Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIW4_LEIMA

TriTrypDb:

LmjF.06.1120 , LMJLV39_060017700 , LMJSD75_060017900

Length:

274

Annotations

LeishMANIAdb annotations

A short well-folded TM protein, possibly with GPI anchor. Structurally weakly similar to PBN1, a GPI anchor biogenesis protein.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 0
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	4
GO:0016020	membrane	2	8
GO:0031090	organelle membrane	3	4
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4QIW4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIW4

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	4
GO:0006505	GPI anchor metabolic process	6	4
GO:0006506	GPI anchor biosynthetic process	6	4
GO:0006629	lipid metabolic process	3	4
GO:0006643	membrane lipid metabolic process	4	4
GO:0006644	phospholipid metabolic process	4	4
GO:0006650	glycerophospholipid metabolic process	5	4
GO:0006661	phosphatidylinositol biosynthetic process	6	4
GO:0006664	glycolipid metabolic process	5	4
GO:0006793	phosphorus metabolic process	3	4
GO:0006796	phosphate-containing compound metabolic process	4	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0008152	metabolic process	1	4
GO:0008610	lipid biosynthetic process	4	4
GO:0008654	phospholipid biosynthetic process	5	4
GO:0009058	biosynthetic process	2	4
GO:0009247	glycolipid biosynthetic process	5	4
GO:0009987	cellular process	1	4
GO:0019538	protein metabolic process	3	4
GO:0019637	organophosphate metabolic process	3	4
GO:0036211	protein modification process	4	4
GO:0043170	macromolecule metabolic process	3	4
GO:0043412	macromolecule modification	4	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0044249	cellular biosynthetic process	3	4
GO:0044255	cellular lipid metabolic process	3	4
GO:0045017	glycerolipid biosynthetic process	4	4
GO:0046467	membrane lipid biosynthetic process	4	4
GO:0046474	glycerophospholipid biosynthetic process	5	4
GO:0046486	glycerolipid metabolic process	4	4
GO:0046488	phosphatidylinositol metabolic process	6	4
GO:0071704	organic substance metabolic process	2	4
GO:0090407	organophosphate biosynthetic process	4	4
GO:1901135	carbohydrate derivative metabolic process	3	4
GO:1901137	carbohydrate derivative biosynthetic process	4	4
GO:1901564	organonitrogen compound metabolic process	3	4
GO:1901576	organic substance biosynthetic process	3	4
GO:1903509	liposaccharide metabolic process	4	4

