Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIW2_LEIMA

TriTrypDb:

LmjF.06.1140 , LMJLV39_060017900 , LMJSD75_060018100

Length:

847

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QIW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIW2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	552	556	PF00656	0.625
CLV_C14_Caspase3-7	632	636	PF00656	0.417
CLV_MEL_PAP_1	381	387	PF00089	0.482
CLV_MEL_PAP_1	536	542	PF00089	0.543
CLV_NRD_NRD_1	145	147	PF00675	0.552
CLV_NRD_NRD_1	2	4	PF00675	0.529
CLV_NRD_NRD_1	358	360	PF00675	0.618
CLV_NRD_NRD_1	523	525	PF00675	0.641
CLV_NRD_NRD_1	538	540	PF00675	0.500
CLV_NRD_NRD_1	654	656	PF00675	0.455
CLV_NRD_NRD_1	673	675	PF00675	0.455
CLV_NRD_NRD_1	766	768	PF00675	0.413
CLV_NRD_NRD_1	788	790	PF00675	0.436
CLV_NRD_NRD_1	819	821	PF00675	0.638
CLV_NRD_NRD_1	825	827	PF00675	0.643
CLV_NRD_NRD_1	839	841	PF00675	0.505
CLV_PCSK_KEX2_1	144	146	PF00082	0.545
CLV_PCSK_KEX2_1	2	4	PF00082	0.529
CLV_PCSK_KEX2_1	358	360	PF00082	0.618
CLV_PCSK_KEX2_1	521	523	PF00082	0.642
CLV_PCSK_KEX2_1	538	540	PF00082	0.618
CLV_PCSK_KEX2_1	788	790	PF00082	0.436
CLV_PCSK_KEX2_1	819	821	PF00082	0.637
CLV_PCSK_KEX2_1	839	841	PF00082	0.518
CLV_PCSK_KEX2_1	844	846	PF00082	0.815
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.618
CLV_PCSK_PC1ET2_1	521	523	PF00082	0.635
CLV_PCSK_PC1ET2_1	844	846	PF00082	0.662
CLV_PCSK_PC7_1	354	360	PF00082	0.574
CLV_PCSK_PC7_1	840	846	PF00082	0.602
CLV_PCSK_SKI1_1	145	149	PF00082	0.512
CLV_PCSK_SKI1_1	268	272	PF00082	0.404
CLV_PCSK_SKI1_1	584	588	PF00082	0.566
CLV_PCSK_SKI1_1	614	618	PF00082	0.464
CLV_PCSK_SKI1_1	68	72	PF00082	0.487
CLV_PCSK_SKI1_1	693	697	PF00082	0.515
CLV_PCSK_SKI1_1	718	722	PF00082	0.469
CLV_PCSK_SKI1_1	782	786	PF00082	0.366
DEG_Nend_UBRbox_1	1	4	PF02207	0.532
DEG_SPOP_SBC_1	241	245	PF00917	0.600
DEG_SPOP_SBC_1	751	755	PF00917	0.530
DOC_CYCLIN_RxL_1	638	648	PF00134	0.457
DOC_MAPK_gen_1	639	647	PF00069	0.453
DOC_MAPK_gen_1	767	775	PF00069	0.406
DOC_MAPK_MEF2A_6	639	647	PF00069	0.392
DOC_MAPK_RevD_3	347	361	PF00069	0.549
DOC_PP2B_LxvP_1	643	646	PF13499	0.406
DOC_PP2B_LxvP_1	726	729	PF13499	0.357
DOC_PP2B_PxIxI_1	411	417	PF00149	0.635
DOC_PP4_FxxP_1	774	777	PF00568	0.424
DOC_USP7_MATH_1	174	178	PF00917	0.623
DOC_USP7_MATH_1	258	262	PF00917	0.520
