290	296	PF00069	0.687
MOD_SUMO_rev_2	190	199	PF00179	0.612
TRG_DiLeu_BaEn_1	114	119	PF01217	0.519
TRG_DiLeu_BaEn_1	40	45	PF01217	0.499
TRG_DiLeu_BaEn_1	9	14	PF01217	0.466
TRG_DiLeu_BaEn_2	429	435	PF01217	0.748
TRG_DiLeu_LyEn_5	40	45	PF01217	0.574
TRG_ENDOCYTIC_2	222	225	PF00928	0.647
TRG_ENDOCYTIC_2	267	270	PF00928	0.620
TRG_ENDOCYTIC_2	48	51	PF00928	0.460
TRG_ER_diArg_1	404	407	PF00400	0.679
TRG_Pf-PMV_PEXEL_1	82	86	PF00026	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKD5	Leptomonas seymouri	63%	100%
A0A1X0NKR8	Trypanosomatidae	37%	100%
A0A3R7KW02	Trypanosoma rangeli	37%	100%
A0A3S5H5T3	Leishmania donovani	92%	100%
A4H4Q5	Leishmania braziliensis	73%	96%
A4HSY4	Leishmania infantum	92%	100%
E9AKX0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5BXU6	Trypanosoma cruzi	33%	100%