Protein bicaudal D

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Protein bicaudal D

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIW7_LEIMA

TriTrypDb:

LmjF.06.1090 , LMJLV39_060017400 , LMJSD75_060017600

Length:

595

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0034451	centriolar satellite	2	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QIW7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIW7

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0030030	cell projection organization	4	2
GO:0030031	cell projection assembly	5	2
GO:0044782	cilium organization	5	2
GO:0060271	cilium assembly	6	2
GO:0070925	organelle assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0120031	plasma membrane bounded cell projection assembly	6	2
GO:0120036	plasma membrane bounded cell projection organization	5	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	398	400	PF00675	0.444
CLV_NRD_NRD_1	574	576	PF00675	0.646
CLV_NRD_NRD_1	73	75	PF00675	0.652
CLV_NRD_NRD_1	9	11	PF00675	0.621
CLV_NRD_NRD_1	96	98	PF00675	0.483
CLV_PCSK_KEX2_1	197	199	PF00082	0.465
CLV_PCSK_KEX2_1	409	411	PF00082	0.414
CLV_PCSK_KEX2_1	574	576	PF00082	0.646
CLV_PCSK_KEX2_1	73	75	PF00082	0.652
CLV_PCSK_KEX2_1	9	11	PF00082	0.621
CLV_PCSK_KEX2_1	96	98	PF00082	0.483
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.522
CLV_PCSK_PC1ET2_1	409	411	PF00082	0.405
CLV_PCSK_PC7_1	5	11	PF00082	0.766
CLV_PCSK_PC7_1	92	98	PF00082	0.517
CLV_PCSK_SKI1_1	30	34	PF00082	0.634
CLV_PCSK_SKI1_1	443	447	PF00082	0.440
CLV_PCSK_SKI1_1	458	462	PF00082	0.435
CLV_PCSK_SKI1_1	496	500	PF00082	0.525
CLV_PCSK_SKI1_1	509	513	PF00082	0.492
CLV_PCSK_SKI1_1	81	85	PF00082	0.646
CLV_Separin_Metazoa	504	508	PF03568	0.417
DEG_APCC_DBOX_1	442	450	PF00400	0.579
DEG_APCC_DBOX_1	501	509	PF00400	0.406
DEG_APCC_DBOX_1	80	88	PF00400	0.635
DEG_SCF_FBW7_2	35	41	PF00400	0.531
DEG_SPOP_SBC_1	56	60	PF00917	0.614
DOC_CKS1_1	35	40	PF01111	0.528
DOC_CYCLIN_RxL_1	407	415	PF00134	0.388
DOC_CYCLIN_RxL_1	507	519	PF00134	0.483
DOC_MAPK_FxFP_2	521	524	PF00069	0.647
DOC_MAPK_gen_1	397	407	PF00069	0.417
DOC_MAPK_gen_1	481	488	PF00069	0.479
DOC_MAPK_gen_1	507	517	PF00069	0.557
DOC_MAPK_MEF2A_6	144	151	PF00069	0.608
DOC_MAPK_MEF2A_6	481	488	PF00069	0.479
DOC_MAPK_NFAT4_5	481	489	PF00069	0.481
DOC_PP2B_LxvP_1	393	396	PF13499	0.468
DOC_PP4_FxxP_1	521	524	PF00568	0.688
DOC_USP7_MATH_1	135	139	PF00917	0.483
DOC_USP7_MATH_1	364	368	PF00917	0.532
DOC_USP7_MATH_1	378	382	PF00917	0.596
DOC_USP7_MATH_1	545	549	PF00917	0.697
DOC_USP7_MATH_1	56	60	PF00917	0.761
DOC_USP7_MATH_1	562	566	PF00917	0.795
DOC_WW_Pin1_4	34	39	PF00397	0.801
DOC_WW_Pin1_4	44	49	PF00397	0.759
DOC_WW_Pin1_4	448	453	PF00397	0.427
DOC_WW_Pin1_4	578	583	PF00397	0.734
DOC_WW_Pin1_4	87	92	PF00397	0.577
