Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIW5_LEIMA

TriTrypDb:

LmjF.06.1110 , LMJLV39_060017600 , LMJSD75_060017800

Length:

1108

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QIW5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIW5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	291	295	PF00656	0.716
CLV_C14_Caspase3-7	941	945	PF00656	0.511
CLV_NRD_NRD_1	1101	1103	PF00675	0.681
CLV_NRD_NRD_1	195	197	PF00675	0.582
CLV_NRD_NRD_1	240	242	PF00675	0.810
CLV_NRD_NRD_1	447	449	PF00675	0.784
CLV_NRD_NRD_1	468	470	PF00675	0.599
CLV_NRD_NRD_1	535	537	PF00675	0.595
CLV_NRD_NRD_1	546	548	PF00675	0.606
CLV_NRD_NRD_1	611	613	PF00675	0.632
CLV_NRD_NRD_1	698	700	PF00675	0.713
CLV_NRD_NRD_1	755	757	PF00675	0.650
CLV_NRD_NRD_1	849	851	PF00675	0.717
CLV_NRD_NRD_1	899	901	PF00675	0.637
CLV_PCSK_KEX2_1	195	197	PF00082	0.524
CLV_PCSK_KEX2_1	240	242	PF00082	0.810
CLV_PCSK_KEX2_1	468	470	PF00082	0.598
CLV_PCSK_KEX2_1	535	537	PF00082	0.595
CLV_PCSK_KEX2_1	546	548	PF00082	0.606
CLV_PCSK_KEX2_1	755	757	PF00082	0.630
CLV_PCSK_KEX2_1	849	851	PF00082	0.736
CLV_PCSK_SKI1_1	106	110	PF00082	0.561
CLV_PCSK_SKI1_1	1060	1064	PF00082	0.763
CLV_PCSK_SKI1_1	182	186	PF00082	0.699
CLV_PCSK_SKI1_1	508	512	PF00082	0.633
CLV_PCSK_SKI1_1	535	539	PF00082	0.621
CLV_PCSK_SKI1_1	635	639	PF00082	0.608
CLV_PCSK_SKI1_1	688	692	PF00082	0.774
CLV_PCSK_SKI1_1	775	779	PF00082	0.500
CLV_Separin_Metazoa	1017	1021	PF03568	0.567
DEG_COP1_1	1045	1055	PF00400	0.566
DEG_ODPH_VHL_1	269	280	PF01847	0.737
DOC_MAPK_gen_1	316	326	PF00069	0.756
DOC_MAPK_gen_1	512	521	PF00069	0.697
DOC_MAPK_gen_1	900	910	PF00069	0.646
DOC_PP1_RVXF_1	65	72	PF00149	0.720
DOC_PP2B_LxvP_1	177	180	PF13499	0.680
DOC_PP2B_LxvP_1	278	281	PF13499	0.730
DOC_USP7_MATH_1	1067	1071	PF00917	0.646
DOC_USP7_MATH_1	128	132	PF00917	0.729
DOC_USP7_MATH_1	259	263	PF00917	0.733
DOC_USP7_MATH_1	288	292	PF00917	0.717
DOC_USP7_MATH_1	351	355	PF00917	0.767
DOC_USP7_MATH_1	385	389	PF00917	0.737
DOC_USP7_MATH_1	442	446	PF00917	0.738
DOC_USP7_MATH_1	480	484	PF00917	0.566
DOC_USP7_MATH_1	63	67	PF00917	0.801
DOC_USP7_MATH_1	742	746	PF00917	0.632
DOC_USP7_MATH_1	842	846	PF00917	0.761
DOC_USP7_UBL2_3	1099	1103	PF12436	0.678
