Protein disulfide isomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein disulfide isomerase

Species:

Leishmania major

UniProt:

Q4QIX1_LEIMA

TriTrypDb:

LmjF.06.1050 , LMJLV39_060016900 , LMJSD75_060017100

Length:

133

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 7, no: 2
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QIX1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIX1

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	2
GO:0009987	cellular process	1	2

Molecular functions
Term	Name	Level	Count
GO:0003756	protein disulfide isomerase activity	3	10
GO:0003824	catalytic activity	1	10
GO:0016853	isomerase activity	2	10
GO:0016860	intramolecular oxidoreductase activity	3	10
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	4	10
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	4	6	PF00675	0.536
CLV_PCSK_KEX2_1	106	108	PF00082	0.332
CLV_PCSK_PC1ET2_1	106	108	PF00082	0.332
CLV_PCSK_SKI1_1	35	39	PF00082	0.368
CLV_PCSK_SKI1_1	42	46	PF00082	0.287
DEG_APCC_DBOX_1	4	12	PF00400	0.575
DEG_Nend_Nbox_1	1	3	PF02207	0.411
DOC_MAPK_gen_1	5	12	PF00069	0.515
DOC_MAPK_HePTP_8	2	14	PF00069	0.397
DOC_MAPK_JIP1_4	60	66	PF00069	0.332
DOC_MAPK_MEF2A_6	5	14	PF00069	0.511
DOC_MAPK_MEF2A_6	96	103	PF00069	0.225
DOC_PP4_FxxP_1	48	51	PF00568	0.312
DOC_USP7_UBL2_3	102	106	PF12436	0.346
DOC_USP7_UBL2_3	38	42	PF12436	0.355
LIG_14-3-3_CanoR_1	5	9	PF00244	0.604
LIG_FHA_1	5	11	PF00498	0.580
LIG_FHA_2	70	76	PF00498	0.380
LIG_GBD_Chelix_1	8	16	PF00786	0.485
LIG_LIR_Apic_2	112	118	PF02991	0.301
LIG_LIR_Nem_3	122	127	PF02991	0.377
LIG_LIR_Nem_3	84	89	PF02991	0.311
LIG_NRBOX	7	13	PF00104	0.487
LIG_Pex14_2	48	52	PF04695	0.287
LIG_REV1ctd_RIR_1	101	111	PF16727	0.310
LIG_SH2_CRK	115	119	PF00017	0.272
LIG_SH2_CRK	86	90	PF00017	0.355
LIG_SH2_STAT5	127	130	PF00017	0.426
LIG_SH3_3	34	40	PF00018	0.346
LIG_SUMO_SIM_anti_2	7	12	PF11976	0.489
MOD_GlcNHglycan	108	112	PF01048	0.444
MOD_GlcNHglycan	120	124	PF01048	0.222
MOD_PKA_2	4	10	PF00069	0.595
MOD_Plk_1	119	125	PF00069	0.435
MOD_SUMO_for_1	21	24	PF00179	0.536
TRG_DiLeu_BaEn_2	119	125	PF01217	0.310
TRG_ENDOCYTIC_2	86	89	PF00928	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I216	Leptomonas seymouri	32%	94%
A0A0N1I5T9	Leptomonas seymouri	52%	100%
A0A0N1IJS7	Leptomonas seymouri	26%	81%
A0A0S4JA26	Bodo saltans	49%	80%
A0A1X0NGQ4	Trypanosomatidae	33%	90%
A0A1X0NT33	Trypanosomatidae	26%	80%
A0A3R7NHA8	Trypanosoma rangeli	49%	73%
A0A422NM49	Trypanosoma rangeli	32%	89%
A4H4R8	Leishmania braziliensis	78%	100%
A4H4T0	Leishmania braziliensis	29%	90%
A4HSZ7	Leishmania infantum	89%	100%
A4HT10	Leishmania infantum	30%	90%
C9ZTP4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	88%
C9ZTP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	99%
E9AKY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
E9AKZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	90%
G4NFB7	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	29%	78%
O64432	Brassica campestris	30%	100%
P07591	Spinacia oleracea	32%	73%
P07887	Corynebacterium nephridii	31%	100%
P09856	Spinacia oleracea	33%	70%
P0AA25	Escherichia coli (strain K12)	32%	100%
P0AA26	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	32%	100%
P0AA27	Escherichia coli O157:H7	32%	100%
P0AA28	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	32%	100%
P0AA29	Salmonella typhi	32%	100%
P0AA30	Shigella flexneri	32%	100%
P23400	Chlamydomonas reinhardtii	33%	95%
P29451	Macaca mulatta	32%	100%
P43785	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	30%	100%
P48384	Pisum sativum	33%	77%
P52228	Corynebacterium nephridii	30%	92%
P52233	Acidithiobacillus ferridurans	34%	100%
P66928	Helicobacter pylori (strain ATCC 700392 / 26695)	36%	100%
P66929	Helicobacter pylori (strain J99 / ATCC 700824)	36%	100%
P68176	Brassica oleracea	29%	100%
P68177	Brassica napus	29%	100%
P80579	Alicyclobacillus acidocaldarius subsp. acidocaldarius	33%	100%
Q09433	Caenorhabditis elegans	28%	100%
Q10N04	Oryza sativa subsp. japonica	28%	90%
Q1RQI9	Malassezia sympodialis	33%	100%
Q4QIV7	Leishmania major	31%	70%
Q7M1B9	Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)	31%	100%
Q8GYD1	Arabidopsis thaliana	25%	91%
Q8I7Z7	Leishmania donovani	90%	100%
Q9UW02	Coprinus comatus	28%	100%