TNase-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Staphylococcal nuclease homologue, putative

Species:

Leishmania major

UniProt:

Q4QIW8_LEIMA

TriTrypDb:

LmjF.06.1080 , LMJLV39_060017300 , LMJSD75_060017500

Length:

224

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QIW8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIW8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003824	catalytic activity	1	2
GO:0004518	nuclease activity	4	2
GO:0005488	binding	1	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	161	163	PF00675	0.376
CLV_NRD_NRD_1	172	174	PF00675	0.502
CLV_PCSK_KEX2_1	83	85	PF00082	0.441
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.441
CLV_PCSK_SKI1_1	174	178	PF00082	0.561
DEG_APCC_DBOX_1	56	64	PF00400	0.477
DOC_CKS1_1	177	182	PF01111	0.545
DOC_CKS1_1	94	99	PF01111	0.465
DOC_CYCLIN_RxL_1	102	115	PF00134	0.515
DOC_MAPK_gen_1	102	111	PF00069	0.400
DOC_MAPK_gen_1	55	63	PF00069	0.452
DOC_MAPK_HePTP_8	48	60	PF00069	0.601
DOC_MAPK_MEF2A_6	104	113	PF00069	0.511
DOC_MAPK_MEF2A_6	51	60	PF00069	0.591
DOC_PP1_RVXF_1	179	186	PF00149	0.515
DOC_PP4_FxxP_1	138	141	PF00568	0.477
DOC_PP4_FxxP_1	177	180	PF00568	0.509
DOC_USP7_MATH_1	13	17	PF00917	0.765
DOC_USP7_MATH_1	141	145	PF00917	0.480
DOC_USP7_MATH_1	155	159	PF00917	0.441
DOC_USP7_MATH_1	87	91	PF00917	0.493
DOC_USP7_UBL2_3	91	95	PF12436	0.441
DOC_WW_Pin1_4	137	142	PF00397	0.482
DOC_WW_Pin1_4	176	181	PF00397	0.539
DOC_WW_Pin1_4	194	199	PF00397	0.605
DOC_WW_Pin1_4	212	217	PF00397	0.541
DOC_WW_Pin1_4	93	98	PF00397	0.465
LIG_14-3-3_CanoR_1	107	112	PF00244	0.413
LIG_14-3-3_CanoR_1	199	205	PF00244	0.544
LIG_BIR_III_2	28	32	PF00653	0.589
LIG_BRCT_BRCA1_1	109	113	PF00533	0.462
LIG_BRCT_BRCA1_1	22	26	PF00533	0.584
LIG_Clathr_ClatBox_1	60	64	PF01394	0.434
LIG_FHA_1	45	51	PF00498	0.440
LIG_FHA_2	47	53	PF00498	0.552
LIG_HCF-1_HBM_1	40	43	PF13415	0.500
LIG_LIR_Apic_2	137	141	PF02991	0.477
LIG_LIR_Gen_1	103	113	PF02991	0.376
LIG_NRP_CendR_1	221	224	PF00754	0.554
LIG_SH2_NCK_1	139	143	PF00017	0.441
LIG_SH2_STAP1	74	78	PF00017	0.519
LIG_SH2_STAT5	81	84	PF00017	0.402
LIG_SH3_3	111	117	PF00018	0.402
LIG_SH3_3	216	222	PF00018	0.528
LIG_SUMO_SIM_par_1	46	52	PF11976	0.468
LIG_WRC_WIRS_1	135	140	PF05994	0.477
MOD_CDC14_SPxK_1	215	218	PF00782	0.551
MOD_CDK_SPK_2	176	181	PF00069	0.518
MOD_CDK_SPK_2	194	199	PF00069	0.356
MOD_CDK_SPxK_1	212	218	PF00069	0.550
MOD_CK1_1	115	121	PF00069	0.477
MOD_CK2_1	46	52	PF00069	0.543
MOD_GlcNHglycan	117	120	PF01048	0.449
MOD_GlcNHglycan	15	18	PF01048	0.693
MOD_GlcNHglycan	157	160	PF01048	0.441
MOD_GlcNHglycan	204	207	PF01048	0.561
MOD_GSK3_1	137	144	PF00069	0.508
MOD_GSK3_1	185	192	PF00069	0.545
MOD_GSK3_1	208	215	PF00069	0.583
MOD_GSK3_1	9	16	PF00069	0.725
MOD_N-GLC_2	3	5	PF02516	0.750
MOD_NEK2_2	134	139	PF00069	0.477
MOD_NMyristoyl	1	7	PF02799	0.650
MOD_PIKK_1	141	147	PF00454	0.473
MOD_Plk_1	35	41	PF00069	0.523
MOD_Plk_2-3	46	52	PF00069	0.513
MOD_Plk_4	107	113	PF00069	0.441
MOD_Plk_4	134	140	PF00069	0.434
MOD_ProDKin_1	137	143	PF00069	0.482
MOD_ProDKin_1	176	182	PF00069	0.539
MOD_ProDKin_1	194	200	PF00069	0.603
MOD_ProDKin_1	212	218	PF00069	0.550
MOD_ProDKin_1	93	99	PF00069	0.465
TRG_DiLeu_BaLyEn_6	56	61	PF01217	0.425
TRG_ENDOCYTIC_2	105	108	PF00928	0.392
TRG_ER_diArg_1	55	58	PF00400	0.537
TRG_NLS_Bipartite_1	162	177	PF00514	0.542
TRG_Pf-PMV_PEXEL_1	202	207	PF00026	0.382
TRG_Pf-PMV_PEXEL_1	59	64	PF00026	0.392

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4K0	Leptomonas seymouri	53%	100%
A0A0S4IY10	Bodo saltans	31%	92%
A0A1X0NDZ2	Trypanosomatidae	41%	100%
A0A1X0NKT8	Trypanosomatidae	40%	100%
A0A3S7WPM0	Leishmania donovani	96%	100%
A4HT00	Leishmania infantum	95%	100%
E9AI24	Leishmania braziliensis	73%	100%
E9AKY7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%