Protein POLLEN DEFECTIVE IN GUIDANCE 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic membrane protein family, putative

Species:

Leishmania major

UniProt:

Q4QIS9_LEIMA

TriTrypDb:

LmjF.07.0150 , LMJLV39_070007000 , LMJSD75_070007000

Length:

616

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4QIS9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIS9

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	2
GO:0032507	maintenance of protein location in cell	3	2
GO:0035437	maintenance of protein localization in endoplasmic reticulum	5	2
GO:0045185	maintenance of protein location	3	2
GO:0051179	localization	1	2
GO:0051235	maintenance of location	2	2
GO:0051651	maintenance of location in cell	2	2
GO:0072595	maintenance of protein localization in organelle	4	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	123	125	PF00675	0.516
CLV_NRD_NRD_1	162	164	PF00675	0.235
CLV_NRD_NRD_1	532	534	PF00675	0.510
CLV_NRD_NRD_1	69	71	PF00675	0.522
CLV_NRD_NRD_1	79	81	PF00675	0.406
CLV_PCSK_KEX2_1	123	125	PF00082	0.531
CLV_PCSK_KEX2_1	162	164	PF00082	0.235
CLV_PCSK_KEX2_1	437	439	PF00082	0.221
CLV_PCSK_KEX2_1	532	534	PF00082	0.461
CLV_PCSK_KEX2_1	613	615	PF00082	0.542
CLV_PCSK_KEX2_1	69	71	PF00082	0.517
CLV_PCSK_PC1ET2_1	437	439	PF00082	0.278
CLV_PCSK_PC1ET2_1	613	615	PF00082	0.525
CLV_PCSK_SKI1_1	117	121	PF00082	0.631
CLV_PCSK_SKI1_1	223	227	PF00082	0.258
CLV_PCSK_SKI1_1	249	253	PF00082	0.282
CLV_PCSK_SKI1_1	365	369	PF00082	0.236
CLV_PCSK_SKI1_1	434	438	PF00082	0.291
CLV_PCSK_SKI1_1	480	484	PF00082	0.409
DEG_APCC_DBOX_1	123	131	PF00400	0.282
DEG_APCC_DBOX_1	492	500	PF00400	0.580
DEG_SCF_FBW7_1	552	559	PF00400	0.726
DEG_SPOP_SBC_1	571	575	PF00917	0.648
DOC_CDC14_PxL_1	397	405	PF14671	0.482
DOC_CKS1_1	243	248	PF01111	0.482
DOC_CKS1_1	424	429	PF01111	0.482
DOC_CKS1_1	553	558	PF01111	0.648
DOC_CYCLIN_RxL_1	244	255	PF00134	0.514
DOC_CYCLIN_yCln2_LP_2	112	118	PF00134	0.390
DOC_MAPK_gen_1	162	169	PF00069	0.435
DOC_MAPK_MEF2A_6	128	135	PF00069	0.224
DOC_MAPK_MEF2A_6	162	171	PF00069	0.421
DOC_MAPK_MEF2A_6	591	599	PF00069	0.593
DOC_MAPK_MEF2A_6	85	93	PF00069	0.478
DOC_MAPK_NFAT4_5	128	136	PF00069	0.282
DOC_PP2B_LxvP_1	112	115	PF13499	0.279
DOC_USP7_MATH_1	407	411	PF00917	0.421
DOC_USP7_MATH_1	51	55	PF00917	0.701
DOC_USP7_MATH_1	510	514	PF00917	0.759
DOC_USP7_MATH_1	560	564	PF00917	0.590
DOC_USP7_MATH_1	571	575	PF00917	0.676
DOC_USP7_MATH_1	58	62	PF00917	0.649
DOC_WW_Pin1_4	216	221	PF00397	0.550