DOC_USP7_MATH_1	275	279	PF00917	0.357
DOC_USP7_MATH_1	284	288	PF00917	0.573
DOC_USP7_MATH_1	290	294	PF00917	0.464
DOC_USP7_MATH_1	367	371	PF00917	0.612
DOC_USP7_MATH_1	402	406	PF00917	0.637
DOC_USP7_MATH_1	443	447	PF00917	0.716
DOC_USP7_MATH_1	509	513	PF00917	0.693
DOC_USP7_MATH_1	556	560	PF00917	0.669
DOC_USP7_MATH_1	751	755	PF00917	0.675
DOC_USP7_MATH_1	756	760	PF00917	0.618
DOC_USP7_MATH_1	77	81	PF00917	0.642
DOC_USP7_MATH_1	829	833	PF00917	0.623
DOC_USP7_MATH_1	92	96	PF00917	0.483
DOC_WW_Pin1_4	200	205	PF00397	0.550
DOC_WW_Pin1_4	211	216	PF00397	0.596
DOC_WW_Pin1_4	314	319	PF00397	0.647
DOC_WW_Pin1_4	336	341	PF00397	0.569
DOC_WW_Pin1_4	4	9	PF00397	0.527
DOC_WW_Pin1_4	432	437	PF00397	0.664
DOC_WW_Pin1_4	562	567	PF00397	0.563
DOC_WW_Pin1_4	693	698	PF00397	0.473
DOC_WW_Pin1_4	758	763	PF00397	0.530
DOC_WW_Pin1_4	825	830	PF00397	0.622
DOC_WW_Pin1_4	834	839	PF00397	0.612
LIG_14-3-3_CanoR_1	27	33	PF00244	0.545
LIG_14-3-3_CanoR_1	277	281	PF00244	0.462
LIG_14-3-3_CanoR_1	303	309	PF00244	0.535
LIG_14-3-3_CanoR_1	428	438	PF00244	0.779
LIG_14-3-3_CanoR_1	440	448	PF00244	0.669
LIG_14-3-3_CanoR_1	639	644	PF00244	0.386
LIG_14-3-3_CanoR_1	788	797	PF00244	0.489
LIG_14-3-3_CanoR_1	830	838	PF00244	0.631
LIG_14-3-3_CanoR_1	91	97	PF00244	0.513
LIG_Actin_WH2_2	582	600	PF00022	0.408
LIG_Actin_WH2_2	654	672	PF00022	0.510
LIG_BIR_III_4	376	380	PF00653	0.557
LIG_BRCT_BRCA1_1	66	70	PF00533	0.480
LIG_CSL_BTD_1	215	218	PF09270	0.403
LIG_FHA_1	102	108	PF00498	0.684
LIG_FHA_1	212	218	PF00498	0.502
LIG_FHA_1	305	311	PF00498	0.486
LIG_FHA_1	324	330	PF00498	0.576
LIG_FHA_1	339	345	PF00498	0.404
LIG_FHA_1	380	386	PF00498	0.515
LIG_FHA_1	462	468	PF00498	0.661
LIG_FHA_1	471	477	PF00498	0.701
LIG_FHA_1	515	521	PF00498	0.639
LIG_FHA_1	638	644	PF00498	0.400
LIG_FHA_1	715	721	PF00498	0.391
LIG_FHA_1	759	765	PF00498	0.448
LIG_FHA_2	124	130	PF00498	0.683
LIG_FHA_2	476	482	PF00498	0.689
LIG_FHA_2	563	569	PF00498	0.545
LIG_FHA_2	583	589	PF00498	0.365
LIG_FHA_2	694	700	PF00498	0.489
LIG_FHA_2	95	101	PF00498	0.582
LIG_Integrin_isoDGR_2	420	422	PF01839	0.628
LIG_LIR_Gen_1	332	340	PF02991	0.506
LIG_LIR_Gen_1	796	807	PF02991	0.406
LIG_LIR_LC3C_4	189	193	PF02991	0.334
LIG_LIR_Nem_3	21	26	PF02991	0.499
LIG_LIR_Nem_3	213	219	PF02991	0.487