DOC_WW_Pin1_4	1092	1097	PF00397	0.612
DOC_WW_Pin1_4	214	219	PF00397	0.772
DOC_WW_Pin1_4	263	268	PF00397	0.697
DOC_WW_Pin1_4	354	359	PF00397	0.815
DOC_WW_Pin1_4	373	378	PF00397	0.778
DOC_WW_Pin1_4	409	414	PF00397	0.616
DOC_WW_Pin1_4	577	582	PF00397	0.722
DOC_WW_Pin1_4	708	713	PF00397	0.692
DOC_WW_Pin1_4	851	856	PF00397	0.628
DOC_WW_Pin1_4	872	877	PF00397	0.795
DOC_WW_Pin1_4	956	961	PF00397	0.785
LIG_14-3-3_CanoR_1	1020	1028	PF00244	0.800
LIG_14-3-3_CanoR_1	1047	1051	PF00244	0.753
LIG_14-3-3_CanoR_1	195	201	PF00244	0.684
LIG_14-3-3_CanoR_1	260	267	PF00244	0.681
LIG_14-3-3_CanoR_1	342	346	PF00244	0.775
LIG_14-3-3_CanoR_1	353	357	PF00244	0.614
LIG_14-3-3_CanoR_1	379	386	PF00244	0.793
LIG_14-3-3_CanoR_1	41	46	PF00244	0.599
LIG_14-3-3_CanoR_1	514	519	PF00244	0.644
LIG_14-3-3_CanoR_1	546	552	PF00244	0.702
LIG_14-3-3_CanoR_1	67	72	PF00244	0.726
LIG_14-3-3_CanoR_1	7	12	PF00244	0.829
LIG_14-3-3_CanoR_1	728	734	PF00244	0.816
LIG_14-3-3_CanoR_1	755	761	PF00244	0.605
LIG_14-3-3_CanoR_1	844	849	PF00244	0.735
LIG_14-3-3_CanoR_1	953	961	PF00244	0.638
LIG_Actin_WH2_2	181	197	PF00022	0.532
LIG_Actin_WH2_2	834	851	PF00022	0.538
LIG_BIR_II_1	1	5	PF00653	0.639
LIG_BRCT_BRCA1_1	633	637	PF00533	0.685
LIG_BRCT_BRCA1_1	69	73	PF00533	0.716
LIG_Clathr_ClatBox_1	621	625	PF01394	0.521
LIG_FHA_1	1047	1053	PF00498	0.723
LIG_FHA_1	403	409	PF00498	0.585
LIG_FHA_1	436	442	PF00498	0.596
LIG_FHA_1	546	552	PF00498	0.643
LIG_FHA_1	599	605	PF00498	0.651
LIG_FHA_1	802	808	PF00498	0.648
LIG_FHA_2	227	233	PF00498	0.617
LIG_FHA_2	284	290	PF00498	0.692
LIG_FHA_2	361	367	PF00498	0.679
LIG_LIR_Apic_2	1048	1053	PF02991	0.607
LIG_LIR_Gen_1	164	173	PF02991	0.723
LIG_LIR_Gen_1	605	614	PF02991	0.619
LIG_LIR_Gen_1	958	965	PF02991	0.588
LIG_LIR_Nem_3	1086	1090	PF02991	0.570
LIG_LIR_Nem_3	164	168	PF02991	0.754
LIG_LIR_Nem_3	605	610	PF02991	0.625
LIG_LIR_Nem_3	958	964	PF02991	0.705
LIG_LIR_Nem_3	996	1001	PF02991	0.695
LIG_MYND_1	267	271	PF01753	0.729
LIG_PCNA_PIPBox_1	758	767	PF02747	0.695
LIG_Rb_LxCxE_1	906	921	PF01857	0.424
LIG_REV1ctd_RIR_1	458	468	PF16727	0.478
LIG_SH2_CRK	1010	1014	PF00017	0.685
LIG_SH2_CRK	1050	1054	PF00017	0.570
LIG_SH2_CRK	165	169	PF00017	0.724
LIG_SH2_NCK_1	1010	1014	PF00017	0.576
LIG_SH2_STAP1	525	529	PF00017	0.721
