Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIV0_LEIMA

TriTrypDb:

LmjF.06.1250 , LMJLV39_060019300 , LMJSD75_060019400

Length:

238

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4QIV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIV0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	20	22	PF00675	0.383
CLV_NRD_NRD_1	24	26	PF00675	0.383
CLV_PCSK_KEX2_1	11	13	PF00082	0.382
CLV_PCSK_KEX2_1	167	169	PF00082	0.479
CLV_PCSK_KEX2_1	19	21	PF00082	0.351
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.434
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.526
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.384
DOC_MAPK_DCC_7	125	134	PF00069	0.396
DOC_MAPK_MEF2A_6	125	134	PF00069	0.435
DOC_MAPK_MEF2A_6	199	208	PF00069	0.498
DOC_MAPK_MEF2A_6	53	62	PF00069	0.483
DOC_MAPK_NFAT4_5	199	207	PF00069	0.514
DOC_PP1_RVXF_1	154	161	PF00149	0.620
DOC_PP2B_PxIxI_1	55	61	PF00149	0.306
DOC_PP4_FxxP_1	93	96	PF00568	0.643
DOC_USP7_MATH_2	96	102	PF00917	0.463
DOC_WW_Pin1_4	151	156	PF00397	0.508
DOC_WW_Pin1_4	47	52	PF00397	0.661
LIG_14-3-3_CanoR_1	114	123	PF00244	0.497
LIG_14-3-3_CanoR_1	159	165	PF00244	0.640
LIG_Actin_WH2_2	146	161	PF00022	0.508
LIG_APCC_ABBA_1	214	219	PF00400	0.260
LIG_BIR_II_1	1	5	PF00653	0.621
LIG_BRCT_BRCA1_1	153	157	PF00533	0.576
LIG_Clathr_ClatBox_1	215	219	PF01394	0.346
LIG_deltaCOP1_diTrp_1	75	82	PF00928	0.247
LIG_eIF4E_1	137	143	PF01652	0.353
LIG_FAT_LD_1	200	208	PF03623	0.528
LIG_FHA_1	103	109	PF00498	0.349
LIG_FHA_1	37	43	PF00498	0.688
LIG_FHA_1	50	56	PF00498	0.588
LIG_LIR_Apic_2	117	123	PF02991	0.455
LIG_LIR_Gen_1	154	164	PF02991	0.727
LIG_LIR_Gen_1	181	192	PF02991	0.596
LIG_LIR_Gen_1	31	42	PF02991	0.643
LIG_LIR_Gen_1	75	84	PF02991	0.239
LIG_LIR_Gen_1	87	96	PF02991	0.291
LIG_LIR_Gen_1	97	107	PF02991	0.473
LIG_LIR_Nem_3	154	160	PF02991	0.685
LIG_LIR_Nem_3	181	187	PF02991	0.595
LIG_LIR_Nem_3	31	37	PF02991	0.641
LIG_LIR_Nem_3	75	79	PF02991	0.247
LIG_LIR_Nem_3	87	91	PF02991	0.287
LIG_LIR_Nem_3	97	102	PF02991	0.463
LIG_NRBOX	199	205	PF00104	0.528
LIG_NRBOX	58	64	PF00104	0.353
LIG_SH2_CRK	120	124	PF00017	0.431
LIG_SH2_NCK_1	120	124	PF00017	0.471
LIG_SH2_PTP2	137	140	PF00017	0.380
LIG_SH2_PTP2	152	155	PF00017	0.408
LIG_SH2_SRC	34	37	PF00017	0.665
LIG_SH2_STAT5	137	140	PF00017	0.336
LIG_SH2_STAT5	149	152	PF00017	0.319
LIG_SH2_STAT5	217	220	PF00017	0.415
LIG_SH2_STAT5	34	37	PF00017	0.641
LIG_SH3_3	62	68	PF00018	0.345
LIG_SUMO_SIM_anti_2	198	204	PF11976	0.576
LIG_SUMO_SIM_anti_2	33	39	PF11976	0.639
LIG_TYR_ITIM	135	140	PF00017	0.370
LIG_TYR_ITIM	215	220	PF00017	0.398
LIG_WRC_WIRS_1	85	90	PF05994	0.295
MOD_CDC14_SPxK_1	50	53	PF00782	0.632
MOD_CDK_SPK_2	151	156	PF00069	0.508
MOD_CDK_SPxK_1	47	53	PF00069	0.644
MOD_CK1_1	101	107	PF00069	0.377
MOD_CK1_1	2	8	PF00069	0.656
MOD_CK2_1	2	8	PF00069	0.613
MOD_Cter_Amidation	165	168	PF01082	0.447
MOD_GlcNHglycan	172	175	PF01048	0.439
MOD_GSK3_1	45	52	PF00069	0.670
MOD_GSK3_1	94	101	PF00069	0.642
MOD_N-GLC_1	108	113	PF02516	0.295
MOD_NEK2_1	158	163	PF00069	0.711
MOD_NEK2_1	63	68	PF00069	0.405
MOD_NEK2_1	91	96	PF00069	0.472
MOD_PKA_2	113	119	PF00069	0.516
MOD_PKA_2	158	164	PF00069	0.631
MOD_PKA_2	169	175	PF00069	0.687
MOD_PKA_2	45	51	PF00069	0.635
MOD_PKB_1	168	176	PF00069	0.655
MOD_Plk_1	108	114	PF00069	0.232
MOD_Plk_4	102	108	PF00069	0.201
MOD_Plk_4	54	60	PF00069	0.363
MOD_Plk_4	84	90	PF00069	0.331
MOD_ProDKin_1	151	157	PF00069	0.511
MOD_ProDKin_1	47	53	PF00069	0.659
TRG_DiLeu_BaEn_1	198	203	PF01217	0.616
TRG_DiLeu_BaEn_4	195	201	PF01217	0.665
TRG_DiLeu_BaLyEn_6	127	132	PF01217	0.457
TRG_DiLeu_BaLyEn_6	232	237	PF01217	0.462
TRG_ENDOCYTIC_2	137	140	PF00928	0.342
TRG_ENDOCYTIC_2	184	187	PF00928	0.599
TRG_ENDOCYTIC_2	217	220	PF00928	0.399
TRG_ENDOCYTIC_2	34	37	PF00928	0.641
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBC2	Leptomonas seymouri	66%	100%
A0A0S4JA41	Bodo saltans	29%	100%
A0A1X0NGU0	Trypanosomatidae	36%	100%
A0A3S5H5V0	Leishmania donovani	95%	100%
A4H4T7	Leishmania braziliensis	84%	100%
A4HT17	Leishmania infantum	95%	100%
C9ZTQ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AL05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%