Putative kinesin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative kinesin

Gene product:

kinesin, putative

Species:

Leishmania major

UniProt:

Q4QIX3_LEIMA

TriTrypDb:

LmjF.06.1030 , LMJLV39_060016700 , LMJSD75_060016900

Length:

886

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 35

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	4
GO:0005875	microtubule associated complex	2	4
GO:0032991	protein-containing complex	1	4
GO:0035869	ciliary transition zone	2	2
GO:0110165	cellular anatomical entity	1	4
GO:0005871	kinesin complex	3	2
GO:0005874	microtubule	6	2
GO:0051286	cell tip	3	2
GO:0060187	cell pole	2	2
GO:0099080	supramolecular complex	2	2
GO:0099081	supramolecular polymer	3	2
GO:0099512	supramolecular fiber	4	2
GO:0099513	polymeric cytoskeletal fiber	5	2

Expansion

Sequence features

Q4QIX3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIX3

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0006996	organelle organization	4	2
GO:0007010	cytoskeleton organization	5	2
GO:0007017	microtubule-based process	2	15
GO:0007018	microtubule-based movement	3	15
GO:0007051	spindle organization	3	2
GO:0007052	mitotic spindle organization	4	2
GO:0009987	cellular process	1	15
GO:0016043	cellular component organization	3	2
GO:0022402	cell cycle process	2	2
GO:0051231	spindle elongation	3	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:1902850	microtubule cytoskeleton organization involved in mitosis	4	2
GO:1903047	mitotic cell cycle process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	15
GO:0003774	cytoskeletal motor activity	1	15
GO:0003777	microtubule motor activity	2	15
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	15
GO:0005515	protein binding	2	15
GO:0005524	ATP binding	5	15
GO:0008017	microtubule binding	5	15
GO:0008092	cytoskeletal protein binding	3	15
GO:0015631	tubulin binding	4	15
GO:0016787	hydrolase activity	2	11
GO:0017076	purine nucleotide binding	4	15
GO:0030554	adenyl nucleotide binding	5	15
GO:0032553	ribonucleotide binding	3	15
GO:0032555	purine ribonucleotide binding	4	15
GO:0032559	adenyl ribonucleotide binding	5	15
GO:0035639	purine ribonucleoside triphosphate binding	4	15
GO:0036094	small molecule binding	2	15
GO:0043167	ion binding	2	15
GO:0043168	anion binding	3	15
GO:0097159	organic cyclic compound binding	2	15
GO:0097367	carbohydrate derivative binding	2	15
GO:0140657	ATP-dependent activity	1	15
GO:1901265	nucleoside phosphate binding	3	15