LIG_LIR_Nem_3	332	336	PF02991	0.477
LIG_LIR_Nem_3	736	741	PF02991	0.474
LIG_LIR_Nem_3	778	784	PF02991	0.363
LIG_LIR_Nem_3	796	802	PF02991	0.447
LIG_LYPXL_SIV_4	387	395	PF13949	0.409
LIG_MYND_1	155	159	PF01753	0.492
LIG_SH2_CRK	219	223	PF00017	0.465
LIG_SH2_CRK	602	606	PF00017	0.457
LIG_SH2_STAP1	24	28	PF00017	0.511
LIG_SH2_STAP1	602	606	PF00017	0.457
LIG_SH2_STAT5	388	391	PF00017	0.411
LIG_SH2_STAT5	624	627	PF00017	0.444
LIG_SH3_1	198	204	PF00018	0.413
LIG_SH3_2	821	826	PF14604	0.635
LIG_SH3_3	198	204	PF00018	0.438
LIG_SH3_3	212	218	PF00018	0.451
LIG_SH3_3	259	265	PF00018	0.437
LIG_SH3_3	315	321	PF00018	0.645
LIG_SH3_3	396	402	PF00018	0.595
LIG_SH3_3	694	700	PF00018	0.486
LIG_SH3_3	792	798	PF00018	0.332
LIG_SH3_3	818	824	PF00018	0.634
LIG_SUMO_SIM_anti_2	103	112	PF11976	0.617
LIG_SUMO_SIM_anti_2	724	729	PF11976	0.438
LIG_SUMO_SIM_par_1	103	112	PF11976	0.617
LIG_TRAF2_1	138	141	PF00917	0.631
LIG_TRAF2_1	696	699	PF00917	0.572
MOD_CDC14_SPxK_1	837	840	PF00782	0.590
MOD_CDK_SPK_2	825	830	PF00069	0.617
MOD_CDK_SPK_2	834	839	PF00069	0.621
MOD_CDK_SPxK_1	834	840	PF00069	0.599
MOD_CDK_SPxxK_3	834	841	PF00069	0.660
MOD_CK1_1	109	115	PF00069	0.770
MOD_CK1_1	117	123	PF00069	0.650
MOD_CK1_1	175	181	PF00069	0.563
MOD_CK1_1	203	209	PF00069	0.733
MOD_CK1_1	210	216	PF00069	0.501
MOD_CK1_1	239	245	PF00069	0.604
MOD_CK1_1	252	258	PF00069	0.619
MOD_CK1_1	323	329	PF00069	0.562
MOD_CK1_1	339	345	PF00069	0.467
MOD_CK1_1	407	413	PF00069	0.727
MOD_CK1_1	429	435	PF00069	0.789
MOD_CK1_1	463	469	PF00069	0.609
MOD_CK1_1	480	486	PF00069	0.635
MOD_CK1_1	489	495	PF00069	0.641
MOD_CK1_1	512	518	PF00069	0.626
MOD_CK1_1	561	567	PF00069	0.601
MOD_CK1_1	660	666	PF00069	0.490
MOD_CK1_1	752	758	PF00069	0.594
MOD_CK1_1	791	797	PF00069	0.491
MOD_CK1_1	822	828	PF00069	0.714
MOD_CK2_1	174	180	PF00069	0.608
MOD_CK2_1	475	481	PF00069	0.579
MOD_CK2_1	489	495	PF00069	0.650
MOD_CK2_1	562	568	PF00069	0.635
MOD_CK2_1	576	582	PF00069	0.382
MOD_CK2_1	693	699	PF00069	0.482
MOD_CK2_1	94	100	PF00069	0.582
MOD_Cter_Amidation	817	820	PF01082	0.643
MOD_GlcNHglycan	116	119	PF01048	0.641
MOD_GlcNHglycan	165	169	PF01048	0.677
MOD_GlcNHglycan	174	177	PF01048	0.624
MOD_GlcNHglycan	247	250	PF01048	0.627
MOD_GlcNHglycan	252	255	PF01048	0.583
MOD_GlcNHglycan	286	289	PF01048	0.676
