2,4-dienoyl-coa reductase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2,4-dienoyl-coa reductase-like protein

Species:

Leishmania major

UniProt:

Q4QIY4_LEIMA

TriTrypDb:

LmjF.06.0930 , LMJLV39_060015600 , LMJSD75_060015700

Length:

730

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	18
GO:0110165	cellular anatomical entity	1	18

Expansion

Sequence features

Q4QIY4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIY4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	18
GO:0003824	catalytic activity	1	18
GO:0005488	binding	1	18
GO:0010181	FMN binding	4	18
GO:0016491	oxidoreductase activity	2	18
GO:0032553	ribonucleotide binding	3	18
GO:0036094	small molecule binding	2	18
GO:0043167	ion binding	2	18
GO:0043168	anion binding	3	18
GO:0097159	organic cyclic compound binding	2	18
GO:0097367	carbohydrate derivative binding	2	18
GO:1901265	nucleoside phosphate binding	3	18
GO:1901363	heterocyclic compound binding	2	18
GO:0008670	2,4-dienoyl-CoA reductase (NADPH) activity	5	5
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	5
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	204	208	PF00656	0.567
CLV_C14_Caspase3-7	701	705	PF00656	0.362
CLV_NRD_NRD_1	131	133	PF00675	0.252
CLV_NRD_NRD_1	215	217	PF00675	0.283
CLV_NRD_NRD_1	406	408	PF00675	0.418
CLV_NRD_NRD_1	428	430	PF00675	0.278
CLV_NRD_NRD_1	506	508	PF00675	0.259
CLV_NRD_NRD_1	537	539	PF00675	0.286
CLV_NRD_NRD_1	650	652	PF00675	0.278
CLV_PCSK_KEX2_1	133	135	PF00082	0.223
CLV_PCSK_KEX2_1	215	217	PF00082	0.281
CLV_PCSK_KEX2_1	428	430	PF00082	0.278
CLV_PCSK_KEX2_1	450	452	PF00082	0.422
CLV_PCSK_KEX2_1	506	508	PF00082	0.259
CLV_PCSK_KEX2_1	537	539	PF00082	0.286
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.278
CLV_PCSK_PC1ET2_1	450	452	PF00082	0.422
CLV_PCSK_PC7_1	129	135	PF00082	0.222
CLV_PCSK_SKI1_1	21	25	PF00082	0.339
CLV_PCSK_SKI1_1	346	350	PF00082	0.256
CLV_PCSK_SKI1_1	402	406	PF00082	0.546
CLV_PCSK_SKI1_1	594	598	PF00082	0.332
CLV_PCSK_SKI1_1	651	655	PF00082	0.287
CLV_PCSK_SKI1_1	92	96	PF00082	0.293
DEG_APCC_DBOX_1	241	249	PF00400	0.514
DEG_APCC_DBOX_1	304	312	PF00400	0.445
DEG_APCC_KENBOX_2	454	458	PF00400	0.459
DEG_SCF_FBW7_2	250	257	PF00400	0.462
DOC_CKS1_1	22	27	PF01111	0.457
DOC_CYCLIN_RxL_1	343	351	PF00134	0.434
DOC_CYCLIN_yCln2_LP_2	22	28	PF00134	0.435
DOC_MAPK_gen_1	215	223	PF00069	0.494
DOC_MAPK_gen_1	402	412	PF00069	0.321
DOC_MAPK_gen_1	428	435	PF00069	0.278
DOC_MAPK_gen_1	467	476	PF00069	0.342
DOC_MAPK_gen_1	560	569	PF00069	0.259
DOC_MAPK_gen_1	588	598	PF00069	0.264
DOC_MAPK_gen_1	89	97	PF00069	0.515
DOC_MAPK_MEF2A_6	215	223	PF00069	0.456
DOC_MAPK_MEF2A_6	470	478	PF00069	0.335
DOC_MAPK_MEF2A_6	560	569	PF00069	0.259
DOC_PP2B_LxvP_1	521	524	PF13499	0.303
DOC_PP2B_LxvP_1	587	590	PF13499	0.292
DOC_PP4_FxxP_1	653	656	PF00568	0.342
DOC_USP7_MATH_1	112	116	PF00917	0.485
DOC_USP7_MATH_1	17	21	PF00917	0.392
DOC_USP7_MATH_1	360	364	PF00917	0.517
DOC_USP7_MATH_1	514	518	PF00917	0.319
DOC_USP7_MATH_1	559	563	PF00917	0.315
DOC_USP7_UBL2_3	332	336	PF12436	0.502