GO:1901363	heterocyclic compound binding	2	15
GO:0016462	pyrophosphatase activity	5	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0016887	ATP hydrolysis activity	7	2
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	193	197	PF00656	0.255
CLV_C14_Caspase3-7	552	556	PF00656	0.609
CLV_C14_Caspase3-7	624	628	PF00656	0.622
CLV_C14_Caspase3-7	719	723	PF00656	0.565
CLV_C14_Caspase3-7	768	772	PF00656	0.594
CLV_NRD_NRD_1	231	233	PF00675	0.310
CLV_NRD_NRD_1	390	392	PF00675	0.547
CLV_NRD_NRD_1	398	400	PF00675	0.515
CLV_NRD_NRD_1	427	429	PF00675	0.518
CLV_NRD_NRD_1	485	487	PF00675	0.407
CLV_NRD_NRD_1	506	508	PF00675	0.596
CLV_NRD_NRD_1	511	513	PF00675	0.495
CLV_NRD_NRD_1	743	745	PF00675	0.569
CLV_NRD_NRD_1	775	777	PF00675	0.624
CLV_NRD_NRD_1	789	791	PF00675	0.548
CLV_NRD_NRD_1	820	822	PF00675	0.579
CLV_PCSK_FUR_1	388	392	PF00082	0.486
CLV_PCSK_FUR_1	425	429	PF00082	0.520
CLV_PCSK_KEX2_1	231	233	PF00082	0.268
CLV_PCSK_KEX2_1	390	392	PF00082	0.536
CLV_PCSK_KEX2_1	398	400	PF00082	0.511
CLV_PCSK_KEX2_1	427	429	PF00082	0.518
CLV_PCSK_KEX2_1	510	512	PF00082	0.470
CLV_PCSK_KEX2_1	775	777	PF00082	0.831
CLV_PCSK_KEX2_1	789	791	PF00082	0.553
CLV_PCSK_KEX2_1	820	822	PF00082	0.579
CLV_PCSK_PC7_1	227	233	PF00082	0.290
CLV_PCSK_PC7_1	507	513	PF00082	0.422
CLV_PCSK_PC7_1	816	822	PF00082	0.545
CLV_PCSK_SKI1_1	144	148	PF00082	0.333
CLV_PCSK_SKI1_1	166	170	PF00082	0.290
CLV_PCSK_SKI1_1	187	191	PF00082	0.232
CLV_PCSK_SKI1_1	231	235	PF00082	0.274
CLV_PCSK_SKI1_1	40	44	PF00082	0.290
CLV_PCSK_SKI1_1	477	481	PF00082	0.480
CLV_PCSK_SKI1_1	512	516	PF00082	0.464
CLV_PCSK_SKI1_1	561	565	PF00082	0.590
CLV_PCSK_SKI1_1	568	572	PF00082	0.537
CLV_PCSK_SKI1_1	700	704	PF00082	0.504
CLV_PCSK_SKI1_1	87	91	PF00082	0.290
CLV_PCSK_SKI1_1	881	885	PF00082	0.436
CLV_Separin_Metazoa	841	845	PF03568	0.459
DEG_APCC_DBOX_1	873	881	PF00400	0.401
DEG_SPOP_SBC_1	118	122	PF00917	0.255
DEG_SPOP_SBC_1	518	522	PF00917	0.526
DOC_CDC14_PxL_1	125	133	PF14671	0.215
DOC_CYCLIN_RxL_1	184	194	PF00134	0.210
DOC_CYCLIN_RxL_1	437	448	PF00134	0.436
DOC_CYCLIN_RxL_1	565	575	PF00134	0.521
DOC_CYCLIN_yCln2_LP_2	147	153	PF00134	0.278
DOC_MAPK_gen_1	271	280	PF00069	0.297
DOC_MAPK_gen_1	866	875	PF00069	0.390
DOC_MAPK_MEF2A_6	273	282	PF00069	0.290
DOC_MAPK_MEF2A_6	4	11	PF00069	0.376
DOC_MAPK_MEF2A_6	581	588	PF00069	0.595
DOC_MAPK_MEF2A_6	868	877	PF00069	0.383
DOC_USP7_MATH_1	118	122	PF00917	0.267
DOC_USP7_MATH_1	152	156	PF00917	0.288
DOC_USP7_MATH_1	233	237	PF00917	0.296
DOC_USP7_MATH_1	241	245	PF00917	0.280
