SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QIX6_LEIMA

TriTrypDb:

LmjF.06.1000 , LMJLV39_060016400 , LMJSD75_060016600

Length:

501

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QIX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIX6

Function

Biological processes
Term	Name	Level	Count
GO:0009892	negative regulation of metabolic process	4	2
GO:0010468	regulation of gene expression	5	2
GO:0010605	negative regulation of macromolecule metabolic process	5	2
GO:0010629	negative regulation of gene expression	6	2
GO:0019222	regulation of metabolic process	3	2
GO:0040029	epigenetic regulation of gene expression	6	2
GO:0045814	negative regulation of gene expression, epigenetic	7	2
GO:0048519	negative regulation of biological process	3	2
GO:0050789	regulation of biological process	2	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0034968	histone lysine methylation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0005488	binding	1	10
GO:0008168	methyltransferase activity	4	3
GO:0008170	N-methyltransferase activity	5	3
GO:0008276	protein methyltransferase activity	3	3
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	3
GO:0016278	lysine N-methyltransferase activity	6	3
GO:0016279	protein-lysine N-methyltransferase activity	4	3
GO:0016740	transferase activity	2	3
GO:0016741	transferase activity, transferring one-carbon groups	3	3
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	3
GO:0042054	histone methyltransferase activity	4	3
GO:0042799	histone H4K20 methyltransferase activity	6	2
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0140096	catalytic activity, acting on a protein	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	266	270	PF00656	0.518
CLV_NRD_NRD_1	170	172	PF00675	0.547
CLV_NRD_NRD_1	234	236	PF00675	0.238
CLV_NRD_NRD_1	442	444	PF00675	0.289
CLV_NRD_NRD_1	480	482	PF00675	0.400
CLV_NRD_NRD_1	499	501	PF00675	0.421
CLV_NRD_NRD_1	83	85	PF00675	0.487
CLV_PCSK_KEX2_1	134	136	PF00082	0.612
CLV_PCSK_KEX2_1	170	172	PF00082	0.535
CLV_PCSK_KEX2_1	234	236	PF00082	0.238
CLV_PCSK_KEX2_1	31	33	PF00082	0.548
CLV_PCSK_KEX2_1	442	444	PF00082	0.308
CLV_PCSK_KEX2_1	499	501	PF00082	0.492
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.411
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.401
CLV_PCSK_SKI1_1	175	179	PF00082	0.545
CLV_PCSK_SKI1_1	295	299	PF00082	0.354
CLV_PCSK_SKI1_1	323	327	PF00082	0.244
CLV_PCSK_SKI1_1	481	485	PF00082	0.330
DEG_APCC_DBOX_1	322	330	PF00400	0.461
DEG_SPOP_SBC_1	105	109	PF00917	0.523
DOC_MAPK_gen_1	456	466	PF00069	0.451
DOC_PP2B_LxvP_1	346	349	PF13499	0.475
DOC_USP7_MATH_1	106	110	PF00917	0.752
DOC_USP7_MATH_1	112	116	PF00917	0.724
DOC_USP7_MATH_1	187	191	PF00917	0.445
DOC_USP7_MATH_1	204	208	PF00917	0.575
DOC_USP7_MATH_1	247	251	PF00917	0.452
DOC_USP7_MATH_1	426	430	PF00917	0.518
DOC_USP7_MATH_1	438	442	PF00917	0.518
DOC_WW_Pin1_4	101	106	PF00397	0.701
DOC_WW_Pin1_4	175	180	PF00397	0.442
DOC_WW_Pin1_4	209	214	PF00397	0.526
DOC_WW_Pin1_4	430	435	PF00397	0.601
LIG_14-3-3_CanoR_1	101	105	PF00244	0.608
LIG_14-3-3_CanoR_1	323	331	PF00244	0.530
LIG_14-3-3_CanoR_1	442	452	PF00244	0.512
LIG_14-3-3_CanoR_1	63	71	PF00244	0.454
LIG_Actin_WH2_2	162	177	PF00022	0.434
LIG_EH1_1	410	418	PF00400	0.518
LIG_FHA_1	111	117	PF00498	0.496
LIG_FHA_1	144	150	PF00498	0.723
LIG_FHA_1	176	182	PF00498	0.403
LIG_FHA_1	197	203	PF00498	0.529
LIG_FHA_1	471	477	PF00498	0.417
LIG_FHA_1	50	56	PF00498	0.403
LIG_FHA_1	89	95	PF00498	0.365
LIG_FHA_2	472	478	PF00498	0.371
LIG_GBD_Chelix_1	372	380	PF00786	0.251
LIG_LIR_Gen_1	392	402	PF02991	0.463
LIG_LIR_Nem_3	269	275	PF02991	0.468
LIG_LIR_Nem_3	392	397	PF02991	0.473
LIG_LIR_Nem_3	462	468	PF02991	0.446
