Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QIV5_LEIMA

TriTrypDb:

LmjF.06.1210 , LMJLV39_060018800 , LMJSD75_060018900

Length:

589

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QIV5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIV5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.541
CLV_C14_Caspase3-7	556	560	PF00656	0.661
CLV_NRD_NRD_1	125	127	PF00675	0.583
CLV_NRD_NRD_1	381	383	PF00675	0.576
CLV_NRD_NRD_1	482	484	PF00675	0.632
CLV_PCSK_FUR_1	480	484	PF00082	0.588
CLV_PCSK_KEX2_1	125	127	PF00082	0.593
CLV_PCSK_KEX2_1	378	380	PF00082	0.531
CLV_PCSK_KEX2_1	482	484	PF00082	0.632
CLV_PCSK_KEX2_1	576	578	PF00082	0.679
CLV_PCSK_PC1ET2_1	378	380	PF00082	0.511
CLV_PCSK_PC1ET2_1	576	578	PF00082	0.615
CLV_PCSK_SKI1_1	393	397	PF00082	0.588
CLV_PCSK_SKI1_1	545	549	PF00082	0.715
CLV_PCSK_SKI1_1	573	577	PF00082	0.613
CLV_PCSK_SKI1_1	74	78	PF00082	0.642
DEG_Nend_Nbox_1	1	3	PF02207	0.622
DEG_SPOP_SBC_1	164	168	PF00917	0.530
DEG_SPOP_SBC_1	37	41	PF00917	0.649
DOC_CKS1_1	110	115	PF01111	0.564
DOC_CKS1_1	349	354	PF01111	0.606
DOC_MAPK_gen_1	240	249	PF00069	0.557
DOC_MAPK_gen_1	382	390	PF00069	0.471
DOC_MAPK_gen_1	503	510	PF00069	0.585
DOC_MAPK_MEF2A_6	240	249	PF00069	0.557
DOC_PP1_RVXF_1	55	61	PF00149	0.611
DOC_USP7_MATH_1	165	169	PF00917	0.627
DOC_USP7_MATH_1	231	235	PF00917	0.714
DOC_USP7_MATH_1	345	349	PF00917	0.575
DOC_USP7_MATH_1	426	430	PF00917	0.591
DOC_USP7_MATH_1	65	69	PF00917	0.544
DOC_USP7_UBL2_3	246	250	PF12436	0.445
DOC_WW_Pin1_4	109	114	PF00397	0.589
DOC_WW_Pin1_4	232	237	PF00397	0.575
DOC_WW_Pin1_4	348	353	PF00397	0.563
DOC_WW_Pin1_4	38	43	PF00397	0.670
LIG_14-3-3_CanoR_1	163	173	PF00244	0.541
LIG_14-3-3_CanoR_1	274	281	PF00244	0.375
LIG_14-3-3_CanoR_1	407	417	PF00244	0.639
LIG_14-3-3_CanoR_1	469	475	PF00244	0.667
LIG_14-3-3_CanoR_1	57	65	PF00244	0.689
LIG_14-3-3_CanoR_1	582	586	PF00244	0.685
LIG_APCC_ABBA_1	155	160	PF00400	0.422
LIG_APCC_ABBA_1	217	222	PF00400	0.496
LIG_APCC_ABBAyCdc20_2	326	332	PF00400	0.510
LIG_BIR_III_4	121	125	PF00653	0.532
LIG_BIR_III_4	303	307	PF00653	0.600
LIG_BIR_III_4	320	324	PF00653	0.465
LIG_BRCT_BRCA1_1	364	368	PF00533	0.501
LIG_BRCT_BRCA1_1	537	541	PF00533	0.663
LIG_Clathr_ClatBox_1	105	109	PF01394	0.670
LIG_FAT_LD_1	335	343	PF03623	0.454
LIG_FHA_1	152	158	PF00498	0.348
