Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Serine/threonine-protein kinase NEK14, putative

Species:

Leishmania major

UniProt:

Q4QIS8_LEIMA

TriTrypDb:

LmjF.07.0160 , LMJLV39_140022000 , LMJSD75_140021700

Length:

847

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QIS8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIS8

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016310	phosphorylation	5	6
GO:0019538	protein metabolic process	3	6
GO:0036211	protein modification process	4	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004672	protein kinase activity	3	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140096	catalytic activity, acting on a protein	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	325	327	PF00675	0.794
CLV_NRD_NRD_1	483	485	PF00675	0.757
CLV_NRD_NRD_1	489	491	PF00675	0.660
CLV_NRD_NRD_1	535	537	PF00675	0.646
CLV_NRD_NRD_1	652	654	PF00675	0.625
CLV_NRD_NRD_1	678	680	PF00675	0.709
CLV_NRD_NRD_1	815	817	PF00675	0.615
CLV_NRD_NRD_1	820	822	PF00675	0.655
CLV_PCSK_FUR_1	792	796	PF00082	0.591
CLV_PCSK_KEX2_1	327	329	PF00082	0.617
CLV_PCSK_KEX2_1	34	36	PF00082	0.452
CLV_PCSK_KEX2_1	483	485	PF00082	0.741
CLV_PCSK_KEX2_1	535	537	PF00082	0.646
CLV_PCSK_KEX2_1	565	567	PF00082	0.692
CLV_PCSK_KEX2_1	652	654	PF00082	0.625
CLV_PCSK_KEX2_1	677	679	PF00082	0.704
CLV_PCSK_KEX2_1	794	796	PF00082	0.625
CLV_PCSK_KEX2_1	817	819	PF00082	0.664
CLV_PCSK_PC1ET2_1	327	329	PF00082	0.617
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.523
CLV_PCSK_PC1ET2_1	565	567	PF00082	0.692
CLV_PCSK_PC1ET2_1	794	796	PF00082	0.560
CLV_PCSK_PC1ET2_1	817	819	PF00082	0.612
CLV_PCSK_SKI1_1	123	127	PF00082	0.523
CLV_PCSK_SKI1_1	246	250	PF00082	0.394
CLV_PCSK_SKI1_1	253	257	PF00082	0.425
CLV_PCSK_SKI1_1	328	332	PF00082	0.611
CLV_PCSK_SKI1_1	449	453	PF00082	0.588
CLV_PCSK_SKI1_1	565	569	PF00082	0.698
CLV_PCSK_SKI1_1	598	602	PF00082	0.692
CLV_PCSK_SKI1_1	644	648	PF00082	0.661
DEG_SCF_FBW7_1	337	344	PF00400	0.632
DEG_SCF_FBW7_1	369	374	PF00400	0.718
DEG_SPOP_SBC_1	347	351	PF00917	0.629
DEG_SPOP_SBC_1	381	385	PF00917	0.530
DOC_CKS1_1	338	343	PF01111	0.635
DOC_CKS1_1	696	701	PF01111	0.717
DOC_CKS1_1	709	714	PF01111	0.585
DOC_CYCLIN_yCln2_LP_2	195	201	PF00134	0.394
DOC_MAPK_gen_1	123	132	PF00069	0.523
DOC_MAPK_gen_1	51	60	PF00069	0.394
DOC_MAPK_gen_1	771	778	PF00069	0.639