DOC_USP7_MATH_1	314	318	PF00917	0.317
DOC_USP7_MATH_1	329	333	PF00917	0.317
DOC_USP7_MATH_1	449	453	PF00917	0.485
DOC_USP7_MATH_1	590	594	PF00917	0.673
DOC_USP7_MATH_1	694	698	PF00917	0.532
DOC_USP7_MATH_1	735	739	PF00917	0.647
DOC_USP7_MATH_1	747	751	PF00917	0.519
DOC_USP7_MATH_1	759	763	PF00917	0.570
DOC_USP7_MATH_1	766	770	PF00917	0.570
DOC_WW_Pin1_4	176	181	PF00397	0.270
DOC_WW_Pin1_4	197	202	PF00397	0.271
DOC_WW_Pin1_4	391	396	PF00397	0.720
DOC_WW_Pin1_4	398	403	PF00397	0.550
DOC_WW_Pin1_4	406	411	PF00397	0.514
DOC_WW_Pin1_4	615	620	PF00397	0.616
DOC_WW_Pin1_4	659	664	PF00397	0.627
DOC_WW_Pin1_4	687	692	PF00397	0.599
DOC_WW_Pin1_4	778	783	PF00397	0.587
LIG_14-3-3_CanoR_1	166	173	PF00244	0.265
LIG_14-3-3_CanoR_1	581	587	PF00244	0.617
LIG_14-3-3_CanoR_1	611	619	PF00244	0.686
LIG_14-3-3_CanoR_1	744	751	PF00244	0.576
LIG_Actin_WH2_2	95	111	PF00022	0.281
LIG_APCC_ABBA_1	136	141	PF00400	0.337
LIG_BIR_II_1	1	5	PF00653	0.416
LIG_BIR_III_4	577	581	PF00653	0.573
LIG_Clathr_ClatBox_1	189	193	PF01394	0.232
LIG_Clathr_ClatBox_1	872	876	PF01394	0.409
LIG_CtBP_PxDLS_1	410	414	PF00389	0.582
LIG_EH1_1	88	96	PF00400	0.268
LIG_FHA_1	24	30	PF00498	0.475
LIG_FHA_1	273	279	PF00498	0.422
LIG_FHA_1	288	294	PF00498	0.221
LIG_FHA_1	334	340	PF00498	0.343
LIG_FHA_1	347	353	PF00498	0.343
LIG_FHA_1	491	497	PF00498	0.531
LIG_FHA_1	52	58	PF00498	0.293
LIG_FHA_1	562	568	PF00498	0.569
LIG_FHA_1	65	71	PF00498	0.268
LIG_FHA_1	793	799	PF00498	0.526
LIG_FHA_1	832	838	PF00498	0.418
LIG_FHA_1	86	92	PF00498	0.418
LIG_FHA_2	471	477	PF00498	0.403
LIG_FHA_2	550	556	PF00498	0.608
LIG_FHA_2	688	694	PF00498	0.564
LIG_FHA_2	772	778	PF00498	0.566
LIG_FHA_2	846	852	PF00498	0.426
LIG_Integrin_isoDGR_2	38	40	PF01839	0.221
LIG_Integrin_RGD_1	227	229	PF01839	0.255
LIG_LIR_Gen_1	368	379	PF02991	0.268
LIG_LIR_Gen_1	448	457	PF02991	0.425
LIG_LIR_Nem_3	137	142	PF02991	0.235
LIG_LIR_Nem_3	368	374	PF02991	0.270
LIG_LIR_Nem_3	448	453	PF02991	0.425
LIG_LIR_Nem_3	633	638	PF02991	0.777
LIG_LIR_Nem_3	697	701	PF02991	0.514
LIG_NRBOX	334	340	PF00104	0.343
LIG_Pex14_2	69	73	PF04695	0.268
LIG_SH2_CRK	371	375	PF00017	0.268
LIG_SH2_CRK	450	454	PF00017	0.422
LIG_SH2_PTP2	135	138	PF00017	0.268
LIG_SH2_SRC	135	138	PF00017	0.268
LIG_SH2_STAP1	257	261	PF00017	0.268
LIG_SH2_STAP1	457	461	PF00017	0.431
LIG_SH2_STAT3	457	460	PF00017	0.410
LIG_SH2_STAT5	132	135	PF00017	0.288
LIG_SH2_STAT5	371	374	PF00017	0.274
LIG_SH2_STAT5	701	704	PF00017	0.534
LIG_SH3_3	25	31	PF00018	0.413