LIG_SH2_STAP1	85	89	PF00017	0.553
LIG_SH2_STAT3	528	531	PF00017	0.514
LIG_SH2_STAT3	891	894	PF00017	0.563
LIG_SH2_STAT5	946	949	PF00017	0.686
LIG_SH2_STAT5	980	983	PF00017	0.691
LIG_SH3_1	849	855	PF00018	0.747
LIG_SH3_3	1095	1101	PF00018	0.577
LIG_SH3_3	141	147	PF00018	0.632
LIG_SH3_3	210	216	PF00018	0.753
LIG_SH3_3	355	361	PF00018	0.762
LIG_SH3_3	43	49	PF00018	0.694
LIG_SH3_3	50	56	PF00018	0.721
LIG_SH3_3	796	802	PF00018	0.699
LIG_SH3_3	849	855	PF00018	0.747
LIG_SUMO_SIM_anti_2	189	195	PF11976	0.585
LIG_SUMO_SIM_par_1	600	608	PF11976	0.670
LIG_TRAF2_1	1079	1082	PF00917	0.585
LIG_TRAF2_1	229	232	PF00917	0.743
LIG_TRAF2_1	787	790	PF00917	0.682
LIG_TRAF2_1	822	825	PF00917	0.453
LIG_TRAF2_1	857	860	PF00917	0.782
LIG_TRAF2_1	913	916	PF00917	0.570
LIG_TRAF2_1	960	963	PF00917	0.583
LIG_WRC_WIRS_1	129	134	PF05994	0.685
LIG_WRC_WIRS_1	939	944	PF05994	0.663
MOD_CDC14_SPxK_1	217	220	PF00782	0.758
MOD_CDC14_SPxK_1	357	360	PF00782	0.726
MOD_CDC14_SPxK_1	376	379	PF00782	0.760
MOD_CDK_SPK_2	708	713	PF00069	0.714
MOD_CDK_SPK_2	851	856	PF00069	0.628
MOD_CDK_SPxK_1	214	220	PF00069	0.755
MOD_CDK_SPxK_1	354	360	PF00069	0.801
MOD_CDK_SPxK_1	373	379	PF00069	0.765
MOD_CDK_SPxxK_3	1092	1099	PF00069	0.631
MOD_CK1_1	10	16	PF00069	0.712
MOD_CK1_1	1002	1008	PF00069	0.641
MOD_CK1_1	1054	1060	PF00069	0.584
MOD_CK1_1	131	137	PF00069	0.746
MOD_CK1_1	186	192	PF00069	0.653
MOD_CK1_1	2	8	PF00069	0.800
MOD_CK1_1	354	360	PF00069	0.775
MOD_CK1_1	419	425	PF00069	0.756
MOD_CK1_1	567	573	PF00069	0.703
MOD_CK1_1	631	637	PF00069	0.769
MOD_CK1_1	711	717	PF00069	0.787
MOD_CK1_1	918	924	PF00069	0.716
MOD_CK1_1	956	962	PF00069	0.746
MOD_CK1_1	991	997	PF00069	0.724
MOD_CK2_1	1011	1017	PF00069	0.805
MOD_CK2_1	1040	1046	PF00069	0.760
MOD_CK2_1	1076	1082	PF00069	0.619
MOD_CK2_1	226	232	PF00069	0.618
MOD_CK2_1	283	289	PF00069	0.649
MOD_CK2_1	368	374	PF00069	0.745
MOD_CK2_1	480	486	PF00069	0.517
MOD_CK2_1	602	608	PF00069	0.682
MOD_CK2_1	754	760	PF00069	0.609
MOD_CK2_1	77	83	PF00069	0.700
MOD_CK2_1	956	962	PF00069	0.669
MOD_GlcNHglycan	101	104	PF01048	0.727
MOD_GlcNHglycan	1022	1025	PF01048	0.691
MOD_GlcNHglycan	1069	1072	PF01048	0.743
MOD_GlcNHglycan	13	16	PF01048	0.695
MOD_GlcNHglycan	261	264	PF01048	0.718
