Putative pteridine transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pteridine transporter, putative

Species:

Leishmania major

UniProt:

Q4QIU9_LEIMA

TriTrypDb:

LmjF.06.1260 , LMJLV39_060019500 , LMJSD75_060019600

Length:

653

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 52

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 71
NetGPI	no	yes: 0, no: 71

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	72
GO:0110165	cellular anatomical entity	1	72
GO:0005737	cytoplasm	2	6
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

Q4QIU9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIU9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015877	biopterin transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015224	biopterin transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	10	14	PF00656	0.734
CLV_C14_Caspase3-7	289	293	PF00656	0.542
CLV_NRD_NRD_1	259	261	PF00675	0.321
CLV_NRD_NRD_1	365	367	PF00675	0.397
CLV_NRD_NRD_1	623	625	PF00675	0.426
CLV_NRD_NRD_1	650	652	PF00675	0.585
CLV_PCSK_KEX2_1	132	134	PF00082	0.291
CLV_PCSK_KEX2_1	259	261	PF00082	0.267
CLV_PCSK_KEX2_1	271	273	PF00082	0.290
CLV_PCSK_KEX2_1	365	367	PF00082	0.397
CLV_PCSK_KEX2_1	485	487	PF00082	0.520
CLV_PCSK_KEX2_1	623	625	PF00082	0.439
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.291
CLV_PCSK_PC1ET2_1	271	273	PF00082	0.351
CLV_PCSK_PC1ET2_1	485	487	PF00082	0.520
CLV_PCSK_SKI1_1	103	107	PF00082	0.348
CLV_PCSK_SKI1_1	261	265	PF00082	0.306
CLV_PCSK_SKI1_1	268	272	PF00082	0.276
CLV_PCSK_SKI1_1	366	370	PF00082	0.397
CLV_PCSK_SKI1_1	38	42	PF00082	0.296
CLV_PCSK_SKI1_1	461	465	PF00082	0.223
DOC_CDC14_PxL_1	40	48	PF14671	0.528
DOC_CDC14_PxL_1	571	579	PF14671	0.330
DOC_CKS1_1	583	588	PF01111	0.431
DOC_CYCLIN_yCln2_LP_2	385	391	PF00134	0.441
DOC_CYCLIN_yCln2_LP_2	583	589	PF00134	0.385
DOC_MAPK_gen_1	132	138	PF00069	0.498
DOC_MAPK_gen_1	259	267	PF00069	0.552
DOC_MAPK_gen_1	459	467	PF00069	0.440
DOC_MAPK_gen_1	485	493	PF00069	0.321
DOC_MAPK_gen_1	599	608	PF00069	0.587
DOC_MAPK_MEF2A_6	225	233	PF00069	0.322
DOC_MAPK_MEF2A_6	393	400	PF00069	0.490
DOC_MAPK_MEF2A_6	485	493	PF00069	0.356
DOC_MAPK_MEF2A_6	572	579	PF00069	0.276
DOC_MAPK_MEF2A_6	62	69	PF00069	0.534
DOC_MAPK_NFAT4_5	62	70	PF00069	0.605
DOC_PP2B_LxvP_1	385	388	PF13499	0.441
DOC_PP2B_LxvP_1	406	409	PF13499	0.372
DOC_PP2B_LxvP_1	588	591	PF13499	0.363
DOC_PP2B_LxvP_1	595	598	PF13499	0.327
DOC_PP4_FxxP_1	316	319	PF00568	0.456
DOC_USP7_MATH_1	155	159	PF00917	0.263
DOC_USP7_MATH_1	544	548	PF00917	0.396
DOC_USP7_MATH_1	551	555	PF00917	0.388
DOC_WW_Pin1_4	305	310	PF00397	0.448
DOC_WW_Pin1_4	582	587	PF00397	0.413
LIG_14-3-3_CanoR_1	103	108	PF00244	0.489
LIG_APCC_ABBA_1	247	252	PF00400	0.404
LIG_APCC_ABBA_1	49	54	PF00400	0.631
LIG_BIR_II_1	1	5	PF00653	0.753
LIG_BIR_III_3	1	5	PF00653	0.617
