Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QIV4_LEIMA

TriTrypDb:

LmjF.06.1220 , LMJLV39_060018900 , LMJSD75_060019000

Length:

790

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QIV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIV4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.409
CLV_NRD_NRD_1	306	308	PF00675	0.575
CLV_NRD_NRD_1	380	382	PF00675	0.599
CLV_NRD_NRD_1	43	45	PF00675	0.568
CLV_NRD_NRD_1	442	444	PF00675	0.618
CLV_NRD_NRD_1	509	511	PF00675	0.552
CLV_NRD_NRD_1	556	558	PF00675	0.585
CLV_NRD_NRD_1	601	603	PF00675	0.588
CLV_NRD_NRD_1	644	646	PF00675	0.674
CLV_NRD_NRD_1	668	670	PF00675	0.548
CLV_NRD_NRD_1	737	739	PF00675	0.548
CLV_NRD_NRD_1	750	752	PF00675	0.545
CLV_PCSK_KEX2_1	43	45	PF00082	0.568
CLV_PCSK_KEX2_1	442	444	PF00082	0.618
CLV_PCSK_KEX2_1	509	511	PF00082	0.552
CLV_PCSK_KEX2_1	556	558	PF00082	0.585
CLV_PCSK_KEX2_1	601	603	PF00082	0.588
CLV_PCSK_KEX2_1	643	645	PF00082	0.668
CLV_PCSK_KEX2_1	668	670	PF00082	0.551
CLV_PCSK_KEX2_1	750	752	PF00082	0.635
CLV_PCSK_KEX2_1	92	94	PF00082	0.537
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.537
CLV_PCSK_SKI1_1	164	168	PF00082	0.476
CLV_PCSK_SKI1_1	2	6	PF00082	0.594
CLV_PCSK_SKI1_1	35	39	PF00082	0.507
CLV_PCSK_SKI1_1	365	369	PF00082	0.534
CLV_PCSK_SKI1_1	393	397	PF00082	0.656
CLV_PCSK_SKI1_1	475	479	PF00082	0.566
CLV_PCSK_SKI1_1	492	496	PF00082	0.532
CLV_PCSK_SKI1_1	591	595	PF00082	0.608
CLV_PCSK_SKI1_1	601	605	PF00082	0.616
CLV_PCSK_SKI1_1	644	648	PF00082	0.575
CLV_PCSK_SKI1_1	66	70	PF00082	0.508
CLV_PCSK_SKI1_1	777	781	PF00082	0.611
CLV_PCSK_SKI1_1	785	789	PF00082	0.530
DEG_APCC_DBOX_1	324	332	PF00400	0.558
DEG_APCC_DBOX_1	364	372	PF00400	0.697
DEG_Nend_UBRbox_1	1	4	PF02207	0.584
DEG_SPOP_SBC_1	567	571	PF00917	0.679
DEG_SPOP_SBC_1	593	597	PF00917	0.511
DEG_SPOP_SBC_1	681	685	PF00917	0.502
DOC_ANK_TNKS_1	495	502	PF00023	0.567
DOC_CKS1_1	196	201	PF01111	0.514
DOC_CKS1_1	603	608	PF01111	0.577
DOC_CYCLIN_RxL_1	362	369	PF00134	0.529
DOC_CYCLIN_yCln2_LP_2	534	540	PF00134	0.516
DOC_MAPK_DCC_7	532	540	PF00069	0.525
DOC_MAPK_DCC_7	777	786	PF00069	0.591
DOC_MAPK_gen_1	279	286	PF00069	0.601
DOC_MAPK_gen_1	601	609	PF00069	0.597
DOC_MAPK_gen_1	735	743	PF00069	0.561
DOC_MAPK_gen_1	775	784	PF00069	0.569
DOC_MAPK_MEF2A_6	236	245	PF00069	0.417
DOC_MAPK_MEF2A_6	256	264	PF00069	0.378
DOC_MAPK_MEF2A_6	532	540	PF00069	0.522
DOC_MAPK_MEF2A_6	777	786	PF00069	0.559
