LeishMANIAdb
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SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
SET domain-containing protein
Gene product:
SET domain containing protein, putative
Species:
Leishmania major
UniProt:
Q4QIX6_LEIMA
TriTrypDb:
LmjF.06.1000 , LMJLV39_060016400 * , LMJSD75_060016600 *
Length:
501

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 16
NetGPI no yes: 0, no: 16
Cellular components
TermNameLevelCount
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1
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Expansion

Sequence features

Q4QIX6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIX6

Function

Biological processes
TermNameLevelCount
GO:0006479 protein methylation 4 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0008213 protein alkylation 5 1
GO:0009892 negative regulation of metabolic process 4 2
GO:0009987 cellular process 1 1
GO:0010468 regulation of gene expression 5 2
GO:0010605 negative regulation of macromolecule metabolic process 5 2
GO:0010629 negative regulation of gene expression 6 2
GO:0016570 histone modification 5 1
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Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 3
GO:0005488 binding 1 10
GO:0008168 methyltransferase activity 4 3
GO:0008170 N-methyltransferase activity 5 3
GO:0008276 protein methyltransferase activity 3 3
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 5 3
GO:0016278 lysine N-methyltransferase activity 6 3
GO:0016279 protein-lysine N-methyltransferase activity 4 3
GO:0016740 transferase activity 2 3
GO:0016741 transferase activity, transferring one-carbon groups 3 3
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 266 270 PF00656 0.518
CLV_NRD_NRD_1 170 172 PF00675 0.547
CLV_NRD_NRD_1 234 236 PF00675 0.238
CLV_NRD_NRD_1 442 444 PF00675 0.289
CLV_NRD_NRD_1 480 482 PF00675 0.400
CLV_NRD_NRD_1 499 501 PF00675 0.421
CLV_NRD_NRD_1 83 85 PF00675 0.487
CLV_PCSK_KEX2_1 134 136 PF00082 0.612
CLV_PCSK_KEX2_1 170 172 PF00082 0.535
CLV_PCSK_KEX2_1 234 236 PF00082 0.238
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P571 Leptomonas seymouri 65% 100%
A0A0S4JRV8 Bodo saltans 39% 100%
A0A1X0NL17 Trypanosomatidae 48% 100%
A0A3R7KQ99 Trypanosoma rangeli 46% 100%
A0A3S7WPJ6 Leishmania donovani 94% 100%
A0A3S7WYH0 Leishmania donovani 26% 100%
A4H4R3 Leishmania braziliensis 79% 100%
A4HDM9 Leishmania braziliensis 28% 100%
A4HSZ2 Leishmania infantum 95% 100%
C9ZTM3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS