Fe2OG dioxygenase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2OG-Fe(II) oxygenase superfamily, putative

Species:

Leishmania major

UniProt:

Q4QIX0_LEIMA

TriTrypDb:

LmjF.06.1060 , LMJLV39_060017000 , LMJSD75_060017200

Length:

322

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QIX0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIX0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	5
GO:0016491	oxidoreductase activity	2	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5
GO:0051213	dioxygenase activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	17	21	PF00656	0.636
CLV_NRD_NRD_1	243	245	PF00675	0.238
CLV_NRD_NRD_1	319	321	PF00675	0.707
CLV_PCSK_FUR_1	316	320	PF00082	0.620
CLV_PCSK_KEX2_1	242	244	PF00082	0.237
CLV_PCSK_KEX2_1	315	317	PF00082	0.685
CLV_PCSK_KEX2_1	318	320	PF00082	0.692
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.736
CLV_PCSK_PC1ET2_1	318	320	PF00082	0.742
CLV_PCSK_SKI1_1	187	191	PF00082	0.262
CLV_PCSK_SKI1_1	312	316	PF00082	0.734
DOC_CKS1_1	227	232	PF01111	0.448
DOC_CYCLIN_RxL_1	184	194	PF00134	0.448
DOC_MAPK_FxFP_2	200	203	PF00069	0.437
DOC_MAPK_gen_1	171	181	PF00069	0.434
DOC_MAPK_MEF2A_6	174	183	PF00069	0.437
DOC_PP1_RVXF_1	185	192	PF00149	0.437
DOC_PP1_SILK_1	66	71	PF00149	0.473
DOC_PP4_FxxP_1	119	122	PF00568	0.416
DOC_PP4_FxxP_1	200	203	PF00568	0.437
DOC_PP4_MxPP_1	293	296	PF00568	0.570
DOC_SPAK_OSR1_1	234	238	PF12202	0.437
DOC_USP7_MATH_1	185	189	PF00917	0.462
DOC_USP7_MATH_1	296	300	PF00917	0.661
DOC_USP7_MATH_1	34	38	PF00917	0.545
DOC_WW_Pin1_4	226	231	PF00397	0.458
LIG_14-3-3_CanoR_1	22	28	PF00244	0.535
LIG_14-3-3_CanoR_1	265	270	PF00244	0.575
LIG_14-3-3_CanoR_1	87	93	PF00244	0.543
LIG_BRCT_BRCA1_1	125	129	PF00533	0.451
LIG_BRCT_BRCA1_1	187	191	PF00533	0.462
LIG_deltaCOP1_diTrp_1	112	119	PF00928	0.472
LIG_FHA_1	176	182	PF00498	0.437
LIG_FHA_1	184	190	PF00498	0.437
LIG_FHA_1	211	217	PF00498	0.437
LIG_FHA_1	219	225	PF00498	0.437
LIG_FHA_2	126	132	PF00498	0.504
LIG_FHA_2	15	21	PF00498	0.639
LIG_FHA_2	266	272	PF00498	0.449
LIG_LIR_Apic_2	199	203	PF02991	0.539
LIG_LIR_Gen_1	126	137	PF02991	0.440
LIG_LIR_Gen_1	233	239	PF02991	0.436
LIG_LIR_Gen_1	63	73	PF02991	0.426
LIG_LIR_Nem_3	126	132	PF02991	0.437
LIG_LIR_Nem_3	138	142	PF02991	0.437
LIG_LIR_Nem_3	199	205	PF02991	0.527
LIG_LIR_Nem_3	233	238	PF02991	0.436
LIG_LIR_Nem_3	37	41	PF02991	0.517
LIG_LIR_Nem_3	63	68	PF02991	0.368
LIG_SH2_CRK	89	93	PF00017	0.374
LIG_SH2_STAP1	145	149	PF00017	0.447
LIG_SH2_STAT5	139	142	PF00017	0.415
LIG_SH2_STAT5	75	78	PF00017	0.315
LIG_SH3_3	10	16	PF00018	0.663
LIG_SH3_3	224	230	PF00018	0.423
LIG_SH3_3	3	9	PF00018	0.674
MOD_CK1_1	123	129	PF00069	0.404
MOD_CK1_1	218	224	PF00069	0.388
MOD_CK2_1	125	131	PF00069	0.554
MOD_Cter_Amidation	240	243	PF01082	0.237
MOD_DYRK1A_RPxSP_1	226	230	PF00069	0.432
MOD_GlcNHglycan	106	109	PF01048	0.553
MOD_GlcNHglycan	255	258	PF01048	0.675
MOD_GlcNHglycan	298	301	PF01048	0.714
MOD_GlcNHglycan	303	306	PF01048	0.675
MOD_GlcNHglycan	53	56	PF01048	0.580
MOD_GSK3_1	175	182	PF00069	0.467
MOD_GSK3_1	296	303	PF00069	0.698
MOD_NEK2_1	104	109	PF00069	0.529
MOD_NEK2_1	183	188	PF00069	0.448
MOD_NEK2_1	88	93	PF00069	0.507
MOD_NEK2_2	34	39	PF00069	0.382
MOD_PIKK_1	123	129	PF00454	0.417
MOD_PIKK_1	153	159	PF00454	0.539
MOD_PIKK_1	193	199	PF00454	0.539
MOD_PKA_2	233	239	PF00069	0.441
MOD_Plk_1	175	181	PF00069	0.437
MOD_Plk_1	63	69	PF00069	0.520
MOD_Plk_4	215	221	PF00069	0.388
MOD_Plk_4	23	29	PF00069	0.463
MOD_Plk_4	64	70	PF00069	0.430
MOD_ProDKin_1	226	232	PF00069	0.458
MOD_SUMO_for_1	92	95	PF00179	0.370
TRG_ENDOCYTIC_2	139	142	PF00928	0.448
TRG_ENDOCYTIC_2	89	92	PF00928	0.355
TRG_ER_diArg_1	242	244	PF00400	0.448
TRG_ER_diArg_1	28	31	PF00400	0.559
TRG_ER_diArg_1	319	321	PF00400	0.625
TRG_NES_CRM1_1	131	143	PF08389	0.452
TRG_NLS_MonoExtC_3	314	319	PF00514	0.592
TRG_NLS_MonoExtN_4	312	319	PF00514	0.592
TRG_Pf-PMV_PEXEL_1	171	175	PF00026	0.257
TRG_Pf-PMV_PEXEL_1	244	248	PF00026	0.280

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKD0	Leptomonas seymouri	74%	87%
A0A0S4JRX9	Bodo saltans	47%	100%
A0A1X0NKP4	Trypanosomatidae	65%	100%
A0A3R7KF49	Trypanosoma rangeli	58%	95%
A0A3S7WPM5	Leishmania donovani	94%	100%
A4H4R9	Leishmania braziliensis	82%	100%
A4HSZ8	Leishmania infantum	94%	94%
C9ZTN1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9AKY5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	96%
V5BXY4	Trypanosoma cruzi	58%	100%