LIG_BIR_III_4	443	447	PF00653	0.196
LIG_BRCT_BRCA1_1	429	433	PF00533	0.316
LIG_EVH1_2	567	571	PF00568	0.359
LIG_FHA_1	348	354	PF00498	0.347
LIG_FHA_1	446	452	PF00498	0.395
LIG_FHA_1	467	473	PF00498	0.323
LIG_FHA_1	528	534	PF00498	0.472
LIG_FHA_1	578	584	PF00498	0.421
LIG_FHA_1	68	74	PF00498	0.561
LIG_FHA_2	8	14	PF00498	0.644
LIG_GBD_Chelix_1	467	475	PF00786	0.473
LIG_GBD_Chelix_1	505	513	PF00786	0.504
LIG_LIR_Apic_2	29	34	PF02991	0.633
LIG_LIR_Apic_2	313	319	PF02991	0.528
LIG_LIR_Gen_1	402	412	PF02991	0.339
LIG_LIR_Gen_1	432	441	PF02991	0.322
LIG_LIR_Gen_1	477	484	PF02991	0.332
LIG_LIR_Gen_1	532	541	PF02991	0.509
LIG_LIR_Nem_3	227	231	PF02991	0.303
LIG_LIR_Nem_3	241	247	PF02991	0.335
LIG_LIR_Nem_3	402	408	PF02991	0.337
LIG_LIR_Nem_3	430	434	PF02991	0.295
LIG_LIR_Nem_3	477	482	PF02991	0.333
LIG_LIR_Nem_3	532	538	PF02991	0.471
LIG_LIR_Nem_3	558	563	PF02991	0.299
LIG_NRBOX	399	405	PF00104	0.219
LIG_Pex14_1	204	208	PF04695	0.379
LIG_Pex14_2	168	172	PF04695	0.364
LIG_Pex14_2	243	247	PF04695	0.290
LIG_Pex14_2	429	433	PF04695	0.304
LIG_Pex14_2	453	457	PF04695	0.363
LIG_Pex14_2	59	63	PF04695	0.490
LIG_PTB_Apo_2	570	577	PF02174	0.319
LIG_PTB_Phospho_1	570	576	PF10480	0.319
LIG_REV1ctd_RIR_1	454	463	PF16727	0.395
LIG_SH2_CRK	101	105	PF00017	0.511
LIG_SH2_CRK	135	139	PF00017	0.365
LIG_SH2_CRK	150	154	PF00017	0.319
LIG_SH2_CRK	345	349	PF00017	0.344
LIG_SH2_CRK	370	374	PF00017	0.353
LIG_SH2_CRK	434	438	PF00017	0.296
LIG_SH2_CRK	462	466	PF00017	0.494
LIG_SH2_GRB2like	399	402	PF00017	0.380
LIG_SH2_NCK_1	31	35	PF00017	0.654
LIG_SH2_NCK_1	370	374	PF00017	0.414
LIG_SH2_PTP2	228	231	PF00017	0.206
LIG_SH2_PTP2	48	51	PF00017	0.637
LIG_SH2_PTP2	490	493	PF00017	0.399
LIG_SH2_SRC	31	34	PF00017	0.635
LIG_SH2_SRC	399	402	PF00017	0.509
LIG_SH2_SRC	576	579	PF00017	0.206
LIG_SH2_STAP1	130	134	PF00017	0.499
LIG_SH2_STAP1	345	349	PF00017	0.392
LIG_SH2_STAP1	462	466	PF00017	0.500
LIG_SH2_STAP1	507	511	PF00017	0.404
LIG_SH2_STAT5	130	133	PF00017	0.497
LIG_SH2_STAT5	228	231	PF00017	0.343
LIG_SH2_STAT5	399	402	PF00017	0.348
LIG_SH2_STAT5	405	408	PF00017	0.338
LIG_SH2_STAT5	416	419	PF00017	0.278
LIG_SH2_STAT5	431	434	PF00017	0.260
LIG_SH2_STAT5	48	51	PF00017	0.595
LIG_SH2_STAT5	490	493	PF00017	0.301
LIG_SH2_STAT5	499	502	PF00017	0.292
LIG_SH2_STAT5	576	579	PF00017	0.360
LIG_SH2_STAT5	71	74	PF00017	0.516
LIG_SH3_3	421	427	PF00018	0.278
LIG_SH3_3	624	630	PF00018	0.722
LIG_Sin3_3	593	600	PF02671	0.206
LIG_SUMO_SIM_anti_2	175	181	PF11976	0.417
LIG_SUMO_SIM_anti_2	480	485	PF11976	0.313
LIG_SUMO_SIM_anti_2	585	591	PF11976	0.422
LIG_TRAF2_1	6	9	PF00917	0.765
LIG_TRAF2_1	619	622	PF00917	0.543
LIG_TRFH_1	150	154	PF08558	0.360
LIG_TRFH_1	594	598	PF08558	0.289
LIG_TYR_ITIM	148	153	PF00017	0.375
LIG_TYR_ITIM	226	231	PF00017	0.206
LIG_TYR_ITIM	343	348	PF00017	0.245
LIG_TYR_ITIM	368	373	PF00017	0.372
