DUF4379 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4379), putative

Species:

Leishmania major

UniProt:

Q4QIW1_LEIMA

TriTrypDb:

LmjF.06.1150 , LMJLV39_060018000 , LMJSD75_060018200

Length:

509

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0020023	kinetoplast	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QIW1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIW1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.707
CLV_MEL_PAP_1	248	254	PF00089	0.205
CLV_NRD_NRD_1	2	4	PF00675	0.650
CLV_NRD_NRD_1	297	299	PF00675	0.552
CLV_NRD_NRD_1	312	314	PF00675	0.528
CLV_NRD_NRD_1	474	476	PF00675	0.496
CLV_PCSK_FUR_1	471	475	PF00082	0.515
CLV_PCSK_KEX2_1	2	4	PF00082	0.650
CLV_PCSK_KEX2_1	297	299	PF00082	0.533
CLV_PCSK_KEX2_1	312	314	PF00082	0.445
CLV_PCSK_KEX2_1	473	475	PF00082	0.520
CLV_PCSK_SKI1_1	404	408	PF00082	0.364
CLV_PCSK_SKI1_1	444	448	PF00082	0.442
DEG_APCC_DBOX_1	399	407	PF00400	0.426
DEG_Nend_UBRbox_1	1	4	PF02207	0.599
DEG_SPOP_SBC_1	225	229	PF00917	0.326
DEG_SPOP_SBC_1	300	304	PF00917	0.422
DEG_SPOP_SBC_1	55	59	PF00917	0.476
DOC_CKS1_1	115	120	PF01111	0.331
DOC_CKS1_1	167	172	PF01111	0.801
DOC_CYCLIN_RxL_1	473	486	PF00134	0.546
DOC_CYCLIN_yCln2_LP_2	167	173	PF00134	0.523
DOC_MAPK_gen_1	2	9	PF00069	0.486
DOC_MAPK_gen_1	251	259	PF00069	0.252
DOC_MAPK_gen_1	375	384	PF00069	0.459
DOC_MAPK_gen_1	400	408	PF00069	0.419
DOC_MAPK_gen_1	473	483	PF00069	0.547
DOC_MAPK_MEF2A_6	2	9	PF00069	0.534
DOC_PP1_RVXF_1	230	236	PF00149	0.374
DOC_PP4_FxxP_1	112	115	PF00568	0.428
DOC_USP7_MATH_1	137	141	PF00917	0.340
DOC_USP7_MATH_1	163	167	PF00917	0.644
DOC_USP7_MATH_1	179	183	PF00917	0.748
DOC_USP7_MATH_1	238	242	PF00917	0.424
DOC_USP7_MATH_1	300	304	PF00917	0.611
DOC_USP7_MATH_1	370	374	PF00917	0.368
DOC_USP7_MATH_1	440	444	PF00917	0.429
DOC_WW_Pin1_4	114	119	PF00397	0.375
DOC_WW_Pin1_4	166	171	PF00397	0.677
DOC_WW_Pin1_4	273	278	PF00397	0.792
DOC_WW_Pin1_4	307	312	PF00397	0.545
DOC_WW_Pin1_4	61	66	PF00397	0.587
LIG_14-3-3_CanoR_1	127	135	PF00244	0.368
LIG_14-3-3_CanoR_1	184	192	PF00244	0.687
LIG_14-3-3_CanoR_1	2	8	PF00244	0.586
LIG_14-3-3_CanoR_1	254	258	PF00244	0.468
LIG_14-3-3_CanoR_1	297	306	PF00244	0.585
LIG_14-3-3_CanoR_1	335	344	PF00244	0.412
LIG_14-3-3_CanoR_1	347	355	PF00244	0.267
LIG_14-3-3_CanoR_1	375	380	PF00244	0.431
LIG_14-3-3_CanoR_1	492	498	PF00244	0.630
LIG_14-3-3_CanoR_1	56	66	PF00244	0.527
LIG_Actin_WH2_2	391	406	PF00022	0.518
LIG_APCC_ABBA_1	327	332	PF00400	0.495
LIG_APCC_ABBA_1	406	411	PF00400	0.361
LIG_BIR_III_2	197	201	PF00653	0.449
LIG_BRCT_BRCA1_1	349	353	PF00533	0.326
LIG_BRCT_BRCA1_1	442	446	PF00533	0.480
LIG_BRCT_BRCA1_1	63	67	PF00533	0.436
LIG_Clathr_ClatBox_1	66	70	PF01394	0.493
LIG_FHA_1	16	22	PF00498	0.648
LIG_FHA_1	283	289	PF00498	0.535
LIG_FHA_1	374	380	PF00498	0.511
LIG_FHA_2	100	106	PF00498	0.694
LIG_FHA_2	405	411	PF00498	0.335
LIG_FHA_2	494	500	PF00498	0.557
LIG_LIR_Nem_3	197	202	PF02991	0.387
LIG_LIR_Nem_3	420	425	PF02991	0.477
LIG_LYPXL_yS_3	199	202	PF13949	0.368
LIG_PCNA_PIPBox_1	88	97	PF02747	0.459
LIG_PCNA_yPIPBox_3	88	99	PF02747	0.575
LIG_SH2_PTP2	405	408	PF00017	0.475
LIG_SH2_STAP1	255	259	PF00017	0.388
LIG_SH2_STAP1	355	359	PF00017	0.390
LIG_SH2_STAT3	157	160	PF00017	0.496
LIG_SH2_STAT5	405	408	PF00017	0.475
LIG_SH3_2	308	313	PF14604	0.468
LIG_SH3_3	112	118	PF00018	0.503
LIG_SH3_3	167	173	PF00018	0.745
