Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIX5_LEIMA

TriTrypDb:

LmjF.06.1010 , LMJLV39_060016500 , LMJSD75_060016700

Length:

769

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QIX5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIX5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.795
CLV_C14_Caspase3-7	295	299	PF00656	0.575
CLV_C14_Caspase3-7	459	463	PF00656	0.599
CLV_C14_Caspase3-7	593	597	PF00656	0.736
CLV_NRD_NRD_1	128	130	PF00675	0.720
CLV_NRD_NRD_1	163	165	PF00675	0.708
CLV_NRD_NRD_1	170	172	PF00675	0.627
CLV_NRD_NRD_1	296	298	PF00675	0.772
CLV_NRD_NRD_1	499	501	PF00675	0.557
CLV_NRD_NRD_1	51	53	PF00675	0.729
CLV_NRD_NRD_1	661	663	PF00675	0.435
CLV_NRD_NRD_1	763	765	PF00675	0.664
CLV_PCSK_KEX2_1	128	130	PF00082	0.723
CLV_PCSK_KEX2_1	163	165	PF00082	0.784
CLV_PCSK_KEX2_1	170	172	PF00082	0.714
CLV_PCSK_KEX2_1	296	298	PF00082	0.768
CLV_PCSK_KEX2_1	499	501	PF00082	0.557
CLV_PCSK_KEX2_1	661	663	PF00082	0.435
CLV_PCSK_KEX2_1	763	765	PF00082	0.668
CLV_PCSK_SKI1_1	100	104	PF00082	0.578
CLV_PCSK_SKI1_1	114	118	PF00082	0.492
CLV_PCSK_SKI1_1	214	218	PF00082	0.559
CLV_PCSK_SKI1_1	280	284	PF00082	0.556
CLV_PCSK_SKI1_1	347	351	PF00082	0.485
CLV_PCSK_SKI1_1	382	386	PF00082	0.555
CLV_PCSK_SKI1_1	499	503	PF00082	0.566
CLV_PCSK_SKI1_1	653	657	PF00082	0.551
CLV_PCSK_SKI1_1	704	708	PF00082	0.583
CLV_PCSK_SKI1_1	740	744	PF00082	0.635
DEG_APCC_DBOX_1	346	354	PF00400	0.436
DEG_APCC_DBOX_1	498	506	PF00400	0.557
DEG_APCC_DBOX_1	703	711	PF00400	0.574
DEG_COP1_1	27	35	PF00400	0.557
DEG_Nend_Nbox_1	1	3	PF02207	0.656
DOC_CYCLIN_RxL_1	100	109	PF00134	0.506
DOC_CYCLIN_RxL_1	379	388	PF00134	0.552
DOC_CYCLIN_RxL_1	521	532	PF00134	0.571
DOC_CYCLIN_RxL_1	737	747	PF00134	0.650
DOC_CYCLIN_yCln2_LP_2	262	268	PF00134	0.548
DOC_MAPK_gen_1	702	709	PF00069	0.532
DOC_MAPK_HePTP_8	658	675	PF00069	0.452
DOC_MAPK_MEF2A_6	666	675	PF00069	0.452
DOC_PP2B_LxvP_1	262	265	PF13499	0.508
DOC_PP2B_LxvP_1	735	738	PF13499	0.583
DOC_USP7_MATH_1	120	124	PF00917	0.658
DOC_USP7_MATH_1	133	137	PF00917	0.608
DOC_USP7_MATH_1	26	30	PF00917	0.579
DOC_USP7_MATH_1	31	35	PF00917	0.603
DOC_USP7_MATH_1	318	322	PF00917	0.784
DOC_USP7_MATH_1	410	414	PF00917	0.777
DOC_USP7_MATH_1	575	579	PF00917	0.728
DOC_WW_Pin1_4	2	7	PF00397	0.459
DOC_WW_Pin1_4	313	318	PF00397	0.826