LIG_SH3_3	616	622	PF00018	0.571
LIG_SH3_3	660	666	PF00018	0.623
LIG_SH3_3	688	694	PF00018	0.570
LIG_SUMO_SIM_anti_2	833	841	PF11976	0.464
LIG_SUMO_SIM_par_1	25	30	PF11976	0.384
LIG_SUMO_SIM_par_1	409	415	PF11976	0.583
LIG_SUMO_SIM_par_1	442	448	PF11976	0.418
LIG_SUMO_SIM_par_1	833	841	PF11976	0.397
LIG_SUMO_SIM_par_1	95	101	PF11976	0.290
LIG_TRAF2_1	498	501	PF00917	0.441
LIG_TRAF2_1	637	640	PF00917	0.588
LIG_TYR_ITIM	133	138	PF00017	0.268
LIG_TYR_ITIM	369	374	PF00017	0.268
LIG_UBA3_1	98	106	PF00899	0.267
MOD_CDC14_SPxK_1	181	184	PF00782	0.232
MOD_CDC14_SPxK_1	618	621	PF00782	0.601
MOD_CDK_SPxK_1	178	184	PF00069	0.232
MOD_CDK_SPxK_1	615	621	PF00069	0.602
MOD_CDK_SPxxK_3	391	398	PF00069	0.528
MOD_CK1_1	243	249	PF00069	0.334
MOD_CK1_1	333	339	PF00069	0.343
MOD_CK1_1	409	415	PF00069	0.572
MOD_CK1_1	470	476	PF00069	0.466
MOD_CK1_1	615	621	PF00069	0.616
MOD_CK1_1	738	744	PF00069	0.523
MOD_CK1_1	746	752	PF00069	0.556
MOD_CK1_1	762	768	PF00069	0.547
MOD_CK2_1	266	272	PF00069	0.322
MOD_CK2_1	409	415	PF00069	0.602
MOD_CK2_1	470	476	PF00069	0.410
MOD_CK2_1	687	693	PF00069	0.577
MOD_CK2_1	771	777	PF00069	0.565
MOD_CK2_1	809	815	PF00069	0.527
MOD_CK2_1	845	851	PF00069	0.443
MOD_DYRK1A_RPxSP_1	176	180	PF00069	0.262
MOD_DYRK1A_RPxSP_1	391	395	PF00069	0.515
MOD_GlcNHglycan	109	112	PF01048	0.297
MOD_GlcNHglycan	316	319	PF01048	0.226
MOD_GlcNHglycan	346	349	PF01048	0.268
MOD_GlcNHglycan	402	405	PF01048	0.536
MOD_GlcNHglycan	447	450	PF01048	0.428
MOD_GlcNHglycan	600	603	PF01048	0.710
MOD_GlcNHglycan	614	617	PF01048	0.613
MOD_GlcNHglycan	682	685	PF01048	0.610
MOD_GlcNHglycan	745	748	PF01048	0.541
MOD_GSK3_1	227	234	PF00069	0.350
MOD_GSK3_1	329	336	PF00069	0.329
MOD_GSK3_1	445	452	PF00069	0.491
MOD_GSK3_1	463	470	PF00069	0.450
MOD_GSK3_1	519	526	PF00069	0.558
MOD_GSK3_1	549	556	PF00069	0.716
MOD_GSK3_1	734	741	PF00069	0.534
MOD_GSK3_1	743	750	PF00069	0.527
MOD_GSK3_1	761	768	PF00069	0.538
MOD_N-GLC_1	561	566	PF02516	0.527
MOD_N-GLC_1	73	78	PF02516	0.268
MOD_NEK2_1	167	172	PF00069	0.277
MOD_NEK2_1	282	287	PF00069	0.268
MOD_NEK2_1	339	344	PF00069	0.311
MOD_NEK2_1	467	472	PF00069	0.504
MOD_NEK2_1	582	587	PF00069	0.606
MOD_NEK2_1	73	78	PF00069	0.278
MOD_NEK2_1	739	744	PF00069	0.533
MOD_NEK2_1	794	799	PF00069	0.547
MOD_NEK2_2	248	253	PF00069	0.278
MOD_PIKK_1	322	328	PF00454	0.221
MOD_PIKK_1	436	442	PF00454	0.544
MOD_PIKK_1	490	496	PF00454	0.427
MOD_PIKK_1	590	596	PF00454	0.618
MOD_PIKK_1	630	636	PF00454	0.578
MOD_PKA_1	231	237	PF00069	0.268