DOC_MAPK_RevD_3	429	443	PF00069	0.571
DOC_PP1_RVXF_1	783	789	PF00149	0.564
DOC_PP2B_LxvP_1	534	537	PF13499	0.549
DOC_PP4_FxxP_1	533	536	PF00568	0.642
DOC_USP7_MATH_1	146	150	PF00917	0.637
DOC_USP7_MATH_1	191	195	PF00917	0.483
DOC_USP7_MATH_1	222	226	PF00917	0.418
DOC_USP7_MATH_1	435	439	PF00917	0.558
DOC_USP7_MATH_1	477	481	PF00917	0.620
DOC_USP7_MATH_1	500	504	PF00917	0.616
DOC_USP7_MATH_1	593	597	PF00917	0.556
DOC_USP7_MATH_1	68	72	PF00917	0.438
DOC_USP7_MATH_1	681	685	PF00917	0.614
DOC_USP7_UBL2_3	735	739	PF12436	0.579
DOC_WW_Pin1_4	101	106	PF00397	0.575
DOC_WW_Pin1_4	114	119	PF00397	0.598
DOC_WW_Pin1_4	132	137	PF00397	0.633
DOC_WW_Pin1_4	17	22	PF00397	0.586
DOC_WW_Pin1_4	195	200	PF00397	0.537
DOC_WW_Pin1_4	296	301	PF00397	0.650
DOC_WW_Pin1_4	408	413	PF00397	0.683
DOC_WW_Pin1_4	425	430	PF00397	0.538
DOC_WW_Pin1_4	563	568	PF00397	0.721
DOC_WW_Pin1_4	585	590	PF00397	0.593
DOC_WW_Pin1_4	602	607	PF00397	0.472
DOC_WW_Pin1_4	611	616	PF00397	0.602
DOC_WW_Pin1_4	655	660	PF00397	0.612
DOC_WW_Pin1_4	688	693	PF00397	0.587
DOC_WW_Pin1_4	770	775	PF00397	0.606
LIG_14-3-3_CanoR_1	10	19	PF00244	0.648
LIG_14-3-3_CanoR_1	208	217	PF00244	0.413
LIG_14-3-3_CanoR_1	325	329	PF00244	0.539
LIG_14-3-3_CanoR_1	387	397	PF00244	0.590
LIG_14-3-3_CanoR_1	43	51	PF00244	0.547
LIG_14-3-3_CanoR_1	442	450	PF00244	0.556
LIG_14-3-3_CanoR_1	456	464	PF00244	0.536
LIG_14-3-3_CanoR_1	556	561	PF00244	0.598
LIG_14-3-3_CanoR_1	577	586	PF00244	0.651
LIG_14-3-3_CanoR_1	591	599	PF00244	0.641
LIG_14-3-3_CanoR_1	601	606	PF00244	0.591
LIG_14-3-3_CanoR_1	623	631	PF00244	0.650
LIG_14-3-3_CanoR_1	662	670	PF00244	0.678
LIG_14-3-3_CanoR_1	680	690	PF00244	0.550
LIG_14-3-3_CanoR_1	738	744	PF00244	0.563
LIG_14-3-3_CanoR_1	750	755	PF00244	0.497
LIG_AP2alpha_2	341	343	PF02296	0.603
LIG_AP2alpha_2	354	356	PF02296	0.484
LIG_APCC_ABBA_1	179	184	PF00400	0.477
LIG_BRCT_BRCA1_1	123	127	PF00533	0.537
LIG_BRCT_BRCA1_1	447	451	PF00533	0.599
LIG_BRCT_BRCA1_1	595	599	PF00533	0.591
LIG_BRCT_BRCA1_1	86	90	PF00533	0.492
LIG_BRCT_BRCA1_2	86	92	PF00533	0.492
LIG_Clathr_ClatBox_1	180	184	PF01394	0.432
LIG_CSL_BTD_1	754	757	PF09270	0.515
LIG_DLG_GKlike_1	556	564	PF00625	0.570
LIG_FHA_1	175	181	PF00498	0.381
LIG_FHA_1	20	26	PF00498	0.635
LIG_FHA_1	598	604	PF00498	0.630
LIG_FHA_1	649	655	PF00498	0.545
LIG_FHA_1	673	679	PF00498	0.523
LIG_FHA_1	694	700	PF00498	0.531
LIG_FHA_1	738	744	PF00498	0.497
LIG_FHA_2	151	157	PF00498	0.511
