FAD_binding_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FAD binding domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QIV2_LEIMA

TriTrypDb:

LmjF.06.1240 , LMJLV39_060019100 , LMJSD75_060019200

Length:

494

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QIV2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIV2

Function

Biological processes
Term	Name	Level	Count
GO:0006743	ubiquinone metabolic process	5	2
GO:0006744	ubiquinone biosynthetic process	6	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009987	cellular process	1	2
GO:0042180	cellular ketone metabolic process	3	2
GO:0042181	ketone biosynthetic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0044283	small molecule biosynthetic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901576	organic substance biosynthetic process	3	2
GO:1901661	quinone metabolic process	4	2
GO:1901663	quinone biosynthetic process	5	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	9
GO:0004497	monooxygenase activity	3	9
GO:0005488	binding	1	11
GO:0016491	oxidoreductase activity	2	9
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	5
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	4	5
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0050660	flavin adenine dinucleotide binding	4	11
GO:0071949	FAD binding	5	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	344	348	PF00656	0.456
CLV_NRD_NRD_1	153	155	PF00675	0.556
CLV_NRD_NRD_1	3	5	PF00675	0.665
CLV_NRD_NRD_1	324	326	PF00675	0.384
CLV_PCSK_KEX2_1	3	5	PF00082	0.665
CLV_PCSK_KEX2_1	324	326	PF00082	0.331
CLV_PCSK_KEX2_1	67	69	PF00082	0.512
CLV_PCSK_PC1ET2_1	67	69	PF00082	0.499
CLV_PCSK_SKI1_1	242	246	PF00082	0.331
CLV_PCSK_SKI1_1	308	312	PF00082	0.423
CLV_PCSK_SKI1_1	371	375	PF00082	0.311
CLV_PCSK_SKI1_1	443	447	PF00082	0.547
CLV_PCSK_SKI1_1	59	63	PF00082	0.366
DEG_APCC_DBOX_1	2	10	PF00400	0.638
DEG_Nend_Nbox_1	1	3	PF02207	0.611
DEG_SCF_FBW7_1	83	90	PF00400	0.360
DEG_SPOP_SBC_1	299	303	PF00917	0.384
DEG_SPOP_SBC_1	341	345	PF00917	0.456
DOC_CKS1_1	245	250	PF01111	0.423
DOC_CYCLIN_RxL_1	305	314	PF00134	0.423
DOC_CYCLIN_yCln2_LP_2	153	159	PF00134	0.394
DOC_MAPK_gen_1	154	162	PF00069	0.512
DOC_MAPK_HePTP_8	138	150	PF00069	0.544
DOC_MAPK_MEF2A_6	141	150	PF00069	0.587
DOC_PP1_RVXF_1	153	160	PF00149	0.405
DOC_USP7_MATH_1	353	357	PF00917	0.381
DOC_USP7_MATH_1	399	403	PF00917	0.360
DOC_USP7_MATH_1	407	411	PF00917	0.295
DOC_USP7_MATH_1	459	463	PF00917	0.522
DOC_USP7_MATH_1	464	468	PF00917	0.502