DOC_USP7_UBL2_3	681	685	PF12436	0.400
DOC_WW_Pin1_4	139	144	PF00397	0.450
DOC_WW_Pin1_4	21	26	PF00397	0.270
DOC_WW_Pin1_4	250	255	PF00397	0.462
DOC_WW_Pin1_4	280	285	PF00397	0.448
DOC_WW_Pin1_4	581	586	PF00397	0.425
LIG_14-3-3_CanoR_1	134	143	PF00244	0.440
LIG_14-3-3_CanoR_1	150	154	PF00244	0.441
LIG_14-3-3_CanoR_1	384	392	PF00244	0.292
LIG_14-3-3_CanoR_1	407	411	PF00244	0.248
LIG_14-3-3_CanoR_1	470	478	PF00244	0.321
LIG_14-3-3_CanoR_1	506	513	PF00244	0.296
LIG_Actin_WH2_2	234	251	PF00022	0.435
LIG_APCC_ABBA_1	565	570	PF00400	0.259
LIG_BIR_II_1	1	5	PF00653	0.507
LIG_BIR_III_4	207	211	PF00653	0.422
LIG_BIR_III_4	637	641	PF00653	0.390
LIG_BRCT_BRCA1_1	19	23	PF00533	0.363
LIG_BRCT_BRCA1_1	649	653	PF00533	0.254
LIG_FHA_1	108	114	PF00498	0.445
LIG_FHA_1	218	224	PF00498	0.478
LIG_FHA_1	256	262	PF00498	0.432
LIG_FHA_1	324	330	PF00498	0.450
LIG_FHA_1	384	390	PF00498	0.308
LIG_FHA_1	419	425	PF00498	0.301
LIG_FHA_1	464	470	PF00498	0.298
LIG_FHA_1	613	619	PF00498	0.271
LIG_FHA_1	82	88	PF00498	0.422
LIG_FHA_2	202	208	PF00498	0.478
LIG_FHA_2	432	438	PF00498	0.279
LIG_FHA_2	481	487	PF00498	0.322
LIG_HOMEOBOX	677	680	PF00046	0.376
LIG_LIR_Apic_2	152	158	PF02991	0.523
LIG_LIR_Apic_2	650	656	PF02991	0.371
LIG_LIR_Gen_1	167	176	PF02991	0.482
LIG_LIR_Gen_1	456	464	PF02991	0.250
LIG_LIR_Gen_1	674	684	PF02991	0.349
LIG_LIR_Nem_3	167	172	PF02991	0.491
LIG_LIR_Nem_3	178	184	PF02991	0.425
LIG_LIR_Nem_3	20	26	PF02991	0.304
LIG_LIR_Nem_3	456	461	PF02991	0.201
LIG_LIR_Nem_3	693	697	PF02991	0.349
LIG_PCNA_PIPBox_1	59	68	PF02747	0.435
LIG_PCNA_yPIPBox_3	373	384	PF02747	0.326
LIG_PDZ_Class_2	725	730	PF00595	0.337
LIG_PTB_Apo_2	33	40	PF02174	0.515
LIG_PTB_Apo_2	666	673	PF02174	0.422
LIG_PTB_Phospho_1	33	39	PF10480	0.515
LIG_PTB_Phospho_1	666	672	PF10480	0.390
LIG_REV1ctd_RIR_1	63	73	PF16727	0.478
LIG_SH2_CRK	155	159	PF00017	0.422
LIG_SH2_CRK	39	43	PF00017	0.422
LIG_SH2_CRK	458	462	PF00017	0.198
LIG_SH2_GRB2like	44	47	PF00017	0.422
LIG_SH2_SRC	291	294	PF00017	0.515
LIG_SH2_SRC	724	727	PF00017	0.335
LIG_SH2_STAP1	169	173	PF00017	0.478
LIG_SH2_STAT3	380	383	PF00017	0.356
LIG_SH2_STAT3	395	398	PF00017	0.354
LIG_SH2_STAT5	119	122	PF00017	0.515
LIG_SH2_STAT5	135	138	PF00017	0.515
LIG_SH2_STAT5	164	167	PF00017	0.431
LIG_SH2_STAT5	291	294	PF00017	0.467
LIG_SH2_STAT5	354	357	PF00017	0.514
LIG_SH2_STAT5	44	47	PF00017	0.422
LIG_SH2_STAT5	568	571	PF00017	0.291
LIG_SH2_STAT5	697	700	PF00017	0.323
LIG_SH2_STAT5	706	709	PF00017	0.531
LIG_SH3_2	145	150	PF14604	0.470
LIG_SH3_3	142	148	PF00018	0.470
LIG_SH3_3	181	187	PF00018	0.515
LIG_SH3_3	341	347	PF00018	0.515
LIG_SUMO_SIM_anti_2	409	414	PF11976	0.303
LIG_SUMO_SIM_par_1	325	331	PF11976	0.400
LIG_TRAF2_1	483	486	PF00917	0.382
LIG_WRC_WIRS_1	551	556	PF05994	0.390
LIG_WRC_WIRS_1	97	102	PF05994	0.515
MOD_CDK_SPxK_1	21	27	PF00069	0.390
MOD_CDK_SPxxK_3	581	588	PF00069	0.259
MOD_CK1_1	107	113	PF00069	0.437
MOD_CK1_1	138	144	PF00069	0.423
MOD_CK1_1	189	195	PF00069	0.511
MOD_CK1_1	363	369	PF00069	0.561
MOD_CK1_1	4	10	PF00069	0.502