LIG_FHA_2	18	24	PF00498	0.663
LIG_FHA_2	184	190	PF00498	0.488
LIG_FHA_2	210	216	PF00498	0.497
LIG_FHA_2	349	355	PF00498	0.594
LIG_FHA_2	4	10	PF00498	0.649
LIG_FHA_2	637	643	PF00498	0.568
LIG_GBD_Chelix_1	159	167	PF00786	0.452
LIG_LIR_Gen_1	153	163	PF02991	0.411
LIG_LIR_Gen_1	311	318	PF02991	0.536
LIG_LIR_Nem_3	153	158	PF02991	0.428
LIG_LIR_Nem_3	311	317	PF02991	0.514
LIG_LIR_Nem_3	448	454	PF02991	0.592
LIG_LIR_Nem_3	700	706	PF02991	0.536
LIG_LYPXL_S_1	702	706	PF13949	0.527
LIG_LYPXL_yS_3	703	706	PF13949	0.527
LIG_MLH1_MIPbox_1	595	599	PF16413	0.591
LIG_NRBOX	162	168	PF00104	0.465
LIG_REV1ctd_RIR_1	596	605	PF16727	0.545
LIG_REV1ctd_RIR_1	606	614	PF16727	0.586
LIG_RPA_C_Fungi	382	394	PF08784	0.520
LIG_RPA_C_Fungi	740	752	PF08784	0.472
LIG_SH2_CRK	155	159	PF00017	0.460
LIG_SH2_STAP1	155	159	PF00017	0.396
LIG_SH2_STAT3	50	53	PF00017	0.488
LIG_SH2_STAT5	333	336	PF00017	0.594
LIG_SH2_STAT5	433	436	PF00017	0.656
LIG_SH2_STAT5	50	53	PF00017	0.532
LIG_SH3_1	76	82	PF00018	0.572
LIG_SH3_1	775	781	PF00018	0.578
LIG_SH3_2	409	414	PF14604	0.661
LIG_SH3_2	586	591	PF14604	0.536
LIG_SH3_3	110	116	PF00018	0.669
LIG_SH3_3	193	199	PF00018	0.553
LIG_SH3_3	232	238	PF00018	0.469
LIG_SH3_3	372	378	PF00018	0.503
LIG_SH3_3	392	398	PF00018	0.558
LIG_SH3_3	406	412	PF00018	0.535
LIG_SH3_3	426	432	PF00018	0.523
LIG_SH3_3	515	521	PF00018	0.668
LIG_SH3_3	583	589	PF00018	0.615
LIG_SH3_3	751	757	PF00018	0.558
LIG_SH3_3	76	82	PF00018	0.525
LIG_SH3_3	765	771	PF00018	0.532
LIG_SH3_3	775	781	PF00018	0.529
LIG_TRAF2_1	274	277	PF00917	0.563
LIG_TRAF2_2	615	620	PF00917	0.621
LIG_WRC_WIRS_1	85	90	PF05994	0.502
LIG_WW_3	439	443	PF00397	0.615
LIG_WW_3	529	533	PF00397	0.646
MOD_CDC14_SPxK_1	411	414	PF00782	0.663
MOD_CDC14_SPxK_1	588	591	PF00782	0.581
MOD_CDK_SPK_2	425	430	PF00069	0.593
MOD_CDK_SPK_2	770	775	PF00069	0.606
MOD_CDK_SPxK_1	408	414	PF00069	0.687
MOD_CDK_SPxK_1	585	591	PF00069	0.582
MOD_CDK_SPxxK_3	296	303	PF00069	0.588
MOD_CDK_SPxxK_3	655	662	PF00069	0.532
MOD_CDK_SPxxK_3	770	777	PF00069	0.601
MOD_CK1_1	121	127	PF00069	0.593
MOD_CK1_1	13	19	PF00069	0.794
MOD_CK1_1	135	141	PF00069	0.532
MOD_CK1_1	172	178	PF00069	0.395
MOD_CK1_1	324	330	PF00069	0.554
MOD_CK1_1	400	406	PF00069	0.573
MOD_CK1_1	548	554	PF00069	0.620
MOD_CK1_1	559	565	PF00069	0.590
MOD_CK1_1	626	632	PF00069	0.820
MOD_CK1_1	648	654	PF00069	0.626
MOD_CK1_1	685	691	PF00069	0.581
MOD_CK1_1	693	699	PF00069	0.554
