Thioredoxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

thioredoxin, putative

Species:

Leishmania major

UniProt:

Q4QIV7_LEIMA

TriTrypDb:

LmjF.06.1190 , LMJLV39_060018400

Length:

189

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 13, no: 4
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0016020	membrane	2	2
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3
GO:0005783	endoplasmic reticulum	5	1

Expansion

Sequence features

Q4QIV7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIV7

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0003756	protein disulfide isomerase activity	3	7
GO:0003824	catalytic activity	1	9
GO:0016853	isomerase activity	2	9
GO:0016860	intramolecular oxidoreductase activity	3	7
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	4	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	31	33	PF00675	0.397
CLV_NRD_NRD_1	41	43	PF00675	0.425
CLV_PCSK_FUR_1	39	43	PF00082	0.353
CLV_PCSK_KEX2_1	149	151	PF00082	0.458
CLV_PCSK_KEX2_1	31	33	PF00082	0.374
CLV_PCSK_KEX2_1	41	43	PF00082	0.356
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.477
CLV_PCSK_SKI1_1	112	116	PF00082	0.453
CLV_PCSK_SKI1_1	131	135	PF00082	0.483
CLV_PCSK_SKI1_1	7	11	PF00082	0.368
DEG_Nend_Nbox_1	1	3	PF02207	0.556
DOC_CKS1_1	161	166	PF01111	0.338
DOC_MAPK_DCC_7	47	56	PF00069	0.413
DOC_MAPK_MEF2A_6	47	56	PF00069	0.513
DOC_PP4_FxxP_1	161	164	PF00568	0.335
DOC_USP7_MATH_1	175	179	PF00917	0.260
DOC_USP7_MATH_1	33	37	PF00917	0.579
DOC_USP7_MATH_1	75	79	PF00917	0.374
DOC_WW_Pin1_4	160	165	PF00397	0.319
LIG_14-3-3_CanoR_1	109	115	PF00244	0.273
LIG_14-3-3_CanoR_1	120	130	PF00244	0.209
LIG_14-3-3_CanoR_1	31	40	PF00244	0.711
LIG_14-3-3_CanoR_1	41	45	PF00244	0.675
LIG_14-3-3_CanoR_1	5	10	PF00244	0.531
LIG_BRCT_BRCA1_1	10	14	PF00533	0.535
LIG_BRCT_BRCA1_1	182	186	PF00533	0.253
LIG_BRCT_BRCA1_1	96	100	PF00533	0.309
LIG_FHA_1	46	52	PF00498	0.568
LIG_FHA_1	97	103	PF00498	0.300
LIG_GBD_Chelix_1	54	62	PF00786	0.319
LIG_LIR_Apic_2	158	164	PF02991	0.347
LIG_LIR_Apic_2	171	175	PF02991	0.383
LIG_LIR_Gen_1	115	123	PF02991	0.237
LIG_LIR_Gen_1	96	105	PF02991	0.264
LIG_LIR_Nem_3	115	121	PF02991	0.264
LIG_LIR_Nem_3	142	147	PF02991	0.303
LIG_LIR_Nem_3	86	91	PF02991	0.219
LIG_LIR_Nem_3	96	101	PF02991	0.237
LIG_LYPXL_yS_3	144	147	PF13949	0.250
LIG_NRBOX	57	63	PF00104	0.381
LIG_PCNA_yPIPBox_3	120	134	PF02747	0.223
LIG_Pex14_2	184	188	PF04695	0.377
LIG_SH2_CRK	162	166	PF00017	0.321
LIG_SH2_CRK	172	176	PF00017	0.308
LIG_SH2_CRK	98	102	PF00017	0.356
LIG_SH2_SRC	138	141	PF00017	0.335
LIG_SH2_STAP1	98	102	PF00017	0.381
LIG_SH2_STAT5	103	106	PF00017	0.201
LIG_SH2_STAT5	138	141	PF00017	0.323
LIG_SH2_STAT5	162	165	PF00017	0.262
LIG_SH2_STAT5	179	182	PF00017	0.209
LIG_SH2_STAT5	2	5	PF00017	0.541
LIG_SH2_STAT5	91	94	PF00017	0.324
LIG_SH2_STAT5	98	101	PF00017	0.235
LIG_SH3_3	89	95	PF00018	0.293
LIG_SUMO_SIM_par_1	78	84	PF11976	0.270
LIG_TYR_ITIM	160	165	PF00017	0.315
LIG_WRC_WIRS_1	181	186	PF05994	0.240
MOD_CDK_SPxxK_3	160	167	PF00069	0.180
MOD_CK1_1	8	14	PF00069	0.536
MOD_CK2_1	123	129	PF00069	0.328
MOD_GlcNHglycan	70	73	PF01048	0.593
MOD_GSK3_1	119	126	PF00069	0.322
MOD_GSK3_1	27	34	PF00069	0.563
MOD_GSK3_1	8	15	PF00069	0.544
MOD_NEK2_1	121	126	PF00069	0.257
MOD_NEK2_1	14	19	PF00069	0.614
MOD_NEK2_1	180	185	PF00069	0.287
MOD_NEK2_1	40	45	PF00069	0.634
MOD_NEK2_1	65	70	PF00069	0.477
MOD_PIKK_1	112	118	PF00454	0.269
MOD_PIKK_1	121	127	PF00454	0.244
MOD_PK_1	5	11	PF00069	0.536
MOD_PKA_1	31	37	PF00069	0.540
MOD_PKA_2	119	125	PF00069	0.321
MOD_PKA_2	175	181	PF00069	0.333
MOD_PKA_2	31	37	PF00069	0.693
MOD_PKA_2	40	46	PF00069	0.695
MOD_PKA_2	84	90	PF00069	0.330
MOD_Plk_1	75	81	PF00069	0.427
MOD_Plk_4	155	161	PF00069	0.254
MOD_Plk_4	175	181	PF00069	0.277
MOD_Plk_4	96	102	PF00069	0.281
MOD_ProDKin_1	160	166	PF00069	0.319
TRG_DiLeu_BaLyEn_6	49	54	PF01217	0.234
TRG_ENDOCYTIC_2	144	147	PF00928	0.294
TRG_ENDOCYTIC_2	162	165	PF00928	0.202
TRG_ENDOCYTIC_2	98	101	PF00928	0.359
TRG_ER_diArg_1	38	41	PF00400	0.670

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I216	Leptomonas seymouri	64%	100%
A0A0N1IJS7	Leptomonas seymouri	27%	100%
A0A0S4JA26	Bodo saltans	28%	100%
A0A1X0NGQ4	Trypanosomatidae	53%	100%
A0A3S5H5U6	Leishmania donovani	86%	90%
A0A422NM49	Trypanosoma rangeli	47%	100%
A4H4R8	Leishmania braziliensis	29%	100%
A4H4T0	Leishmania braziliensis	79%	100%
A4HSZ7	Leishmania infantum	31%	100%
A4HT10	Leishmania infantum	90%	100%
C9ZTP4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
C9ZTP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AKY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9AKZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QIX1	Leishmania major	31%	100%
Q8I7Z7	Leishmania donovani	31%	100%