Cysteine dioxygenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1637), putative

Species:

Leishmania major

UniProt:

Q4QIV3_LEIMA

TriTrypDb:

LmjF.06.1230 , LMJLV39_060019000 , LMJSD75_060019100

Length:

293

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QIV3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIV3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	11
GO:0016491	oxidoreductase activity	2	12
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	3	12
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	4	12
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0051213	dioxygenase activity	3	12
GO:0047800	cysteamine dioxygenase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.484
CLV_C14_Caspase3-7	56	60	PF00656	0.562
CLV_NRD_NRD_1	6	8	PF00675	0.564
CLV_PCSK_FUR_1	21	25	PF00082	0.475
CLV_PCSK_KEX2_1	23	25	PF00082	0.441
CLV_PCSK_KEX2_1	6	8	PF00082	0.594
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.557
CLV_PCSK_PC7_1	19	25	PF00082	0.493
DEG_APCC_DBOX_1	148	156	PF00400	0.525
DEG_Nend_UBRbox_1	1	4	PF02207	0.649
DOC_CYCLIN_RxL_1	126	135	PF00134	0.581
DOC_CYCLIN_yCln2_LP_2	253	259	PF00134	0.498
DOC_PP4_FxxP_1	123	126	PF00568	0.487
DOC_USP7_MATH_1	233	237	PF00917	0.513
DOC_USP7_MATH_1	98	102	PF00917	0.550
DOC_USP7_UBL2_3	268	272	PF12436	0.581
DOC_WW_Pin1_4	10	15	PF00397	0.658
DOC_WW_Pin1_4	195	200	PF00397	0.584
DOC_WW_Pin1_4	224	229	PF00397	0.481
DOC_WW_Pin1_4	92	97	PF00397	0.556
LIG_14-3-3_CanoR_1	24	30	PF00244	0.378
LIG_14-3-3_CanoR_1	6	15	PF00244	0.617
LIG_14-3-3_CanoR_1	86	96	PF00244	0.557
LIG_BIR_III_2	187	191	PF00653	0.525
LIG_FHA_1	167	173	PF00498	0.557
LIG_FHA_1	248	254	PF00498	0.582
LIG_FHA_1	89	95	PF00498	0.576
LIG_FHA_2	196	202	PF00498	0.529
LIG_FHA_2	33	39	PF00498	0.566
LIG_FHA_2	45	51	PF00498	0.487
LIG_LIR_Apic_2	279	284	PF02991	0.495
LIG_LIR_Gen_1	41	51	PF02991	0.449
LIG_LIR_Nem_3	119	125	PF02991	0.539
LIG_LIR_Nem_3	41	46	PF02991	0.382
LIG_LIR_Nem_3	50	54	PF02991	0.538
LIG_MAD2	129	137	PF02301	0.442
LIG_RPA_C_Fungi	81	93	PF08784	0.242
LIG_SH2_CRK	281	285	PF00017	0.372
LIG_SH2_NCK_1	230	234	PF00017	0.385
LIG_SH2_NCK_1	69	73	PF00017	0.242
LIG_SH2_STAT5	242	245	PF00017	0.407
LIG_SH2_STAT5	54	57	PF00017	0.363
LIG_SH2_STAT5	63	66	PF00017	0.363
LIG_SH3_3	121	127	PF00018	0.378
LIG_TRFH_1	123	127	PF08558	0.437
MOD_CK1_1	10	16	PF00069	0.705
MOD_CK1_1	103	109	PF00069	0.441
MOD_CK1_1	161	167	PF00069	0.342
MOD_CK1_1	33	39	PF00069	0.501
MOD_CK1_1	44	50	PF00069	0.406
MOD_CK1_1	88	94	PF00069	0.445
MOD_CK2_1	32	38	PF00069	0.570
MOD_CK2_1	67	73	PF00069	0.412
MOD_Cter_Amidation	4	7	PF01082	0.521
MOD_GlcNHglycan	281	284	PF01048	0.475
MOD_GlcNHglycan	3	6	PF01048	0.598
MOD_GlcNHglycan	87	90	PF01048	0.447
MOD_GlcNHglycan	9	12	PF01048	0.746
MOD_GSK3_1	10	17	PF00069	0.720
MOD_GSK3_1	158	165	PF00069	0.440
MOD_GSK3_1	30	37	PF00069	0.411
MOD_GSK3_1	88	95	PF00069	0.396
MOD_GSK3_1	99	106	PF00069	0.374
MOD_N-GLC_1	103	108	PF02516	0.393
MOD_N-GLC_1	172	177	PF02516	0.466
MOD_N-GLC_1	247	252	PF02516	0.402
MOD_N-GLC_1	279	284	PF02516	0.475
MOD_NEK2_1	1	6	PF00069	0.568
MOD_NEK2_1	247	252	PF00069	0.415
MOD_NEK2_1	25	30	PF00069	0.480
MOD_NEK2_1	32	37	PF00069	0.508
MOD_NEK2_1	87	92	PF00069	0.416
MOD_NEK2_2	108	113	PF00069	0.344
MOD_NEK2_2	14	19	PF00069	0.570
MOD_OFUCOSY	12	18	PF10250	0.479
MOD_PIKK_1	158	164	PF00454	0.387
MOD_PIKK_1	214	220	PF00454	0.452
MOD_PKA_2	85	91	PF00069	0.475
MOD_PKB_1	274	282	PF00069	0.242
MOD_Plk_1	103	109	PF00069	0.351
MOD_Plk_2-3	67	73	PF00069	0.441
MOD_Plk_4	108	114	PF00069	0.336
MOD_Plk_4	137	143	PF00069	0.348
MOD_Plk_4	172	178	PF00069	0.406
MOD_Plk_4	233	239	PF00069	0.317
MOD_Plk_4	249	255	PF00069	0.432
MOD_ProDKin_1	10	16	PF00069	0.656
MOD_ProDKin_1	195	201	PF00069	0.480
MOD_ProDKin_1	224	230	PF00069	0.335
MOD_ProDKin_1	92	98	PF00069	0.441
TRG_DiLeu_BaLyEn_6	21	26	PF01217	0.434
TRG_ER_diArg_1	19	22	PF00400	0.415
TRG_ER_diArg_1	273	276	PF00400	0.393
TRG_ER_diArg_1	6	9	PF00400	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3C5	Leptomonas seymouri	54%	100%
A0A0S4IQ52	Bodo saltans	27%	100%
A0A1X0NH28	Trypanosomatidae	37%	100%
A0A3S5H5U9	Leishmania donovani	92%	100%
A0A422NM88	Trypanosoma rangeli	30%	100%
A4H4T5	Leishmania braziliensis	78%	100%
A4HT14	Leishmania infantum	93%	100%
C9ZTQ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AL02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BT74	Trypanosoma cruzi	38%	100%