Putative Golgi/lysosome glycoprotein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Golgi/lysosome glycoprotein 1, putative

Species:

Leishmania major

UniProt:

Q4QIT6_LEIMA

TriTrypDb:

LmjF.07.0080 , LMJLV39_070006100 , LMJSD75_070006100

Length:

623

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 10, no: 0
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000323	lytic vacuole	6	2
GO:0005764	lysosome	7	2
GO:0005765	lysosomal membrane	7	2
GO:0005773	vacuole	5	2
GO:0005774	vacuolar membrane	5	2
GO:0005794	Golgi apparatus	5	2
GO:0016020	membrane	2	10
GO:0031090	organelle membrane	3	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0098588	bounding membrane of organelle	4	2
GO:0098852	lytic vacuole membrane	6	2
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4QIT6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIT6

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	1
GO:0006952	defense response	3	1
GO:0050896	response to stimulus	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	381	383	PF00675	0.563
CLV_NRD_NRD_1	571	573	PF00675	0.491
CLV_PCSK_KEX2_1	31	33	PF00082	0.650
CLV_PCSK_KEX2_1	381	383	PF00082	0.542
CLV_PCSK_KEX2_1	464	466	PF00082	0.662
CLV_PCSK_KEX2_1	571	573	PF00082	0.491
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.640
CLV_PCSK_PC1ET2_1	381	383	PF00082	0.517
CLV_PCSK_PC1ET2_1	464	466	PF00082	0.649
CLV_PCSK_PC7_1	567	573	PF00082	0.465
CLV_PCSK_SKI1_1	157	161	PF00082	0.526
CLV_PCSK_SKI1_1	192	196	PF00082	0.521
CLV_PCSK_SKI1_1	253	257	PF00082	0.551
CLV_PCSK_SKI1_1	438	442	PF00082	0.537
CLV_PCSK_SKI1_1	465	469	PF00082	0.545
CLV_PCSK_SKI1_1	5	9	PF00082	0.601
CLV_PCSK_SKI1_1	542	546	PF00082	0.456
DEG_COP1_1	405	414	PF00400	0.383
DEG_Nend_Nbox_1	1	3	PF02207	0.618
DOC_CKS1_1	411	416	PF01111	0.334
DOC_CYCLIN_RxL_1	151	161	PF00134	0.293
DOC_MAPK_gen_1	3	12	PF00069	0.609
DOC_MAPK_gen_1	381	387	PF00069	0.353
DOC_MAPK_gen_1	436	444	PF00069	0.395
DOC_MAPK_gen_1	571	578	PF00069	0.604
DOC_MAPK_MEF2A_6	3	11	PF00069	0.546
DOC_MAPK_MEF2A_6	438	446	PF00069	0.358
DOC_MAPK_MEF2A_6	480	487	PF00069	0.316
DOC_PP1_RVXF_1	251	258	PF00149	0.285
DOC_PP1_RVXF_1	326	333	PF00149	0.441
DOC_PP1_RVXF_1	478	485	PF00149	0.329
DOC_PP4_FxxP_1	257	260	PF00568	0.373
DOC_SPAK_OSR1_1	138	142	PF12202	0.239
DOC_USP7_MATH_1	18	22	PF00917	0.665
DOC_USP7_MATH_1	190	194	PF00917	0.407
DOC_USP7_MATH_1	269	273	PF00917	0.376
DOC_USP7_MATH_1	403	407	PF00917	0.494
DOC_USP7_UBL2_3	163	167	PF12436	0.282
DOC_USP7_UBL2_3	377	381	PF12436	0.272
DOC_WW_Pin1_4	178	183	PF00397	0.395
DOC_WW_Pin1_4	410	415	PF00397	0.442
LIG_14-3-3_CanoR_1	138	142	PF00244	0.375
LIG_14-3-3_CanoR_1	157	163	PF00244	0.315