DOC_MAPK_gen_1	816	828	PF00069	0.629
DOC_MAPK_MEF2A_6	423	430	PF00069	0.576
DOC_MAPK_MEF2A_6	463	472	PF00069	0.645
DOC_MAPK_MEF2A_6	594	603	PF00069	0.627
DOC_MAPK_MEF2A_6	821	830	PF00069	0.656
DOC_PP2B_LxvP_1	462	465	PF13499	0.663
DOC_PP2B_LxvP_1	540	543	PF13499	0.639
DOC_PP2B_LxvP_1	601	604	PF13499	0.633
DOC_PP4_FxxP_1	199	202	PF00568	0.394
DOC_PP4_FxxP_1	477	480	PF00568	0.624
DOC_PP4_FxxP_1	685	688	PF00568	0.651
DOC_PP4_MxPP_1	697	700	PF00568	0.660
DOC_USP7_MATH_1	276	280	PF00917	0.789
DOC_USP7_MATH_1	313	317	PF00917	0.671
DOC_USP7_MATH_1	339	343	PF00917	0.745
DOC_USP7_MATH_1	358	362	PF00917	0.598
DOC_USP7_MATH_1	394	398	PF00917	0.779
DOC_USP7_MATH_1	748	752	PF00917	0.703
DOC_USP7_UBL2_3	552	556	PF12436	0.710
DOC_USP7_UBL2_3	594	598	PF12436	0.652
DOC_USP7_UBL2_3	602	606	PF12436	0.601
DOC_WW_Pin1_4	159	164	PF00397	0.523
DOC_WW_Pin1_4	214	219	PF00397	0.394
DOC_WW_Pin1_4	263	268	PF00397	0.714
DOC_WW_Pin1_4	287	292	PF00397	0.720
DOC_WW_Pin1_4	299	304	PF00397	0.570
DOC_WW_Pin1_4	320	325	PF00397	0.741
DOC_WW_Pin1_4	337	342	PF00397	0.565
DOC_WW_Pin1_4	367	372	PF00397	0.719
DOC_WW_Pin1_4	395	400	PF00397	0.723
DOC_WW_Pin1_4	406	411	PF00397	0.792
DOC_WW_Pin1_4	422	427	PF00397	0.565
DOC_WW_Pin1_4	452	457	PF00397	0.735
DOC_WW_Pin1_4	512	517	PF00397	0.638
DOC_WW_Pin1_4	581	586	PF00397	0.844
DOC_WW_Pin1_4	677	682	PF00397	0.781
DOC_WW_Pin1_4	684	689	PF00397	0.691
DOC_WW_Pin1_4	695	700	PF00397	0.697
DOC_WW_Pin1_4	708	713	PF00397	0.568
DOC_WW_Pin1_4	729	734	PF00397	0.665
DOC_WW_Pin1_4	836	841	PF00397	0.548
DOC_WW_Pin1_4	92	97	PF00397	0.368
LIG_14-3-3_CanoR_1	242	249	PF00244	0.394
LIG_14-3-3_CanoR_1	287	291	PF00244	0.650
LIG_14-3-3_CanoR_1	328	337	PF00244	0.568
LIG_14-3-3_CanoR_1	393	399	PF00244	0.664
LIG_14-3-3_CanoR_1	525	532	PF00244	0.667
LIG_14-3-3_CanoR_1	703	712	PF00244	0.663
LIG_14-3-3_CanoR_1	736	741	PF00244	0.734
LIG_14-3-3_CanoR_1	754	759	PF00244	0.587
LIG_14-3-3_CanoR_1	773	779	PF00244	0.569
LIG_14-3-3_CanoR_1	94	104	PF00244	0.342
LIG_BIR_III_2	613	617	PF00653	0.648
LIG_BRCT_BRCA1_1	758	762	PF00533	0.660
LIG_CtBP_PxDLS_1	500	504	PF00389	0.538
LIG_deltaCOP1_diTrp_1	181	189	PF00928	0.394
LIG_FHA_1	134	140	PF00498	0.422
LIG_FHA_1	150	156	PF00498	0.238
LIG_FHA_1	38	44	PF00498	0.394
LIG_FHA_1	398	404	PF00498	0.569
LIG_FHA_1	527	533	PF00498	0.631
LIG_FHA_1	549	555	PF00498	0.772
