Cytochrome b5 heme-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QIU6_LEIMA

TriTrypDb:

LmjF.06.1290 , LMJLV39_060019800 , LMJSD75_060019900

Length:

123

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043231	intracellular membrane-bounded organelle	4	5
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4QIU6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIU6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0020037	heme binding	4	5
GO:0046906	tetrapyrrole binding	3	5
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	120	122	PF00675	0.607
CLV_PCSK_KEX2_1	100	102	PF00082	0.441
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.410
DEG_Nend_UBRbox_3	1	3	PF02207	0.621
DOC_MAPK_gen_1	100	109	PF00069	0.473
DOC_MAPK_gen_1	15	25	PF00069	0.457
DOC_MAPK_MEF2A_6	18	25	PF00069	0.493
DOC_SPAK_OSR1_1	104	108	PF12202	0.214
DOC_USP7_MATH_1	31	35	PF00917	0.462
DOC_USP7_MATH_1	5	9	PF00917	0.588
DOC_USP7_MATH_1	75	79	PF00917	0.611
DOC_USP7_UBL2_3	47	51	PF12436	0.457
DOC_USP7_UBL2_3	94	98	PF12436	0.640
LIG_deltaCOP1_diTrp_1	64	72	PF00928	0.587
LIG_EH1_1	108	116	PF00400	0.258
LIG_FHA_2	114	120	PF00498	0.238
LIG_LIR_Gen_1	46	56	PF02991	0.455
LIG_LIR_Gen_1	99	109	PF02991	0.456
LIG_LIR_Nem_3	99	105	PF02991	0.589
LIG_Pex14_2	105	109	PF04695	0.214
LIG_SH2_CRK	19	23	PF00017	0.457
LIG_SH2_STAT5	3	6	PF00017	0.621
LIG_SH3_3	1	7	PF00018	0.578
MOD_CK1_1	113	119	PF00069	0.255
MOD_CK1_1	78	84	PF00069	0.632
MOD_CK2_1	113	119	PF00069	0.238
MOD_GlcNHglycan	77	80	PF01048	0.470
MOD_N-GLC_1	52	57	PF02516	0.303
MOD_PIKK_1	87	93	PF00454	0.616
MOD_Plk_1	52	58	PF00069	0.462
MOD_Plk_4	110	116	PF00069	0.322
MOD_Plk_4	32	38	PF00069	0.445
MOD_SUMO_rev_2	64	72	PF00179	0.533
TRG_NES_CRM1_1	50	64	PF08389	0.446

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IH82	Leptomonas seymouri	35%	100%
A0A3Q8ICI2	Leishmania donovani	38%	100%
A0A3Q8ILC3	Leishmania donovani	87%	100%
A0A3S7WPP2	Leishmania donovani	88%	100%
A0A3S7X4C9	Leishmania donovani	28%	100%
A4H4U1	Leishmania braziliensis	76%	100%
A4HJ97	Leishmania braziliensis	32%	100%
A4HJ98	Leishmania braziliensis	38%	100%
A4HT20	Leishmania infantum	89%	100%
A4I6P2	Leishmania infantum	28%	100%
A4I6P3	Leishmania infantum	38%	100%
A4I6P6	Leishmania infantum	29%	92%
E9ACS1	Leishmania major	95%	100%
E9AGY1	Leishmania infantum	87%	100%
E9AL09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9AVI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E9B1R4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B1R5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
Q4Q6E3	Leishmania major	30%	100%
Q4Q6E6	Leishmania major	36%	97%