TLDc domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIY3_LEIMA

TriTrypDb:

LmjF.06.0940 , LMJLV39_060015700 , LMJSD75_060015800 , LMJSD75_060015900

Length:

593

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QIY3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIY3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.471
CLV_C14_Caspase3-7	129	133	PF00656	0.502
CLV_C14_Caspase3-7	489	493	PF00656	0.784
CLV_C14_Caspase3-7	531	535	PF00656	0.672
CLV_NRD_NRD_1	16	18	PF00675	0.638
CLV_NRD_NRD_1	199	201	PF00675	0.779
CLV_NRD_NRD_1	422	424	PF00675	0.469
CLV_NRD_NRD_1	52	54	PF00675	0.655
CLV_PCSK_KEX2_1	199	201	PF00082	0.779
CLV_PCSK_KEX2_1	524	526	PF00082	0.567
CLV_PCSK_PC1ET2_1	524	526	PF00082	0.674
CLV_PCSK_SKI1_1	18	22	PF00082	0.555
CLV_PCSK_SKI1_1	305	309	PF00082	0.655
DEG_APCC_DBOX_1	88	96	PF00400	0.579
DEG_COP1_1	474	483	PF00400	0.503
DEG_Nend_Nbox_1	1	3	PF02207	0.641
DEG_SPOP_SBC_1	170	174	PF00917	0.519
DEG_SPOP_SBC_1	288	292	PF00917	0.711
DEG_SPOP_SBC_1	365	369	PF00917	0.535
DEG_SPOP_SBC_1	40	44	PF00917	0.496
DOC_CKS1_1	74	79	PF01111	0.521
DOC_CKS1_1	80	85	PF01111	0.480
DOC_CYCLIN_yClb1_LxF_4	107	112	PF00134	0.453
DOC_CYCLIN_yCln2_LP_2	346	349	PF00134	0.586
DOC_CYCLIN_yCln2_LP_2	395	401	PF00134	0.692
DOC_MAPK_DCC_7	500	510	PF00069	0.684
DOC_PP1_RVXF_1	107	113	PF00149	0.448
DOC_PP1_RVXF_1	137	144	PF00149	0.567
DOC_PP1_RVXF_1	512	519	PF00149	0.448
DOC_PP2B_LxvP_1	179	182	PF13499	0.508
DOC_PP2B_LxvP_1	32	35	PF13499	0.471
DOC_PP2B_LxvP_1	346	349	PF13499	0.586
DOC_PP4_FxxP_1	462	465	PF00568	0.572
DOC_PP4_FxxP_1	589	592	PF00568	0.671
DOC_PP4_FxxP_1	74	77	PF00568	0.487
DOC_USP7_MATH_1	133	137	PF00917	0.626
DOC_USP7_MATH_1	164	168	PF00917	0.671
DOC_USP7_MATH_1	193	197	PF00917	0.633
DOC_USP7_MATH_1	288	292	PF00917	0.774
DOC_USP7_MATH_1	319	323	PF00917	0.781
DOC_USP7_MATH_1	329	333	PF00917	0.685
DOC_USP7_MATH_1	364	368	PF00917	0.662
DOC_USP7_MATH_1	372	376	PF00917	0.627
DOC_USP7_MATH_1	40	44	PF00917	0.597
DOC_USP7_MATH_1	45	49	PF00917	0.564
DOC_USP7_MATH_1	475	479	PF00917	0.610
DOC_USP7_MATH_1	533	537	PF00917	0.676
DOC_USP7_MATH_1	553	557	PF00917	0.690
DOC_WW_Pin1_4	160	165	PF00397	0.676
DOC_WW_Pin1_4	171	176	PF00397	0.601
DOC_WW_Pin1_4	214	219	PF00397	0.454
DOC_WW_Pin1_4	341	346	PF00397	0.675
DOC_WW_Pin1_4	356	361	PF00397	0.683
DOC_WW_Pin1_4	384	389	PF00397	0.672
DOC_WW_Pin1_4	490	495	PF00397	0.717
DOC_WW_Pin1_4	570	575	PF00397	0.693
DOC_WW_Pin1_4	73	78	PF00397	0.516
