Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIX2_LEIMA

TriTrypDb:

LmjF.06.1040 , LMJLV39_060016800 , LMJSD75_060017000

Length:

724

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4QIX2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIX2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	403	407	PF00656	0.661
CLV_NRD_NRD_1	142	144	PF00675	0.570
CLV_NRD_NRD_1	162	164	PF00675	0.313
CLV_NRD_NRD_1	165	167	PF00675	0.502
CLV_NRD_NRD_1	251	253	PF00675	0.523
CLV_NRD_NRD_1	318	320	PF00675	0.580
CLV_NRD_NRD_1	346	348	PF00675	0.682
CLV_NRD_NRD_1	419	421	PF00675	0.602
CLV_NRD_NRD_1	43	45	PF00675	0.561
CLV_NRD_NRD_1	518	520	PF00675	0.629
CLV_NRD_NRD_1	61	63	PF00675	0.532
CLV_NRD_NRD_1	624	626	PF00675	0.559
CLV_NRD_NRD_1	651	653	PF00675	0.720
CLV_NRD_NRD_1	718	720	PF00675	0.627
CLV_PCSK_FUR_1	140	144	PF00082	0.581
CLV_PCSK_KEX2_1	140	142	PF00082	0.596
CLV_PCSK_KEX2_1	210	212	PF00082	0.529
CLV_PCSK_KEX2_1	250	252	PF00082	0.523
CLV_PCSK_KEX2_1	318	320	PF00082	0.573
CLV_PCSK_KEX2_1	346	348	PF00082	0.691
CLV_PCSK_KEX2_1	43	45	PF00082	0.560
CLV_PCSK_KEX2_1	61	63	PF00082	0.541
CLV_PCSK_KEX2_1	624	626	PF00082	0.559
CLV_PCSK_KEX2_1	628	630	PF00082	0.534
CLV_PCSK_KEX2_1	651	653	PF00082	0.720
CLV_PCSK_KEX2_1	718	720	PF00082	0.620
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.529
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.523
CLV_PCSK_PC1ET2_1	628	630	PF00082	0.546
CLV_PCSK_PC7_1	624	630	PF00082	0.534
CLV_PCSK_PC7_1	647	653	PF00082	0.700
CLV_PCSK_SKI1_1	132	136	PF00082	0.501
CLV_PCSK_SKI1_1	167	171	PF00082	0.549
CLV_PCSK_SKI1_1	328	332	PF00082	0.527
CLV_PCSK_SKI1_1	336	340	PF00082	0.523
CLV_PCSK_SKI1_1	466	470	PF00082	0.502
CLV_PCSK_SKI1_1	480	484	PF00082	0.649
CLV_PCSK_SKI1_1	591	595	PF00082	0.567
CLV_PCSK_SKI1_1	647	651	PF00082	0.642
CLV_PCSK_SKI1_1	718	722	PF00082	0.651
DEG_APCC_DBOX_1	155	163	PF00400	0.614
DEG_APCC_DBOX_1	310	318	PF00400	0.499
DEG_APCC_DBOX_1	42	50	PF00400	0.674
DEG_APCC_DBOX_1	81	89	PF00400	0.651
DEG_Nend_UBRbox_1	1	4	PF02207	0.665
DEG_SCF_FBW7_2	396	402	PF00400	0.764
DOC_CKS1_1	396	401	PF01111	0.804
DOC_CKS1_1	491	496	PF01111	0.656
DOC_MAPK_gen_1	250	256	PF00069	0.510
DOC_MAPK_gen_1	346	354	PF00069	0.548
DOC_MAPK_MEF2A_6	346	354	PF00069	0.548
DOC_PP1_RVXF_1	550	557	PF00149	0.570
DOC_PP4_FxxP_1	8	11	PF00568	0.681
DOC_USP7_MATH_1	176	180	PF00917	0.549
DOC_USP7_MATH_1	283	287	PF00917	0.564
DOC_USP7_MATH_1	518	522	PF00917	0.725
DOC_WW_Pin1_4	395	400	PF00397	0.809
DOC_WW_Pin1_4	490	495	PF00397	0.704
DOC_WW_Pin1_4	638	643	PF00397	0.706
DOC_WW_Pin1_4	680	685	PF00397	0.553
LIG_14-3-3_CanoR_1	105	109	PF00244	0.670
LIG_14-3-3_CanoR_1	12	21	PF00244	0.682
LIG_14-3-3_CanoR_1	130	138	PF00244	0.643
LIG_14-3-3_CanoR_1	346	351	PF00244	0.763
LIG_14-3-3_CanoR_1	480	485	PF00244	0.735
LIG_14-3-3_CanoR_1	614	622	PF00244	0.611