MOD_CK2_1	148	154	PF00069	0.548
MOD_CK2_1	227	233	PF00069	0.507
MOD_CK2_1	3	9	PF00069	0.625
MOD_CK2_1	343	349	PF00069	0.621
MOD_CK2_1	476	482	PF00069	0.632
MOD_CK2_1	516	522	PF00069	0.657
MOD_CK2_1	636	642	PF00069	0.614
MOD_CK2_1	668	674	PF00069	0.542
MOD_CK2_1	725	731	PF00069	0.545
MOD_GlcNHglycan	150	153	PF01048	0.518
MOD_GlcNHglycan	167	170	PF01048	0.595
MOD_GlcNHglycan	203	206	PF01048	0.501
MOD_GlcNHglycan	229	232	PF01048	0.606
MOD_GlcNHglycan	270	273	PF01048	0.591
MOD_GlcNHglycan	399	402	PF01048	0.548
MOD_GlcNHglycan	459	462	PF01048	0.638
MOD_GlcNHglycan	46	49	PF01048	0.582
MOD_GlcNHglycan	479	482	PF01048	0.611
MOD_GlcNHglycan	561	564	PF01048	0.592
MOD_GlcNHglycan	625	628	PF01048	0.599
MOD_GlcNHglycan	647	650	PF01048	0.680
MOD_GlcNHglycan	670	673	PF01048	0.586
MOD_GlcNHglycan	70	73	PF01048	0.504
MOD_GSK3_1	10	17	PF00069	0.789
MOD_GSK3_1	114	121	PF00069	0.619
MOD_GSK3_1	131	138	PF00069	0.760
MOD_GSK3_1	146	153	PF00069	0.552
MOD_GSK3_1	165	172	PF00069	0.334
MOD_GSK3_1	191	198	PF00069	0.432
MOD_GSK3_1	223	230	PF00069	0.434
MOD_GSK3_1	246	253	PF00069	0.650
MOD_GSK3_1	31	38	PF00069	0.537
MOD_GSK3_1	313	320	PF00069	0.518
MOD_GSK3_1	397	404	PF00069	0.610
MOD_GSK3_1	441	448	PF00069	0.524
MOD_GSK3_1	545	552	PF00069	0.725
MOD_GSK3_1	555	562	PF00069	0.575
MOD_GSK3_1	563	570	PF00069	0.612
MOD_GSK3_1	580	587	PF00069	0.670
MOD_GSK3_1	593	600	PF00069	0.535
MOD_GSK3_1	668	675	PF00069	0.685
MOD_GSK3_1	681	688	PF00069	0.508
MOD_GSK3_1	755	762	PF00069	0.602
MOD_LATS_1	301	307	PF00433	0.569
MOD_N-GLC_1	11	16	PF02516	0.636
MOD_N-GLC_1	44	49	PF02516	0.606
MOD_N-GLC_1	636	641	PF02516	0.552
MOD_NEK2_1	119	124	PF00069	0.611
MOD_NEK2_1	131	136	PF00069	0.539
MOD_NEK2_1	227	232	PF00069	0.492
MOD_NEK2_1	246	251	PF00069	0.338
MOD_NEK2_1	3	8	PF00069	0.605
MOD_NEK2_1	317	322	PF00069	0.581
MOD_NEK2_1	343	348	PF00069	0.623
MOD_NEK2_1	592	597	PF00069	0.537
MOD_NEK2_1	725	730	PF00069	0.609
MOD_NEK2_2	223	228	PF00069	0.468
MOD_NEK2_2	572	577	PF00069	0.634
MOD_PIKK_1	441	447	PF00454	0.593
MOD_PIKK_1	59	65	PF00454	0.500
MOD_PIKK_1	682	688	PF00454	0.586
MOD_PIKK_1	759	765	PF00454	0.614
MOD_PK_1	739	745	PF00069	0.544
MOD_PK_1	750	756	PF00069	0.528
MOD_PKA_1	381	387	PF00069	0.600
MOD_PKA_1	556	562	PF00069	0.590
MOD_PKA_1	601	607	PF00069	0.592
MOD_PKA_1	668	674	PF00069	0.522
MOD_PKA_1	750	756	PF00069	0.587
MOD_PKA_2	141	147	PF00069	0.660
MOD_PKA_2	324	330	PF00069	0.554
MOD_PKA_2	388	394	PF00069	0.591