MOD_GlcNHglycan	387	390	PF01048	0.769
MOD_GlcNHglycan	418	421	PF01048	0.753
MOD_GlcNHglycan	426	429	PF01048	0.730
MOD_GlcNHglycan	444	447	PF01048	0.827
MOD_GlcNHglycan	482	485	PF01048	0.723
MOD_GlcNHglycan	566	569	PF01048	0.774
MOD_GlcNHglycan	572	575	PF01048	0.769
MOD_GlcNHglycan	587	590	PF01048	0.718
MOD_GlcNHglycan	638	641	PF01048	0.638
MOD_GlcNHglycan	651	654	PF01048	0.516
MOD_GlcNHglycan	660	663	PF01048	0.546
MOD_GlcNHglycan	708	711	PF01048	0.793
MOD_GlcNHglycan	725	728	PF01048	0.607
MOD_GlcNHglycan	729	732	PF01048	0.716
MOD_GlcNHglycan	740	743	PF01048	0.601
MOD_GlcNHglycan	79	82	PF01048	0.690
MOD_GlcNHglycan	844	847	PF01048	0.731
MOD_GlcNHglycan	929	932	PF01048	0.462
MOD_GlcNHglycan	955	958	PF01048	0.671
MOD_GlcNHglycan	993	996	PF01048	0.779
MOD_GSK3_1	1042	1049	PF00069	0.757
MOD_GSK3_1	118	125	PF00069	0.630
MOD_GSK3_1	183	190	PF00069	0.669
MOD_GSK3_1	222	229	PF00069	0.682
MOD_GSK3_1	259	266	PF00069	0.779
MOD_GSK3_1	279	286	PF00069	0.485
MOD_GSK3_1	360	367	PF00069	0.711
MOD_GSK3_1	409	416	PF00069	0.719
MOD_GSK3_1	494	501	PF00069	0.851
MOD_GSK3_1	566	573	PF00069	0.823
MOD_GSK3_1	598	605	PF00069	0.657
MOD_GSK3_1	63	70	PF00069	0.769
MOD_GSK3_1	649	656	PF00069	0.576
MOD_GSK3_1	7	14	PF00069	0.843
MOD_GSK3_1	723	730	PF00069	0.707
MOD_GSK3_1	734	741	PF00069	0.727
MOD_GSK3_1	79	86	PF00069	0.570
MOD_GSK3_1	984	991	PF00069	0.734
MOD_LATS_1	347	353	PF00433	0.728
MOD_LATS_1	39	45	PF00433	0.700
MOD_N-GLC_1	186	191	PF02516	0.574
MOD_N-GLC_1	552	557	PF02516	0.633
MOD_N-GLC_1	67	72	PF02516	0.793
MOD_N-GLC_1	734	739	PF02516	0.702
MOD_NEK2_1	11	16	PF00069	0.733
MOD_NEK2_1	136	141	PF00069	0.717
MOD_NEK2_1	585	590	PF00069	0.614
MOD_NEK2_1	988	993	PF00069	0.772
MOD_NEK2_2	653	658	PF00069	0.578
MOD_NEK2_2	749	754	PF00069	0.561
MOD_PIKK_1	2	8	PF00454	0.739
MOD_PIKK_1	364	370	PF00454	0.660
MOD_PIKK_1	419	425	PF00454	0.715
MOD_PIKK_1	667	673	PF00454	0.606
MOD_PIKK_1	754	760	PF00454	0.655
MOD_PIKK_1	999	1005	PF00454	0.548
MOD_PK_1	514	520	PF00069	0.644
MOD_PKA_1	448	454	PF00069	0.763
MOD_PKA_2	1046	1052	PF00069	0.745
MOD_PKA_2	259	265	PF00069	0.707
MOD_PKA_2	341	347	PF00069	0.731
MOD_PKA_2	352	358	PF00069	0.609
MOD_PKA_2	416	422	PF00069	0.651
MOD_PKA_2	545	551	PF00069	0.717