DOC_USP7_MATH_1	87	91	PF00917	0.377
DOC_WW_Pin1_4	117	122	PF00397	0.455
DOC_WW_Pin1_4	244	249	PF00397	0.439
DOC_WW_Pin1_4	342	347	PF00397	0.378
DOC_WW_Pin1_4	446	451	PF00397	0.585
DOC_WW_Pin1_4	83	88	PF00397	0.364
DOC_WW_Pin1_4	9	14	PF00397	0.630
LIG_14-3-3_CanoR_1	128	133	PF00244	0.565
LIG_14-3-3_CanoR_1	141	148	PF00244	0.491
LIG_14-3-3_CanoR_1	237	242	PF00244	0.460
LIG_14-3-3_CanoR_1	3	7	PF00244	0.614
LIG_14-3-3_CanoR_1	324	330	PF00244	0.433
LIG_14-3-3_CanoR_1	458	464	PF00244	0.488
LIG_14-3-3_CanoR_1	46	53	PF00244	0.570
LIG_BRCT_BRCA1_1	128	132	PF00533	0.564
LIG_BRCT_BRCA1_1	296	300	PF00533	0.222
LIG_Clathr_ClatBox_1	60	64	PF01394	0.397
LIG_FHA_1	133	139	PF00498	0.626
LIG_FHA_1	245	251	PF00498	0.352
LIG_FHA_1	255	261	PF00498	0.282
LIG_FHA_1	293	299	PF00498	0.308
LIG_FHA_1	399	405	PF00498	0.384
LIG_FHA_1	430	436	PF00498	0.530
LIG_FHA_1	447	453	PF00498	0.454
LIG_FHA_1	80	86	PF00498	0.379
LIG_FHA_2	140	146	PF00498	0.588
LIG_FHA_2	289	295	PF00498	0.342
LIG_FHA_2	312	318	PF00498	0.406
LIG_FHA_2	342	348	PF00498	0.339
LIG_FHA_2	435	441	PF00498	0.421
LIG_GBD_Chelix_1	318	326	PF00786	0.301
LIG_GBD_Chelix_1	53	61	PF00786	0.449
LIG_LIR_Gen_1	149	157	PF02991	0.412
LIG_LIR_Gen_1	275	280	PF02991	0.369
LIG_LIR_Nem_3	149	153	PF02991	0.441
LIG_LIR_Nem_3	225	231	PF02991	0.357
LIG_LIR_Nem_3	275	279	PF02991	0.339
LIG_MLH1_MIPbox_1	129	133	PF16413	0.660
LIG_PCNA_yPIPBox_3	167	179	PF02747	0.333
LIG_Pex14_2	276	280	PF04695	0.311
LIG_REV1ctd_RIR_1	277	285	PF16727	0.423
LIG_SH2_NCK_1	71	75	PF00017	0.540
LIG_SH2_STAP1	254	258	PF00017	0.331
LIG_SH2_STAP1	395	399	PF00017	0.311
LIG_SH3_3	197	203	PF00018	0.453
LIG_SH3_3	364	370	PF00018	0.319
LIG_SUMO_SIM_par_1	81	86	PF11976	0.354
LIG_TRAF2_1	203	206	PF00917	0.604
LIG_UBA3_1	435	444	PF00899	0.509
LIG_WRC_WIRS_1	273	278	PF05994	0.410
LIG_WRC_WIRS_1	326	331	PF05994	0.378
MOD_CDK_SPxxK_3	342	349	PF00069	0.378
MOD_CK1_1	204	210	PF00069	0.567
MOD_CK1_1	211	217	PF00069	0.494
MOD_CK1_1	246	252	PF00069	0.369
MOD_CK1_1	292	298	PF00069	0.284
MOD_CK2_1	139	145	PF00069	0.615
MOD_CK2_1	310	316	PF00069	0.404
MOD_CK2_1	399	405	PF00069	0.423
MOD_CK2_1	434	440	PF00069	0.415
MOD_Cter_Amidation	65	68	PF01082	0.554
MOD_GlcNHglycan	213	216	PF01048	0.470
MOD_GlcNHglycan	218	221	PF01048	0.445
MOD_GlcNHglycan	23	26	PF01048	0.379
MOD_GlcNHglycan	409	412	PF01048	0.427
MOD_GlcNHglycan	461	464	PF01048	0.569
MOD_GlcNHglycan	47	50	PF01048	0.613
MOD_GlcNHglycan	478	481	PF01048	0.358
MOD_GlcNHglycan	64	67	PF01048	0.548