LIG_FHA_1	96	102	PF00498	0.394
LIG_FHA_2	338	344	PF00498	0.663
LIG_FHA_2	349	355	PF00498	0.567
LIG_Integrin_isoDGR_2	763	765	PF01839	0.714
LIG_LIR_Apic_2	162	168	PF02991	0.523
LIG_LIR_Apic_2	474	480	PF02991	0.622
LIG_LIR_Apic_2	683	688	PF02991	0.656
LIG_LIR_Gen_1	203	211	PF02991	0.394
LIG_LIR_Gen_1	4	12	PF02991	0.514
LIG_LIR_Gen_1	69	76	PF02991	0.394
LIG_LIR_Nem_3	203	207	PF02991	0.394
LIG_LIR_Nem_3	212	216	PF02991	0.306
LIG_LIR_Nem_3	4	9	PF02991	0.622
LIG_LIR_Nem_3	83	89	PF02991	0.458
LIG_MAD2	552	560	PF02301	0.689
LIG_PALB2_WD40_1	100	108	PF16756	0.523
LIG_Pex14_2	60	64	PF04695	0.394
LIG_SH2_CRK	6	10	PF00017	0.498
LIG_SH2_NCK_1	190	194	PF00017	0.394
LIG_SH2_STAP1	178	182	PF00017	0.438
LIG_SH2_STAP1	190	194	PF00017	0.399
LIG_SH2_STAT3	634	637	PF00017	0.581
LIG_SH2_STAT3	740	743	PF00017	0.693
LIG_SH2_STAT3	88	91	PF00017	0.394
LIG_SH2_STAT5	114	117	PF00017	0.400
LIG_SH2_STAT5	140	143	PF00017	0.394
LIG_SH2_STAT5	6	9	PF00017	0.494
LIG_SH2_STAT5	634	637	PF00017	0.633
LIG_SH2_STAT5	740	743	PF00017	0.615
LIG_SH2_STAT5	838	841	PF00017	0.548
LIG_SH2_STAT5	88	91	PF00017	0.478
LIG_SH3_1	300	306	PF00018	0.651
LIG_SH3_3	157	163	PF00018	0.368
LIG_SH3_3	233	239	PF00018	0.347
LIG_SH3_3	266	272	PF00018	0.735
LIG_SH3_3	300	306	PF00018	0.768
LIG_SH3_3	307	313	PF00018	0.689
LIG_SH3_3	333	339	PF00018	0.658
LIG_SH3_3	349	355	PF00018	0.532
LIG_SH3_3	396	402	PF00018	0.750
LIG_SH3_3	409	415	PF00018	0.709
LIG_SH3_3	432	438	PF00018	0.614
LIG_SH3_3	450	456	PF00018	0.501
LIG_SH3_3	507	513	PF00018	0.618
LIG_SH3_3	575	581	PF00018	0.763
LIG_SH3_3	601	607	PF00018	0.645
LIG_SH3_3	685	691	PF00018	0.696
LIG_SH3_3	693	699	PF00018	0.738
LIG_SH3_3	707	713	PF00018	0.726
LIG_SH3_3	741	747	PF00018	0.643
LIG_SH3_4	598	605	PF00018	0.684
LIG_Sin3_3	427	434	PF02671	0.632
LIG_SUMO_SIM_par_1	233	238	PF11976	0.394
LIG_SUMO_SIM_par_1	353	362	PF11976	0.656
LIG_TRAF2_1	777	780	PF00917	0.606
LIG_WRC_WIRS_1	61	66	PF05994	0.394
LIG_WW_3	284	288	PF00397	0.643
LIG_WW_3	323	327	PF00397	0.666
LIG_WW_3	576	580	PF00397	0.654
LIG_WW_3	698	702	PF00397	0.758
MOD_CDC14_SPxK_1	268	271	PF00782	0.647
MOD_CDC14_SPxK_1	584	587	PF00782	0.716
MOD_CDK_SPxK_1	265	271	PF00069	0.619
MOD_CDK_SPxK_1	320	326	PF00069	0.663
MOD_CDK_SPxK_1	581	587	PF00069	0.721
MOD_CDK_SPxK_1	695	701	PF00069	0.716
MOD_CDK_SPxxK_3	320	327	PF00069	0.666