MOD_GlcNHglycan	365	368	PF01048	0.666
MOD_GlcNHglycan	39	42	PF01048	0.535
MOD_GlcNHglycan	404	407	PF01048	0.642
MOD_GlcNHglycan	428	431	PF01048	0.820
MOD_GlcNHglycan	441	444	PF01048	0.669
MOD_GlcNHglycan	445	448	PF01048	0.633
MOD_GlcNHglycan	490	494	PF01048	0.752
MOD_GlcNHglycan	693	696	PF01048	0.633
MOD_GlcNHglycan	711	714	PF01048	0.245
MOD_GlcNHglycan	754	757	PF01048	0.602
MOD_GlcNHglycan	79	82	PF01048	0.507
MOD_GlcNHglycan	790	793	PF01048	0.490
MOD_GSK3_1	112	119	PF00069	0.629
MOD_GSK3_1	123	130	PF00069	0.659
MOD_GSK3_1	132	139	PF00069	0.491
MOD_GSK3_1	172	179	PF00069	0.598
MOD_GSK3_1	199	206	PF00069	0.644
MOD_GSK3_1	207	214	PF00069	0.541
MOD_GSK3_1	228	235	PF00069	0.544
MOD_GSK3_1	236	243	PF00069	0.593
MOD_GSK3_1	245	252	PF00069	0.706
MOD_GSK3_1	319	326	PF00069	0.588
MOD_GSK3_1	363	370	PF00069	0.655
MOD_GSK3_1	439	446	PF00069	0.724
MOD_GSK3_1	466	473	PF00069	0.713
MOD_GSK3_1	512	519	PF00069	0.627
MOD_GSK3_1	556	563	PF00069	0.614
MOD_GSK3_1	745	752	PF00069	0.612
MOD_GSK3_1	754	761	PF00069	0.587
MOD_GSK3_1	77	84	PF00069	0.635
MOD_GSK3_1	825	832	PF00069	0.811
MOD_GSK3_1	839	846	PF00069	0.619
MOD_GSK3_1	90	97	PF00069	0.539
MOD_N-GLC_1	136	141	PF02516	0.491
MOD_NEK2_1	164	169	PF00069	0.606
MOD_NEK2_1	266	271	PF00069	0.513
MOD_NEK2_1	488	493	PF00069	0.697
MOD_NEK2_1	571	576	PF00069	0.418
MOD_NEK2_1	612	617	PF00069	0.385
MOD_NEK2_1	63	68	PF00069	0.634
MOD_NEK2_1	669	674	PF00069	0.432
MOD_NEK2_1	70	75	PF00069	0.598
MOD_NEK2_1	745	750	PF00069	0.597
MOD_NEK2_1	790	795	PF00069	0.404
MOD_NEK2_2	304	309	PF00069	0.489
MOD_NEK2_2	379	384	PF00069	0.486
MOD_PIKK_1	429	435	PF00454	0.716
MOD_PIKK_1	501	507	PF00454	0.664
MOD_PIKK_1	819	825	PF00454	0.632
MOD_PIKK_1	831	837	PF00454	0.643
MOD_PKA_1	2	8	PF00069	0.526
MOD_PKA_1	360	366	PF00069	0.655
MOD_PKA_1	788	794	PF00069	0.444
MOD_PKA_1	819	825	PF00069	0.631
MOD_PKA_1	839	845	PF00069	0.520
MOD_PKA_2	2	8	PF00069	0.526
MOD_PKA_2	276	282	PF00069	0.453
MOD_PKA_2	360	366	PF00069	0.679
MOD_PKA_2	402	408	PF00069	0.668
MOD_PKA_2	439	445	PF00069	0.746
MOD_PKA_2	576	582	PF00069	0.435
MOD_PKA_2	669	675	PF00069	0.505
MOD_PKA_2	749	755	PF00069	0.705
MOD_PKA_2	788	794	PF00069	0.444
MOD_PKA_2	808	814	PF00069	0.529
MOD_PKA_2	819	825	PF00069	0.549
MOD_PKA_2	829	835	PF00069	0.641