LIG_SH3_3	278	284	PF00018	0.584
LIG_SH3_3	305	311	PF00018	0.620
LIG_SH3_3	31	37	PF00018	0.714
LIG_SH3_3	382	388	PF00018	0.541
LIG_SH3_3	409	415	PF00018	0.416
LIG_SUMO_SIM_anti_2	287	292	PF11976	0.411
LIG_TYR_ITIM	403	408	PF00017	0.488
MOD_CDC14_SPxK_1	310	313	PF00782	0.490
MOD_CDK_SPK_2	307	312	PF00069	0.538
MOD_CDK_SPxK_1	307	313	PF00069	0.528
MOD_CK1_1	133	139	PF00069	0.388
MOD_CK1_1	140	146	PF00069	0.298
MOD_CK1_1	166	172	PF00069	0.670
MOD_CK1_1	183	189	PF00069	0.558
MOD_CK1_1	228	234	PF00069	0.356
MOD_CK1_1	247	253	PF00069	0.197
MOD_CK1_1	263	269	PF00069	0.563
MOD_CK1_1	272	278	PF00069	0.790
MOD_CK1_1	301	307	PF00069	0.485
MOD_CK1_1	337	343	PF00069	0.417
MOD_CK1_1	373	379	PF00069	0.439
MOD_CK1_1	39	45	PF00069	0.745
MOD_CK1_1	57	63	PF00069	0.600
MOD_CK2_1	218	224	PF00069	0.414
MOD_CK2_1	240	246	PF00069	0.217
MOD_CK2_1	493	499	PF00069	0.564
MOD_GlcNHglycan	107	110	PF01048	0.694
MOD_GlcNHglycan	135	138	PF01048	0.343
MOD_GlcNHglycan	163	166	PF01048	0.593
MOD_GlcNHglycan	228	231	PF01048	0.392
MOD_GlcNHglycan	303	306	PF01048	0.571
MOD_GlcNHglycan	372	375	PF01048	0.447
MOD_GlcNHglycan	468	471	PF01048	0.526
MOD_GSK3_1	11	18	PF00069	0.722
MOD_GSK3_1	126	133	PF00069	0.387
MOD_GSK3_1	179	186	PF00069	0.754
MOD_GSK3_1	220	227	PF00069	0.370
MOD_GSK3_1	240	247	PF00069	0.235
MOD_GSK3_1	266	273	PF00069	0.721
MOD_GSK3_1	35	42	PF00069	0.707
MOD_GSK3_1	392	399	PF00069	0.471
MOD_GSK3_1	447	454	PF00069	0.545
MOD_GSK3_1	56	63	PF00069	0.634
MOD_GSK3_1	95	102	PF00069	0.586
MOD_NEK2_1	15	20	PF00069	0.644
MOD_NEK2_1	239	244	PF00069	0.205
MOD_NEK2_1	270	275	PF00069	0.586
MOD_NEK2_1	446	451	PF00069	0.481
MOD_NEK2_1	481	486	PF00069	0.581
MOD_NEK2_1	493	498	PF00069	0.496
MOD_NEK2_1	9	14	PF00069	0.671
MOD_NEK2_2	17	22	PF00069	0.696
MOD_PIKK_1	130	136	PF00454	0.347
MOD_PIKK_1	447	453	PF00454	0.419
MOD_PK_1	3	9	PF00069	0.485
MOD_PK_1	375	381	PF00069	0.302
MOD_PKA_2	126	132	PF00069	0.374
MOD_PKA_2	137	143	PF00069	0.352
MOD_PKA_2	183	189	PF00069	0.744
MOD_PKA_2	250	256	PF00069	0.385
MOD_PKA_2	282	288	PF00069	0.570
MOD_PKA_2	334	340	PF00069	0.465
MOD_PKA_2	425	431	PF00069	0.392
MOD_PKA_2	55	61	PF00069	0.672
MOD_PKA_2	95	101	PF00069	0.538
MOD_PKB_1	402	410	PF00069	0.421
MOD_Plk_4	240	246	PF00069	0.334
MOD_Plk_4	339	345	PF00069	0.278
MOD_ProDKin_1	114	120	PF00069	0.375
MOD_ProDKin_1	166	172	PF00069	0.679
MOD_ProDKin_1	273	279	PF00069	0.791
MOD_ProDKin_1	307	313	PF00069	0.535
MOD_ProDKin_1	61	67	PF00069	0.571
TRG_DiLeu_BaLyEn_6	197	202	PF01217	0.446
TRG_ENDOCYTIC_2	199	202	PF00928	0.368
TRG_ENDOCYTIC_2	405	408	PF00928	0.475
TRG_ER_diArg_1	1	3	PF00400	0.715
TRG_ER_diArg_1	311	313	PF00400	0.567
TRG_ER_diArg_1	346	349	PF00400	0.315
TRG_ER_diArg_1	400	403	PF00400	0.542
TRG_ER_diArg_1	471	474	PF00400	0.557
TRG_ER_diArg_1	476	479	PF00400	0.552
TRG_NES_CRM1_1	72	85	PF08389	0.459
TRG_Pf-PMV_PEXEL_1	313	317	PF00026	0.385
TRG_Pf-PMV_PEXEL_1	362	367	PF00026	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ62	Leptomonas seymouri	62%	100%
A0A0S4KFW8	Bodo saltans	29%	100%
A0A1X0NIH3	Trypanosomatidae	38%	100%
A0A3R7NRE8	Trypanosoma rangeli	38%	100%
A0A3S5H5U3	Leishmania donovani	93%	98%
A4H4S6	Leishmania braziliensis	75%	98%
A4HT07	Leishmania infantum	93%	98%
C9ZTN9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	90%
E9AKZ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	98%
V5BNK9	Trypanosoma cruzi	37%	100%