Leucine-rich repeat protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Leucine Rich Repeat, putative

Species:

Leishmania major

UniProt:

Q4QIX9_LEIMA

TriTrypDb:

LmjF.06.0980 , LMJLV39_060016100 , LMJSD75_060016300

Length:

1031

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11

Expansion

Sequence features

Q4QIX9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIX9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	385	389	PF00656	0.445
CLV_C14_Caspase3-7	623	627	PF00656	0.693
CLV_C14_Caspase3-7	658	662	PF00656	0.742
CLV_NRD_NRD_1	1001	1003	PF00675	0.686
CLV_NRD_NRD_1	1017	1019	PF00675	0.729
CLV_NRD_NRD_1	474	476	PF00675	0.637
CLV_NRD_NRD_1	629	631	PF00675	0.689
CLV_NRD_NRD_1	875	877	PF00675	0.685
CLV_PCSK_FUR_1	187	191	PF00082	0.573
CLV_PCSK_KEX2_1	1001	1003	PF00082	0.654
CLV_PCSK_KEX2_1	1017	1019	PF00082	0.741
CLV_PCSK_KEX2_1	189	191	PF00082	0.578
CLV_PCSK_KEX2_1	211	213	PF00082	0.585
CLV_PCSK_KEX2_1	286	288	PF00082	0.730
CLV_PCSK_KEX2_1	359	361	PF00082	0.517
CLV_PCSK_KEX2_1	474	476	PF00082	0.646
CLV_PCSK_KEX2_1	629	631	PF00082	0.681
CLV_PCSK_KEX2_1	653	655	PF00082	0.630
CLV_PCSK_KEX2_1	869	871	PF00082	0.704
CLV_PCSK_KEX2_1	875	877	PF00082	0.679
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.578
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.595
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.730
CLV_PCSK_PC1ET2_1	359	361	PF00082	0.517
CLV_PCSK_PC1ET2_1	653	655	PF00082	0.688
CLV_PCSK_PC1ET2_1	869	871	PF00082	0.815
CLV_PCSK_SKI1_1	1017	1021	PF00082	0.731
CLV_PCSK_SKI1_1	145	149	PF00082	0.519
CLV_PCSK_SKI1_1	283	287	PF00082	0.647
CLV_PCSK_SKI1_1	475	479	PF00082	0.614
CLV_PCSK_SKI1_1	514	518	PF00082	0.596
CLV_PCSK_SKI1_1	521	525	PF00082	0.508
CLV_PCSK_SKI1_1	526	530	PF00082	0.552
CLV_PCSK_SKI1_1	549	553	PF00082	0.455
CLV_PCSK_SKI1_1	554	558	PF00082	0.453
CLV_PCSK_SKI1_1	608	612	PF00082	0.657
CLV_PCSK_SKI1_1	71	75	PF00082	0.601
CLV_PCSK_SKI1_1	738	742	PF00082	0.546
CLV_PCSK_SKI1_1	756	760	PF00082	0.442
CLV_PCSK_SKI1_1	869	873	PF00082	0.832
DEG_APCC_DBOX_1	211	219	PF00400	0.567
DEG_APCC_DBOX_1	854	862	PF00400	0.731
DEG_SPOP_SBC_1	27	31	PF00917	0.741
DOC_AGCK_PIF_3	1028	1031	PF00069	0.735
DOC_CDC14_PxL_1	113	121	PF14671	0.480
DOC_CDC14_PxL_1	135	143	PF14671	0.543
DOC_CDC14_PxL_1	528	536	PF14671	0.576
DOC_CYCLIN_RxL_1	137	148	PF00134	0.565
DOC_CYCLIN_RxL_1	259	268	PF00134	0.545
DOC_CYCLIN_RxL_1	472	481	PF00134	0.610
DOC_CYCLIN_RxL_1	82	94	PF00134	0.512
DOC_MAPK_FxFP_2	522	525	PF00069	0.572
DOC_MAPK_gen_1	105	114	PF00069	0.411
