G-patch domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

G-patch domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QIX4_LEIMA

TriTrypDb:

LmjF.06.1020 , LMJLV39_060016600 , LMJSD75_060016800

Length:

230

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QIX4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIX4

Function

Biological processes
Term	Name	Level	Count
GO:0044087	regulation of cellular component biogenesis	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0065007	biological regulation	1	2
GO:0090069	regulation of ribosome biogenesis	5	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	162	166	PF00656	0.654
CLV_C14_Caspase3-7	47	51	PF00656	0.407
CLV_NRD_NRD_1	122	124	PF00675	0.564
CLV_NRD_NRD_1	155	157	PF00675	0.611
CLV_NRD_NRD_1	47	49	PF00675	0.289
CLV_PCSK_KEX2_1	122	124	PF00082	0.448
CLV_PCSK_KEX2_1	142	144	PF00082	0.564
CLV_PCSK_KEX2_1	153	155	PF00082	0.504
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.564
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.504
CLV_PCSK_SKI1_1	123	127	PF00082	0.488
CLV_PCSK_SKI1_1	19	23	PF00082	0.319
DEG_Kelch_Keap1_1	157	162	PF01344	0.518
DOC_CYCLIN_RxL_1	15	25	PF00134	0.417
DOC_CYCLIN_yCln2_LP_2	181	187	PF00134	0.563
DOC_MAPK_gen_1	45	55	PF00069	0.291
DOC_MAPK_MEF2A_6	182	189	PF00069	0.565
DOC_USP7_MATH_1	96	100	PF00917	0.696
DOC_USP7_UBL2_3	15	19	PF12436	0.465
DOC_USP7_UBL2_3	195	199	PF12436	0.661
DOC_USP7_UBL2_3	45	49	PF12436	0.302
DOC_WW_Pin1_4	180	185	PF00397	0.514
DOC_WW_Pin1_4	203	208	PF00397	0.661
DOC_WW_Pin1_4	223	228	PF00397	0.547
DOC_WW_Pin1_4	94	99	PF00397	0.670
LIG_14-3-3_CanoR_1	78	87	PF00244	0.523
LIG_14-3-3_CanoR_1	9	17	PF00244	0.456
LIG_BIR_II_1	1	5	PF00653	0.556
LIG_BRCT_BRCA1_1	68	72	PF00533	0.415
LIG_deltaCOP1_diTrp_1	63	72	PF00928	0.466
LIG_FHA_1	126	132	PF00498	0.480
LIG_FHA_1	224	230	PF00498	0.574
LIG_FHA_1	65	71	PF00498	0.461
LIG_FHA_1	82	88	PF00498	0.503
LIG_FHA_2	102	108	PF00498	0.631
LIG_FHA_2	192	198	PF00498	0.607
LIG_FHA_2	199	205	PF00498	0.591
LIG_FHA_2	45	51	PF00498	0.400
LIG_LIR_Gen_1	69	79	PF02991	0.405
LIG_LIR_Nem_3	114	120	PF02991	0.623
LIG_LIR_Nem_3	69	75	PF02991	0.440
LIG_PDZ_Class_2	225	230	PF00595	0.620
LIG_SH3_1	215	221	PF00018	0.491
LIG_SH3_3	215	221	PF00018	0.487
LIG_SUMO_SIM_par_1	208	214	PF11976	0.553
LIG_UBA3_1	186	195	PF00899	0.502
LIG_UBA3_1	210	215	PF00899	0.479
MOD_CK1_1	136	142	PF00069	0.499
MOD_CK1_1	172	178	PF00069	0.729
MOD_CK1_1	25	31	PF00069	0.362
MOD_CK1_1	97	103	PF00069	0.664
MOD_CK2_1	101	107	PF00069	0.774
MOD_CK2_1	191	197	PF00069	0.677
MOD_CK2_1	8	14	PF00069	0.522
MOD_GlcNHglycan	135	138	PF01048	0.564
MOD_GlcNHglycan	148	151	PF01048	0.545
MOD_GlcNHglycan	159	162	PF01048	0.657
MOD_GlcNHglycan	176	179	PF01048	0.723
MOD_GlcNHglycan	24	27	PF01048	0.346
MOD_GSK3_1	169	176	PF00069	0.634
MOD_GSK3_1	81	88	PF00069	0.565
MOD_GSK3_1	94	101	PF00069	0.605
MOD_N-GLC_1	169	174	PF02516	0.729
MOD_N-GLC_1	5	10	PF02516	0.472
MOD_NEK2_1	190	195	PF00069	0.532
MOD_NEK2_1	22	27	PF00069	0.314
MOD_PIKK_1	169	175	PF00454	0.626
MOD_PIKK_1	64	70	PF00454	0.492
MOD_PKA_2	191	197	PF00069	0.651
MOD_PKA_2	8	14	PF00069	0.522
MOD_ProDKin_1	180	186	PF00069	0.507
MOD_ProDKin_1	203	209	PF00069	0.660
MOD_ProDKin_1	223	229	PF00069	0.550
MOD_ProDKin_1	94	100	PF00069	0.672
MOD_SUMO_for_1	126	129	PF00179	0.489
MOD_SUMO_rev_2	101	111	PF00179	0.574
MOD_SUMO_rev_2	136	144	PF00179	0.549
MOD_SUMO_rev_2	193	201	PF00179	0.679
TRG_DiLeu_BaLyEn_6	181	186	PF01217	0.500
TRG_ER_diArg_1	154	156	PF00400	0.697

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5L2	Leptomonas seymouri	67%	89%
A0A0S4JRZ3	Bodo saltans	44%	100%
A0A1X0NMG7	Trypanosomatidae	42%	95%
A0A3R7RBC9	Trypanosoma rangeli	53%	100%
A0A3S7WPL1	Leishmania donovani	94%	100%
A4H4R5	Leishmania braziliensis	80%	100%
A4HSZ4	Leishmania infantum	94%	100%
C9ZTM6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	85%
E9AKY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BNM6	Trypanosoma cruzi	51%	100%