Transcription and mRNA export factor ENY2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Transcription factor e(y)2, putative

Species:

Leishmania major

UniProt:

Q4QIV1_LEIMA

TriTrypDb:

LmjF.06.1245 , LMJLV39_060019200 , LMJSD75_060019300

Length:

148

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 4
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0000123	histone acetyltransferase complex	4	6
GO:0000124	SAGA complex	4	6
GO:0005643	nuclear pore	3	6
GO:0031248	protein acetyltransferase complex	3	6
GO:0032991	protein-containing complex	1	6
GO:0070390	transcription export complex 2	3	5
GO:0070461	SAGA-type complex	5	6
GO:0071819	DUBm complex	3	5
GO:0140513	nuclear protein-containing complex	2	6
GO:0140535	intracellular protein-containing complex	2	6
GO:1902493	acetyltransferase complex	4	6
GO:1902494	catalytic complex	2	6
GO:1905368	peptidase complex	3	6
GO:1990234	transferase complex	3	6

Expansion

Sequence features

Q4QIV1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIV1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	5
GO:0006325	chromatin organization	4	5
GO:0006354	DNA-templated transcription elongation	6	5
GO:0006368	transcription elongation by RNA polymerase II	7	5
GO:0006405	RNA export from nucleus	5	6
GO:0006406	mRNA export from nucleus	6	6
GO:0006508	proteolysis	4	5
GO:0006725	cellular aromatic compound metabolic process	3	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0006810	transport	3	6
GO:0006913	nucleocytoplasmic transport	5	6
GO:0008104	protein localization	4	5
GO:0008152	metabolic process	1	5
GO:0009058	biosynthetic process	2	5
GO:0009059	macromolecule biosynthetic process	4	5
GO:0009987	cellular process	1	6
GO:0015031	protein transport	4	5
GO:0015931	nucleobase-containing compound transport	5	6
GO:0016043	cellular component organization	3	5
GO:0016070	RNA metabolic process	5	5
GO:0016570	histone modification	5	5
GO:0016578	histone deubiquitination	6	5
GO:0016579	protein deubiquitination	6	5
GO:0018130	heterocycle biosynthetic process	4	5
GO:0019438	aromatic compound biosynthetic process	4	5
GO:0019538	protein metabolic process	3	5
GO:0032774	RNA biosynthetic process	5	5
GO:0033036	macromolecule localization	2	5
GO:0034641	cellular nitrogen compound metabolic process	3	5
GO:0034654	nucleobase-containing compound biosynthetic process	4	5
GO:0036211	protein modification process	4	5
GO:0043170	macromolecule metabolic process	3	5
GO:0043412	macromolecule modification	4	5
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	5
GO:0044249	cellular biosynthetic process	3	5
GO:0044271	cellular nitrogen compound biosynthetic process	4	5
GO:0045184	establishment of protein localization	3	5
GO:0046483	heterocycle metabolic process	3	5
GO:0046907	intracellular transport	3	6
GO:0050657	nucleic acid transport	6	6
GO:0050658	RNA transport	4	6
GO:0051028	mRNA transport	5	6
GO:0051168	nuclear export	6	6
GO:0051169	nuclear transport	4	6
GO:0051179	localization	1	6
GO:0051234	establishment of localization	2	6
GO:0051236	establishment of RNA localization	3	6
GO:0051641	cellular localization	2	6
GO:0051649	establishment of localization in cell	3	6
GO:0070646	protein modification by small protein removal	5	5
GO:0070647	protein modification by small protein conjugation or removal	5	5
GO:0070727	cellular macromolecule localization	3	5
GO:0071702	organic substance transport	4	6
GO:0071704	organic substance metabolic process	2	5
GO:0071705	nitrogen compound transport	4	6
GO:0071840	cellular component organization or biogenesis	2	5
GO:0090304	nucleic acid metabolic process	4	5
GO:1901360	organic cyclic compound metabolic process	3	5
GO:1901362	organic cyclic compound biosynthetic process	4	5
GO:1901564	organonitrogen compound metabolic process	3	5
GO:1901576	organic substance biosynthetic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0003712	transcription coregulator activity	2	6
GO:0003713	transcription coactivator activity	3	6
GO:0140110	transcription regulator activity	1	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	105	107	PF00675	0.259
CLV_NRD_NRD_1	140	142	PF00675	0.296
CLV_NRD_NRD_1	92	94	PF00675	0.296
CLV_PCSK_KEX2_1	105	107	PF00082	0.262
CLV_PCSK_KEX2_1	140	142	PF00082	0.296
CLV_PCSK_KEX2_1	92	94	PF00082	0.296
CLV_PCSK_SKI1_1	140	144	PF00082	0.313
DEG_Nend_Nbox_1	1	3	PF02207	0.443
DOC_WW_Pin1_4	28	33	PF00397	0.639
DOC_WW_Pin1_4	9	14	PF00397	0.437
LIG_14-3-3_CanoR_1	92	99	PF00244	0.582
LIG_FHA_1	141	147	PF00498	0.478
LIG_FHA_1	15	21	PF00498	0.421
LIG_FHA_2	39	45	PF00498	0.524
LIG_FHA_2	52	58	PF00498	0.527
LIG_LIR_Nem_3	136	142	PF02991	0.459
LIG_SH2_CRK	10	14	PF00017	0.440
LIG_SH2_STAP1	48	52	PF00017	0.504
LIG_SH2_STAT5	48	51	PF00017	0.521
LIG_TYR_ITIM	61	66	PF00017	0.480
MOD_CDK_SPxK_1	28	34	PF00069	0.485
MOD_CK1_1	84	90	PF00069	0.494
MOD_CK2_1	38	44	PF00069	0.650
MOD_CK2_1	51	57	PF00069	0.503
MOD_CK2_1	84	90	PF00069	0.424
MOD_GlcNHglycan	108	111	PF01048	0.269
MOD_GlcNHglycan	127	130	PF01048	0.403
MOD_GlcNHglycan	54	57	PF01048	0.463
MOD_GlcNHglycan	86	89	PF01048	0.264
MOD_GSK3_1	82	89	PF00069	0.594
MOD_NEK2_1	46	51	PF00069	0.500
MOD_NEK2_1	8	13	PF00069	0.606
MOD_NEK2_1	82	87	PF00069	0.542
MOD_PIKK_1	92	98	PF00454	0.474
MOD_PKA_1	140	146	PF00069	0.478
MOD_PKA_1	92	98	PF00069	0.496
MOD_PKA_2	140	146	PF00069	0.478
MOD_PKA_2	92	98	PF00069	0.558
MOD_Plk_4	2	8	PF00069	0.529
MOD_Plk_4	23	29	PF00069	0.372
MOD_ProDKin_1	28	34	PF00069	0.647
MOD_ProDKin_1	9	15	PF00069	0.438
TRG_ENDOCYTIC_2	63	66	PF00928	0.418
TRG_ER_diArg_1	139	141	PF00400	0.484
TRG_ER_diArg_1	91	93	PF00400	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3R7MII2	Trypanosoma rangeli	39%	100%
A0A3S7WPN6	Leishmania donovani	93%	100%
A4HT16	Leishmania infantum	93%	100%
E9AL04	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%