LIG_FHA_1	303	309	PF00498	0.621
LIG_FHA_1	372	378	PF00498	0.626
LIG_FHA_1	42	48	PF00498	0.645
LIG_FHA_1	434	440	PF00498	0.527
LIG_FHA_1	553	559	PF00498	0.735
LIG_FHA_1	569	575	PF00498	0.521
LIG_FHA_1	82	88	PF00498	0.635
LIG_FHA_2	204	210	PF00498	0.547
LIG_LIR_Apic_2	144	150	PF02991	0.579
LIG_LIR_Gen_1	252	262	PF02991	0.415
LIG_LIR_Gen_1	538	547	PF02991	0.661
LIG_LIR_LC3C_4	275	280	PF02991	0.394
LIG_LIR_Nem_3	172	178	PF02991	0.592
LIG_LIR_Nem_3	218	223	PF02991	0.504
LIG_LIR_Nem_3	252	258	PF02991	0.420
LIG_LIR_Nem_3	538	544	PF02991	0.662
LIG_MLH1_MIPbox_1	364	368	PF16413	0.501
LIG_NRBOX	334	340	PF00104	0.452
LIG_PCNA_yPIPBox_3	196	210	PF02747	0.418
LIG_PCNA_yPIPBox_3	391	399	PF02747	0.546
LIG_Pex14_2	203	207	PF04695	0.494
LIG_RPA_C_Fungi	577	589	PF08784	0.543
LIG_SH2_CRK	147	151	PF00017	0.575
LIG_SH2_CRK	405	409	PF00017	0.551
LIG_SH2_GRB2like	223	226	PF00017	0.405
LIG_SH2_NCK_1	330	334	PF00017	0.476
LIG_SH2_PTP2	107	110	PF00017	0.525
LIG_SH2_SRC	330	333	PF00017	0.488
LIG_SH2_STAP1	215	219	PF00017	0.494
LIG_SH2_STAP1	330	334	PF00017	0.476
LIG_SH2_STAT5	107	110	PF00017	0.670
LIG_SH2_STAT5	191	194	PF00017	0.383
LIG_SH2_STAT5	223	226	PF00017	0.550
LIG_SH2_STAT5	261	264	PF00017	0.469
LIG_SH2_STAT5	59	62	PF00017	0.543
LIG_SH2_STAT5	75	78	PF00017	0.695
LIG_SH3_3	199	205	PF00018	0.413
LIG_SH3_3	469	475	PF00018	0.740
LIG_SH3_3	505	511	PF00018	0.591
LIG_SH3_3	92	98	PF00018	0.632
LIG_TRAF2_1	206	209	PF00917	0.413
LIG_TYR_ITIM	105	110	PF00017	0.525
LIG_UBA3_1	540	548	PF00899	0.640
LIG_WRC_WIRS_1	204	209	PF05994	0.521
LIG_WRC_WIRS_1	364	369	PF05994	0.364
MOD_CDK_SPxK_1	348	354	PF00069	0.557
MOD_CK1_1	168	174	PF00069	0.524
MOD_CK1_1	286	292	PF00069	0.571
MOD_CK1_1	294	300	PF00069	0.561
MOD_CK1_1	348	354	PF00069	0.605
MOD_CK1_1	409	415	PF00069	0.645
MOD_CK1_1	41	47	PF00069	0.644
MOD_CK1_1	465	471	PF00069	0.602
MOD_CK1_1	496	502	PF00069	0.556
MOD_CK1_1	525	531	PF00069	0.621
MOD_CK1_1	581	587	PF00069	0.657
MOD_CK1_1	67	73	PF00069	0.483
MOD_CK2_1	203	209	PF00069	0.390
MOD_CK2_1	363	369	PF00069	0.506
MOD_CK2_1	543	549	PF00069	0.599
MOD_Cter_Amidation	123	126	PF01082	0.594
MOD_GlcNHglycan	133	136	PF01048	0.632
MOD_GlcNHglycan	167	170	PF01048	0.613
MOD_GlcNHglycan	288	291	PF01048	0.594
MOD_GlcNHglycan	413	416	PF01048	0.608
MOD_GlcNHglycan	447	450	PF01048	0.512