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.418
CLV_NRD_NRD_1	201	203	PF00675	0.591
CLV_PCSK_KEX2_1	201	203	PF00082	0.589
CLV_PCSK_SKI1_1	191	195	PF00082	0.642
CLV_PCSK_SKI1_1	202	206	PF00082	0.572
CLV_PCSK_SKI1_1	69	73	PF00082	0.516
DEG_APCC_DBOX_1	200	208	PF00400	0.453
DEG_SPOP_SBC_1	227	231	PF00917	0.451
DOC_CYCLIN_yCln2_LP_2	52	58	PF00134	0.420
DOC_MAPK_gen_1	167	174	PF00069	0.349
DOC_MAPK_gen_1	201	209	PF00069	0.380
DOC_MAPK_MEF2A_6	167	174	PF00069	0.311
DOC_MAPK_MEF2A_6	238	247	PF00069	0.389
DOC_MAPK_MEF2A_6	3	12	PF00069	0.530
DOC_PP1_RVXF_1	60	66	PF00149	0.366
DOC_PP2B_LxvP_1	170	173	PF13499	0.302
DOC_PP4_FxxP_1	65	68	PF00568	0.358
DOC_USP7_MATH_1	107	111	PF00917	0.261
DOC_USP7_MATH_1	173	177	PF00917	0.380
DOC_USP7_MATH_1	215	219	PF00917	0.451
DOC_USP7_UBL2_3	234	238	PF12436	0.379
DOC_WW_Pin1_4	32	37	PF00397	0.406
LIG_14-3-3_CanoR_1	106	112	PF00244	0.371
LIG_14-3-3_CanoR_1	216	222	PF00244	0.444
LIG_14-3-3_CanoR_1	62	66	PF00244	0.389
LIG_Actin_WH2_2	178	193	PF00022	0.318
LIG_Actin_WH2_2	97	114	PF00022	0.454
LIG_BIR_II_1	1	5	PF00653	0.562
LIG_BRCT_BRCA1_1	28	32	PF00533	0.452
LIG_BRCT_BRCA1_1	37	41	PF00533	0.304
LIG_eIF4E_1	253	259	PF01652	0.441
LIG_FHA_1	130	136	PF00498	0.356
LIG_FHA_1	94	100	PF00498	0.372
LIG_FHA_2	203	209	PF00498	0.386
LIG_FHA_2	227	233	PF00498	0.437
LIG_GBD_Chelix_1	6	14	PF00786	0.532
LIG_Integrin_RGD_1	212	214	PF01839	0.485
LIG_LIR_Apic_2	53	57	PF02991	0.377
LIG_LIR_Apic_2	64	68	PF02991	0.317
LIG_LIR_Gen_1	105	113	PF02991	0.344
LIG_LIR_Gen_1	138	147	PF02991	0.391
LIG_LIR_Gen_1	176	186	PF02991	0.434
LIG_LIR_Gen_1	38	46	PF02991	0.407
LIG_LIR_Nem_3	105	111	PF02991	0.330
LIG_LIR_Nem_3	138	142	PF02991	0.332
LIG_LIR_Nem_3	176	181	PF02991	0.414
LIG_LIR_Nem_3	38	42	PF02991	0.357
LIG_NRBOX	257	263	PF00104	0.441
LIG_SH2_CRK	108	112	PF00017	0.330
LIG_SH2_CRK	255	259	PF00017	0.350
LIG_SH2_CRK	39	43	PF00017	0.391
LIG_SH2_SRC	253	256	PF00017	0.441
LIG_SH2_STAP1	117	121	PF00017	0.400
LIG_SH2_STAT5	130	133	PF00017	0.396
LIG_SH2_STAT5	154	157	PF00017	0.450
LIG_SH2_STAT5	199	202	PF00017	0.424
LIG_SH2_STAT5	253	256	PF00017	0.347
LIG_SH2_STAT5	39	42	PF00017	0.379
LIG_SH3_3	238	244	PF00018	0.319
LIG_SH3_4	234	241	PF00018	0.379
LIG_SUMO_SIM_anti_2	2	8	PF11976	0.548
LIG_TRAF2_1	230	233	PF00917	0.457
LIG_WRC_WIRS_1	136	141	PF05994	0.270
LIG_WW_1	36	39	PF00397	0.389
MOD_CK1_1	218	224	PF00069	0.472
MOD_CK1_1	35	41	PF00069	0.392
MOD_CK2_1	173	179	PF00069	0.376
MOD_CK2_1	226	232	PF00069	0.423
MOD_GlcNHglycan	217	220	PF01048	0.646
MOD_GlcNHglycan	224	227	PF01048	0.569
MOD_GlcNHglycan	87	90	PF01048	0.645
MOD_GSK3_1	102	109	PF00069	0.372
MOD_GSK3_1	218	225	PF00069	0.412
MOD_GSK3_1	31	38	PF00069	0.392
MOD_N-GLC_1	128	133	PF02516	0.599
MOD_NEK2_1	111	116	PF00069	0.359
MOD_NEK2_2	107	112	PF00069	0.266
MOD_PIKK_1	112	118	PF00454	0.391
MOD_PIKK_1	90	96	PF00454	0.472
MOD_PKA_2	111	117	PF00069	0.386
MOD_PKA_2	215	221	PF00069	0.461
MOD_PKA_2	222	228	PF00069	0.464
MOD_PKA_2	26	32	PF00069	0.378
MOD_PKA_2	61	67	PF00069	0.384
MOD_Plk_4	146	152	PF00069	0.432
MOD_Plk_4	37	43	PF00069	0.388
MOD_Plk_4	67	73	PF00069	0.331
MOD_ProDKin_1	32	38	PF00069	0.402
MOD_SUMO_rev_2	176	186	PF00179	0.383
MOD_SUMO_rev_2	231	235	PF00179	0.435
TRG_ENDOCYTIC_2	108	111	PF00928	0.324
TRG_ENDOCYTIC_2	178	181	PF00928	0.375
TRG_ENDOCYTIC_2	255	258	PF00928	0.334
TRG_ENDOCYTIC_2	39	42	PF00928	0.377
TRG_ER_diArg_1	166	169	PF00400	0.436
TRG_ER_diArg_1	200	202	PF00400	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4M9	Leptomonas seymouri	55%	98%
A0A1X0NHE9	Trypanosomatidae	34%	98%
A0A422NM30	Trypanosoma rangeli	35%	100%
A4H4S3	Leishmania braziliensis	77%	100%
A4HT04	Leishmania infantum	89%	100%
C9ZTN6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	92%
E9AKZ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%