DOC_WW_Pin1_4	414	419	PF00397	0.757
DOC_WW_Pin1_4	51	56	PF00397	0.619
DOC_WW_Pin1_4	578	583	PF00397	0.699
LIG_14-3-3_CanoR_1	207	212	PF00244	0.421
LIG_14-3-3_CanoR_1	280	285	PF00244	0.475
LIG_14-3-3_CanoR_1	382	388	PF00244	0.460
LIG_14-3-3_CanoR_1	457	465	PF00244	0.624
LIG_14-3-3_CanoR_1	507	513	PF00244	0.504
LIG_14-3-3_CanoR_1	666	671	PF00244	0.543
LIG_14-3-3_CanoR_1	702	707	PF00244	0.439
LIG_14-3-3_CanoR_1	9	15	PF00244	0.541
LIG_Actin_WH2_2	264	282	PF00022	0.436
LIG_APCC_ABBAyCdc20_2	538	544	PF00400	0.546
LIG_BIR_III_4	151	155	PF00653	0.563
LIG_BIR_III_4	298	302	PF00653	0.676
LIG_Clathr_ClatBox_1	525	529	PF01394	0.575
LIG_DLG_GKlike_1	666	673	PF00625	0.552
LIG_FHA_1	185	191	PF00498	0.553
LIG_FHA_1	215	221	PF00498	0.444
LIG_FHA_1	231	237	PF00498	0.566
LIG_FHA_1	246	252	PF00498	0.353
LIG_FHA_1	279	285	PF00498	0.373
LIG_FHA_1	322	328	PF00498	0.534
LIG_FHA_1	402	408	PF00498	0.606
LIG_FHA_1	429	435	PF00498	0.610
LIG_FHA_1	478	484	PF00498	0.474
LIG_FHA_1	604	610	PF00498	0.546
LIG_FHA_1	646	652	PF00498	0.490
LIG_FHA_1	684	690	PF00498	0.499
LIG_FHA_1	73	79	PF00498	0.462
LIG_FHA_2	148	154	PF00498	0.792
LIG_FHA_2	290	296	PF00498	0.707
LIG_FHA_2	301	307	PF00498	0.736
LIG_FHA_2	34	40	PF00498	0.540
LIG_FHA_2	369	375	PF00498	0.637
LIG_FHA_2	457	463	PF00498	0.603
LIG_FHA_2	466	472	PF00498	0.505
LIG_FHA_2	530	536	PF00498	0.611
LIG_FHA_2	579	585	PF00498	0.717
LIG_FHA_2	744	750	PF00498	0.698
LIG_Integrin_RGD_1	662	664	PF01839	0.420
LIG_LIR_Apic_2	174	178	PF02991	0.639
LIG_LIR_Gen_1	269	277	PF02991	0.542
LIG_LIR_Gen_1	355	364	PF02991	0.513
LIG_LIR_Gen_1	632	642	PF02991	0.516
LIG_LIR_Gen_1	705	714	PF02991	0.446
LIG_LIR_Gen_1	76	87	PF02991	0.510
LIG_LIR_Nem_3	269	273	PF02991	0.544
LIG_LIR_Nem_3	355	360	PF02991	0.498
LIG_LIR_Nem_3	632	637	PF02991	0.443
LIG_LIR_Nem_3	705	709	PF02991	0.444
LIG_LIR_Nem_3	76	82	PF02991	0.506
LIG_NRBOX	81	87	PF00104	0.523
LIG_PCNA_PIPBox_1	392	401	PF02747	0.589
LIG_PCNA_yPIPBox_3	704	718	PF02747	0.509
LIG_Pex14_2	212	216	PF04695	0.488
LIG_PTB_Apo_2	351	358	PF02174	0.430
LIG_Rb_pABgroove_1	442	450	PF01858	0.508
LIG_SH2_CRK	175	179	PF00017	0.639
LIG_SH2_CRK	634	638	PF00017	0.428
LIG_SH2_CRK	642	646	PF00017	0.456
LIG_SH2_GRB2like	352	355	PF00017	0.427
LIG_SH2_GRB2like	677	680	PF00017	0.541