MOD_CDK_SPxxK_3	677	684	PF00069	0.655
MOD_CDK_SPxxK_3	729	736	PF00069	0.655
MOD_CK1_1	133	139	PF00069	0.394
MOD_CK1_1	146	152	PF00069	0.267
MOD_CK1_1	153	159	PF00069	0.440
MOD_CK1_1	177	183	PF00069	0.368
MOD_CK1_1	200	206	PF00069	0.394
MOD_CK1_1	277	283	PF00069	0.658
MOD_CK1_1	316	322	PF00069	0.675
MOD_CK1_1	342	348	PF00069	0.771
MOD_CK1_1	350	356	PF00069	0.724
MOD_CK1_1	374	380	PF00069	0.747
MOD_CK1_1	397	403	PF00069	0.725
MOD_CK1_1	422	428	PF00069	0.560
MOD_CK1_1	515	521	PF00069	0.650
MOD_CK1_1	528	534	PF00069	0.587
MOD_CK1_1	544	550	PF00069	0.687
MOD_CK1_1	662	668	PF00069	0.515
MOD_CK1_1	680	686	PF00069	0.747
MOD_CK1_1	75	81	PF00069	0.394
MOD_CK1_1	753	759	PF00069	0.723
MOD_CK1_1	92	98	PF00069	0.229
MOD_CK2_1	287	293	PF00069	0.687
MOD_CK2_1	774	780	PF00069	0.698
MOD_GlcNHglycan	145	148	PF01048	0.394
MOD_GlcNHglycan	199	202	PF01048	0.394
MOD_GlcNHglycan	279	282	PF01048	0.758
MOD_GlcNHglycan	318	321	PF01048	0.672
MOD_GlcNHglycan	376	379	PF01048	0.672
MOD_GlcNHglycan	547	550	PF01048	0.670
MOD_GlcNHglycan	661	664	PF01048	0.649
MOD_GlcNHglycan	673	676	PF01048	0.693
MOD_GlcNHglycan	715	718	PF01048	0.747
MOD_GlcNHglycan	77	80	PF01048	0.394
MOD_GlcNHglycan	806	809	PF01048	0.537
MOD_GSK3_1	146	153	PF00069	0.426
MOD_GSK3_1	155	162	PF00069	0.394
MOD_GSK3_1	177	184	PF00069	0.368
MOD_GSK3_1	226	233	PF00069	0.452
MOD_GSK3_1	276	283	PF00069	0.772
MOD_GSK3_1	304	311	PF00069	0.787
MOD_GSK3_1	312	319	PF00069	0.739
MOD_GSK3_1	337	344	PF00069	0.736
MOD_GSK3_1	346	353	PF00069	0.643
MOD_GSK3_1	367	374	PF00069	0.742
MOD_GSK3_1	394	401	PF00069	0.813
MOD_GSK3_1	404	411	PF00069	0.632
MOD_GSK3_1	471	478	PF00069	0.690
MOD_GSK3_1	511	518	PF00069	0.755
MOD_GSK3_1	526	533	PF00069	0.533
MOD_GSK3_1	541	548	PF00069	0.640
MOD_GSK3_1	680	687	PF00069	0.658
MOD_GSK3_1	750	757	PF00069	0.667
MOD_N-GLC_1	153	158	PF02516	0.394
MOD_N-GLC_1	46	51	PF02516	0.394
MOD_N-GLC_1	66	71	PF02516	0.199
MOD_NEK2_1	12	17	PF00069	0.539
MOD_NEK2_1	150	155	PF00069	0.394
MOD_NEK2_1	171	176	PF00069	0.394
MOD_NEK2_1	330	335	PF00069	0.656
MOD_NEK2_1	46	51	PF00069	0.433
MOD_NEK2_1	470	475	PF00069	0.650
MOD_NEK2_1	60	65	PF00069	0.258
MOD_NEK2_1	758	763	PF00069	0.735
MOD_NEK2_1	89	94	PF00069	0.342
MOD_NEK2_2	66	71	PF00069	0.394
MOD_PIKK_1	308	314	PF00454	0.656
MOD_PIKK_1	328	334	PF00454	0.658
MOD_PIKK_1	37	43	PF00454	0.394
MOD_PIKK_1	382	388	PF00454	0.646