LIG_14-3-3_CanoR_1	132	140	PF00244	0.475
LIG_14-3-3_CanoR_1	288	292	PF00244	0.466
LIG_14-3-3_CanoR_1	30	35	PF00244	0.749
LIG_14-3-3_CanoR_1	496	505	PF00244	0.541
LIG_14-3-3_CanoR_1	547	556	PF00244	0.630
LIG_14-3-3_CanoR_1	563	567	PF00244	0.747
LIG_14-3-3_CanoR_1	574	582	PF00244	0.682
LIG_Actin_WH2_2	174	191	PF00022	0.553
LIG_Actin_WH2_2	504	520	PF00022	0.514
LIG_APCC_ABBAyCdc20_2	409	415	PF00400	0.537
LIG_BRCT_BRCA1_1	355	359	PF00533	0.449
LIG_CtBP_PxDLS_1	590	594	PF00389	0.619
LIG_FHA_1	109	115	PF00498	0.534
LIG_FHA_1	124	130	PF00498	0.357
LIG_FHA_1	276	282	PF00498	0.403
LIG_FHA_1	402	408	PF00498	0.454
LIG_FHA_2	154	160	PF00498	0.493
LIG_FHA_2	227	233	PF00498	0.563
LIG_FHA_2	346	352	PF00498	0.415
LIG_FHA_2	523	529	PF00498	0.594
LIG_HP1_1	562	566	PF01393	0.516
LIG_LIR_Apic_2	519	524	PF02991	0.676
LIG_LIR_Gen_1	157	166	PF02991	0.553
LIG_LIR_Gen_1	390	396	PF02991	0.471
LIG_LIR_Gen_1	451	460	PF02991	0.424
LIG_LIR_LC3C_4	404	407	PF02991	0.558
LIG_LIR_Nem_3	157	163	PF02991	0.483
LIG_LIR_Nem_3	319	324	PF02991	0.415
LIG_LIR_Nem_3	390	395	PF02991	0.473
LIG_LIR_Nem_3	451	456	PF02991	0.425
LIG_LIR_Nem_3	584	588	PF02991	0.713
LIG_PCNA_yPIPBox_3	170	183	PF02747	0.489
LIG_SH2_CRK	182	186	PF00017	0.415
LIG_SH2_PTP2	453	456	PF00017	0.568
LIG_SH2_STAP1	322	326	PF00017	0.379
LIG_SH2_STAT3	266	269	PF00017	0.415
LIG_SH2_STAT5	266	269	PF00017	0.457
LIG_SH2_STAT5	453	456	PF00017	0.568
LIG_SH3_3	12	18	PF00018	0.742
LIG_SH3_3	32	38	PF00018	0.525
LIG_SH3_3	5	11	PF00018	0.768
LIG_SH3_3	85	91	PF00018	0.559
LIG_SUMO_SIM_anti_2	172	178	PF11976	0.488
LIG_SUMO_SIM_par_1	331	336	PF11976	0.467
LIG_SUMO_SIM_par_1	403	408	PF11976	0.454
LIG_TRAF2_1	156	159	PF00917	0.523
LIG_TRAF2_1	341	344	PF00917	0.436
LIG_WW_3	10	14	PF00397	0.671
MOD_CDK_SPK_2	87	92	PF00069	0.622
MOD_CK1_1	123	129	PF00069	0.425
MOD_CK1_1	42	48	PF00069	0.719
MOD_CK1_1	494	500	PF00069	0.436
MOD_CK1_1	54	60	PF00069	0.626
MOD_CK1_1	548	554	PF00069	0.713
MOD_CK1_1	565	571	PF00069	0.695
MOD_CK1_1	581	587	PF00069	0.683
MOD_CK2_1	153	159	PF00069	0.492
MOD_CK2_1	226	232	PF00069	0.570
MOD_CK2_1	522	528	PF00069	0.612
MOD_CK2_1	566	572	PF00069	0.725
MOD_CK2_1	574	580	PF00069	0.766
MOD_DYRK1A_RPxSP_1	44	48	PF00069	0.764
MOD_GlcNHglycan	273	276	PF01048	0.511
MOD_GlcNHglycan	379	383	PF01048	0.579
MOD_GlcNHglycan	547	550	PF01048	0.710
MOD_GlcNHglycan	551	554	PF01048	0.703
MOD_GlcNHglycan	568	571	PF01048	0.798
MOD_GlcNHglycan	576	579	PF01048	0.607
MOD_GlcNHglycan	59	62	PF01048	0.714
MOD_GSK3_1	149	156	PF00069	0.563
MOD_GSK3_1	184	191	PF00069	0.425
MOD_GSK3_1	222	229	PF00069	0.544
MOD_GSK3_1	271	278	PF00069	0.409
MOD_GSK3_1	30	37	PF00069	0.693
MOD_GSK3_1	358	365	PF00069	0.608
MOD_GSK3_1	40	47	PF00069	0.631
MOD_GSK3_1	401	408	PF00069	0.460
MOD_GSK3_1	48	55	PF00069	0.565
