Separase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Separase

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIW0_LEIMA

TriTrypDb:

LmjF.06.1160 , LMJLV39_060018100 , LMJSD75_060018300

Length:

1099

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QIW0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIW0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	244	248	PF00656	0.580
CLV_C14_Caspase3-7	526	530	PF00656	0.627
CLV_C14_Caspase3-7	798	802	PF00656	0.579
CLV_NRD_NRD_1	1092	1094	PF00675	0.656
CLV_NRD_NRD_1	125	127	PF00675	0.594
CLV_NRD_NRD_1	132	134	PF00675	0.546
CLV_NRD_NRD_1	322	324	PF00675	0.408
CLV_NRD_NRD_1	806	808	PF00675	0.717
CLV_NRD_NRD_1	850	852	PF00675	0.484
CLV_PCSK_KEX2_1	125	127	PF00082	0.594
CLV_PCSK_KEX2_1	132	134	PF00082	0.546
CLV_PCSK_KEX2_1	241	243	PF00082	0.731
CLV_PCSK_KEX2_1	322	324	PF00082	0.456
CLV_PCSK_KEX2_1	806	808	PF00082	0.624
CLV_PCSK_KEX2_1	849	851	PF00082	0.482
CLV_PCSK_PC1ET2_1	241	243	PF00082	0.555
CLV_PCSK_SKI1_1	27	31	PF00082	0.464
CLV_PCSK_SKI1_1	375	379	PF00082	0.625
CLV_PCSK_SKI1_1	452	456	PF00082	0.511
CLV_PCSK_SKI1_1	556	560	PF00082	0.473
CLV_PCSK_SKI1_1	612	616	PF00082	0.432
CLV_PCSK_SKI1_1	666	670	PF00082	0.561
CLV_PCSK_SKI1_1	689	693	PF00082	0.528
CLV_PCSK_SKI1_1	877	881	PF00082	0.387
CLV_PCSK_SKI1_1	913	917	PF00082	0.404
CLV_PCSK_SKI1_1	959	963	PF00082	0.587
CLV_Separin_Metazoa	694	698	PF03568	0.407
DEG_APCC_DBOX_1	374	382	PF00400	0.572
DEG_APCC_DBOX_1	640	648	PF00400	0.434
DEG_APCC_DBOX_1	665	673	PF00400	0.613
DEG_APCC_DBOX_1	688	696	PF00400	0.470
DEG_Nend_UBRbox_2	1	3	PF02207	0.641
DEG_SPOP_SBC_1	659	663	PF00917	0.592
DOC_ANK_TNKS_1	769	776	PF00023	0.370
DOC_CKS1_1	385	390	PF01111	0.604
DOC_CYCLIN_RxL_1	663	671	PF00134	0.365
DOC_CYCLIN_RxL_1	685	694	PF00134	0.498
DOC_MAPK_MEF2A_6	13	21	PF00069	0.349
DOC_MAPK_MEF2A_6	375	383	PF00069	0.634
DOC_MAPK_MEF2A_6	448	457	PF00069	0.448
DOC_MAPK_MEF2A_6	990	997	PF00069	0.421
DOC_PP1_RVXF_1	118	125	PF00149	0.706
DOC_PP1_RVXF_1	48	54	PF00149	0.471
DOC_PP1_RVXF_1	687	694	PF00149	0.537
DOC_PP2B_LxvP_1	345	348	PF13499	0.485
DOC_PP2B_LxvP_1	497	500	PF13499	0.424
DOC_PP2B_PxIxI_1	259	265	PF00149	0.506
DOC_PP4_FxxP_1	588	591	PF00568	0.507
DOC_PP4_FxxP_1	710	713	PF00568	0.495
DOC_PP4_FxxP_1	835	838	PF00568	0.545
DOC_USP7_MATH_1	116	120	PF00917	0.624
DOC_USP7_MATH_1	164	168	PF00917	0.665
DOC_USP7_MATH_1	287	291	PF00917	0.504
