Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QIV6_LEIMA

TriTrypDb:

LmjF.06.1200 , LMJLV39_060018700 , LMJSD75_060018800

Length:

394

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QIV6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIV6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	281	285	PF00656	0.796
CLV_NRD_NRD_1	143	145	PF00675	0.687
CLV_NRD_NRD_1	163	165	PF00675	0.758
CLV_NRD_NRD_1	306	308	PF00675	0.699
CLV_NRD_NRD_1	325	327	PF00675	0.818
CLV_NRD_NRD_1	386	388	PF00675	0.660
CLV_PCSK_KEX2_1	163	165	PF00082	0.723
CLV_PCSK_KEX2_1	308	310	PF00082	0.730
CLV_PCSK_KEX2_1	325	327	PF00082	0.714
CLV_PCSK_KEX2_1	386	388	PF00082	0.660
CLV_PCSK_KEX2_1	63	65	PF00082	0.589
CLV_PCSK_PC1ET2_1	308	310	PF00082	0.731
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.607
CLV_PCSK_PC7_1	304	310	PF00082	0.759
CLV_PCSK_PC7_1	59	65	PF00082	0.618
CLV_PCSK_SKI1_1	154	158	PF00082	0.784
DEG_APCC_DBOX_1	386	394	PF00400	0.624
DEG_SPOP_SBC_1	342	346	PF00917	0.586
DOC_AGCK_PIF_3	391	394	PF00069	0.612
DOC_ANK_TNKS_1	162	169	PF00023	0.563
DOC_CKS1_1	17	22	PF01111	0.588
DOC_CYCLIN_RxL_1	329	341	PF00134	0.717
DOC_PP1_RVXF_1	331	338	PF00149	0.703
DOC_PP2B_LxvP_1	41	44	PF13499	0.681
DOC_USP7_MATH_1	166	170	PF00917	0.729
DOC_USP7_MATH_1	175	179	PF00917	0.634
DOC_USP7_MATH_1	342	346	PF00917	0.586
DOC_USP7_MATH_1	78	82	PF00917	0.615
DOC_WW_Pin1_4	16	21	PF00397	0.727
DOC_WW_Pin1_4	176	181	PF00397	0.591
DOC_WW_Pin1_4	230	235	PF00397	0.669
DOC_WW_Pin1_4	286	291	PF00397	0.821
DOC_WW_Pin1_4	296	301	PF00397	0.633
DOC_WW_Pin1_4	347	352	PF00397	0.768
DOC_WW_Pin1_4	359	364	PF00397	0.787
DOC_WW_Pin1_4	47	52	PF00397	0.709
LIG_14-3-3_CanoR_1	12	20	PF00244	0.590
LIG_14-3-3_CanoR_1	329	337	PF00244	0.628
LIG_14-3-3_CanoR_1	386	391	PF00244	0.606
LIG_APCC_ABBA_1	276	281	PF00400	0.799
LIG_BIR_II_1	1	5	PF00653	0.562
LIG_BRCT_BRCA1_1	217	221	PF00533	0.670
LIG_Clathr_ClatBox_1	219	223	PF01394	0.632
LIG_DLG_GKlike_1	386	393	PF00625	0.620
LIG_FHA_1	107	113	PF00498	0.623
LIG_FHA_2	241	247	PF00498	0.787
LIG_FHA_2	313	319	PF00498	0.714
LIG_FHA_2	348	354	PF00498	0.731
LIG_FHA_2	369	375	PF00498	0.664
LIG_Integrin_RGD_1	296	298	PF01839	0.737
LIG_Integrin_RGD_1	311	313	PF01839	0.665
LIG_IRF3_LxIS_1	41	46	PF10401	0.734
LIG_LIR_Gen_1	389	394	PF02991	0.626
LIG_LIR_Nem_3	109	114	PF02991	0.616
LIG_LIR_Nem_3	2	7	PF02991	0.561
LIG_LIR_Nem_3	273	279	PF02991	0.561
LIG_LIR_Nem_3	389	394	PF02991	0.640
LIG_LYPXL_yS_3	4	7	PF13949	0.635
LIG_PDZ_Class_1	389	394	PF00595	0.618
LIG_SH2_CRK	99	103	PF00017	0.573
LIG_SH2_PTP2	6	9	PF00017	0.635
LIG_SH2_STAT5	230	233	PF00017	0.728
LIG_SH2_STAT5	242	245	PF00017	0.559
LIG_SH2_STAT5	266	269	PF00017	0.553
LIG_SH2_STAT5	6	9	PF00017	0.655
LIG_SH3_3	174	180	PF00018	0.699