LIG_14-3-3_CanoR_1	247	253	PF00244	0.421
LIG_14-3-3_CanoR_1	268	278	PF00244	0.420
LIG_14-3-3_CanoR_1	3	8	PF00244	0.624
LIG_14-3-3_CanoR_1	465	471	PF00244	0.424
LIG_14-3-3_CanoR_1	60	65	PF00244	0.371
LIG_14-3-3_CanoR_1	613	619	PF00244	0.643
LIG_Actin_WH2_2	450	466	PF00022	0.336
LIG_BRCT_BRCA1_1	139	143	PF00533	0.261
LIG_deltaCOP1_diTrp_1	431	437	PF00928	0.399
LIG_DLG_GKlike_1	122	129	PF00625	0.312
LIG_DLG_GKlike_1	3	10	PF00625	0.527
LIG_FHA_1	20	26	PF00498	0.654
LIG_FHA_1	206	212	PF00498	0.341
LIG_FHA_1	238	244	PF00498	0.418
LIG_FHA_1	260	266	PF00498	0.309
LIG_FHA_1	360	366	PF00498	0.318
LIG_FHA_1	49	55	PF00498	0.404
LIG_FHA_1	527	533	PF00498	0.451
LIG_FHA_1	59	65	PF00498	0.320
LIG_FHA_2	254	260	PF00498	0.418
LIG_FHA_2	367	373	PF00498	0.413
LIG_FHA_2	417	423	PF00498	0.445
LIG_LIR_Apic_2	256	260	PF02991	0.432
LIG_LIR_Gen_1	137	147	PF02991	0.323
LIG_LIR_Gen_1	326	335	PF02991	0.373
LIG_LIR_Gen_1	82	89	PF02991	0.447
LIG_LIR_Gen_1	93	104	PF02991	0.308
LIG_LIR_Nem_3	140	146	PF02991	0.328
LIG_LIR_Nem_3	326	332	PF02991	0.432
LIG_LIR_Nem_3	431	437	PF02991	0.355
LIG_LIR_Nem_3	82	88	PF02991	0.401
LIG_LIR_Nem_3	93	99	PF02991	0.254
LIG_NRBOX	456	462	PF00104	0.320
LIG_PCNA_yPIPBox_3	151	160	PF02747	0.374
LIG_Pex14_2	139	143	PF04695	0.316
LIG_PTB_Apo_2	284	291	PF02174	0.307
LIG_PTB_Phospho_1	284	290	PF10480	0.307
LIG_Rb_pABgroove_1	583	591	PF01858	0.659
LIG_SH2_CRK	291	295	PF00017	0.352
LIG_SH2_CRK	96	100	PF00017	0.265
LIG_SH2_NCK_1	291	295	PF00017	0.408
LIG_SH2_NCK_1	603	607	PF00017	0.724
LIG_SH2_NCK_1	71	75	PF00017	0.378
LIG_SH2_STAP1	186	190	PF00017	0.369
LIG_SH2_STAP1	589	593	PF00017	0.715
LIG_SH2_STAP1	96	100	PF00017	0.358
LIG_SH2_STAT3	267	270	PF00017	0.324
LIG_SH2_STAT5	104	107	PF00017	0.231
LIG_SH2_STAT5	233	236	PF00017	0.405
LIG_SH2_STAT5	472	475	PF00017	0.392
LIG_SH2_STAT5	508	511	PF00017	0.313
LIG_SH2_STAT5	85	88	PF00017	0.382
LIG_SH3_3	128	134	PF00018	0.279
LIG_SH3_3	408	414	PF00018	0.391
LIG_SUMO_SIM_anti_2	193	198	PF11976	0.303
LIG_SUMO_SIM_anti_2	207	215	PF11976	0.330
LIG_SUMO_SIM_par_1	176	181	PF11976	0.339
LIG_SUMO_SIM_par_1	193	198	PF11976	0.186
LIG_SUMO_SIM_par_1	207	215	PF11976	0.394
LIG_SUMO_SIM_par_1	617	623	PF11976	0.671
LIG_TYR_ITIM	69	74	PF00017	0.378
LIG_UBA3_1	1	8	PF00899	0.540
LIG_UBA3_1	460	464	PF00899	0.302
LIG_UBA3_1	467	474	PF00899	0.318
LIG_WRC_WIRS_1	54	59	PF05994	0.344
MOD_CK1_1	137	143	PF00069	0.281
MOD_CK1_1	181	187	PF00069	0.339
MOD_CK1_1	21	27	PF00069	0.557
MOD_CK1_1	217	223	PF00069	0.424
MOD_CK1_1	45	51	PF00069	0.418
MOD_CK1_1	455	461	PF00069	0.383
MOD_CK1_1	466	472	PF00069	0.381
MOD_CK1_1	498	504	PF00069	0.396
MOD_CK1_1	58	64	PF00069	0.254
MOD_CK2_1	122	128	PF00069	0.405
