Rhomboid-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIT0_LEIMA

TriTrypDb:

LmjF.07.0140 , LMJLV39_070006900 , LMJSD75_070006900

Length:

351

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	2
GO:0016020	membrane	2	7
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4QIT0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIT0

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	6	7
GO:0016192	vesicle-mediated transport	4	7
GO:0048193	Golgi vesicle transport	5	7
GO:0051179	localization	1	7
GO:0051234	establishment of localization	2	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	342	346	PF00656	0.650
CLV_NRD_NRD_1	218	220	PF00675	0.463
CLV_NRD_NRD_1	252	254	PF00675	0.497
CLV_NRD_NRD_1	326	328	PF00675	0.487
CLV_PCSK_KEX2_1	218	220	PF00082	0.463
CLV_PCSK_KEX2_1	252	254	PF00082	0.497
CLV_PCSK_KEX2_1	326	328	PF00082	0.487
CLV_PCSK_SKI1_1	218	222	PF00082	0.520
CLV_PCSK_SKI1_1	321	325	PF00082	0.478
CLV_PCSK_SKI1_1	50	54	PF00082	0.564
DEG_APCC_DBOX_1	167	175	PF00400	0.547
DEG_Nend_Nbox_1	1	3	PF02207	0.726
DEG_SCF_FBW7_1	276	282	PF00400	0.806
DEG_SPOP_SBC_1	297	301	PF00917	0.779
DOC_CKS1_1	276	281	PF01111	0.810
DOC_CYCLIN_yCln2_LP_2	262	265	PF00134	0.773
DOC_MAPK_FxFP_2	233	236	PF00069	0.671
DOC_MAPK_gen_1	158	166	PF00069	0.713
DOC_MAPK_RevD_3	203	219	PF00069	0.436
DOC_PP2B_LxvP_1	262	265	PF13499	0.773
DOC_PP4_FxxP_1	233	236	PF00568	0.671
DOC_PP4_FxxP_1	261	264	PF00568	0.716
DOC_USP7_MATH_1	223	227	PF00917	0.744
DOC_USP7_MATH_1	291	295	PF00917	0.723
DOC_USP7_MATH_1	335	339	PF00917	0.700
DOC_USP7_MATH_1	343	347	PF00917	0.633
DOC_USP7_MATH_1	75	79	PF00917	0.443
DOC_USP7_MATH_1	82	86	PF00917	0.587
DOC_WW_Pin1_4	254	259	PF00397	0.703
DOC_WW_Pin1_4	275	280	PF00397	0.781
LIG_14-3-3_CanoR_1	149	157	PF00244	0.686
LIG_14-3-3_CanoR_1	50	55	PF00244	0.424
LIG_Actin_WH2_2	101	117	PF00022	0.513
LIG_Actin_WH2_2	144	162	PF00022	0.615
LIG_Actin_WH2_2	227	242	PF00022	0.747
LIG_Clathr_ClatBox_1	108	112	PF01394	0.397
LIG_EH_1	287	291	PF12763	0.658
LIG_eIF4E_1	88	94	PF01652	0.356
LIG_FHA_1	104	110	PF00498	0.380
LIG_FHA_1	15	21	PF00498	0.416
LIG_FHA_1	299	305	PF00498	0.821
LIG_FHA_1	51	57	PF00498	0.385
LIG_FHA_1	68	74	PF00498	0.480
LIG_FHA_1	88	94	PF00498	0.425
LIG_FHA_1	97	103	PF00498	0.395
LIG_FHA_2	306	312	PF00498	0.774
LIG_LIR_Apic_2	231	236	PF02991	0.742
LIG_LIR_Gen_1	41	52	PF02991	0.444
LIG_LIR_Gen_1	85	94	PF02991	0.580
LIG_LIR_LC3C_4	184	187	PF02991	0.397