MOD_PKA_1	427	433	PF00069	0.494
MOD_PKA_2	231	237	PF00069	0.340
MOD_PKA_2	330	336	PF00069	0.343
MOD_PKA_2	427	433	PF00069	0.545
MOD_PKA_2	743	749	PF00069	0.554
MOD_PKA_2	845	851	PF00069	0.401
MOD_PKB_1	425	433	PF00069	0.501
MOD_Plk_1	362	368	PF00069	0.278
MOD_Plk_1	630	636	PF00069	0.535
MOD_Plk_1	73	79	PF00069	0.268
MOD_Plk_4	120	126	PF00069	0.290
MOD_Plk_4	208	214	PF00069	0.267
MOD_Plk_4	23	29	PF00069	0.465
MOD_Plk_4	248	254	PF00069	0.268
MOD_Plk_4	346	352	PF00069	0.339
MOD_Plk_4	694	700	PF00069	0.509
MOD_Plk_4	73	79	PF00069	0.302
MOD_Plk_4	831	837	PF00069	0.420
MOD_Plk_4	90	96	PF00069	0.449
MOD_ProDKin_1	176	182	PF00069	0.270
MOD_ProDKin_1	197	203	PF00069	0.271
MOD_ProDKin_1	391	397	PF00069	0.722
MOD_ProDKin_1	398	404	PF00069	0.548
MOD_ProDKin_1	406	412	PF00069	0.514
MOD_ProDKin_1	615	621	PF00069	0.618
MOD_ProDKin_1	659	665	PF00069	0.629
MOD_ProDKin_1	687	693	PF00069	0.591
MOD_ProDKin_1	778	784	PF00069	0.583
MOD_SUMO_rev_2	269	275	PF00179	0.292
MOD_SUMO_rev_2	429	439	PF00179	0.506
MOD_SUMO_rev_2	876	883	PF00179	0.387
TRG_DiLeu_BaEn_1	23	28	PF01217	0.414
TRG_DiLeu_BaLyEn_6	126	131	PF01217	0.290
TRG_DiLeu_BaLyEn_6	334	339	PF01217	0.337
TRG_DiLeu_BaLyEn_6	61	66	PF01217	0.290
TRG_DiLeu_BaLyEn_6	93	98	PF01217	0.268
TRG_ENDOCYTIC_2	135	138	PF00928	0.268
TRG_ENDOCYTIC_2	139	142	PF00928	0.268
TRG_ENDOCYTIC_2	371	374	PF00928	0.268
TRG_ENDOCYTIC_2	386	389	PF00928	0.512
TRG_ENDOCYTIC_2	450	453	PF00928	0.424
TRG_ENDOCYTIC_2	635	638	PF00928	0.708
TRG_ER_diArg_1	388	391	PF00400	0.539
TRG_ER_diArg_1	425	428	PF00400	0.522
TRG_ER_diArg_1	509	512	PF00400	0.428
TRG_ER_diArg_1	843	846	PF00400	0.413
TRG_ER_diArg_1	9	12	PF00400	0.384
TRG_NLS_MonoExtC_3	506	511	PF00514	0.579
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.268
TRG_Pf-PMV_PEXEL_1	337	341	PF00026	0.337
TRG_Pf-PMV_PEXEL_1	377	381	PF00026	0.363
TRG_Pf-PMV_PEXEL_1	483	488	PF00026	0.460

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P569	Leptomonas seymouri	44%	100%
A0A3Q8IHG6	Leishmania donovani	29%	100%
A0A3S7WPL3	Leishmania donovani	91%	99%
A4H4R6	Leishmania braziliensis	75%	100%
A4H7S0	Leishmania braziliensis	27%	82%
A4HHN8	Leishmania braziliensis	28%	100%
A4HSZ5	Leishmania infantum	92%	99%
A4I4V2	Leishmania infantum	29%	100%
E9AEA0	Leishmania major	29%	100%
E9AEA1	Leishmania major	29%	100%
E9AKY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9ALI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9ALI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%