LIG_TYR_ITIM	403	408	PF00017	0.331
LIG_TYR_ITIM	46	51	PF00017	0.465
LIG_TYR_ITIM	574	579	PF00017	0.384
LIG_TYR_ITSM	430	437	PF00017	0.402
LIG_UBA3_1	217	225	PF00899	0.206
LIG_UBA3_1	246	254	PF00899	0.390
LIG_UBA3_1	478	485	PF00899	0.321
MOD_CK1_1	198	204	PF00069	0.345
MOD_CK2_1	185	191	PF00069	0.200
MOD_CK2_1	26	32	PF00069	0.518
MOD_Cter_Amidation	649	652	PF01082	0.525
MOD_GlcNHglycan	138	141	PF01048	0.388
MOD_GlcNHglycan	157	161	PF01048	0.350
MOD_GlcNHglycan	2	5	PF01048	0.663
MOD_GlcNHglycan	233	236	PF01048	0.370
MOD_GlcNHglycan	292	295	PF01048	0.437
MOD_GlcNHglycan	542	545	PF01048	0.396
MOD_GlcNHglycan	563	566	PF01048	0.452
MOD_GSK3_1	106	113	PF00069	0.395
MOD_GSK3_1	204	211	PF00069	0.309
MOD_GSK3_1	286	293	PF00069	0.378
MOD_GSK3_1	429	436	PF00069	0.368
MOD_GSK3_1	451	458	PF00069	0.358
MOD_GSK3_1	540	547	PF00069	0.374
MOD_GSK3_1	63	70	PF00069	0.303
MOD_N-GLC_1	254	259	PF02516	0.378
MOD_N-GLC_1	82	87	PF02516	0.375
MOD_NEK2_1	110	115	PF00069	0.374
MOD_NEK2_1	117	122	PF00069	0.351
MOD_NEK2_1	128	133	PF00069	0.281
MOD_NEK2_1	136	141	PF00069	0.336
MOD_NEK2_1	172	177	PF00069	0.349
MOD_NEK2_1	185	190	PF00069	0.366
MOD_NEK2_1	208	213	PF00069	0.323
MOD_NEK2_1	347	352	PF00069	0.351
MOD_NEK2_1	429	434	PF00069	0.354
MOD_NEK2_1	466	471	PF00069	0.361
MOD_NEK2_1	511	516	PF00069	0.365
MOD_NEK2_1	577	582	PF00069	0.456
MOD_NEK2_1	63	68	PF00069	0.429
MOD_NEK2_1	69	74	PF00069	0.439
MOD_NEK2_1	7	12	PF00069	0.513
MOD_NEK2_2	374	379	PF00069	0.385
MOD_PIKK_1	178	184	PF00454	0.325
MOD_PIKK_1	352	358	PF00454	0.202
MOD_PKA_2	527	533	PF00069	0.333
MOD_Plk_4	103	109	PF00069	0.269
MOD_Plk_4	195	201	PF00069	0.338
MOD_Plk_4	204	210	PF00069	0.334
MOD_Plk_4	224	230	PF00069	0.331
MOD_Plk_4	238	244	PF00069	0.198
MOD_Plk_4	374	380	PF00069	0.417
MOD_Plk_4	399	405	PF00069	0.369
MOD_Plk_4	429	435	PF00069	0.436
MOD_Plk_4	467	473	PF00069	0.309
MOD_Plk_4	474	480	PF00069	0.319
MOD_Plk_4	511	517	PF00069	0.319
MOD_Plk_4	551	557	PF00069	0.337
MOD_ProDKin_1	305	311	PF00069	0.277
MOD_ProDKin_1	582	588	PF00069	0.413
MOD_SUMO_rev_2	222	227	PF00179	0.408
MOD_SUMO_rev_2	289	299	PF00179	0.439
MOD_SUMO_rev_2	615	620	PF00179	0.610
TRG_DiLeu_BaLyEn_6	338	343	PF01217	0.376
TRG_DiLeu_BaLyEn_6	385	390	PF01217	0.357
TRG_DiLeu_BaLyEn_6	583	588	PF01217	0.319
TRG_ENDOCYTIC_2	101	104	PF00928	0.319
TRG_ENDOCYTIC_2	135	138	PF00928	0.344
TRG_ENDOCYTIC_2	150	153	PF00928	0.334
TRG_ENDOCYTIC_2	228	231	PF00928	0.206
TRG_ENDOCYTIC_2	345	348	PF00928	0.345
TRG_ENDOCYTIC_2	370	373	PF00928	0.356
TRG_ENDOCYTIC_2	405	408	PF00928	0.350
TRG_ENDOCYTIC_2	434	437	PF00928	0.349
TRG_ENDOCYTIC_2	462	465	PF00928	0.340
TRG_ENDOCYTIC_2	48	51	PF00928	0.472
TRG_ENDOCYTIC_2	490	493	PF00928	0.480
TRG_ENDOCYTIC_2	576	579	PF00928	0.394
TRG_NES_CRM1_1	238	252	PF08389	0.370
TRG_NES_CRM1_1	320	334	PF08389	0.223
TRG_NES_CRM1_1	503	519	PF08389	0.206

