Protein POLLEN DEFECTIVE IN GUIDANCE 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic membrane protein family, putative

Species:

Leishmania major

UniProt:

Q4QIS9_LEIMA

TriTrypDb:

LmjF.07.0150 , LMJLV39_070007000 , LMJSD75_070007000

Length:

616

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

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Expansion

Sequence features

Q4QIS9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIS9

Function

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Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	2
GO:0032507	maintenance of protein location in cell	3	2
GO:0035437	maintenance of protein localization in endoplasmic reticulum	5	2
GO:0045185	maintenance of protein location	3	2
GO:0051179	localization	1	2
GO:0051235	maintenance of location	2	2
GO:0051651	maintenance of location in cell	2	2
GO:0072595	maintenance of protein localization in organelle	4	2

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	123	125	PF00675	0.516
CLV_NRD_NRD_1	162	164	PF00675	0.235
CLV_NRD_NRD_1	532	534	PF00675	0.510
CLV_NRD_NRD_1	69	71	PF00675	0.522
CLV_NRD_NRD_1	79	81	PF00675	0.406
CLV_PCSK_KEX2_1	123	125	PF00082	0.531
CLV_PCSK_KEX2_1	162	164	PF00082	0.235
CLV_PCSK_KEX2_1	437	439	PF00082	0.221
CLV_PCSK_KEX2_1	532	534	PF00082	0.461
CLV_PCSK_KEX2_1	613	615	PF00082	0.542

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JBJ3	Bodo saltans	34%	100%
A0A1X0NLV9	Trypanosomatidae	38%	100%
A0A3S7WPS5	Leishmania donovani	93%	100%
A0A422NTF0	Trypanosoma rangeli	42%	100%
A4H4V9	Leishmania braziliensis	79%	100%
A4HT53	Leishmania infantum	93%	100%
C9ZUV5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	98%
E9AL25	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4VBD2	Mus musculus	26%	100%
Q5ZLG8	Gallus gallus	25%	100%

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