DOC_MAPK_gen_1	187	196	PF00069	0.544
DOC_MAPK_gen_1	211	220	PF00069	0.562
DOC_MAPK_gen_1	262	269	PF00069	0.493
DOC_MAPK_gen_1	453	460	PF00069	0.633
DOC_MAPK_gen_1	464	473	PF00069	0.556
DOC_MAPK_gen_1	629	636	PF00069	0.653
DOC_MAPK_MEF2A_6	105	114	PF00069	0.441
DOC_MAPK_MEF2A_6	453	460	PF00069	0.618
DOC_PP1_RVXF_1	1015	1022	PF00149	0.725
DOC_PP1_RVXF_1	260	267	PF00149	0.555
DOC_PP1_RVXF_1	434	441	PF00149	0.572
DOC_PP1_RVXF_1	552	559	PF00149	0.461
DOC_PP1_RVXF_1	639	646	PF00149	0.583
DOC_PP1_RVXF_1	754	761	PF00149	0.597
DOC_PP1_SILK_1	922	927	PF00149	0.648
DOC_PP2B_LxvP_1	251	254	PF13499	0.565
DOC_PP2B_LxvP_1	789	792	PF13499	0.763
DOC_PP2B_PxIxI_1	175	181	PF00149	0.529
DOC_PP2B_PxIxI_1	882	888	PF00149	0.612
DOC_PP4_FxxP_1	227	230	PF00568	0.558
DOC_PP4_FxxP_1	522	525	PF00568	0.572
DOC_PP4_FxxP_1	827	830	PF00568	0.771
DOC_USP7_MATH_1	1000	1004	PF00917	0.700
DOC_USP7_MATH_1	1012	1016	PF00917	0.688
DOC_USP7_MATH_1	128	132	PF00917	0.531
DOC_USP7_MATH_1	27	31	PF00917	0.741
DOC_USP7_MATH_1	333	337	PF00917	0.764
DOC_USP7_MATH_1	419	423	PF00917	0.670
DOC_USP7_MATH_1	713	717	PF00917	0.622
DOC_USP7_MATH_1	830	834	PF00917	0.738
DOC_USP7_MATH_1	839	843	PF00917	0.722
DOC_USP7_MATH_1	864	868	PF00917	0.647
DOC_USP7_MATH_1	939	943	PF00917	0.692
DOC_USP7_UBL2_3	189	193	PF12436	0.475
DOC_USP7_UBL2_3	373	377	PF12436	0.537
DOC_USP7_UBL2_3	816	820	PF12436	0.797
DOC_WW_Pin1_4	28	33	PF00397	0.781
DOC_WW_Pin1_4	447	452	PF00397	0.636
LIG_14-3-3_CanoR_1	1017	1022	PF00244	0.775
LIG_14-3-3_CanoR_1	121	127	PF00244	0.467
LIG_14-3-3_CanoR_1	140	145	PF00244	0.493
LIG_14-3-3_CanoR_1	212	220	PF00244	0.469
LIG_14-3-3_CanoR_1	360	364	PF00244	0.485
LIG_14-3-3_CanoR_1	464	469	PF00244	0.630
LIG_14-3-3_CanoR_1	71	77	PF00244	0.413
LIG_14-3-3_CanoR_1	794	799	PF00244	0.702
LIG_14-3-3_CanoR_1	848	856	PF00244	0.749
LIG_14-3-3_CanoR_1	870	874	PF00244	0.777
LIG_APCC_ABBA_1	933	938	PF00400	0.651
LIG_BRCT_BRCA1_1	30	34	PF00533	0.732
LIG_Clathr_ClatBox_1	907	911	PF01394	0.590
LIG_deltaCOP1_diTrp_1	642	651	PF00928	0.589
LIG_deltaCOP1_diTrp_1	693	699	PF00928	0.429
LIG_deltaCOP1_diTrp_1	744	754	PF00928	0.620
LIG_DLG_GKlike_1	140	147	PF00625	0.536
LIG_eIF4E_1	902	908	PF01652	0.582
LIG_FHA_1	274	280	PF00498	0.483
LIG_FHA_1	333	339	PF00498	0.740
LIG_FHA_1	351	357	PF00498	0.609
LIG_FHA_1	405	411	PF00498	0.552
LIG_FHA_1	477	483	PF00498	0.655
LIG_FHA_1	676	682	PF00498	0.661
LIG_FHA_1	773	779	PF00498	0.683
LIG_FHA_1	794	800	PF00498	0.750
LIG_FHA_1	848	854	PF00498	0.611
LIG_FHA_1	882	888	PF00498	0.616
LIG_FHA_1	894	900	PF00498	0.580