LIG_SH2_NCK_1	175	179	PF00017	0.532
LIG_SH2_NCK_1	399	403	PF00017	0.574
LIG_SH2_NCK_1	448	452	PF00017	0.509
LIG_SH2_SRC	448	451	PF00017	0.514
LIG_SH2_STAP1	542	546	PF00017	0.473
LIG_SH2_STAT3	377	380	PF00017	0.512
LIG_SH2_STAT5	352	355	PF00017	0.491
LIG_SH2_STAT5	383	386	PF00017	0.493
LIG_SH2_STAT5	399	402	PF00017	0.582
LIG_SH2_STAT5	4	7	PF00017	0.454
LIG_SH2_STAT5	497	500	PF00017	0.551
LIG_SH3_1	314	320	PF00018	0.586
LIG_SH3_2	317	322	PF14604	0.556
LIG_SH3_3	314	320	PF00018	0.652
LIG_SH3_3	716	722	PF00018	0.526
LIG_SUMO_SIM_anti_2	449	455	PF11976	0.514
LIG_SUMO_SIM_anti_2	686	691	PF11976	0.485
LIG_SUMO_SIM_par_1	186	191	PF11976	0.643
LIG_SUMO_SIM_par_1	275	281	PF11976	0.507
LIG_SUMO_SIM_par_1	383	388	PF11976	0.485
LIG_SUMO_SIM_par_1	524	532	PF11976	0.577
LIG_SUMO_SIM_par_1	654	660	PF11976	0.539
LIG_TRAF2_1	291	294	PF00917	0.583
LIG_TRAF2_1	468	471	PF00917	0.572
LIG_TRAF2_1	728	731	PF00917	0.489
LIG_TRFH_1	179	183	PF08558	0.735
LIG_TYR_ITIM	106	111	PF00017	0.568
LIG_TYR_ITIM	268	273	PF00017	0.492
LIG_UBA3_1	81	88	PF00899	0.576
LIG_WW_3	316	320	PF00397	0.735
LIG_WW_3	737	741	PF00397	0.643
MOD_CDC14_SPxK_1	316	319	PF00782	0.743
MOD_CDK_SPxK_1	313	319	PF00069	0.748
MOD_CDK_SPxxK_3	2	9	PF00069	0.460
MOD_CK1_1	123	129	PF00069	0.644
MOD_CK1_1	142	148	PF00069	0.694
MOD_CK1_1	184	190	PF00069	0.648
MOD_CK1_1	321	327	PF00069	0.617
MOD_CK1_1	401	407	PF00069	0.555
MOD_CK1_1	408	414	PF00069	0.660
MOD_CK1_1	416	422	PF00069	0.748
MOD_CK1_1	548	554	PF00069	0.507
MOD_CK1_1	578	584	PF00069	0.739
MOD_CK2_1	106	112	PF00069	0.470
MOD_CK2_1	289	295	PF00069	0.679
MOD_CK2_1	465	471	PF00069	0.557
MOD_CK2_1	529	535	PF00069	0.615
MOD_CK2_1	548	554	PF00069	0.519
MOD_CK2_1	721	727	PF00069	0.481
MOD_GlcNHglycan	10	13	PF01048	0.603
MOD_GlcNHglycan	108	111	PF01048	0.541
MOD_GlcNHglycan	18	21	PF01048	0.560
MOD_GlcNHglycan	190	193	PF01048	0.611
MOD_GlcNHglycan	197	200	PF01048	0.502
MOD_GlcNHglycan	242	246	PF01048	0.437
MOD_GlcNHglycan	33	36	PF01048	0.608
MOD_GlcNHglycan	400	403	PF01048	0.592
MOD_GlcNHglycan	407	410	PF01048	0.690
MOD_GlcNHglycan	577	580	PF01048	0.767
MOD_GlcNHglycan	752	755	PF01048	0.675
MOD_GSK3_1	16	23	PF00069	0.499
MOD_GSK3_1	177	184	PF00069	0.633
MOD_GSK3_1	227	234	PF00069	0.609
MOD_GSK3_1	241	248	PF00069	0.524
MOD_GSK3_1	393	400	PF00069	0.517