DOC_WW_Pin1_4	242	247	PF00397	0.482
DOC_WW_Pin1_4	306	311	PF00397	0.282
DOC_WW_Pin1_4	423	428	PF00397	0.478
DOC_WW_Pin1_4	499	504	PF00397	0.637
DOC_WW_Pin1_4	548	553	PF00397	0.653
DOC_WW_Pin1_4	556	561	PF00397	0.681
DOC_WW_Pin1_4	590	595	PF00397	0.560
DOC_WW_Pin1_4	60	65	PF00397	0.783
LIG_14-3-3_CanoR_1	162	167	PF00244	0.458
LIG_14-3-3_CanoR_1	342	348	PF00244	0.282
LIG_14-3-3_CanoR_1	381	389	PF00244	0.453
LIG_14-3-3_CanoR_1	493	497	PF00244	0.611
LIG_14-3-3_CanoR_1	532	538	PF00244	0.685
LIG_14-3-3_CanoR_1	9	14	PF00244	0.586
LIG_Actin_WH2_2	112	130	PF00022	0.451
LIG_Actin_WH2_2	285	303	PF00022	0.314
LIG_DLG_GKlike_1	533	541	PF00625	0.628
LIG_EH1_1	106	114	PF00400	0.345
LIG_eIF4E_1	327	333	PF01652	0.362
LIG_eIF4E_1	383	389	PF01652	0.514
LIG_EVH1_2	376	380	PF00568	0.445
LIG_FHA_1	10	16	PF00498	0.626
LIG_FHA_1	130	136	PF00498	0.374
LIG_FHA_1	148	154	PF00498	0.185
LIG_FHA_1	162	168	PF00498	0.436
LIG_FHA_1	274	280	PF00498	0.243
LIG_FHA_1	496	502	PF00498	0.601
LIG_FHA_1	536	542	PF00498	0.752
LIG_FHA_1	591	597	PF00498	0.544
LIG_FHA_2	414	420	PF00498	0.538
LIG_GBD_Chelix_1	328	336	PF00786	0.371
LIG_HCF-1_HBM_1	73	76	PF13415	0.572
LIG_LIR_Apic_2	395	401	PF02991	0.434
LIG_LIR_Gen_1	151	161	PF02991	0.459
LIG_LIR_Gen_1	164	173	PF02991	0.413
LIG_LIR_Gen_1	192	203	PF02991	0.482
LIG_LIR_Gen_1	341	351	PF02991	0.243
LIG_LIR_Gen_1	38	48	PF02991	0.641
LIG_LIR_Gen_1	505	514	PF02991	0.563
LIG_LIR_Gen_1	73	83	PF02991	0.580
LIG_LIR_Gen_1	88	98	PF02991	0.468
LIG_LIR_LC3C_4	498	501	PF02991	0.551
LIG_LIR_Nem_3	151	157	PF02991	0.478
LIG_LIR_Nem_3	164	169	PF02991	0.431
LIG_LIR_Nem_3	192	198	PF02991	0.514
LIG_LIR_Nem_3	2	8	PF02991	0.677
LIG_LIR_Nem_3	341	346	PF02991	0.235
LIG_LIR_Nem_3	350	355	PF02991	0.279
LIG_LIR_Nem_3	378	383	PF02991	0.451
LIG_LIR_Nem_3	505	509	PF02991	0.633
LIG_LIR_Nem_3	73	79	PF02991	0.590
LIG_LIR_Nem_3	94	99	PF02991	0.333
LIG_MYND_3	400	404	PF01753	0.482
LIG_NRBOX	107	113	PF00104	0.281
LIG_NRBOX	267	273	PF00104	0.345
LIG_NRBOX	287	293	PF00104	0.125
LIG_NRBOX	331	337	PF00104	0.229
LIG_NRBOX	595	601	PF00104	0.518
LIG_Pex14_2	368	372	PF04695	0.421
LIG_Rb_LxCxE_1	350	362	PF01857	0.345
LIG_SH2_CRK	154	158	PF00017	0.460
LIG_SH2_CRK	383	387	PF00017	0.435
LIG_SH2_CRK	446	450	PF00017	0.304
LIG_SH2_CRK	76	80	PF00017	0.604
LIG_SH2_GRB2like	238	241	PF00017	0.371
LIG_SH2_NCK_1	195	199	PF00017	0.482
LIG_SH2_SRC	156	159	PF00017	0.435
LIG_SH2_SRC	238	241	PF00017	0.371
LIG_SH2_STAP1	154	158	PF00017	0.426
LIG_SH2_STAP1	37	41	PF00017	0.627