LIG_FHA_2	146	152	PF00498	0.551
LIG_FHA_2	214	220	PF00498	0.514
LIG_FHA_2	224	230	PF00498	0.558
LIG_FHA_2	465	471	PF00498	0.660
LIG_FHA_2	515	521	PF00498	0.642
LIG_FHA_2	525	531	PF00498	0.509
LIG_FHA_2	591	597	PF00498	0.578
LIG_FHA_2	684	690	PF00498	0.679
LIG_IRF3_LxIS_1	215	221	PF10401	0.459
LIG_LIR_Apic_2	226	230	PF02991	0.555
LIG_LIR_Apic_2	520	525	PF02991	0.582
LIG_LIR_Gen_1	553	563	PF02991	0.520
LIG_LIR_Gen_1	691	700	PF02991	0.629
LIG_LIR_Nem_3	1025	1031	PF02991	0.720
LIG_LIR_Nem_3	125	129	PF02991	0.459
LIG_LIR_Nem_3	425	429	PF02991	0.553
LIG_LIR_Nem_3	491	497	PF02991	0.558
LIG_LIR_Nem_3	553	558	PF02991	0.487
LIG_LIR_Nem_3	604	610	PF02991	0.657
LIG_LIR_Nem_3	642	648	PF02991	0.596
LIG_LIR_Nem_3	751	757	PF02991	0.542
LIG_MYND_1	826	830	PF01753	0.553
LIG_MYND_3	531	535	PF01753	0.465
LIG_Pex14_1	932	936	PF04695	0.599
LIG_PTB_Apo_2	805	812	PF02174	0.784
LIG_REV1ctd_RIR_1	230	237	PF16727	0.645
LIG_SH2_CRK	566	570	PF00017	0.582
LIG_SH2_CRK	581	585	PF00017	0.518
LIG_SH2_CRK	922	926	PF00017	0.686
LIG_SH2_NCK_1	936	940	PF00017	0.691
LIG_SH2_SRC	936	939	PF00017	0.689
LIG_SH2_STAP1	566	570	PF00017	0.605
LIG_SH2_STAP1	936	940	PF00017	0.649
LIG_SH2_STAP1	992	996	PF00017	0.745
LIG_SH2_STAT3	951	954	PF00017	0.670
LIG_SH2_STAT5	374	377	PF00017	0.483
LIG_SH2_STAT5	494	497	PF00017	0.569
LIG_SH2_STAT5	555	558	PF00017	0.458
LIG_SH2_STAT5	757	760	PF00017	0.535
LIG_SH2_STAT5	777	780	PF00017	0.743
LIG_SH2_STAT5	817	820	PF00017	0.671
LIG_SH2_STAT5	940	943	PF00017	0.605
LIG_SH2_STAT5	951	954	PF00017	0.622
LIG_SH3_3	111	117	PF00018	0.429
LIG_SH3_3	349	355	PF00018	0.584
LIG_SH3_3	408	414	PF00018	0.514
LIG_SH3_3	52	58	PF00018	0.566
LIG_SH3_3	566	572	PF00018	0.555
LIG_SH3_3	775	781	PF00018	0.686
LIG_SH3_3	823	829	PF00018	0.698
LIG_SH3_3	954	960	PF00018	0.722
LIG_SUMO_SIM_anti_2	275	281	PF11976	0.491
LIG_SUMO_SIM_anti_2	52	57	PF11976	0.594
LIG_SUMO_SIM_anti_2	575	580	PF11976	0.562
LIG_SUMO_SIM_anti_2	911	917	PF11976	0.705
LIG_SUMO_SIM_par_1	140	146	PF11976	0.497
LIG_SUMO_SIM_par_1	769	776	PF11976	0.486
LIG_TRAF2_1	309	312	PF00917	0.796
LIG_TRAF2_1	783	786	PF00917	0.774
LIG_TYR_ITIM	579	584	PF00017	0.592
LIG_WRC_WIRS_1	607	612	PF05994	0.684
MOD_CDC14_SPxK_1	450	453	PF00782	0.671
MOD_CDK_SPxK_1	447	453	PF00069	0.671
MOD_CK1_1	1023	1029	PF00069	0.728
MOD_CK1_1	143	149	PF00069	0.493
MOD_CK1_1	293	299	PF00069	0.713
MOD_CK1_1	332	338	PF00069	0.688
MOD_CK1_1	341	347	PF00069	0.677
MOD_CK1_1	350	356	PF00069	0.495
MOD_CK1_1	401	407	PF00069	0.545
MOD_CK1_1	6	12	PF00069	0.682