DOC_WW_Pin1_4	79	84	PF00397	0.479
DOC_WW_Pin1_4	97	102	PF00397	0.267
LIG_14-3-3_CanoR_1	102	107	PF00244	0.480
LIG_14-3-3_CanoR_1	528	537	PF00244	0.738
LIG_BRCT_BRCA1_1	115	119	PF00533	0.499
LIG_CSL_BTD_1	179	182	PF09270	0.508
LIG_FHA_1	215	221	PF00498	0.469
LIG_FHA_1	290	296	PF00498	0.583
LIG_FHA_1	500	506	PF00498	0.597
LIG_FHA_1	556	562	PF00498	0.710
LIG_FHA_1	80	86	PF00498	0.543
LIG_FHA_2	112	118	PF00498	0.458
LIG_FHA_2	255	261	PF00498	0.649
LIG_FHA_2	455	461	PF00498	0.478
LIG_FHA_2	557	563	PF00498	0.794
LIG_FHA_2	74	80	PF00498	0.616
LIG_LIR_Apic_2	460	465	PF02991	0.446
LIG_LIR_Nem_3	100	106	PF02991	0.563
LIG_LIR_Nem_3	140	146	PF02991	0.436
LIG_LYPXL_SIV_4	300	308	PF13949	0.657
LIG_MYND_1	345	349	PF01753	0.705
LIG_MYND_1	354	358	PF01753	0.588
LIG_Pex14_1	108	112	PF04695	0.452
LIG_Pex14_1	458	462	PF04695	0.458
LIG_Pex14_2	143	147	PF04695	0.432
LIG_PTB_Apo_2	419	426	PF02174	0.504
LIG_SH2_CRK	303	307	PF00017	0.783
LIG_SH2_STAP1	303	307	PF00017	0.741
LIG_SH2_STAT5	231	234	PF00017	0.531
LIG_SH2_STAT5	445	448	PF00017	0.579
LIG_SH3_1	403	409	PF00018	0.692
LIG_SH3_2	398	403	PF14604	0.761
LIG_SH3_3	215	221	PF00018	0.469
LIG_SH3_3	313	319	PF00018	0.648
LIG_SH3_3	342	348	PF00018	0.606
LIG_SH3_3	382	388	PF00018	0.665
LIG_SH3_3	395	401	PF00018	0.716
LIG_SH3_3	403	409	PF00018	0.573
LIG_SH3_3	424	430	PF00018	0.440
LIG_SH3_3	495	501	PF00018	0.542
LIG_SH3_3	569	575	PF00018	0.711
LIG_SH3_3	78	84	PF00018	0.529
LIG_SUMO_SIM_par_1	94	100	PF11976	0.472
LIG_TRFH_1	177	181	PF08558	0.526
LIG_WW_2	83	86	PF00397	0.531
MOD_CDC14_SPxK_1	359	362	PF00782	0.789
MOD_CDK_SPK_2	384	389	PF00069	0.667
MOD_CDK_SPK_2	97	102	PF00069	0.489
MOD_CDK_SPxK_1	356	362	PF00069	0.787
MOD_CDK_SPxxK_3	384	391	PF00069	0.749
MOD_CK1_1	120	126	PF00069	0.456
MOD_CK1_1	169	175	PF00069	0.671
MOD_CK1_1	234	240	PF00069	0.461
MOD_CK1_1	322	328	PF00069	0.813
MOD_CK1_1	479	485	PF00069	0.633
MOD_CK1_1	486	492	PF00069	0.654
MOD_CK1_1	536	542	PF00069	0.675
MOD_CK1_1	551	557	PF00069	0.668
MOD_CK2_1	186	192	PF00069	0.778
MOD_CK2_1	254	260	PF00069	0.775
MOD_CK2_1	40	46	PF00069	0.498
MOD_CK2_1	454	460	PF00069	0.451
MOD_CK2_1	516	522	PF00069	0.454
MOD_CK2_1	85	91	PF00069	0.505
MOD_GlcNHglycan	168	171	PF01048	0.693
MOD_GlcNHglycan	43	46	PF01048	0.665
MOD_GlcNHglycan	439	442	PF01048	0.458
MOD_GlcNHglycan	47	50	PF01048	0.679
MOD_GlcNHglycan	473	476	PF01048	0.595
MOD_GlcNHglycan	488	491	PF01048	0.778
MOD_GlcNHglycan	494	497	PF01048	0.570