MOD_GSK3_1	128	135	PF00069	0.582
MOD_GSK3_1	204	211	PF00069	0.544
MOD_GSK3_1	216	223	PF00069	0.493
MOD_GSK3_1	288	295	PF00069	0.303
MOD_GSK3_1	79	86	PF00069	0.392
MOD_N-GLC_1	139	144	PF02516	0.617
MOD_N-GLC_2	167	169	PF02516	0.446
MOD_N-GLC_2	272	274	PF02516	0.311
MOD_NEK2_1	132	137	PF00069	0.637
MOD_NEK2_1	2	7	PF00069	0.626
MOD_NEK2_1	208	213	PF00069	0.535
MOD_NEK2_1	259	264	PF00069	0.370
MOD_NEK2_1	300	305	PF00069	0.317
MOD_NEK2_1	310	315	PF00069	0.312
MOD_NEK2_1	33	38	PF00069	0.394
MOD_NEK2_1	429	434	PF00069	0.379
MOD_NEK2_1	44	49	PF00069	0.435
MOD_NEK2_1	465	470	PF00069	0.528
MOD_NEK2_1	475	480	PF00069	0.415
MOD_NEK2_1	52	57	PF00069	0.526
MOD_NEK2_1	62	67	PF00069	0.425
MOD_NEK2_1	76	81	PF00069	0.485
MOD_PIKK_1	201	207	PF00454	0.553
MOD_PIKK_1	300	306	PF00454	0.376
MOD_PK_1	81	87	PF00069	0.478
MOD_PKA_1	324	330	PF00069	0.222
MOD_PKA_1	443	449	PF00069	0.567
MOD_PKA_2	127	133	PF00069	0.658
MOD_PKA_2	140	146	PF00069	0.607
MOD_PKA_2	2	8	PF00069	0.618
MOD_PKA_2	236	242	PF00069	0.460
MOD_PKA_2	324	330	PF00069	0.377
MOD_PKA_2	45	51	PF00069	0.502
MOD_Plk_4	128	134	PF00069	0.551
MOD_Plk_4	294	300	PF00069	0.329
MOD_Plk_4	399	405	PF00069	0.410
MOD_ProDKin_1	117	123	PF00069	0.463
MOD_ProDKin_1	244	250	PF00069	0.439
MOD_ProDKin_1	342	348	PF00069	0.378
MOD_ProDKin_1	446	452	PF00069	0.590
MOD_ProDKin_1	83	89	PF00069	0.361
MOD_ProDKin_1	9	15	PF00069	0.617
TRG_DiLeu_BaLyEn_6	143	148	PF01217	0.480
TRG_DiLeu_BaLyEn_6	48	53	PF01217	0.382
TRG_ENDOCYTIC_2	108	111	PF00928	0.379
TRG_ER_diArg_1	2	4	PF00400	0.627
TRG_ER_diArg_1	324	326	PF00400	0.384
TRG_ER_diArg_1	335	338	PF00400	0.384
TRG_Pf-PMV_PEXEL_1	179	183	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4M2	Leptomonas seymouri	74%	97%
A0A1X0NI75	Trypanosomatidae	57%	96%
A0A3R7KEW4	Trypanosoma rangeli	56%	99%
A0A3S7WPP5	Leishmania donovani	96%	100%
A1KVW0	Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18)	25%	100%
A4H4T6	Leishmania braziliensis	82%	98%
A4HT15	Leishmania infantum	96%	100%
C9ZTQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	96%
E9AL03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
F1RAX8	Danio rerio	28%	100%
O01884	Caenorhabditis elegans	27%	100%
P25535	Escherichia coli (strain K12)	28%	100%
P75728	Escherichia coli (strain K12)	24%	100%
Q2KIL4	Bos taurus	25%	100%
Q68FU7	Rattus norvegicus	27%	100%
Q6DF46	Xenopus tropicalis	29%	100%
Q8R1S0	Mus musculus	27%	100%
Q9Y2Z9	Homo sapiens	25%	100%
V5B825	Trypanosoma cruzi	55%	99%