MOD_CK1_1	716	722	PF00069	0.538
MOD_CK1_1	857	863	PF00069	0.724
MOD_CK2_1	150	156	PF00069	0.467
MOD_CK2_1	237	243	PF00069	0.481
MOD_CK2_1	419	425	PF00069	0.671
MOD_CK2_1	464	470	PF00069	0.666
MOD_CK2_1	497	503	PF00069	0.626
MOD_CK2_1	514	520	PF00069	0.598
MOD_CK2_1	524	530	PF00069	0.601
MOD_CK2_1	590	596	PF00069	0.608
MOD_CK2_1	683	689	PF00069	0.693
MOD_CK2_1	830	836	PF00069	0.760
MOD_CMANNOS	440	443	PF00535	0.523
MOD_Cter_Amidation	1015	1018	PF01082	0.770
MOD_GlcNHglycan	10	13	PF01048	0.738
MOD_GlcNHglycan	1010	1013	PF01048	0.654
MOD_GlcNHglycan	1014	1017	PF01048	0.679
MOD_GlcNHglycan	1022	1025	PF01048	0.699
MOD_GlcNHglycan	219	223	PF01048	0.522
MOD_GlcNHglycan	326	329	PF01048	0.744
MOD_GlcNHglycan	331	334	PF01048	0.713
MOD_GlcNHglycan	35	38	PF01048	0.701
MOD_GlcNHglycan	42	45	PF01048	0.614
MOD_GlcNHglycan	47	51	PF01048	0.486
MOD_GlcNHglycan	637	640	PF01048	0.674
MOD_GlcNHglycan	657	660	PF01048	0.722
MOD_GlcNHglycan	668	671	PF01048	0.702
MOD_GlcNHglycan	701	704	PF01048	0.621
MOD_GlcNHglycan	812	816	PF01048	0.753
MOD_GlcNHglycan	840	844	PF01048	0.779
MOD_GlcNHglycan	850	853	PF01048	0.782
MOD_GlcNHglycan	974	978	PF01048	0.753
MOD_GSK3_1	1008	1015	PF00069	0.651
MOD_GSK3_1	12	19	PF00069	0.734
MOD_GSK3_1	214	221	PF00069	0.434
MOD_GSK3_1	233	240	PF00069	0.544
MOD_GSK3_1	299	306	PF00069	0.782
MOD_GSK3_1	329	336	PF00069	0.672
MOD_GSK3_1	4	11	PF00069	0.758
MOD_GSK3_1	447	454	PF00069	0.619
MOD_GSK3_1	666	673	PF00069	0.738
MOD_GSK3_1	712	719	PF00069	0.589
MOD_GSK3_1	72	79	PF00069	0.455
MOD_GSK3_1	807	814	PF00069	0.659
MOD_GSK3_1	844	851	PF00069	0.703
MOD_N-GLC_1	122	127	PF02516	0.388
MOD_N-GLC_1	249	254	PF02516	0.569
MOD_N-GLC_1	293	298	PF02516	0.709
MOD_N-GLC_1	395	400	PF02516	0.543
MOD_N-GLC_1	4	9	PF02516	0.787
MOD_N-GLC_1	447	452	PF02516	0.624
MOD_N-GLC_1	807	812	PF02516	0.641
MOD_N-GLC_2	737	739	PF02516	0.621
MOD_NEK2_1	10	15	PF00069	0.769
MOD_NEK2_1	213	218	PF00069	0.525
MOD_NEK2_1	233	238	PF00069	0.427
MOD_NEK2_1	249	254	PF00069	0.497
MOD_NEK2_1	635	640	PF00069	0.634
MOD_NEK2_1	655	660	PF00069	0.644
MOD_NEK2_1	69	74	PF00069	0.577
MOD_NEK2_1	699	704	PF00069	0.560
MOD_NEK2_1	726	731	PF00069	0.520
MOD_NEK2_1	76	81	PF00069	0.441
MOD_NEK2_1	811	816	PF00069	0.739
MOD_NEK2_1	925	930	PF00069	0.611
MOD_NEK2_2	128	133	PF00069	0.524
MOD_NEK2_2	395	400	PF00069	0.566
MOD_NEK2_2	582	587	PF00069	0.565
MOD_NMyristoyl	1	7	PF02799	0.715
MOD_PIKK_1	350	356	PF00454	0.642
MOD_PIKK_1	417	423	PF00454	0.696
MOD_PIKK_1	688	694	PF00454	0.621
MOD_PIKK_1	925	931	PF00454	0.662
MOD_PIKK_1	983	989	PF00454	0.724