LIG_14-3-3_CanoR_1	627	634	PF00244	0.480
LIG_14-3-3_CanoR_1	651	657	PF00244	0.737
LIG_14-3-3_CanoR_1	704	714	PF00244	0.607
LIG_14-3-3_CanoR_1	718	724	PF00244	0.534
LIG_APCC_ABBA_1	412	417	PF00400	0.626
LIG_APCC_ABBAyCdc20_2	445	451	PF00400	0.641
LIG_eIF4E_1	242	248	PF01652	0.360
LIG_FHA_1	226	232	PF00498	0.637
LIG_FHA_1	347	353	PF00498	0.620
LIG_FHA_1	511	517	PF00498	0.714
LIG_FHA_1	522	528	PF00498	0.495
LIG_FHA_1	549	555	PF00498	0.560
LIG_FHA_1	600	606	PF00498	0.510
LIG_FHA_1	61	67	PF00498	0.589
LIG_FHA_1	659	665	PF00498	0.710
LIG_FHA_1	681	687	PF00498	0.648
LIG_FHA_1	706	712	PF00498	0.578
LIG_FHA_2	222	228	PF00498	0.623
LIG_FHA_2	232	238	PF00498	0.566
LIG_FHA_2	322	328	PF00498	0.639
LIG_FHA_2	338	344	PF00498	0.630
LIG_FHA_2	592	598	PF00498	0.536
LIG_FHA_2	694	700	PF00498	0.684
LIG_FHA_2	99	105	PF00498	0.591
LIG_LIR_Gen_1	290	299	PF02991	0.509
LIG_LIR_Nem_3	188	193	PF02991	0.615
LIG_LIR_Nem_3	290	296	PF02991	0.511
LIG_LIR_Nem_3	416	422	PF02991	0.491
LIG_LIR_Nem_3	443	449	PF02991	0.512
LIG_PCNA_yPIPBox_3	236	250	PF02747	0.361
LIG_Rb_LxCxE_1	259	277	PF01857	0.610
LIG_SH2_CRK	190	194	PF00017	0.614
LIG_SH2_CRK	244	248	PF00017	0.509
LIG_SH2_CRK	419	423	PF00017	0.590
LIG_SH2_NCK_1	289	293	PF00017	0.508
LIG_SH2_SRC	618	621	PF00017	0.626
LIG_SH2_STAP1	244	248	PF00017	0.512
LIG_SH2_STAP1	289	293	PF00017	0.508
LIG_SH2_STAT5	618	621	PF00017	0.626
LIG_SH3_3	1	7	PF00018	0.712
LIG_SH3_3	485	491	PF00018	0.741
LIG_SH3_3	8	14	PF00018	0.664
LIG_SUMO_SIM_par_1	227	232	PF11976	0.473
LIG_SUMO_SIM_par_1	458	465	PF11976	0.594
LIG_TRAF2_1	330	333	PF00917	0.585
MOD_CDK_SPK_2	638	643	PF00069	0.655
MOD_CK1_1	214	220	PF00069	0.523
MOD_CK1_1	232	238	PF00069	0.404
MOD_CK1_1	364	370	PF00069	0.747
MOD_CK1_1	401	407	PF00069	0.754
MOD_CK1_1	521	527	PF00069	0.720
MOD_CK2_1	231	237	PF00069	0.571
MOD_CK2_1	321	327	PF00069	0.634
MOD_CK2_1	337	343	PF00069	0.625
MOD_CK2_1	583	589	PF00069	0.530
MOD_CK2_1	591	597	PF00069	0.559
MOD_CK2_1	704	710	PF00069	0.606
MOD_CK2_1	92	98	PF00069	0.640
MOD_GlcNHglycan	132	135	PF01048	0.503
MOD_GlcNHglycan	177	181	PF01048	0.506
MOD_GlcNHglycan	363	366	PF01048	0.754
MOD_GlcNHglycan	422	425	PF01048	0.591
MOD_GlcNHglycan	473	476	PF01048	0.614
MOD_GlcNHglycan	520	523	PF01048	0.713
MOD_GlcNHglycan	563	567	PF01048	0.567
MOD_GSK3_1	104	111	PF00069	0.695
MOD_GSK3_1	16	23	PF00069	0.727
MOD_GSK3_1	221	228	PF00069	0.595
MOD_GSK3_1	24	31	PF00069	0.691
MOD_GSK3_1	357	364	PF00069	0.756
MOD_GSK3_1	401	408	PF00069	0.667
MOD_GSK3_1	480	487	PF00069	0.717
MOD_GSK3_1	492	499	PF00069	0.697
MOD_GSK3_1	507	514	PF00069	0.746
MOD_GSK3_1	523	530	PF00069	0.680
MOD_GSK3_1	673	680	PF00069	0.770
MOD_LATS_1	344	350	PF00433	0.590
MOD_N-GLC_2	335	337	PF02516	0.612
MOD_NEK2_1	123	128	PF00069	0.624
MOD_NEK2_1	178	183	PF00069	0.550
MOD_NEK2_1	229	234	PF00069	0.618