MOD_PKA_2	415	421	PF00069	0.674
MOD_PKA_2	435	441	PF00069	0.490
MOD_PKA_2	548	554	PF00069	0.642
MOD_PKA_2	555	561	PF00069	0.579
MOD_PKA_2	578	584	PF00069	0.623
MOD_PKA_2	601	607	PF00069	0.573
MOD_PKA_2	668	674	PF00069	0.522
MOD_PKA_2	737	743	PF00069	0.565
MOD_PKA_2	750	756	PF00069	0.494
MOD_PKA_2	94	100	PF00069	0.598
MOD_PKB_1	643	651	PF00069	0.614
MOD_Plk_1	170	176	PF00069	0.348
MOD_Plk_1	223	229	PF00069	0.477
MOD_Plk_1	445	451	PF00069	0.623
MOD_Plk_2-3	150	156	PF00069	0.406
MOD_Plk_4	154	160	PF00069	0.444
MOD_Plk_4	3	9	PF00069	0.542
MOD_Plk_4	313	319	PF00069	0.544
MOD_Plk_4	324	330	PF00069	0.475
MOD_Plk_4	357	363	PF00069	0.553
MOD_Plk_4	445	451	PF00069	0.649
MOD_Plk_4	46	52	PF00069	0.488
MOD_Plk_4	580	586	PF00069	0.640
MOD_Plk_4	594	600	PF00069	0.513
MOD_Plk_4	750	756	PF00069	0.587
MOD_Plk_4	84	90	PF00069	0.548
MOD_ProDKin_1	101	107	PF00069	0.573
MOD_ProDKin_1	114	120	PF00069	0.598
MOD_ProDKin_1	132	138	PF00069	0.635
MOD_ProDKin_1	17	23	PF00069	0.580
MOD_ProDKin_1	195	201	PF00069	0.542
MOD_ProDKin_1	296	302	PF00069	0.650
MOD_ProDKin_1	408	414	PF00069	0.687
MOD_ProDKin_1	425	431	PF00069	0.536
MOD_ProDKin_1	563	569	PF00069	0.720
MOD_ProDKin_1	585	591	PF00069	0.595
MOD_ProDKin_1	602	608	PF00069	0.475
MOD_ProDKin_1	611	617	PF00069	0.605
MOD_ProDKin_1	655	661	PF00069	0.614
MOD_ProDKin_1	688	694	PF00069	0.584
MOD_ProDKin_1	770	776	PF00069	0.605
TRG_DiLeu_BaEn_1	154	159	PF01217	0.422
TRG_DiLeu_BaEn_1	715	720	PF01217	0.584
TRG_DiLeu_BaLyEn_6	115	120	PF01217	0.656
TRG_ENDOCYTIC_2	155	158	PF00928	0.401
TRG_ENDOCYTIC_2	703	706	PF00928	0.527
TRG_ER_diArg_1	278	281	PF00400	0.607
TRG_ER_diArg_1	362	365	PF00400	0.489
TRG_ER_diArg_1	421	424	PF00400	0.637
TRG_ER_diArg_1	441	443	PF00400	0.628
TRG_ER_diArg_1	508	510	PF00400	0.566
TRG_ER_diArg_1	576	579	PF00400	0.700
TRG_ER_diArg_1	601	603	PF00400	0.588
TRG_ER_diArg_1	643	645	PF00400	0.639
TRG_ER_diArg_1	668	670	PF00400	0.556
TRG_ER_diArg_1	749	751	PF00400	0.625
TRG_ER_diArg_1	93	96	PF00400	0.569
TRG_NES_CRM1_1	700	715	PF08389	0.585
TRG_NLS_MonoExtC_3	91	96	PF00514	0.455
TRG_Pf-PMV_PEXEL_1	289	294	PF00026	0.616
TRG_Pf-PMV_PEXEL_1	365	369	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWN9	Leptomonas seymouri	34%	100%
A0A3S7WPP9	Leishmania donovani	85%	100%
A4H4T4	Leishmania braziliensis	58%	100%
A4HT13	Leishmania infantum	84%	100%
E9AL01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%