Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Isy1-like splicing family, putative

Species:

Leishmania major

UniProt:

Q4QIU3_LEIMA

TriTrypDb:

LmjF.07.0020 , LMJLV39_070005400 , LMJSD75_070005400

Length:

306

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000974	Prp19 complex	2	2
GO:0005681	spliceosomal complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0071013	catalytic step 2 spliceosome	3	2
GO:0071014	post-mRNA release spliceosomal complex	4	2
GO:0071020	post-spliceosomal complex	4	2
GO:0140513	nuclear protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990904	ribonucleoprotein complex	2	2
GO:0005634	nucleus	5	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4QIU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIU3

Function

Biological processes
Term	Name	Level	Count
GO:0000350	generation of catalytic spliceosome for second transesterification step	7	11
GO:0000389	mRNA 3'-splice site recognition	8	2
GO:0006376	mRNA splice site selection	7	2
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0022607	cellular component assembly	4	11
GO:0022618	ribonucleoprotein complex assembly	6	11
GO:0043933	protein-containing complex organization	4	11
GO:0065003	protein-containing complex assembly	5	11
GO:0071826	ribonucleoprotein complex subunit organization	5	11
GO:0071840	cellular component organization or biogenesis	2	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.559
CLV_NRD_NRD_1	140	142	PF00675	0.308
CLV_NRD_NRD_1	161	163	PF00675	0.365
CLV_NRD_NRD_1	290	292	PF00675	0.289
CLV_NRD_NRD_1	54	56	PF00675	0.287
CLV_NRD_NRD_1	66	68	PF00675	0.296
CLV_PCSK_KEX2_1	181	183	PF00082	0.367
CLV_PCSK_KEX2_1	65	67	PF00082	0.307
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.367
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.307
CLV_PCSK_SKI1_1	163	167	PF00082	0.351
CLV_PCSK_SKI1_1	292	296	PF00082	0.315
CLV_PCSK_SKI1_1	92	96	PF00082	0.290
DEG_Nend_UBRbox_2	1	3	PF02207	0.439
DOC_ANK_TNKS_1	181	188	PF00023	0.502
DOC_CYCLIN_yCln2_LP_2	28	34	PF00134	0.425
DOC_MAPK_gen_1	160	167	PF00069	0.576
DOC_PP1_RVXF_1	146	152	PF00149	0.535
DOC_PP1_RVXF_1	161	168	PF00149	0.413
DOC_PP1_RVXF_1	223	229	PF00149	0.555
DOC_PP1_RVXF_1	93	100	PF00149	0.488
DOC_PP2B_LxvP_1	28	31	PF13499	0.436
DOC_USP7_MATH_1	174	178	PF00917	0.550
DOC_USP7_MATH_1	197	201	PF00917	0.586
DOC_USP7_UBL2_3	248	252	PF12436	0.555
DOC_WW_Pin1_4	16	21	PF00397	0.638
LIG_14-3-3_CanoR_1	148	152	PF00244	0.524
LIG_CaM_IQ_9	176	191	PF13499	0.419
LIG_Clathr_ClatBox_1	117	121	PF01394	0.496
LIG_Clathr_ClatBox_1	238	242	PF01394	0.530
LIG_FHA_1	107	113	PF00498	0.539
LIG_FHA_1	23	29	PF00498	0.465
LIG_HCF-1_HBM_1	219	222	PF13415	0.530
LIG_LIR_Gen_1	8	16	PF02991	0.417
LIG_LIR_Nem_3	13	18	PF02991	0.446
LIG_LIR_Nem_3	8	12	PF02991	0.445
LIG_PCNA_yPIPBox_3	129	139	PF02747	0.496
LIG_SH2_STAT5	222	225	PF00017	0.518
LIG_SH2_STAT5	269	272	PF00017	0.496
LIG_SH2_STAT5	96	99	PF00017	0.513
LIG_SH3_3	153	159	PF00018	0.502
LIG_SH3_3	79	85	PF00018	0.496
LIG_SUMO_SIM_anti_2	235	240	PF11976	0.419
LIG_SUMO_SIM_par_1	116	121	PF11976	0.514
LIG_TRAF2_1	199	202	PF00917	0.522
LIG_TRAF2_1	278	281	PF00917	0.470
LIG_TRAF2_1	294	297	PF00917	0.465
LIG_UBA3_1	59	65	PF00899	0.496
LIG_UBA3_1	98	102	PF00899	0.513
LIG_WRC_WIRS_1	12	17	PF05994	0.454
MOD_CK1_1	255	261	PF00069	0.518
MOD_CK2_1	196	202	PF00069	0.505
MOD_GlcNHglycan	231	234	PF01048	0.386
MOD_GlcNHglycan	261	264	PF01048	0.324
MOD_GlcNHglycan	35	38	PF01048	0.390
MOD_GSK3_1	255	262	PF00069	0.550
MOD_GSK3_1	45	52	PF00069	0.565
MOD_NEK2_1	229	234	PF00069	0.587
MOD_NEK2_1	265	270	PF00069	0.562
MOD_NEK2_1	5	10	PF00069	0.427
MOD_PIKK_1	214	220	PF00454	0.500
MOD_PIKK_1	22	28	PF00454	0.608
MOD_PK_1	116	122	PF00069	0.558
MOD_PK_1	252	258	PF00069	0.419
MOD_PKA_1	55	61	PF00069	0.493
MOD_PKA_2	147	153	PF00069	0.586
MOD_Plk_1	174	180	PF00069	0.593
MOD_Plk_4	147	153	PF00069	0.574
MOD_Plk_4	174	180	PF00069	0.441
MOD_Plk_4	24	30	PF00069	0.550
MOD_Plk_4	252	258	PF00069	0.515
MOD_Plk_4	5	11	PF00069	0.417
MOD_Plk_4	55	61	PF00069	0.476
MOD_ProDKin_1	16	22	PF00069	0.636
MOD_SUMO_for_1	101	104	PF00179	0.527
MOD_SUMO_rev_2	242	249	PF00179	0.508
MOD_SUMO_rev_2	268	276	PF00179	0.586
MOD_SUMO_rev_2	86	94	PF00179	0.536
TRG_DiLeu_BaEn_1	134	139	PF01217	0.496
TRG_DiLeu_BaEn_1	201	206	PF01217	0.530
TRG_ENDOCYTIC_2	96	99	PF00928	0.496
TRG_ER_diArg_1	159	162	PF00400	0.556
TRG_ER_diArg_1	182	185	PF00400	0.549
TRG_NLS_Bipartite_1	163	185	PF00514	0.562
TRG_NLS_MonoExtC_3	180	186	PF00514	0.562
TRG_NLS_MonoExtN_4	159	166	PF00514	0.586
TRG_Pf-PMV_PEXEL_1	171	175	PF00026	0.295
TRG_Pf-PMV_PEXEL_1	293	297	PF00026	0.339

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAF4	Leptomonas seymouri	65%	100%
A0A1X0NL28	Trypanosomatidae	43%	100%
A0A3R7KL93	Trypanosoma rangeli	43%	100%
A0A3S5H5V5	Leishmania donovani	89%	100%
A4H4U5	Leishmania braziliensis	82%	100%
A4HT23	Leishmania infantum	89%	100%
C9ZUW9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AL11	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	94%
V5B8Q7	Trypanosoma cruzi	42%	100%