Major DNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIU1_LEIMA

TriTrypDb:

LmjF.07.0030 , LMJLV39_070005600 , LMJSD75_070005600

Length:

276

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QIU1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIU1

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	16
GO:0006520	amino acid metabolic process	3	16
GO:0006525	arginine metabolic process	6	16
GO:0006526	arginine biosynthetic process	7	16
GO:0006807	nitrogen compound metabolic process	2	16
GO:0008152	metabolic process	1	16
GO:0008652	amino acid biosynthetic process	4	16
GO:0009058	biosynthetic process	2	16
GO:0009064	glutamine family amino acid metabolic process	5	16
GO:0009084	glutamine family amino acid biosynthetic process	6	16
GO:0009987	cellular process	1	16
GO:0016053	organic acid biosynthetic process	4	16
GO:0019752	carboxylic acid metabolic process	5	16
GO:0043436	oxoacid metabolic process	4	16
GO:0044237	cellular metabolic process	2	16
GO:0044238	primary metabolic process	2	16
GO:0044249	cellular biosynthetic process	3	16
GO:0044281	small molecule metabolic process	2	16
GO:0044283	small molecule biosynthetic process	3	16
GO:0046394	carboxylic acid biosynthetic process	5	16
GO:0071704	organic substance metabolic process	2	16
GO:1901564	organonitrogen compound metabolic process	3	16
GO:1901566	organonitrogen compound biosynthetic process	4	16
GO:1901576	organic substance biosynthetic process	3	16
GO:1901605	alpha-amino acid metabolic process	4	16
GO:1901607	alpha-amino acid biosynthetic process	5	16

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	19
GO:0008777	acetylornithine deacetylase activity	4	10
GO:0016787	hydrolase activity	2	19
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	10
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	10
GO:0019213	deacetylase activity	3	16
GO:0004180	carboxypeptidase activity	5	7
GO:0008233	peptidase activity	3	7
GO:0008238	exopeptidase activity	4	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	177	181	PF00656	0.477
CLV_NRD_NRD_1	270	272	PF00675	0.518
CLV_PCSK_KEX2_1	72	74	PF00082	0.527
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.324
CLV_PCSK_SKI1_1	186	190	PF00082	0.416
CLV_PCSK_SKI1_1	200	204	PF00082	0.505
CLV_PCSK_SKI1_1	40	44	PF00082	0.592
CLV_PCSK_SKI1_1	95	99	PF00082	0.419
DOC_CDC14_PxL_1	1	9	PF14671	0.397
DOC_CYCLIN_RxL_1	183	193	PF00134	0.311
DOC_CYCLIN_yCln2_LP_2	148	154	PF00134	0.310
DOC_MAPK_gen_1	263	269	PF00069	0.511
DOC_PP1_RVXF_1	11	18	PF00149	0.402
DOC_PP1_RVXF_1	21	28	PF00149	0.432
DOC_PP1_RVXF_1	93	99	PF00149	0.315
DOC_USP7_MATH_1	75	79	PF00917	0.511
DOC_USP7_UBL2_3	68	72	PF12436	0.294
LIG_14-3-3_CanoR_1	115	120	PF00244	0.523
LIG_14-3-3_CanoR_1	208	216	PF00244	0.508
LIG_FHA_1	135	141	PF00498	0.470
LIG_FHA_1	202	208	PF00498	0.464
LIG_FHA_2	221	227	PF00498	0.343
LIG_FHA_2	51	57	PF00498	0.496
LIG_LIR_Gen_1	226	236	PF02991	0.454
LIG_LIR_Gen_1	85	94	PF02991	0.565
LIG_LIR_Nem_3	226	231	PF02991	0.466
LIG_LIR_Nem_3	85	90	PF02991	0.405
LIG_SH2_CRK	228	232	PF00017	0.361
LIG_SH2_NCK_1	178	182	PF00017	0.401
LIG_SH2_NCK_1	228	232	PF00017	0.473
LIG_SH2_STAP1	21	25	PF00017	0.403
LIG_SH2_STAT5	166	169	PF00017	0.501
LIG_SH2_STAT5	260	263	PF00017	0.371
LIG_SH3_1	8	14	PF00018	0.408
LIG_SH3_3	165	171	PF00018	0.349
LIG_SH3_3	8	14	PF00018	0.572
LIG_Sin3_3	203	210	PF02671	0.293
LIG_SUMO_SIM_par_1	115	122	PF11976	0.370
LIG_TRAF2_1	246	249	PF00917	0.374
LIG_UBA3_1	266	272	PF00899	0.365
MOD_CK1_1	118	124	PF00069	0.574
MOD_CK1_1	190	196	PF00069	0.638
MOD_CK1_1	36	42	PF00069	0.308
MOD_CK2_1	50	56	PF00069	0.315
MOD_Cter_Amidation	261	264	PF01082	0.578
MOD_GlcNHglycan	189	192	PF01048	0.439
MOD_GSK3_1	115	122	PF00069	0.450
MOD_GSK3_1	71	78	PF00069	0.467
MOD_N-GLC_1	267	272	PF02516	0.366
MOD_NEK2_1	117	122	PF00069	0.601
MOD_NEK2_1	124	129	PF00069	0.508
MOD_NEK2_1	267	272	PF00069	0.492
MOD_NEK2_1	33	38	PF00069	0.390
MOD_PK_1	115	121	PF00069	0.379
MOD_Plk_4	119	125	PF00069	0.456
TRG_ENDOCYTIC_2	228	231	PF00928	0.355

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2V6	Leptomonas seymouri	48%	70%
A0A0N1I646	Leptomonas seymouri	25%	68%
A0A1X0NPX5	Trypanosomatidae	27%	74%
A0A3Q8IRE4	Leishmania donovani	28%	69%
A0A3S5H5X0	Leishmania donovani	27%	70%
A0A3S7WPP6	Leishmania donovani	76%	97%
A4H4X2	Leishmania braziliensis	24%	70%
A4HHG9	Leishmania braziliensis	28%	69%
A4HT25	Leishmania infantum	77%	100%
A4HT45	Leishmania infantum	27%	70%
A4I4L8	Leishmania infantum	27%	78%
C9ZUW7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	70%
E9AE16	Leishmania major	28%	69%
E9AL37	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	70%
E9ALR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	69%
Q4QIR7	Leishmania major	27%	100%
V5B6I6	Trypanosoma cruzi	31%	68%
V5D8Q5	Trypanosoma cruzi	27%	70%
V5D9A3	Trypanosoma cruzi	36%	70%