DOC_USP7_MATH_1	300	304	PF00917	0.527
DOC_USP7_MATH_1	348	352	PF00917	0.659
DOC_USP7_MATH_1	487	491	PF00917	0.494
DOC_USP7_MATH_1	500	504	PF00917	0.643
DOC_USP7_MATH_1	514	518	PF00917	0.512
DOC_USP7_MATH_1	554	558	PF00917	0.527
DOC_USP7_MATH_1	589	593	PF00917	0.515
DOC_USP7_MATH_1	596	600	PF00917	0.487
DOC_USP7_MATH_1	725	729	PF00917	0.516
DOC_USP7_MATH_1	747	751	PF00917	0.479
DOC_USP7_MATH_1	795	799	PF00917	0.655
DOC_USP7_MATH_1	817	821	PF00917	0.757
DOC_USP7_MATH_1	84	88	PF00917	0.772
DOC_USP7_MATH_1	873	877	PF00917	0.452
DOC_USP7_MATH_1	95	99	PF00917	0.534
DOC_WW_Pin1_4	162	167	PF00397	0.620
DOC_WW_Pin1_4	174	179	PF00397	0.574
DOC_WW_Pin1_4	197	202	PF00397	0.525
DOC_WW_Pin1_4	256	261	PF00397	0.649
DOC_WW_Pin1_4	325	330	PF00397	0.700
DOC_WW_Pin1_4	384	389	PF00397	0.602
DOC_WW_Pin1_4	623	628	PF00397	0.468
DOC_WW_Pin1_4	653	658	PF00397	0.566
DOC_WW_Pin1_4	677	682	PF00397	0.621
LIG_14-3-3_CanoR_1	1014	1022	PF00244	0.538
LIG_14-3-3_CanoR_1	306	314	PF00244	0.587
LIG_14-3-3_CanoR_1	339	349	PF00244	0.677
LIG_14-3-3_CanoR_1	877	883	PF00244	0.366
LIG_14-3-3_CanoR_1	900	906	PF00244	0.499
LIG_14-3-3_CanoR_1	952	961	PF00244	0.548
LIG_Actin_WH2_2	12	29	PF00022	0.405
LIG_BIR_III_2	163	167	PF00653	0.588
LIG_BRCT_BRCA1_1	267	271	PF00533	0.465
LIG_BRCT_BRCA1_1	300	304	PF00533	0.556
LIG_BRCT_BRCA1_1	533	537	PF00533	0.481
LIG_CSL_BTD_1	835	838	PF09270	0.545
LIG_deltaCOP1_diTrp_1	298	304	PF00928	0.483
LIG_eIF4E_1	14	20	PF01652	0.388
LIG_eIF4E_1	686	692	PF01652	0.472
LIG_FHA_1	1043	1049	PF00498	0.579
LIG_FHA_1	105	111	PF00498	0.592
LIG_FHA_1	259	265	PF00498	0.551
LIG_FHA_1	313	319	PF00498	0.398
LIG_FHA_1	385	391	PF00498	0.716
LIG_FHA_1	418	424	PF00498	0.557
LIG_FHA_1	471	477	PF00498	0.477
LIG_FHA_1	641	647	PF00498	0.500
LIG_FHA_1	660	666	PF00498	0.399
LIG_FHA_1	884	890	PF00498	0.456
LIG_FHA_1	958	964	PF00498	0.557
LIG_FHA_1	980	986	PF00498	0.498
LIG_FHA_2	1004	1010	PF00498	0.584
LIG_FHA_2	104	110	PF00498	0.582
LIG_FHA_2	158	164	PF00498	0.623
LIG_FHA_2	198	204	PF00498	0.579
LIG_GBD_Chelix_1	607	615	PF00786	0.491
LIG_Integrin_RGD_1	510	512	PF01839	0.542
LIG_Integrin_RGD_1	564	566	PF01839	0.449
LIG_LIR_Apic_2	585	591	PF02991	0.511
LIG_LIR_Apic_2	708	713	PF02991	0.484
LIG_LIR_Apic_2	832	838	PF02991	0.434
LIG_LIR_Apic_2	87	92	PF02991	0.502
LIG_LIR_Gen_1	203	213	PF02991	0.424
LIG_LIR_Gen_1	690	700	PF02991	0.421
LIG_LIR_Gen_1	782	791	PF02991	0.401
LIG_LIR_Gen_1	859	867	PF02991	0.395