MOD_CK1_1	695	701	PF00069	0.410
MOD_CK2_1	164	170	PF00069	0.453
MOD_CK2_1	390	396	PF00069	0.329
MOD_CK2_1	431	437	PF00069	0.287
MOD_CK2_1	480	486	PF00069	0.352
MOD_Cter_Amidation	535	538	PF01082	0.290
MOD_GlcNHglycan	11	14	PF01048	0.608
MOD_GlcNHglycan	137	140	PF01048	0.294
MOD_GlcNHglycan	199	202	PF01048	0.278
MOD_GlcNHglycan	267	270	PF01048	0.272
MOD_GlcNHglycan	288	291	PF01048	0.340
MOD_GlcNHglycan	392	395	PF01048	0.270
MOD_GSK3_1	1	8	PF00069	0.504
MOD_GSK3_1	135	142	PF00069	0.428
MOD_GSK3_1	17	24	PF00069	0.381
MOD_GSK3_1	197	204	PF00069	0.517
MOD_GSK3_1	223	230	PF00069	0.499
MOD_GSK3_1	280	287	PF00069	0.451
MOD_GSK3_1	293	300	PF00069	0.440
MOD_GSK3_1	323	330	PF00069	0.506
MOD_GSK3_1	418	425	PF00069	0.322
MOD_GSK3_1	559	566	PF00069	0.433
MOD_GSK3_1	577	584	PF00069	0.433
MOD_GSK3_1	698	705	PF00069	0.367
MOD_N-GLC_1	274	279	PF02516	0.274
MOD_N-GLC_1	668	673	PF02516	0.259
MOD_N-GLC_2	373	375	PF02516	0.309
MOD_NEK2_1	1	6	PF00069	0.528
MOD_NEK2_1	197	202	PF00069	0.456
MOD_NEK2_1	217	222	PF00069	0.328
MOD_NEK2_1	255	260	PF00069	0.514
MOD_NEK2_1	265	270	PF00069	0.415
MOD_NEK2_1	273	278	PF00069	0.441
MOD_NEK2_1	297	302	PF00069	0.458
MOD_NEK2_1	469	474	PF00069	0.261
MOD_NEK2_1	529	534	PF00069	0.259
MOD_NEK2_2	692	697	PF00069	0.507
MOD_PIKK_1	107	113	PF00454	0.400
MOD_PIKK_1	612	618	PF00454	0.226
MOD_PK_1	470	476	PF00069	0.390
MOD_PKA_1	506	512	PF00069	0.259
MOD_PKA_2	107	113	PF00069	0.455
MOD_PKA_2	149	155	PF00069	0.566
MOD_PKA_2	306	312	PF00069	0.452
MOD_PKA_2	383	389	PF00069	0.296
MOD_PKA_2	406	412	PF00069	0.390
MOD_PKA_2	469	475	PF00069	0.290
MOD_PKA_2	506	512	PF00069	0.262
MOD_PKA_2	559	565	PF00069	0.279
MOD_PKA_2	702	708	PF00069	0.459
MOD_Plk_1	217	223	PF00069	0.515
MOD_Plk_1	274	280	PF00069	0.507
MOD_Plk_1	363	369	PF00069	0.538
MOD_Plk_1	431	437	PF00069	0.247
MOD_Plk_1	563	569	PF00069	0.259
MOD_Plk_1	668	674	PF00069	0.290
MOD_Plk_1	692	698	PF00069	0.396
MOD_Plk_4	157	163	PF00069	0.407
MOD_Plk_4	189	195	PF00069	0.529
MOD_Plk_4	422	428	PF00069	0.284
MOD_Plk_4	431	437	PF00069	0.290
MOD_Plk_4	550	556	PF00069	0.272
MOD_Plk_4	563	569	PF00069	0.228
MOD_Plk_4	577	583	PF00069	0.397
MOD_Plk_4	594	600	PF00069	0.359
MOD_Plk_4	623	629	PF00069	0.261
MOD_Plk_4	656	662	PF00069	0.317
MOD_Plk_4	671	677	PF00069	0.351
MOD_ProDKin_1	139	145	PF00069	0.450
MOD_ProDKin_1	21	27	PF00069	0.270
MOD_ProDKin_1	250	256	PF00069	0.462
MOD_ProDKin_1	280	286	PF00069	0.448
MOD_ProDKin_1	581	587	PF00069	0.425
TRG_DiLeu_BaEn_1	577	582	PF01217	0.390
TRG_DiLeu_BaLyEn_6	344	349	PF01217	0.419
TRG_DiLeu_BaLyEn_6	517	522	PF01217	0.371
TRG_ENDOCYTIC_2	169	172	PF00928	0.478
TRG_ENDOCYTIC_2	44	47	PF00928	0.422
TRG_ENDOCYTIC_2	458	461	PF00928	0.239
TRG_ENDOCYTIC_2	677	680	PF00928	0.397
TRG_ER_diArg_1	132	135	PF00400	0.387
TRG_ER_diArg_1	215	217	PF00400	0.467
TRG_ER_diArg_1	427	429	PF00400	0.278
TRG_ER_diArg_1	505	507	PF00400	0.259
TRG_ER_diArg_1	537	539	PF00400	0.286
TRG_NLS_MonoExtN_4	129	136	PF00514	0.515
TRG_Pf-PMV_PEXEL_1	346	351	PF00026	0.237
TRG_Pf-PMV_PEXEL_1	467	471	PF00026	0.303