MOD_GSK3_1	401	408	PF00069	0.637
MOD_GSK3_1	410	417	PF00069	0.680
MOD_GSK3_1	544	551	PF00069	0.571
MOD_GSK3_1	721	728	PF00069	0.526
MOD_LATS_1	700	706	PF00433	0.587
MOD_N-GLC_1	139	144	PF02516	0.730
MOD_N-GLC_2	354	356	PF02516	0.327
MOD_NEK2_1	188	193	PF00069	0.545
MOD_NEK2_1	385	390	PF00069	0.501
MOD_NEK2_1	434	439	PF00069	0.580
MOD_NEK2_1	545	550	PF00069	0.426
MOD_NEK2_1	690	695	PF00069	0.490
MOD_NEK2_1	750	755	PF00069	0.602
MOD_NEK2_2	300	305	PF00069	0.798
MOD_PIKK_1	227	233	PF00454	0.640
MOD_PIKK_1	393	399	PF00454	0.506
MOD_PIKK_1	603	609	PF00454	0.557
MOD_PKA_2	184	190	PF00069	0.601
MOD_PKA_2	318	324	PF00069	0.673
MOD_PKA_2	425	431	PF00069	0.685
MOD_PKA_2	456	462	PF00069	0.541
MOD_PKA_2	72	78	PF00069	0.540
MOD_PKA_2	8	14	PF00069	0.572
MOD_Plk_1	123	129	PF00069	0.753
MOD_Plk_1	26	32	PF00069	0.540
MOD_Plk_2-3	529	535	PF00069	0.615
MOD_Plk_4	112	118	PF00069	0.513
MOD_Plk_4	177	183	PF00069	0.672
MOD_Plk_4	184	190	PF00069	0.553
MOD_Plk_4	74	80	PF00069	0.484
MOD_ProDKin_1	2	8	PF00069	0.461
MOD_ProDKin_1	313	319	PF00069	0.826
MOD_ProDKin_1	414	420	PF00069	0.758
MOD_ProDKin_1	51	57	PF00069	0.614
MOD_ProDKin_1	578	584	PF00069	0.703
MOD_SUMO_rev_2	109	116	PF00179	0.442
MOD_SUMO_rev_2	727	735	PF00179	0.466
TRG_DiLeu_BaEn_4	470	476	PF01217	0.605
TRG_DiLeu_BaLyEn_6	521	526	PF01217	0.521
TRG_ENDOCYTIC_2	108	111	PF00928	0.488
TRG_ENDOCYTIC_2	270	273	PF00928	0.485
TRG_ENDOCYTIC_2	4	7	PF00928	0.610
TRG_ENDOCYTIC_2	448	451	PF00928	0.508
TRG_ENDOCYTIC_2	542	545	PF00928	0.447
TRG_ENDOCYTIC_2	634	637	PF00928	0.424
TRG_ENDOCYTIC_2	642	645	PF00928	0.454
TRG_ER_diArg_1	127	129	PF00400	0.720
TRG_ER_diArg_1	498	500	PF00400	0.566
TRG_ER_diArg_1	555	558	PF00400	0.511
TRG_ER_diArg_1	762	764	PF00400	0.688
TRG_NES_CRM1_1	517	531	PF08389	0.547
TRG_NES_CRM1_1	76	90	PF08389	0.503
TRG_Pf-PMV_PEXEL_1	485	490	PF00026	0.514
TRG_Pf-PMV_PEXEL_1	524	529	PF00026	0.572
TRG_Pf-PMV_PEXEL_1	550	554	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXP3	Leptomonas seymouri	54%	100%
A0A3R7K270	Trypanosoma rangeli	34%	100%
A0A3S5H5T7	Leishmania donovani	93%	100%
A4H4R4	Leishmania braziliensis	80%	100%
A4HSZ3	Leishmania infantum	93%	100%
C9ZTM4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AKY0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%