LIG_LIR_Gen_1	989	997	PF02991	0.464
LIG_LIR_Nem_3	203	209	PF02991	0.422
LIG_LIR_Nem_3	440	444	PF02991	0.486
LIG_LIR_Nem_3	629	635	PF02991	0.587
LIG_LIR_Nem_3	680	686	PF02991	0.589
LIG_LIR_Nem_3	690	696	PF02991	0.373
LIG_LIR_Nem_3	782	787	PF02991	0.432
LIG_LIR_Nem_3	859	863	PF02991	0.527
LIG_LIR_Nem_3	881	885	PF02991	0.445
LIG_LIR_Nem_3	989	995	PF02991	0.434
LIG_LYPXL_yS_3	920	923	PF13949	0.506
LIG_NRBOX	394	400	PF00104	0.639
LIG_NRBOX	664	670	PF00104	0.440
LIG_PCNA_yPIPBox_3	358	368	PF02747	0.496
LIG_Rb_pABgroove_1	265	273	PF01858	0.495
LIG_RPA_C_Fungi	121	133	PF08784	0.556
LIG_RPA_C_Fungi	443	455	PF08784	0.502
LIG_SH2_CRK	1031	1035	PF00017	0.464
LIG_SH2_CRK	128	132	PF00017	0.590
LIG_SH2_CRK	651	655	PF00017	0.570
LIG_SH2_CRK	844	848	PF00017	0.540
LIG_SH2_CRK	89	93	PF00017	0.505
LIG_SH2_NCK_1	844	848	PF00017	0.458
LIG_SH2_PTP2	14	17	PF00017	0.389
LIG_SH2_PTP2	860	863	PF00017	0.415
LIG_SH2_SRC	7	10	PF00017	0.461
LIG_SH2_SRC	772	775	PF00017	0.427
LIG_SH2_STAP1	434	438	PF00017	0.415
LIG_SH2_STAP1	44	48	PF00017	0.459
LIG_SH2_STAP1	472	476	PF00017	0.386
LIG_SH2_STAP1	7	11	PF00017	0.513
LIG_SH2_STAP1	878	882	PF00017	0.444
LIG_SH2_STAP1	967	971	PF00017	0.411
LIG_SH2_STAT5	14	17	PF00017	0.411
LIG_SH2_STAT5	438	441	PF00017	0.406
LIG_SH2_STAT5	472	475	PF00017	0.472
LIG_SH2_STAT5	765	768	PF00017	0.480
LIG_SH2_STAT5	776	779	PF00017	0.507
LIG_SH2_STAT5	860	863	PF00017	0.420
LIG_SH2_STAT5	89	92	PF00017	0.601
LIG_SH3_1	254	260	PF00018	0.543
LIG_SH3_3	172	178	PF00018	0.826
LIG_SH3_3	185	191	PF00018	0.581
LIG_SH3_3	233	239	PF00018	0.481
LIG_SH3_3	254	260	PF00018	0.651
LIG_SH3_3	651	657	PF00018	0.573
LIG_SUMO_SIM_anti_2	642	648	PF11976	0.443
LIG_SUMO_SIM_anti_2	991	997	PF11976	0.416
LIG_SUMO_SIM_par_1	655	664	PF11976	0.483
LIG_SUMO_SIM_par_1	870	876	PF11976	0.430
LIG_TRAF2_1	1075	1078	PF00917	0.563
LIG_TRAF2_1	705	708	PF00917	0.489
LIG_TYR_ITIM	842	847	PF00017	0.560
LIG_TYR_ITIM	858	863	PF00017	0.403
LIG_TYR_ITIM	918	923	PF00017	0.513
LIG_WRC_WIRS_1	438	443	PF05994	0.529
MOD_CDK_SPK_2	174	179	PF00069	0.611
MOD_CDK_SPxxK_3	330	337	PF00069	0.659
MOD_CK1_1	115	121	PF00069	0.773
MOD_CK1_1	234	240	PF00069	0.441
MOD_CK1_1	258	264	PF00069	0.468
MOD_CK1_1	330	336	PF00069	0.512
MOD_CK1_1	340	346	PF00069	0.789
MOD_CK1_1	413	419	PF00069	0.587
MOD_CK1_1	440	446	PF00069	0.504
MOD_CK1_1	517	523	PF00069	0.774
MOD_CK1_1	557	563	PF00069	0.539
MOD_CK1_1	677	683	PF00069	0.556