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P302	Leptomonas seymouri	31%	100%
A0A0N0P5L6	Leptomonas seymouri	84%	100%
A0A0S4JCH5	Bodo saltans	55%	100%
A0A0S4JST7	Bodo saltans	32%	100%
A0A1X0NKW1	Trypanosomatidae	68%	100%
A0A1X0NU55	Trypanosomatidae	32%	100%
A0A3S5H5T4	Leishmania donovani	97%	100%
A0A3S7X6G9	Leishmania donovani	32%	100%
A4H4Q6	Leishmania braziliensis	92%	99%
A4HLD7	Leishmania braziliensis	31%	100%
A4HSY5	Leishmania infantum	97%	100%
A4I8U6	Leishmania infantum	32%	100%
A4J778	Desulforamulus reducens (strain ATCC BAA-1160 / DSM 100696 / MI-1)	28%	100%
C9ZTL4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9AKX1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9B3R5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
G9F1Y9	Clostridium sporogenes (strain ATCC 7955 / DSM 767 / NBRC 16411 / NCIMB 8053 / NCTC 8594 / PA 3679)	27%	100%
P16099	Methylophilus methylotrophus	25%	100%
P19410	Clostridium scindens (strain JCM 10418 / VPI 12708)	28%	100%
P32370	Clostridium scindens (strain JCM 10418 / VPI 12708)	28%	100%
P32382	Thermoanaerobacter brockii	28%	100%
P42593	Escherichia coli (strain K12)	31%	100%
Q48303	Hyphomicrobium sp. (strain x)	26%	99%
Q4Q4A9	Leishmania major	32%	100%
V5AR23	Trypanosoma cruzi	32%	100%
V5BNI9	Trypanosoma cruzi	70%	100%