LIG_SH3_3	360	366	PF00018	0.713
LIG_SH3_3	50	56	PF00018	0.799
LIG_TRAF2_1	351	354	PF00917	0.854
LIG_TRAF2_2	21	26	PF00917	0.651
LIG_TYR_ITIM	112	117	PF00017	0.606
LIG_WRC_WIRS_1	235	240	PF05994	0.656
LIG_WW_3	19	23	PF00397	0.619
MOD_CDK_SPK_2	347	352	PF00069	0.768
MOD_CDK_SPxK_1	16	22	PF00069	0.627
MOD_CK1_1	178	184	PF00069	0.737
MOD_CK1_1	262	268	PF00069	0.699
MOD_CK1_1	341	347	PF00069	0.715
MOD_CK1_1	46	52	PF00069	0.656
MOD_CK2_1	207	213	PF00069	0.635
MOD_CK2_1	312	318	PF00069	0.713
MOD_CK2_1	347	353	PF00069	0.769
MOD_CK2_1	368	374	PF00069	0.671
MOD_Cter_Amidation	323	326	PF01082	0.824
MOD_GlcNHglycan	1	4	PF01048	0.795
MOD_GlcNHglycan	300	303	PF01048	0.713
MOD_GlcNHglycan	338	343	PF01048	0.725
MOD_GlcNHglycan	368	371	PF01048	0.682
MOD_GlcNHglycan	80	83	PF01048	0.711
MOD_GSK3_1	230	237	PF00069	0.772
MOD_GSK3_1	241	248	PF00069	0.784
MOD_GSK3_1	253	260	PF00069	0.578
MOD_GSK3_1	282	289	PF00069	0.713
MOD_GSK3_1	338	345	PF00069	0.697
MOD_GSK3_1	364	371	PF00069	0.696
MOD_GSK3_1	43	50	PF00069	0.718
MOD_N-GLC_1	228	233	PF02516	0.683
MOD_NEK2_1	253	258	PF00069	0.774
MOD_NEK2_1	267	272	PF00069	0.454
MOD_NEK2_1	340	345	PF00069	0.751
MOD_NEK2_1	368	373	PF00069	0.665
MOD_PIKK_1	11	17	PF00454	0.583
MOD_PIKK_1	245	251	PF00454	0.749
MOD_PIKK_1	343	349	PF00454	0.831
MOD_PIKK_1	43	49	PF00454	0.687
MOD_PKA_1	386	392	PF00069	0.659
MOD_PKA_2	11	17	PF00069	0.583
MOD_PKA_2	122	128	PF00069	0.680
MOD_PKA_2	328	334	PF00069	0.603
MOD_PKA_2	386	392	PF00069	0.688
MOD_PKB_1	309	317	PF00069	0.832
MOD_Plk_1	222	228	PF00069	0.608
MOD_Plk_1	37	43	PF00069	0.697
MOD_Plk_4	106	112	PF00069	0.566
MOD_Plk_4	215	221	PF00069	0.552
MOD_Plk_4	262	268	PF00069	0.555
MOD_Plk_4	368	374	PF00069	0.759
MOD_Plk_4	386	392	PF00069	0.635
MOD_ProDKin_1	16	22	PF00069	0.726
MOD_ProDKin_1	176	182	PF00069	0.590
MOD_ProDKin_1	230	236	PF00069	0.668
MOD_ProDKin_1	286	292	PF00069	0.818
MOD_ProDKin_1	296	302	PF00069	0.636
MOD_ProDKin_1	347	353	PF00069	0.769
MOD_ProDKin_1	359	365	PF00069	0.782
MOD_ProDKin_1	47	53	PF00069	0.708
TRG_ENDOCYTIC_2	114	117	PF00928	0.639
TRG_ENDOCYTIC_2	4	7	PF00928	0.635
TRG_ENDOCYTIC_2	99	102	PF00928	0.576
TRG_ER_diArg_1	163	165	PF00400	0.567
TRG_ER_diArg_1	385	387	PF00400	0.663
TRG_NLS_MonoExtC_3	306	311	PF00514	0.711
TRG_NLS_MonoExtN_4	304	311	PF00514	0.673
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.630
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	29	34	PF00026	0.737
TRG_Pf-PMV_PEXEL_1	333	338	PF00026	0.794

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4J6	Leptomonas seymouri	41%	100%
A0A3S5H5U8	Leishmania donovani	88%	100%
A4H4T2	Leishmania braziliensis	68%	100%
A4HT11	Leishmania infantum	89%	100%
E9AKZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%