LIG_SH2_STAP1	383	387	PF00017	0.490
LIG_SH2_STAP1	446	450	PF00017	0.307
LIG_SH2_STAT5	156	159	PF00017	0.503
LIG_SH2_STAT5	327	330	PF00017	0.344
LIG_SH2_STAT5	460	463	PF00017	0.282
LIG_SH2_STAT5	96	99	PF00017	0.329
LIG_SH3_3	497	503	PF00018	0.620
LIG_SH3_3	512	518	PF00018	0.723
LIG_SUMO_SIM_anti_2	12	17	PF11976	0.632
LIG_SUMO_SIM_anti_2	129	135	PF11976	0.357
LIG_SUMO_SIM_anti_2	189	195	PF11976	0.453
LIG_SUMO_SIM_anti_2	267	272	PF11976	0.390
LIG_SUMO_SIM_anti_2	287	293	PF11976	0.125
LIG_SUMO_SIM_anti_2	384	390	PF11976	0.453
LIG_SUMO_SIM_anti_2	402	408	PF11976	0.453
LIG_SUMO_SIM_par_1	131	137	PF11976	0.317
LIG_SUMO_SIM_par_1	168	174	PF11976	0.439
LIG_SUMO_SIM_par_1	387	392	PF11976	0.522
LIG_SUMO_SIM_par_1	497	502	PF11976	0.546
LIG_TYR_ITIM	193	198	PF00017	0.482
LIG_TYR_ITIM	444	449	PF00017	0.279
LIG_UBA3_1	111	117	PF00899	0.290
LIG_UBA3_1	172	181	PF00899	0.482
LIG_UBA3_1	471	480	PF00899	0.404
LIG_UBA3_1	595	601	PF00899	0.547
LIG_WRC_WIRS_1	183	188	PF05994	0.408
MOD_CDK_SPK_2	552	557	PF00069	0.724
MOD_CDK_SPxxK_3	216	223	PF00069	0.464
MOD_CDK_SPxxK_3	242	249	PF00069	0.482
MOD_CK1_1	184	190	PF00069	0.422
MOD_CK1_1	264	270	PF00069	0.305
MOD_CK1_1	312	318	PF00069	0.360
MOD_CK1_1	392	398	PF00069	0.445
MOD_CK1_1	502	508	PF00069	0.647
MOD_CK1_1	513	519	PF00069	0.690
MOD_CK1_1	527	533	PF00069	0.697
MOD_CK1_1	536	542	PF00069	0.673
MOD_CK1_1	54	60	PF00069	0.763
MOD_CK1_1	551	557	PF00069	0.715
MOD_CK1_1	564	570	PF00069	0.717
MOD_CK2_1	413	419	PF00069	0.524
MOD_CK2_1	520	526	PF00069	0.754
MOD_Cter_Amidation	67	70	PF01082	0.432
MOD_GlcNHglycan	254	257	PF01048	0.228
MOD_GlcNHglycan	407	410	PF01048	0.317
MOD_GlcNHglycan	411	414	PF01048	0.274
MOD_GlcNHglycan	43	46	PF01048	0.495
MOD_GlcNHglycan	512	515	PF01048	0.497
MOD_GlcNHglycan	526	529	PF01048	0.561
MOD_GlcNHglycan	53	56	PF01048	0.581
MOD_GlcNHglycan	533	536	PF01048	0.433
MOD_GlcNHglycan	569	572	PF01048	0.432
MOD_GlcNHglycan	580	583	PF01048	0.433
MOD_GlcNHglycan	60	63	PF01048	0.447
MOD_GSK3_1	148	155	PF00069	0.281
MOD_GSK3_1	260	267	PF00069	0.323
MOD_GSK3_1	295	302	PF00069	0.273
MOD_GSK3_1	405	412	PF00069	0.519
MOD_GSK3_1	495	502	PF00069	0.592
MOD_GSK3_1	520	527	PF00069	0.761
MOD_GSK3_1	531	538	PF00069	0.727
MOD_GSK3_1	54	61	PF00069	0.729
MOD_GSK3_1	548	555	PF00069	0.657
MOD_GSK3_1	556	563	PF00069	0.677
MOD_GSK3_1	567	574	PF00069	0.727
MOD_N-GLC_1	295	300	PF02516	0.419
MOD_NEK2_1	134	139	PF00069	0.375
MOD_NEK2_1	148	153	PF00069	0.242
MOD_NEK2_1	171	176	PF00069	0.566