MOD_GlcNHglycan	464	467	PF01048	0.646
MOD_GlcNHglycan	472	475	PF01048	0.678
MOD_GlcNHglycan	487	490	PF01048	0.595
MOD_GlcNHglycan	495	498	PF01048	0.578
MOD_GlcNHglycan	527	530	PF01048	0.688
MOD_GlcNHglycan	537	540	PF01048	0.597
MOD_GSK3_1	131	138	PF00069	0.699
MOD_GSK3_1	164	171	PF00069	0.675
MOD_GSK3_1	282	289	PF00069	0.484
MOD_GSK3_1	36	43	PF00069	0.636
MOD_GSK3_1	406	413	PF00069	0.593
MOD_GSK3_1	520	527	PF00069	0.644
MOD_GSK3_1	548	555	PF00069	0.632
MOD_GSK3_1	580	587	PF00069	0.556
MOD_GSK3_1	63	70	PF00069	0.588
MOD_N-GLC_1	552	557	PF02516	0.595
MOD_NEK2_1	178	183	PF00069	0.427
MOD_NEK2_1	273	278	PF00069	0.476
MOD_NEK2_1	373	378	PF00069	0.518
MOD_NEK2_1	408	413	PF00069	0.645
MOD_NEK2_1	445	450	PF00069	0.584
MOD_NEK2_1	457	462	PF00069	0.513
MOD_NEK2_1	535	540	PF00069	0.576
MOD_NEK2_1	552	557	PF00069	0.523
MOD_NEK2_1	578	583	PF00069	0.635
MOD_NEK2_2	363	368	PF00069	0.363
MOD_PIKK_1	135	141	PF00454	0.505
MOD_PIKK_1	261	267	PF00454	0.423
MOD_PIKK_1	283	289	PF00454	0.401
MOD_PIKK_1	294	300	PF00454	0.604
MOD_PIKK_1	433	439	PF00454	0.429
MOD_PKA_2	273	279	PF00069	0.425
MOD_PKA_2	291	297	PF00069	0.588
MOD_PKA_2	406	412	PF00069	0.613
MOD_PKA_2	462	468	PF00069	0.709
MOD_PKA_2	530	536	PF00069	0.673
MOD_PKA_2	581	587	PF00069	0.683
MOD_Plk_1	340	346	PF00069	0.473
MOD_Plk_1	520	526	PF00069	0.549
MOD_Plk_1	548	554	PF00069	0.570
MOD_Plk_4	178	184	PF00069	0.489
MOD_Plk_4	363	369	PF00069	0.490
MOD_Plk_4	530	536	PF00069	0.599
MOD_Plk_4	553	559	PF00069	0.603
MOD_ProDKin_1	109	115	PF00069	0.588
MOD_ProDKin_1	232	238	PF00069	0.573
MOD_ProDKin_1	348	354	PF00069	0.565
MOD_ProDKin_1	38	44	PF00069	0.671
MOD_SUMO_for_1	76	79	PF00179	0.583
TRG_DiLeu_BaLyEn_6	264	269	PF01217	0.439
TRG_DiLeu_BaLyEn_6	83	88	PF01217	0.640
TRG_ENDOCYTIC_2	107	110	PF00928	0.525
TRG_ENDOCYTIC_2	405	408	PF00928	0.545
TRG_ENDOCYTIC_2	75	78	PF00928	0.611
TRG_ER_diArg_1	390	393	PF00400	0.595
TRG_ER_diArg_1	479	482	PF00400	0.604
TRG_Pf-PMV_PEXEL_1	483	487	PF00026	0.603
TRG_Pf-PMV_PEXEL_1	545	549	PF00026	0.620
TRG_Pf-PMV_PEXEL_1	74	79	PF00026	0.590

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDF5	Leptomonas seymouri	33%	100%
A0A3S7WPN2	Leishmania donovani	90%	100%
A4H4T3	Leishmania braziliensis	66%	100%
A4HT12	Leishmania infantum	90%	100%
E9AL00	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%