Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIW3_LEIMA

TriTrypDb:

LmjF.06.1130 , LMJLV39_060017800 , LMJSD75_060018000

Length:

329

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	7
GO:0032991	protein-containing complex	1	7
GO:0043226	organelle	2	7
GO:0043228	non-membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043232	intracellular non-membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7
GO:1990904	ribonucleoprotein complex	2	7

Expansion

Sequence features

Q4QIW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIW3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	204	208	PF00656	0.552
CLV_PCSK_SKI1_1	161	165	PF00082	0.396
DEG_Nend_UBRbox_3	1	3	PF02207	0.517
DEG_SCF_FBW7_2	5	10	PF00400	0.491
DOC_CDC14_PxL_1	13	21	PF14671	0.426
DOC_MAPK_HePTP_8	232	244	PF00069	0.392
DOC_MAPK_MEF2A_6	120	127	PF00069	0.438
DOC_MAPK_MEF2A_6	235	244	PF00069	0.449
DOC_PP4_FxxP_1	322	325	PF00568	0.437
DOC_USP7_MATH_1	134	138	PF00917	0.381
DOC_USP7_MATH_1	145	149	PF00917	0.617
DOC_USP7_MATH_1	159	163	PF00917	0.581
DOC_USP7_MATH_1	31	35	PF00917	0.482
DOC_USP7_MATH_1	36	40	PF00917	0.461
DOC_WW_Pin1_4	3	8	PF00397	0.513
LIG_14-3-3_CanoR_1	138	142	PF00244	0.466
LIG_14-3-3_CanoR_1	161	168	PF00244	0.394
LIG_14-3-3_CanoR_1	213	218	PF00244	0.385
LIG_14-3-3_CanoR_1	45	53	PF00244	0.455
LIG_BIR_III_4	183	187	PF00653	0.356
LIG_FHA_1	150	156	PF00498	0.632
LIG_FHA_1	195	201	PF00498	0.559
LIG_FHA_1	204	210	PF00498	0.461
LIG_FHA_1	239	245	PF00498	0.470
LIG_FHA_1	291	297	PF00498	0.443
LIG_FHA_2	162	168	PF00498	0.449
LIG_FHA_2	276	282	PF00498	0.510
LIG_FHA_2	289	295	PF00498	0.437
LIG_GBD_Chelix_1	79	87	PF00786	0.363
LIG_Integrin_isoDGR_2	93	95	PF01839	0.500
LIG_NRP_CendR_1	328	329	PF00754	0.604
LIG_SH2_CRK	21	25	PF00017	0.335
LIG_SH2_STAP1	256	260	PF00017	0.316
LIG_SH2_STAT5	32	35	PF00017	0.378
LIG_SH3_3	148	154	PF00018	0.657
LIG_SUMO_SIM_par_1	213	218	PF11976	0.526
LIG_SUMO_SIM_par_1	78	84	PF11976	0.362
LIG_TYR_ITIM	19	24	PF00017	0.348
MOD_CDK_SPK_2	3	8	PF00069	0.429
MOD_CK1_1	137	143	PF00069	0.398
MOD_CK1_1	34	40	PF00069	0.458
MOD_CK2_1	172	178	PF00069	0.503
MOD_CK2_1	262	268	PF00069	0.322
MOD_GlcNHglycan	180	183	PF01048	0.372
MOD_GlcNHglycan	236	239	PF01048	0.466
MOD_GlcNHglycan	256	259	PF01048	0.233
MOD_GlcNHglycan	264	267	PF01048	0.271
MOD_GlcNHglycan	288	291	PF01048	0.521
MOD_GlcNHglycan	38	41	PF01048	0.501
MOD_GlcNHglycan	83	86	PF01048	0.471
MOD_GSK3_1	145	152	PF00069	0.575
MOD_GSK3_1	203	210	PF00069	0.491
MOD_GSK3_1	234	241	PF00069	0.453
MOD_GSK3_1	286	293	PF00069	0.477
MOD_GSK3_1	36	43	PF00069	0.465
MOD_NEK2_1	254	259	PF00069	0.424
MOD_NEK2_2	40	45	PF00069	0.420
MOD_PK_1	213	219	PF00069	0.386
MOD_PKA_2	137	143	PF00069	0.464
MOD_PKA_2	234	240	PF00069	0.395
MOD_PKA_2	44	50	PF00069	0.447
MOD_Plk_1	275	281	PF00069	0.417
MOD_Plk_2-3	276	282	PF00069	0.430
MOD_ProDKin_1	3	9	PF00069	0.512
TRG_ENDOCYTIC_2	21	24	PF00928	0.342

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJR4	Leptomonas seymouri	47%	100%
A0A1X0NGN1	Trypanosomatidae	27%	99%
A0A3S5H5U1	Leishmania donovani	93%	100%
A4H4S4	Leishmania braziliensis	72%	100%
A4HT05	Leishmania infantum	93%	100%
C9ZTN7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	82%
E9AKZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%