MOD_NEK2_1	252	257	PF00069	0.316
MOD_NEK2_1	41	46	PF00069	0.641
MOD_NEK2_1	481	486	PF00069	0.306
MOD_NEK2_1	537	542	PF00069	0.717
MOD_NEK2_1	97	102	PF00069	0.283
MOD_NEK2_2	492	497	PF00069	0.534
MOD_NEK2_2	75	80	PF00069	0.531
MOD_OFUCOSY	260	265	PF10250	0.345
MOD_PIKK_1	117	123	PF00454	0.348
MOD_PIKK_1	148	154	PF00454	0.339
MOD_PIKK_1	184	190	PF00454	0.453
MOD_PIKK_1	25	31	PF00454	0.696
MOD_PIKK_1	381	387	PF00454	0.453
MOD_PIKK_1	527	533	PF00454	0.665
MOD_PKA_1	162	168	PF00069	0.435
MOD_PKA_2	161	167	PF00069	0.435
MOD_PKA_2	341	347	PF00069	0.282
MOD_PKA_2	492	498	PF00069	0.612
MOD_PKA_2	531	537	PF00069	0.740
MOD_PKA_2	564	570	PF00069	0.591
MOD_Plk_4	139	145	PF00069	0.282
MOD_Plk_4	152	158	PF00069	0.413
MOD_Plk_4	162	168	PF00069	0.494
MOD_Plk_4	266	272	PF00069	0.288
MOD_Plk_4	284	290	PF00069	0.211
MOD_Plk_4	299	305	PF00069	0.192
MOD_Plk_4	375	381	PF00069	0.439
MOD_Plk_4	392	398	PF00069	0.410
MOD_Plk_4	482	488	PF00069	0.364
MOD_Plk_4	585	591	PF00069	0.513
MOD_ProDKin_1	216	222	PF00069	0.550
MOD_ProDKin_1	242	248	PF00069	0.482
MOD_ProDKin_1	306	312	PF00069	0.282
MOD_ProDKin_1	423	429	PF00069	0.478
MOD_ProDKin_1	499	505	PF00069	0.647
MOD_ProDKin_1	548	554	PF00069	0.655
MOD_ProDKin_1	556	562	PF00069	0.680
MOD_ProDKin_1	590	596	PF00069	0.556
MOD_ProDKin_1	60	66	PF00069	0.779
MOD_SUMO_rev_2	28	36	PF00179	0.612
TRG_DiLeu_BaEn_1	284	289	PF01217	0.235
TRG_DiLeu_BaEn_1	420	425	PF01217	0.482
TRG_DiLeu_BaLyEn_6	591	596	PF01217	0.560
TRG_ENDOCYTIC_2	154	157	PF00928	0.462
TRG_ENDOCYTIC_2	158	161	PF00928	0.478
TRG_ENDOCYTIC_2	195	198	PF00928	0.482
TRG_ENDOCYTIC_2	327	330	PF00928	0.360
TRG_ENDOCYTIC_2	37	40	PF00928	0.627
TRG_ENDOCYTIC_2	383	386	PF00928	0.423
TRG_ENDOCYTIC_2	446	449	PF00928	0.264
TRG_ENDOCYTIC_2	76	79	PF00928	0.606
TRG_ENDOCYTIC_2	96	99	PF00928	0.125
TRG_ER_diArg_1	122	124	PF00400	0.375
TRG_ER_diArg_1	161	163	PF00400	0.435
TRG_ER_diArg_1	69	72	PF00400	0.730
TRG_ER_diLys_1	611	616	PF00400	0.681

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JBJ3	Bodo saltans	34%	100%
A0A1X0NLV9	Trypanosomatidae	38%	100%
A0A3S7WPS5	Leishmania donovani	93%	100%
A0A422NTF0	Trypanosoma rangeli	42%	100%
A4H4V9	Leishmania braziliensis	79%	100%
A4HT53	Leishmania infantum	93%	100%
C9ZUV5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	98%
E9AL25	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4VBD2	Mus musculus	26%	100%
Q5ZLG8	Gallus gallus	25%	100%
Q6NXT6	Homo sapiens	25%	100%
V5D9E0	Trypanosoma cruzi	36%	100%