MOD_GSK3_1	490	497	PF00069	0.552
MOD_GSK3_1	543	550	PF00069	0.747
MOD_GSK3_1	562	569	PF00069	0.702
MOD_GSK3_1	574	581	PF00069	0.781
MOD_N-GLC_1	133	138	PF02516	0.581
MOD_N-GLC_1	261	266	PF02516	0.555
MOD_N-GLC_1	554	559	PF02516	0.529
MOD_NEK2_1	108	113	PF00069	0.454
MOD_NEK2_1	149	154	PF00069	0.588
MOD_NEK2_1	188	193	PF00069	0.538
MOD_NEK2_1	202	207	PF00069	0.565
MOD_NEK2_1	358	363	PF00069	0.450
MOD_NEK2_1	401	406	PF00069	0.428
MOD_NEK2_1	556	561	PF00069	0.739
MOD_NEK2_1	566	571	PF00069	0.711
MOD_NEK2_2	287	292	PF00069	0.481
MOD_NEK2_2	491	496	PF00069	0.436
MOD_PIKK_1	133	139	PF00454	0.444
MOD_PIKK_1	142	148	PF00454	0.471
MOD_PIKK_1	188	194	PF00454	0.572
MOD_PIKK_1	353	359	PF00454	0.492
MOD_PIKK_1	364	370	PF00454	0.440
MOD_PIKK_1	557	563	PF00454	0.703
MOD_PKA_1	574	580	PF00069	0.554
MOD_PKA_2	188	194	PF00069	0.429
MOD_PKA_2	287	293	PF00069	0.488
MOD_PKA_2	383	389	PF00069	0.665
MOD_PKA_2	543	549	PF00069	0.696
MOD_PKA_2	562	568	PF00069	0.689
MOD_PKA_2	573	579	PF00069	0.747
MOD_Plk_1	120	126	PF00069	0.468
MOD_Plk_1	261	267	PF00069	0.552
MOD_Plk_4	261	267	PF00069	0.537
MOD_Plk_4	401	407	PF00069	0.511
MOD_ProDKin_1	34	40	PF00069	0.804
MOD_ProDKin_1	44	50	PF00069	0.758
MOD_ProDKin_1	448	454	PF00069	0.422
MOD_ProDKin_1	578	584	PF00069	0.732
MOD_ProDKin_1	87	93	PF00069	0.574
MOD_SUMO_for_1	317	320	PF00179	0.377
MOD_SUMO_rev_2	212	218	PF00179	0.574
MOD_SUMO_rev_2	308	314	PF00179	0.391
MOD_SUMO_rev_2	319	326	PF00179	0.408
MOD_SUMO_rev_2	342	346	PF00179	0.564
MOD_SUMO_rev_2	478	484	PF00179	0.554
TRG_DiLeu_BaEn_1	110	115	PF01217	0.500
TRG_DiLeu_BaEn_2	354	360	PF01217	0.417
TRG_ENDOCYTIC_2	160	163	PF00928	0.485
TRG_ENDOCYTIC_2	182	185	PF00928	0.418
TRG_ENDOCYTIC_2	321	324	PF00928	0.392
TRG_ENDOCYTIC_2	453	456	PF00928	0.568
TRG_ER_diArg_1	396	399	PF00400	0.457
TRG_ER_diArg_1	73	75	PF00400	0.651
TRG_ER_diArg_1	8	10	PF00400	0.626
TRG_ER_diArg_1	95	97	PF00400	0.481
TRG_NES_CRM1_1	172	184	PF08389	0.486
TRG_NES_CRM1_1	344	355	PF08389	0.403
TRG_Pf-PMV_PEXEL_1	171	175	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	239	244	PF00026	0.358
TRG_Pf-PMV_PEXEL_1	331	336	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	410	415	PF00026	0.416
TRG_Pf-PMV_PEXEL_1	81	86	PF00026	0.572
TRG_Pf-PMV_PEXEL_1	96	100	PF00026	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3D2	Leptomonas seymouri	60%	100%
A0A0S4KJ48	Bodo saltans	38%	100%
A0A1X0NFW7	Trypanosomatidae	53%	100%
A0A1X0NGS8	Trypanosomatidae	53%	98%
A0A3R7KEX6	Trypanosoma rangeli	48%	97%
A0A3S7WPN7	Leishmania donovani	95%	100%
A4H4S1	Leishmania braziliensis	80%	97%
A4HT01	Leishmania infantum	95%	100%
C9ZTN3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9AKY8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BXW3	Trypanosoma cruzi	49%	97%