MOD_PIKK_1	87	93	PF00454	0.394
MOD_PK_1	506	512	PF00069	0.659
MOD_PKA_2	241	247	PF00069	0.523
MOD_PKA_2	286	292	PF00069	0.668
MOD_PKA_2	544	550	PF00069	0.669
MOD_PKA_2	586	592	PF00069	0.565
MOD_PKA_2	753	759	PF00069	0.707
MOD_PKA_2	774	780	PF00069	0.672
MOD_PKB_1	326	334	PF00069	0.608
MOD_PKB_1	504	512	PF00069	0.703
MOD_PKB_1	701	709	PF00069	0.667
MOD_Plk_1	46	52	PF00069	0.394
MOD_Plk_4	155	161	PF00069	0.394
MOD_Plk_4	230	236	PF00069	0.440
MOD_Plk_4	506	512	PF00069	0.550
MOD_Plk_4	60	66	PF00069	0.394
MOD_Plk_4	736	742	PF00069	0.616
MOD_Plk_4	839	845	PF00069	0.526
MOD_Plk_4	97	103	PF00069	0.394
MOD_ProDKin_1	159	165	PF00069	0.523
MOD_ProDKin_1	214	220	PF00069	0.394
MOD_ProDKin_1	263	269	PF00069	0.723
MOD_ProDKin_1	287	293	PF00069	0.723
MOD_ProDKin_1	299	305	PF00069	0.564
MOD_ProDKin_1	320	326	PF00069	0.738
MOD_ProDKin_1	337	343	PF00069	0.570
MOD_ProDKin_1	367	373	PF00069	0.721
MOD_ProDKin_1	395	401	PF00069	0.723
MOD_ProDKin_1	406	412	PF00069	0.789
MOD_ProDKin_1	422	428	PF00069	0.565
MOD_ProDKin_1	452	458	PF00069	0.735
MOD_ProDKin_1	512	518	PF00069	0.641
MOD_ProDKin_1	581	587	PF00069	0.845
MOD_ProDKin_1	677	683	PF00069	0.783
MOD_ProDKin_1	684	690	PF00069	0.690
MOD_ProDKin_1	695	701	PF00069	0.698
MOD_ProDKin_1	708	714	PF00069	0.568
MOD_ProDKin_1	729	735	PF00069	0.664
MOD_ProDKin_1	836	842	PF00069	0.549
MOD_ProDKin_1	92	98	PF00069	0.368
MOD_SUMO_rev_2	133	139	PF00179	0.299
MOD_SUMO_rev_2	361	365	PF00179	0.681
TRG_DiLeu_BaEn_2	518	524	PF01217	0.701
TRG_DiLeu_BaLyEn_6	352	357	PF01217	0.695
TRG_ENDOCYTIC_2	6	9	PF00928	0.624
TRG_ER_diArg_1	325	328	PF00400	0.604
TRG_ER_diArg_1	50	53	PF00400	0.394
TRG_ER_diArg_1	503	506	PF00400	0.700
TRG_ER_diArg_1	677	679	PF00400	0.629
TRG_ER_diArg_1	700	703	PF00400	0.762
TRG_ER_diArg_1	773	776	PF00400	0.763
TRG_ER_diArg_1	799	802	PF00400	0.585
TRG_NLS_MonoCore_2	815	820	PF00514	0.462
TRG_NLS_MonoExtC_3	816	821	PF00514	0.619
TRG_NLS_MonoExtN_4	324	330	PF00514	0.596
TRG_NLS_MonoExtN_4	814	821	PF00514	0.590
TRG_Pf-PMV_PEXEL_1	328	332	PF00026	0.579
TRG_Pf-PMV_PEXEL_1	525	530	PF00026	0.645
TRG_Pf-PMV_PEXEL_1	703	707	PF00026	0.762

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WPQ0	Leishmania donovani	92%	100%
A4H4W0	Leishmania braziliensis	66%	100%
A4HT34	Leishmania infantum	92%	100%
E9AL26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%