MOD_CK1_1	736	742	PF00069	0.490
MOD_CK1_1	794	800	PF00069	0.612
MOD_CK1_1	87	93	PF00069	0.761
MOD_CK2_1	1072	1078	PF00069	0.565
MOD_CK2_1	115	121	PF00069	0.624
MOD_CK2_1	174	180	PF00069	0.658
MOD_CK2_1	623	629	PF00069	0.426
MOD_CK2_1	823	829	PF00069	0.575
MOD_CK2_1	919	925	PF00069	0.458
MOD_GlcNHglycan	1022	1025	PF01048	0.582
MOD_GlcNHglycan	1059	1062	PF01048	0.625
MOD_GlcNHglycan	114	117	PF01048	0.725
MOD_GlcNHglycan	197	200	PF01048	0.757
MOD_GlcNHglycan	243	246	PF01048	0.715
MOD_GlcNHglycan	277	283	PF01048	0.582
MOD_GlcNHglycan	300	303	PF01048	0.539
MOD_GlcNHglycan	329	332	PF01048	0.556
MOD_GlcNHglycan	339	342	PF01048	0.681
MOD_GlcNHglycan	350	353	PF01048	0.594
MOD_GlcNHglycan	406	409	PF01048	0.540
MOD_GlcNHglycan	428	431	PF01048	0.429
MOD_GlcNHglycan	502	505	PF01048	0.663
MOD_GlcNHglycan	506	509	PF01048	0.699
MOD_GlcNHglycan	525	528	PF01048	0.387
MOD_GlcNHglycan	566	569	PF01048	0.690
MOD_GlcNHglycan	598	601	PF01048	0.650
MOD_GlcNHglycan	735	738	PF01048	0.457
MOD_GlcNHglycan	747	750	PF01048	0.424
MOD_GlcNHglycan	793	796	PF01048	0.625
MOD_GlcNHglycan	818	822	PF01048	0.560
MOD_GlcNHglycan	86	89	PF01048	0.586
MOD_GlcNHglycan	901	904	PF01048	0.414
MOD_GlcNHglycan	93	96	PF01048	0.788
MOD_GlcNHglycan	937	940	PF01048	0.489
MOD_GSK3_1	112	119	PF00069	0.704
MOD_GSK3_1	136	143	PF00069	0.700
MOD_GSK3_1	195	202	PF00069	0.733
MOD_GSK3_1	237	244	PF00069	0.517
MOD_GSK3_1	256	263	PF00069	0.490
MOD_GSK3_1	384	391	PF00069	0.748
MOD_GSK3_1	413	420	PF00069	0.713
MOD_GSK3_1	500	507	PF00069	0.620
MOD_GSK3_1	517	524	PF00069	0.463
MOD_GSK3_1	554	561	PF00069	0.433
MOD_GSK3_1	596	603	PF00069	0.586
MOD_GSK3_1	673	680	PF00069	0.502
MOD_GSK3_1	681	688	PF00069	0.507
MOD_GSK3_1	791	798	PF00069	0.451
MOD_GSK3_1	823	830	PF00069	0.623
MOD_GSK3_1	87	94	PF00069	0.593
MOD_GSK3_1	899	906	PF00069	0.510
MOD_N-GLC_1	285	290	PF02516	0.580
MOD_N-GLC_1	500	505	PF02516	0.719
MOD_NEK2_1	1020	1025	PF00069	0.616
MOD_NEK2_1	212	217	PF00069	0.527
MOD_NEK2_1	379	384	PF00069	0.534
MOD_NEK2_1	425	430	PF00069	0.480
MOD_NEK2_1	495	500	PF00069	0.512
MOD_NEK2_1	658	663	PF00069	0.627
MOD_NEK2_1	758	763	PF00069	0.388
MOD_NEK2_1	872	877	PF00069	0.433
MOD_NEK2_1	901	906	PF00069	0.504
MOD_NEK2_1	930	935	PF00069	0.386
MOD_NEK2_1	988	993	PF00069	0.456
MOD_NEK2_2	287	292	PF00069	0.546
MOD_NEK2_2	437	442	PF00069	0.529
MOD_NEK2_2	957	962	PF00069	0.430
MOD_OFUCOSY	1071	1076	PF10250	0.659
MOD_PIKK_1	164	170	PF00454	0.681