MOD_PKA_2	839	845	PF00069	0.520
MOD_PKA_2	90	96	PF00069	0.508
MOD_Plk_1	128	134	PF00069	0.656
MOD_Plk_1	470	476	PF00069	0.586
MOD_Plk_1	582	588	PF00069	0.499
MOD_Plk_1	663	669	PF00069	0.451
MOD_Plk_1	81	87	PF00069	0.490
MOD_Plk_2-3	101	107	PF00069	0.661
MOD_Plk_2-3	582	588	PF00069	0.499
MOD_Plk_4	276	282	PF00069	0.489
MOD_Plk_4	290	296	PF00069	0.614
MOD_Plk_4	463	469	PF00069	0.598
MOD_Plk_4	617	623	PF00069	0.346
MOD_Plk_4	629	635	PF00069	0.362
MOD_Plk_4	704	710	PF00069	0.417
MOD_Plk_4	71	77	PF00069	0.496
MOD_ProDKin_1	200	206	PF00069	0.558
MOD_ProDKin_1	211	217	PF00069	0.586
MOD_ProDKin_1	314	320	PF00069	0.654
MOD_ProDKin_1	336	342	PF00069	0.562
MOD_ProDKin_1	4	10	PF00069	0.530
MOD_ProDKin_1	432	438	PF00069	0.664
MOD_ProDKin_1	562	568	PF00069	0.551
MOD_ProDKin_1	693	699	PF00069	0.482
MOD_ProDKin_1	758	764	PF00069	0.512
MOD_ProDKin_1	825	831	PF00069	0.623
MOD_ProDKin_1	834	840	PF00069	0.611
MOD_SUMO_rev_2	579	586	PF00179	0.415
MOD_SUMO_rev_2	648	658	PF00179	0.404
MOD_SUMO_rev_2	699	708	PF00179	0.486
TRG_DiLeu_BaEn_1	103	108	PF01217	0.619
TRG_DiLeu_BaEn_1	588	593	PF01217	0.484
TRG_DiLeu_BaLyEn_6	50	55	PF01217	0.499
TRG_DiLeu_BaLyEn_6	84	89	PF01217	0.496
TRG_ENDOCYTIC_2	388	391	PF00928	0.411
TRG_ENDOCYTIC_2	602	605	PF00928	0.466
TRG_ER_diArg_1	1	3	PF00400	0.535
TRG_ER_diArg_1	143	146	PF00400	0.545
TRG_ER_diArg_1	324	327	PF00400	0.559
TRG_ER_diArg_1	522	524	PF00400	0.654
TRG_ER_diArg_1	537	539	PF00400	0.696
TRG_ER_diArg_1	638	641	PF00400	0.438
TRG_ER_diArg_1	680	683	PF00400	0.390
TRG_ER_diArg_1	788	790	PF00400	0.436
TRG_ER_diArg_1	819	821	PF00400	0.637
TRG_ER_diArg_1	838	840	PF00400	0.599
TRG_NES_CRM1_1	568	582	PF08389	0.373
TRG_NLS_MonoCore_2	357	362	PF00514	0.597
TRG_NLS_MonoCore_2	520	525	PF00514	0.597
TRG_NLS_MonoExtC_3	520	525	PF00514	0.628
TRG_NLS_MonoExtN_4	358	363	PF00514	0.626
TRG_Pf-PMV_PEXEL_1	146	150	PF00026	0.562
TRG_Pf-PMV_PEXEL_1	584	588	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	604	609	PF00026	0.262
TRG_Pf-PMV_PEXEL_1	739	743	PF00026	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDD2	Leptomonas seymouri	40%	100%
A0A3S5H5U2	Leishmania donovani	90%	100%
A4H4S5	Leishmania braziliensis	70%	100%
A4HT06	Leishmania infantum	90%	100%
E9AKZ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%