LIG_NRBOX	392	398	PF00104	0.537
LIG_PCNA_PIPBox_1	387	396	PF02747	0.454
LIG_PCNA_TLS_4	445	452	PF02747	0.397
LIG_SH2_CRK	411	415	PF00017	0.469
LIG_SH2_NCK_1	34	38	PF00017	0.367
LIG_SH2_NCK_1	360	364	PF00017	0.493
LIG_SH2_SRC	360	363	PF00017	0.554
LIG_SH2_STAP1	34	38	PF00017	0.342
LIG_SH2_STAT3	12	15	PF00017	0.512
LIG_SH2_STAT3	20	23	PF00017	0.387
LIG_SH2_STAT5	155	158	PF00017	0.424
LIG_SH2_STAT5	20	23	PF00017	0.429
LIG_SH2_STAT5	262	265	PF00017	0.493
LIG_SH2_STAT5	40	43	PF00017	0.377
LIG_SH2_STAT5	451	454	PF00017	0.397
LIG_SH2_STAT5	493	496	PF00017	0.482
LIG_SH3_3	249	255	PF00018	0.508
LIG_TRAF2_1	13	16	PF00917	0.425
LIG_TYR_ITIM	409	414	PF00017	0.210
MOD_CK1_1	107	113	PF00069	0.766
MOD_CK1_1	237	243	PF00069	0.401
MOD_CK1_1	279	285	PF00069	0.492
MOD_CK1_1	307	313	PF00069	0.409
MOD_CK1_1	327	333	PF00069	0.311
MOD_CK1_1	412	418	PF00069	0.430
MOD_CK2_1	315	321	PF00069	0.431
MOD_CK2_1	443	449	PF00069	0.487
MOD_CK2_1	86	92	PF00069	0.420
MOD_DYRK1A_RPxSP_1	101	105	PF00069	0.432
MOD_DYRK1A_RPxSP_1	175	179	PF00069	0.441
MOD_GlcNHglycan	120	123	PF01048	0.423
MOD_GlcNHglycan	175	178	PF01048	0.530
MOD_GlcNHglycan	231	234	PF01048	0.333
MOD_GlcNHglycan	249	252	PF01048	0.277
MOD_GlcNHglycan	317	320	PF01048	0.413
MOD_GlcNHglycan	376	379	PF01048	0.430
MOD_GlcNHglycan	405	408	PF01048	0.290
MOD_GlcNHglycan	428	431	PF01048	0.353
MOD_GlcNHglycan	445	448	PF01048	0.327
MOD_GSK3_1	106	113	PF00069	0.727
MOD_GSK3_1	114	121	PF00069	0.568
MOD_GSK3_1	139	146	PF00069	0.545
MOD_GSK3_1	169	176	PF00069	0.505
MOD_GSK3_1	235	242	PF00069	0.378
MOD_GSK3_1	426	433	PF00069	0.384
MOD_GSK3_1	97	104	PF00069	0.478
MOD_N-GLC_1	417	422	PF02516	0.345
MOD_NEK2_1	196	201	PF00069	0.346
MOD_NEK2_1	219	224	PF00069	0.252
MOD_NEK2_1	403	408	PF00069	0.382
MOD_NEK2_1	78	83	PF00069	0.467
MOD_NEK2_2	26	31	PF00069	0.390
MOD_PIKK_1	114	120	PF00454	0.522
MOD_PIKK_1	63	69	PF00454	0.475
MOD_PK_1	235	241	PF00069	0.269
MOD_PKA_1	234	240	PF00069	0.469
MOD_PKA_2	100	106	PF00069	0.540
MOD_PKA_2	139	145	PF00069	0.537
MOD_PKA_2	169	175	PF00069	0.447
MOD_PKA_2	204	210	PF00069	0.375
MOD_PKA_2	234	240	PF00069	0.269
MOD_PKA_2	354	360	PF00069	0.459
MOD_Plk_4	150	156	PF00069	0.431
MOD_Plk_4	16	22	PF00069	0.392
MOD_Plk_4	204	210	PF00069	0.461
MOD_Plk_4	389	395	PF00069	0.323
MOD_Plk_4	409	415	PF00069	0.162
MOD_Plk_4	94	100	PF00069	0.543
MOD_ProDKin_1	101	107	PF00069	0.703
MOD_ProDKin_1	175	181	PF00069	0.435
MOD_ProDKin_1	209	215	PF00069	0.391
MOD_ProDKin_1	430	436	PF00069	0.497
MOD_SUMO_for_1	133	136	PF00179	0.430
MOD_SUMO_for_1	149	152	PF00179	0.596
MOD_SUMO_rev_2	477	484	PF00179	0.357
TRG_DiLeu_BaEn_1	211	216	PF01217	0.430
TRG_DiLeu_BaEn_4	479	485	PF01217	0.353
TRG_DiLeu_BaLyEn_6	210	215	PF01217	0.497
TRG_DiLeu_BaLyEn_6	40	45	PF01217	0.360
TRG_ENDOCYTIC_2	411	414	PF00928	0.283
TRG_ER_diArg_1	169	171	PF00400	0.546
TRG_ER_diArg_1	2	5	PF00400	0.457
TRG_ER_diArg_1	21	24	PF00400	0.344
TRG_ER_diArg_1	234	236	PF00400	0.210
TRG_ER_diArg_1	498	500	PF00400	0.374
TRG_NES_CRM1_1	389	401	PF08389	0.420
TRG_Pf-PMV_PEXEL_1	456	460	PF00026	0.329

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P571	Leptomonas seymouri	65%	100%
A0A0S4JRV8	Bodo saltans	39%	100%
A0A1X0NL17	Trypanosomatidae	48%	100%
A0A3R7KQ99	Trypanosoma rangeli	46%	100%
A0A3S7WPJ6	Leishmania donovani	94%	100%
A0A3S7WYH0	Leishmania donovani	26%	100%
A4H4R3	Leishmania braziliensis	79%	100%
A4HDM9	Leishmania braziliensis	28%	100%
A4HSZ2	Leishmania infantum	95%	100%
C9ZTM3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AH76	Leishmania infantum	26%	100%
E9AKX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9AX14	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
Q4QAG2	Leishmania major	28%	100%
V5BT58	Trypanosoma cruzi	45%	100%