MOD_PIKK_1	305	311	PF00454	0.537
MOD_PIKK_1	381	387	PF00454	0.600
MOD_PIKK_1	417	423	PF00454	0.540
MOD_PKA_1	241	247	PF00069	0.568
MOD_PKA_2	195	201	PF00069	0.666
MOD_PKA_2	237	243	PF00069	0.705
MOD_PKA_2	305	311	PF00069	0.459
MOD_PKA_2	417	423	PF00069	0.538
MOD_PKA_2	504	510	PF00069	0.624
MOD_PKA_2	640	646	PF00069	0.425
MOD_PKA_2	899	905	PF00069	0.517
MOD_PKA_2	951	957	PF00069	0.573
MOD_PKB_1	950	958	PF00069	0.434
MOD_Plk_1	103	109	PF00069	0.699
MOD_Plk_1	120	126	PF00069	0.579
MOD_Plk_1	379	385	PF00069	0.644
MOD_Plk_1	514	520	PF00069	0.604
MOD_Plk_2-3	104	110	PF00069	0.571
MOD_Plk_4	136	142	PF00069	0.753
MOD_Plk_4	231	237	PF00069	0.488
MOD_Plk_4	640	646	PF00069	0.478
MOD_Plk_4	758	764	PF00069	0.431
MOD_ProDKin_1	162	168	PF00069	0.622
MOD_ProDKin_1	174	180	PF00069	0.573
MOD_ProDKin_1	197	203	PF00069	0.517
MOD_ProDKin_1	256	262	PF00069	0.633
MOD_ProDKin_1	325	331	PF00069	0.706
MOD_ProDKin_1	384	390	PF00069	0.604
MOD_ProDKin_1	623	629	PF00069	0.475
MOD_ProDKin_1	653	659	PF00069	0.559
MOD_ProDKin_1	677	683	PF00069	0.620
MOD_SUMO_for_1	29	32	PF00179	0.467
MOD_SUMO_for_1	672	675	PF00179	0.582
MOD_SUMO_rev_2	805	815	PF00179	0.599
TRG_DiLeu_BaEn_1	24	29	PF01217	0.384
TRG_DiLeu_BaEn_1	590	595	PF01217	0.581
TRG_DiLeu_BaEn_1	642	647	PF01217	0.538
TRG_DiLeu_BaLyEn_6	970	975	PF01217	0.408
TRG_DiLeu_LyEn_5	24	29	PF01217	0.384
TRG_ENDOCYTIC_2	1031	1034	PF00928	0.405
TRG_ENDOCYTIC_2	128	131	PF00928	0.729
TRG_ENDOCYTIC_2	14	17	PF00928	0.374
TRG_ENDOCYTIC_2	438	441	PF00928	0.437
TRG_ENDOCYTIC_2	651	654	PF00928	0.575
TRG_ENDOCYTIC_2	844	847	PF00928	0.544
TRG_ENDOCYTIC_2	860	863	PF00928	0.399
TRG_ENDOCYTIC_2	920	923	PF00928	0.506
TRG_ER_diArg_1	124	126	PF00400	0.757
TRG_ER_diArg_1	131	133	PF00400	0.633
TRG_ER_diArg_1	321	323	PF00400	0.351
TRG_ER_diArg_1	806	809	PF00400	0.627
TRG_ER_diArg_1	849	851	PF00400	0.486
TRG_ER_diArg_1	950	953	PF00400	0.420
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	666	670	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	689	694	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV03	Leptomonas seymouri	47%	100%
A0A3R7L2Z7	Trypanosoma rangeli	27%	100%
A0A3S5H5U4	Leishmania donovani	90%	100%
A4H4S7	Leishmania braziliensis	75%	100%
C9ZTP0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AG70	Leishmania infantum	91%	100%
E9AKZ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5B820	Trypanosoma cruzi	26%	100%