MOD_PKA_2	608	614	PF00069	0.609
MOD_PKA_2	667	673	PF00069	0.733
MOD_PKA_2	727	733	PF00069	0.817
MOD_PKA_2	754	760	PF00069	0.616
MOD_PKA_2	77	83	PF00069	0.777
MOD_PKA_2	984	990	PF00069	0.584
MOD_PKB_1	512	520	PF00069	0.655
MOD_Plk_1	1045	1051	PF00069	0.762
MOD_Plk_1	1060	1066	PF00069	0.611
MOD_Plk_1	18	24	PF00069	0.671
MOD_Plk_1	186	192	PF00069	0.571
MOD_Plk_1	231	237	PF00069	0.726
MOD_Plk_1	67	73	PF00069	0.755
MOD_Plk_1	749	755	PF00069	0.561
MOD_Plk_1	918	924	PF00069	0.614
MOD_Plk_2-3	1011	1017	PF00069	0.579
MOD_Plk_2-3	283	289	PF00069	0.594
MOD_Plk_2-3	545	551	PF00069	0.600
MOD_Plk_4	196	202	PF00069	0.693
MOD_Plk_4	514	520	PF00069	0.662
MOD_Plk_4	602	608	PF00069	0.634
MOD_Plk_4	984	990	PF00069	0.703
MOD_Plk_4	993	999	PF00069	0.629
MOD_ProDKin_1	1092	1098	PF00069	0.619
MOD_ProDKin_1	214	220	PF00069	0.775
MOD_ProDKin_1	263	269	PF00069	0.698
MOD_ProDKin_1	354	360	PF00069	0.816
MOD_ProDKin_1	373	379	PF00069	0.779
MOD_ProDKin_1	409	415	PF00069	0.618
MOD_ProDKin_1	577	583	PF00069	0.717
MOD_ProDKin_1	708	714	PF00069	0.693
MOD_ProDKin_1	851	857	PF00069	0.626
MOD_ProDKin_1	872	878	PF00069	0.793
MOD_ProDKin_1	956	962	PF00069	0.786
MOD_SUMO_for_1	537	540	PF00179	0.464
MOD_SUMO_for_1	777	780	PF00179	0.586
MOD_SUMO_for_1	822	825	PF00179	0.453
MOD_SUMO_rev_2	1081	1090	PF00179	0.564
MOD_SUMO_rev_2	445	451	PF00179	0.703
MOD_SUMO_rev_2	692	702	PF00179	0.508
TRG_DiLeu_BaLyEn_6	43	48	PF01217	0.566
TRG_DiLeu_BaLyEn_6	617	622	PF01217	0.506
TRG_ENDOCYTIC_2	165	168	PF00928	0.726
TRG_ER_diArg_1	1019	1022	PF00400	0.717
TRG_ER_diArg_1	176	179	PF00400	0.727
TRG_ER_diArg_1	194	196	PF00400	0.453
TRG_ER_diArg_1	512	515	PF00400	0.711
TRG_ER_diArg_1	814	817	PF00400	0.587
TRG_ER_diArg_1	848	850	PF00400	0.713
TRG_ER_diArg_1	922	925	PF00400	0.557
TRG_Pf-PMV_PEXEL_1	1078	1082	PF00026	0.665
TRG_Pf-PMV_PEXEL_1	620	625	PF00026	0.706
TRG_Pf-PMV_PEXEL_1	903	907	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	999	1003	PF00026	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4J9	Leptomonas seymouri	33%	100%
A0A3S7WPM1	Leishmania donovani	83%	100%
A4H4S2	Leishmania braziliensis	47%	88%
A4HT03	Leishmania infantum	82%	100%
E9AKZ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%