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U2	Leptomonas seymouri	45%	93%
A0A0N1HY49	Leptomonas seymouri	44%	97%
A0A0N1HZ06	Leptomonas seymouri	46%	100%
A0A0N1IHL1	Leptomonas seymouri	40%	91%
A0A0N1PAY4	Leptomonas seymouri	39%	74%
A0A0N1PB77	Leptomonas seymouri	42%	100%
A0A0N1PBZ2	Leptomonas seymouri	43%	97%
A0A0N1PCC1	Leptomonas seymouri	44%	98%
A0A0S4INN8	Bodo saltans	31%	100%
A0A381MBI0	Leishmania infantum	44%	99%
A0A3Q8I8X7	Leishmania donovani	44%	99%
A0A3Q8IAZ0	Leishmania donovani	43%	93%
A0A3Q8IH50	Leishmania donovani	45%	90%
A0A3Q8IVN0	Leishmania donovani	45%	100%
A0A3R7M4J1	Trypanosoma rangeli	46%	100%
A0A3S5H5P4	Leishmania donovani	46%	96%
A0A3S5H5V2	Leishmania donovani	94%	100%
A0A3S5H6F6	Leishmania donovani	44%	94%
A0A3S5H763	Leishmania donovani	44%	97%
A0A3S7WR10	Leishmania donovani	44%	88%
A0A3S7WR14	Leishmania donovani	42%	95%
A0A3S7WR15	Leishmania donovani	42%	77%
A0A3S7WR24	Leishmania donovani	43%	93%
A4H4T8	Leishmania braziliensis	84%	100%
A4H5Y4	Leishmania braziliensis	44%	100%
A4H617	Leishmania braziliensis	45%	94%
A4H618	Leishmania braziliensis	44%	95%
A4H619	Leishmania braziliensis	43%	94%
A4H620	Leishmania braziliensis	45%	92%
A4H6C3	Leishmania braziliensis	45%	100%
A4HNH7	Leishmania braziliensis	44%	100%
A4HSS2	Leishmania infantum	46%	96%
A4HUE4	Leishmania infantum	44%	88%
A4HUE5	Leishmania infantum	42%	95%
A4HUE6	Leishmania infantum	42%	95%
A4HUE7	Leishmania infantum	44%	93%
A4HUE8	Leishmania infantum	44%	93%
A4HUF4	Leishmania infantum	43%	94%
A4HUF5	Leishmania infantum	44%	99%
A4HYA9	Leishmania infantum	44%	97%
A4IC33	Leishmania infantum	44%	100%
C9ZIK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
C9ZIK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
C9ZVE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
C9ZVE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
C9ZVF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
D0A423	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E8NHQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	94%
E9AG72	Leishmania infantum	93%	100%
E9AI40	Leishmania braziliensis	43%	96%
E9AJY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AKQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	96%
E9AL06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9AN44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	88%
E9AN45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9AN46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AN47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	92%
E9ANE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	99%
E9AS42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	97%
E9B741	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
Q4QDC4	Leishmania major	46%	100%
Q4QH81	Leishmania major	46%	100%
Q4QHH7	Leishmania major	44%	100%
Q4QHH8	Leishmania major	44%	100%
Q4QHH9	Leishmania major	44%	100%
Q4QHI0	Leishmania major	44%	100%
Q4QHI1	Leishmania major	46%	100%
Q4QHI2	Leishmania major	43%	100%
Q4QJ48	Leishmania major	47%	97%
Q7KIP2	Leishmania major	44%	100%