MOD_NEK2_2	125	130	PF00069	0.733
MOD_PIKK_1	229	235	PF00454	0.614
MOD_PIKK_1	37	43	PF00454	0.629
MOD_PIKK_1	405	411	PF00454	0.550
MOD_PIKK_1	531	537	PF00454	0.644
MOD_PIKK_1	628	634	PF00454	0.623
MOD_PK_1	211	217	PF00069	0.513
MOD_PKA_1	346	352	PF00069	0.723
MOD_PKA_1	420	426	PF00069	0.596
MOD_PKA_1	627	633	PF00069	0.570
MOD_PKA_2	104	110	PF00069	0.707
MOD_PKA_2	346	352	PF00069	0.651
MOD_PKA_2	360	366	PF00069	0.664
MOD_PKA_2	367	373	PF00069	0.812
MOD_PKA_2	518	524	PF00069	0.613
MOD_PKA_2	60	66	PF00069	0.678
MOD_PKA_2	613	619	PF00069	0.550
MOD_PKA_2	628	634	PF00069	0.453
MOD_PKA_2	650	656	PF00069	0.555
MOD_PKA_2	674	680	PF00069	0.798
MOD_PKB_1	625	633	PF00069	0.558
MOD_Plk_1	401	407	PF00069	0.697
MOD_Plk_1	664	670	PF00069	0.731
MOD_Plk_2-3	92	98	PF00069	0.712
MOD_Plk_4	225	231	PF00069	0.476
MOD_Plk_4	600	606	PF00069	0.610
MOD_Plk_4	664	670	PF00069	0.669
MOD_ProDKin_1	395	401	PF00069	0.806
MOD_ProDKin_1	490	496	PF00069	0.703
MOD_ProDKin_1	638	644	PF00069	0.707
MOD_ProDKin_1	680	686	PF00069	0.552
MOD_SUMO_for_1	134	137	PF00179	0.661
MOD_SUMO_for_1	354	357	PF00179	0.728
MOD_SUMO_rev_2	202	212	PF00179	0.578
MOD_SUMO_rev_2	214	222	PF00179	0.502
MOD_SUMO_rev_2	707	714	PF00179	0.601
TRG_DiLeu_BaEn_1	225	230	PF01217	0.560
TRG_DiLeu_BaEn_1	253	258	PF01217	0.450
TRG_DiLeu_BaEn_1	259	264	PF01217	0.469
TRG_DiLeu_BaEn_1	316	321	PF01217	0.534
TRG_DiLeu_BaEn_1	465	470	PF01217	0.546
TRG_DiLeu_BaEn_4	91	97	PF01217	0.706
TRG_DiLeu_LyEn_5	316	321	PF01217	0.558
TRG_ENDOCYTIC_2	190	193	PF00928	0.615
TRG_ENDOCYTIC_2	244	247	PF00928	0.503
TRG_ENDOCYTIC_2	419	422	PF00928	0.600
TRG_ENDOCYTIC_2	446	449	PF00928	0.524
TRG_ER_diArg_1	140	143	PF00400	0.662
TRG_ER_diArg_1	156	159	PF00400	0.400
TRG_ER_diArg_1	317	319	PF00400	0.584
TRG_ER_diArg_1	42	44	PF00400	0.562
TRG_ER_diArg_1	51	54	PF00400	0.546
TRG_ER_diArg_1	61	64	PF00400	0.542
TRG_ER_diArg_1	624	627	PF00400	0.605
TRG_ER_diArg_1	650	652	PF00400	0.727
TRG_ER_diArg_1	718	720	PF00400	0.575
TRG_NLS_MonoExtC_3	162	167	PF00514	0.642
TRG_NLS_MonoExtN_4	624	631	PF00514	0.539
TRG_Pf-PMV_PEXEL_1	150	154	PF00026	0.567
TRG_Pf-PMV_PEXEL_1	172	177	PF00026	0.564
TRG_Pf-PMV_PEXEL_1	191	196	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	199	203	PF00026	0.514
TRG_Pf-PMV_PEXEL_1	318	323	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	371	375	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	44	48	PF00026	0.599
TRG_Pf-PMV_PEXEL_1	552	557	PF00026	0.605
TRG_Pf-PMV_PEXEL_1	64	68	PF00026	0.339
TRG_Pf-PMV_PEXEL_1	719	723	PF00026	0.710

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4C6	Leptomonas seymouri	46%	96%
A0A1X0NL89	Trypanosomatidae	28%	100%
A0A3S5H5T8	Leishmania donovani	88%	100%
A4H4R7	Leishmania braziliensis	63%	100%
A4HSZ6	Leishmania infantum	88%	100%
E9AKY3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%