MOD_CK2_1	253	259	PF00069	0.406
MOD_CK2_1	366	372	PF00069	0.403
MOD_CK2_1	416	422	PF00069	0.419
MOD_CK2_1	498	504	PF00069	0.432
MOD_CK2_1	614	620	PF00069	0.724
MOD_Cter_Amidation	29	32	PF01082	0.613
MOD_GlcNHglycan	188	191	PF01048	0.637
MOD_GlcNHglycan	438	441	PF01048	0.537
MOD_GlcNHglycan	44	47	PF01048	0.591
MOD_GlcNHglycan	57	60	PF01048	0.601
MOD_GlcNHglycan	596	599	PF01048	0.529
MOD_GSK3_1	137	144	PF00069	0.379
MOD_GSK3_1	186	193	PF00069	0.389
MOD_GSK3_1	205	212	PF00069	0.446
MOD_GSK3_1	269	276	PF00069	0.396
MOD_GSK3_1	361	368	PF00069	0.355
MOD_GSK3_1	37	44	PF00069	0.424
MOD_GSK3_1	412	419	PF00069	0.428
MOD_GSK3_1	448	455	PF00069	0.355
MOD_GSK3_1	45	52	PF00069	0.369
MOD_GSK3_1	495	502	PF00069	0.503
MOD_GSK3_1	521	528	PF00069	0.371
MOD_GSK3_1	58	65	PF00069	0.286
MOD_N-GLC_1	114	119	PF02516	0.599
MOD_N-GLC_1	245	250	PF02516	0.577
MOD_N-GLC_1	359	364	PF02516	0.569
MOD_NEK2_1	19	24	PF00069	0.541
MOD_NEK2_1	365	370	PF00069	0.429
MOD_NEK2_1	453	458	PF00069	0.335
MOD_NEK2_1	463	468	PF00069	0.342
MOD_NEK2_1	550	555	PF00069	0.405
MOD_NEK2_1	64	69	PF00069	0.342
MOD_NEK2_2	279	284	PF00069	0.374
MOD_PIKK_1	214	220	PF00454	0.417
MOD_PIKK_1	245	251	PF00454	0.264
MOD_PIKK_1	273	279	PF00454	0.338
MOD_PIKK_1	404	410	PF00454	0.406
MOD_PIKK_1	45	51	PF00454	0.391
MOD_PK_1	114	120	PF00069	0.395
MOD_PKA_2	137	143	PF00069	0.363
MOD_Plk_1	114	120	PF00069	0.379
MOD_Plk_1	127	133	PF00069	0.279
MOD_Plk_1	190	196	PF00069	0.313
MOD_Plk_1	245	251	PF00069	0.309
MOD_Plk_1	307	313	PF00069	0.314
MOD_Plk_1	359	365	PF00069	0.365
MOD_Plk_1	498	504	PF00069	0.390
MOD_Plk_2-3	209	215	PF00069	0.431
MOD_Plk_2-3	499	505	PF00069	0.342
MOD_Plk_4	181	187	PF00069	0.325
MOD_Plk_4	209	215	PF00069	0.429
MOD_Plk_4	361	367	PF00069	0.301
MOD_Plk_4	456	462	PF00069	0.288
MOD_Plk_4	50	56	PF00069	0.331
MOD_Plk_4	550	556	PF00069	0.327
MOD_Plk_4	614	620	PF00069	0.746
MOD_ProDKin_1	178	184	PF00069	0.393
MOD_ProDKin_1	410	416	PF00069	0.437
MOD_SUMO_rev_2	322	330	PF00179	0.335
MOD_SUMO_rev_2	477	482	PF00179	0.339
TRG_DiLeu_BaEn_1	83	88	PF01217	0.430
TRG_ENDOCYTIC_2	290	293	PF00928	0.318
TRG_ENDOCYTIC_2	71	74	PF00928	0.380
TRG_ENDOCYTIC_2	85	88	PF00928	0.314
TRG_ENDOCYTIC_2	96	99	PF00928	0.266
TRG_ER_diArg_1	154	157	PF00400	0.266

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P769	Leptomonas seymouri	49%	98%
A0A1X0NKD5	Trypanosomatidae	37%	100%
A0A3R7KSB6	Trypanosoma rangeli	37%	100%
A0A3S7WPQ4	Leishmania donovani	91%	100%
A4H4V1	Leishmania braziliensis	72%	100%
A4HT61	Leishmania infantum	91%	100%
C9ZUW2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AL18	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BDE1	Trypanosoma cruzi	37%	100%