MOD_PKA_1	1017	1023	PF00069	0.696
MOD_PKA_1	359	365	PF00069	0.517
MOD_PKA_1	869	875	PF00069	0.736
MOD_PKA_2	1000	1006	PF00069	0.655
MOD_PKA_2	1017	1023	PF00069	0.680
MOD_PKA_2	213	219	PF00069	0.502
MOD_PKA_2	359	365	PF00069	0.515
MOD_PKA_2	655	661	PF00069	0.748
MOD_PKA_2	76	82	PF00069	0.454
MOD_PKA_2	793	799	PF00069	0.715
MOD_PKA_2	847	853	PF00069	0.703
MOD_PKA_2	854	860	PF00069	0.728
MOD_PKA_2	869	875	PF00069	0.755
MOD_PKB_1	212	220	PF00069	0.542
MOD_Plk_1	122	128	PF00069	0.411
MOD_Plk_1	150	156	PF00069	0.497
MOD_Plk_1	395	401	PF00069	0.536
MOD_Plk_1	497	503	PF00069	0.639
MOD_Plk_1	670	676	PF00069	0.717
MOD_Plk_1	743	749	PF00069	0.581
MOD_Plk_1	773	779	PF00069	0.693
MOD_Plk_1	807	813	PF00069	0.662
MOD_Plk_2-3	620	626	PF00069	0.701
MOD_Plk_4	395	401	PF00069	0.548
MOD_Plk_4	482	488	PF00069	0.588
MOD_Plk_4	620	626	PF00069	0.675
MOD_Plk_4	743	749	PF00069	0.627
MOD_Plk_4	759	765	PF00069	0.495
MOD_Plk_4	773	779	PF00069	0.689
MOD_Plk_4	794	800	PF00069	0.711
MOD_Plk_4	869	875	PF00069	0.807
MOD_Plk_4	903	909	PF00069	0.650
MOD_Plk_4	920	926	PF00069	0.492
MOD_ProDKin_1	28	34	PF00069	0.772
MOD_ProDKin_1	447	453	PF00069	0.639
MOD_SPalmitoyl_4	1	7	PF01529	0.747
MOD_SUMO_rev_2	171	181	PF00179	0.556
MOD_SUMO_rev_2	937	947	PF00179	0.697
TRG_DiLeu_BaEn_1	785	790	PF01217	0.787
TRG_DiLeu_BaLyEn_6	137	142	PF01217	0.576
TRG_DiLeu_BaLyEn_6	677	682	PF01217	0.676
TRG_DiLeu_BaLyEn_6	88	93	PF01217	0.513
TRG_ENDOCYTIC_2	494	497	PF00928	0.585
TRG_ENDOCYTIC_2	555	558	PF00928	0.454
TRG_ENDOCYTIC_2	566	569	PF00928	0.512
TRG_ENDOCYTIC_2	581	584	PF00928	0.425
TRG_ENDOCYTIC_2	607	610	PF00928	0.586
TRG_ENDOCYTIC_2	757	760	PF00928	0.523
TRG_ENDOCYTIC_2	803	806	PF00928	0.715
TRG_ENDOCYTIC_2	902	905	PF00928	0.544
TRG_ENDOCYTIC_2	922	925	PF00928	0.688
TRG_ER_diArg_1	1000	1002	PF00400	0.669
TRG_ER_diArg_1	1017	1019	PF00400	0.769
TRG_ER_diArg_1	212	215	PF00400	0.576
TRG_ER_diArg_1	463	466	PF00400	0.691
TRG_ER_diArg_1	473	475	PF00400	0.538
TRG_ER_diArg_1	629	631	PF00400	0.689
TRG_ER_diArg_1	874	876	PF00400	0.621
TRG_Pf-PMV_PEXEL_1	466	470	PF00026	0.668
TRG_Pf-PMV_PEXEL_1	97	102	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBY3	Leptomonas seymouri	69%	98%
A0A0S4JW61	Bodo saltans	27%	100%
A0A3S7WPK9	Leishmania donovani	94%	100%
A0A422NZ80	Trypanosoma rangeli	41%	100%
A4H4R1	Leishmania braziliensis	80%	100%
C9ZTM0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AG69	Leishmania infantum	94%	100%
E9AKX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BNJ3	Trypanosoma cruzi	40%	100%