LIG_LIR_Nem_3	41	47	PF02991	0.472
LIG_LIR_Nem_3	85	91	PF02991	0.552
LIG_NRBOX	25	31	PF00104	0.398
LIG_Pex14_2	47	51	PF04695	0.427
LIG_RPA_C_Fungi	312	324	PF08784	0.709
LIG_SH2_STAP1	216	220	PF00017	0.631
LIG_SH2_STAP1	88	92	PF00017	0.411
LIG_SH2_STAT5	131	134	PF00017	0.362
LIG_SH3_3	283	289	PF00018	0.682
LIG_SUMO_SIM_anti_2	181	187	PF11976	0.513
LIG_SUMO_SIM_anti_2	207	213	PF11976	0.397
LIG_SUMO_SIM_anti_2	99	107	PF11976	0.415
LIG_SUMO_SIM_par_1	25	33	PF11976	0.507
LIG_SUMO_SIM_par_1	99	107	PF11976	0.431
LIG_TRAF2_1	309	312	PF00917	0.633
LIG_TRFH_1	261	265	PF08558	0.653
LIG_TRFH_1	44	48	PF08558	0.642
LIG_WRC_WIRS_1	88	93	PF05994	0.436
MOD_CK1_1	293	299	PF00069	0.706
MOD_CK1_1	333	339	PF00069	0.729
MOD_CK2_1	305	311	PF00069	0.669
MOD_CK2_1	336	342	PF00069	0.678
MOD_GlcNHglycan	151	154	PF01048	0.710
MOD_GlcNHglycan	189	192	PF01048	0.561
MOD_GlcNHglycan	225	228	PF01048	0.608
MOD_GlcNHglycan	333	336	PF01048	0.687
MOD_GlcNHglycan	338	341	PF01048	0.657
MOD_GlcNHglycan	40	43	PF01048	0.503
MOD_GlcNHglycan	77	80	PF01048	0.595
MOD_GSK3_1	275	282	PF00069	0.700
MOD_GSK3_1	291	298	PF00069	0.644
MOD_GSK3_1	30	37	PF00069	0.593
MOD_GSK3_1	331	338	PF00069	0.637
MOD_GSK3_1	343	350	PF00069	0.655
MOD_GSK3_1	83	90	PF00069	0.520
MOD_GSK3_1	92	99	PF00069	0.313
MOD_NEK2_1	1	6	PF00069	0.702
MOD_NEK2_1	204	209	PF00069	0.486
MOD_NEK2_1	210	215	PF00069	0.346
MOD_NEK2_1	28	33	PF00069	0.458
MOD_NEK2_1	281	286	PF00069	0.557
MOD_NEK2_1	56	61	PF00069	0.594
MOD_NEK2_1	92	97	PF00069	0.513
MOD_PIKK_1	2	8	PF00454	0.468
MOD_PKA_1	218	224	PF00069	0.583
MOD_PKA_2	218	224	PF00069	0.583
MOD_PKB_1	147	155	PF00069	0.592
MOD_Plk_1	34	40	PF00069	0.612
MOD_Plk_4	181	187	PF00069	0.513
MOD_Plk_4	210	216	PF00069	0.513
MOD_Plk_4	87	93	PF00069	0.473
MOD_ProDKin_1	254	260	PF00069	0.633
MOD_ProDKin_1	275	281	PF00069	0.740
TRG_DiLeu_BaEn_2	86	92	PF01217	0.513
TRG_ENDOCYTIC_2	131	134	PF00928	0.369
TRG_ENDOCYTIC_2	44	47	PF00928	0.565
TRG_ENDOCYTIC_2	88	91	PF00928	0.438
TRG_ER_diArg_1	157	160	PF00400	0.631
TRG_ER_diArg_1	218	220	PF00400	0.576
TRG_ER_diArg_1	252	254	PF00400	0.623
TRG_ER_diArg_1	315	318	PF00400	0.668
TRG_ER_diArg_1	326	328	PF00400	0.541
TRG_Pf-PMV_PEXEL_1	326	330	PF00026	0.611

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEF2	Leptomonas seymouri	37%	94%
A0A3S5H5W2	Leishmania donovani	90%	100%
A4H4V7	Leishmania braziliensis	70%	100%
A4HT54	Leishmania infantum	90%	100%
E9AL24	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%