MOD_GlcNHglycan	502	505	PF01048	0.670
MOD_GlcNHglycan	530	533	PF01048	0.522
MOD_GlcNHglycan	538	541	PF01048	0.604
MOD_GlcNHglycan	553	556	PF01048	0.501
MOD_GSK3_1	113	120	PF00069	0.565
MOD_GSK3_1	133	140	PF00069	0.280
MOD_GSK3_1	154	161	PF00069	0.605
MOD_GSK3_1	164	171	PF00069	0.750
MOD_GSK3_1	243	250	PF00069	0.697
MOD_GSK3_1	336	343	PF00069	0.607
MOD_GSK3_1	41	48	PF00069	0.566
MOD_GSK3_1	454	461	PF00069	0.419
MOD_GSK3_1	471	478	PF00069	0.486
MOD_GSK3_1	479	486	PF00069	0.711
MOD_GSK3_1	551	558	PF00069	0.719
MOD_GSK3_1	562	569	PF00069	0.694
MOD_N-GLC_1	490	495	PF02516	0.541
MOD_NEK2_1	119	124	PF00069	0.461
MOD_NEK2_1	168	173	PF00069	0.719
MOD_NEK2_1	208	213	PF00069	0.588
MOD_NEK2_1	340	345	PF00069	0.749
MOD_NEK2_1	483	488	PF00069	0.708
MOD_NEK2_1	510	515	PF00069	0.451
MOD_NEK2_1	59	64	PF00069	0.664
MOD_NEK2_2	373	378	PF00069	0.574
MOD_OFUCOSY	545	552	PF10250	0.684
MOD_PIKK_1	133	139	PF00454	0.619
MOD_PIKK_1	262	268	PF00454	0.519
MOD_PKA_1	261	267	PF00069	0.524
MOD_PKA_2	322	328	PF00069	0.776
MOD_PKA_2	499	505	PF00069	0.634
MOD_PKA_2	548	554	PF00069	0.689
MOD_Plk_1	336	342	PF00069	0.639
MOD_Plk_1	475	481	PF00069	0.506
MOD_Plk_1	533	539	PF00069	0.658
MOD_Plk_4	120	126	PF00069	0.456
MOD_Plk_4	208	214	PF00069	0.538
MOD_Plk_4	234	240	PF00069	0.547
MOD_Plk_4	336	342	PF00069	0.680
MOD_Plk_4	479	485	PF00069	0.704
MOD_Plk_4	576	582	PF00069	0.789
MOD_ProDKin_1	160	166	PF00069	0.679
MOD_ProDKin_1	171	177	PF00069	0.605
MOD_ProDKin_1	214	220	PF00069	0.454
MOD_ProDKin_1	341	347	PF00069	0.675
MOD_ProDKin_1	356	362	PF00069	0.686
MOD_ProDKin_1	384	390	PF00069	0.669
MOD_ProDKin_1	490	496	PF00069	0.717
MOD_ProDKin_1	570	576	PF00069	0.691
MOD_ProDKin_1	73	79	PF00069	0.512
MOD_ProDKin_1	97	103	PF00069	0.447
MOD_SUMO_rev_2	129	136	PF00179	0.611
MOD_SUMO_rev_2	258	264	PF00179	0.529
MOD_SUMO_rev_2	327	335	PF00179	0.561
MOD_SUMO_rev_2	519	526	PF00179	0.368
TRG_DiLeu_BaLyEn_6	342	347	PF01217	0.717
TRG_DiLeu_BaLyEn_6	391	396	PF01217	0.770
TRG_DiLeu_BaLyEn_6	406	411	PF01217	0.481
TRG_DiLeu_LyEn_5	351	356	PF01217	0.662
TRG_ENDOCYTIC_2	125	128	PF00928	0.474
TRG_ENDOCYTIC_2	303	306	PF00928	0.731
TRG_ER_diArg_1	199	201	PF00400	0.771
TRG_ER_diArg_1	388	391	PF00400	0.754

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P572	Leptomonas seymouri	41%	90%
A0A3S7WPK2	Leishmania donovani	87%	100%
A4H4Q7	Leishmania braziliensis	60%	90%
A4HSY6	Leishmania infantum	87%	100%
E9AKX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%