LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
Gene product:
phosphatidylglycerolphosphate synthase, mitochondrial, putative
Species:
Leishmania major
UniProt:
Q4QIS4_LEIMA
TriTrypDb:
LmjF.07.0200 , LMJLV39_070007800 * , LMJSD75_070008000 *
Length:
755

Annotations

LeishMANIAdb annotations

Overall very similar to animal mitochondrial PGS1 enzymes, with one key difference: instead a a transit signal, the Kinetoplastid variant has membrane anchor.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005739 mitochondrion 5 9
GO:0043226 organelle 2 9
GO:0043227 membrane-bounded organelle 3 9
GO:0043229 intracellular organelle 3 9
GO:0043231 intracellular membrane-bounded organelle 4 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

Q4QIS4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIS4

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 9
GO:0006644 phospholipid metabolic process 4 9
GO:0006650 glycerophospholipid metabolic process 5 9
GO:0006655 phosphatidylglycerol biosynthetic process 6 9
GO:0006793 phosphorus metabolic process 3 9
GO:0006796 phosphate-containing compound metabolic process 4 9
GO:0008152 metabolic process 1 9
GO:0008610 lipid biosynthetic process 4 9
GO:0008654 phospholipid biosynthetic process 5 9
GO:0009058 biosynthetic process 2 9
GO:0009987 cellular process 1 9
GO:0019637 organophosphate metabolic process 3 9
GO:0032048 cardiolipin metabolic process 7 9
GO:0032049 cardiolipin biosynthetic process 7 9
GO:0044237 cellular metabolic process 2 9
GO:0044238 primary metabolic process 2 9
GO:0044249 cellular biosynthetic process 3 9
GO:0044255 cellular lipid metabolic process 3 9
GO:0045017 glycerolipid biosynthetic process 4 9
GO:0046471 phosphatidylglycerol metabolic process 6 9
GO:0046474 glycerophospholipid biosynthetic process 5 9
GO:0046486 glycerolipid metabolic process 4 9
GO:0071704 organic substance metabolic process 2 9
GO:0090407 organophosphate biosynthetic process 4 9
GO:1901576 organic substance biosynthetic process 3 9
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 9
GO:0003824 catalytic activity 1 9
GO:0005488 binding 1 9
GO:0005524 ATP binding 5 9
GO:0008444 CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity 6 9
GO:0016740 transferase activity 2 9
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 9
GO:0016780 phosphotransferase activity, for other substituted phosphate groups 4 9
GO:0017076 purine nucleotide binding 4 9
GO:0017169 CDP-alcohol phosphatidyltransferase activity 5 9
GO:0030554 adenyl nucleotide binding 5 9
GO:0032553 ribonucleotide binding 3 9
GO:0032555 purine ribonucleotide binding 4 9
GO:0032559 adenyl ribonucleotide binding 5 9
GO:0035639 purine ribonucleoside triphosphate binding 4 9
GO:0036094 small molecule binding 2 9
GO:0043167 ion binding 2 9
GO:0043168 anion binding 3 9
GO:0097159 organic cyclic compound binding 2 9
GO:0097367 carbohydrate derivative binding 2 9
GO:1901265 nucleoside phosphate binding 3 9
GO:1901363 heterocyclic compound binding 2 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 648 652 PF00656 0.732
CLV_C14_Caspase3-7 704 708 PF00656 0.578
CLV_NRD_NRD_1 190 192 PF00675 0.413
CLV_NRD_NRD_1 367 369 PF00675 0.424
CLV_NRD_NRD_1 452 454 PF00675 0.442
CLV_NRD_NRD_1 491 493 PF00675 0.449
CLV_NRD_NRD_1 607 609 PF00675 0.391
CLV_NRD_NRD_1 631 633 PF00675 0.502
CLV_NRD_NRD_1 69 71 PF00675 0.497
CLV_PCSK_KEX2_1 389 391 PF00082 0.442
CLV_PCSK_KEX2_1 491 493 PF00082 0.397
CLV_PCSK_KEX2_1 607 609 PF00082 0.391
CLV_PCSK_KEX2_1 631 633 PF00082 0.493
CLV_PCSK_PC1ET2_1 389 391 PF00082 0.442
CLV_PCSK_PC7_1 385 391 PF00082 0.438
CLV_PCSK_SKI1_1 141 145 PF00082 0.333
CLV_PCSK_SKI1_1 280 284 PF00082 0.367
CLV_PCSK_SKI1_1 301 305 PF00082 0.339
CLV_PCSK_SKI1_1 349 353 PF00082 0.380
CLV_PCSK_SKI1_1 390 394 PF00082 0.447
CLV_PCSK_SKI1_1 527 531 PF00082 0.332
CLV_PCSK_SKI1_1 617 621 PF00082 0.397
CLV_PCSK_SKI1_1 86 90 PF00082 0.382
CLV_Separin_Metazoa 252 256 PF03568 0.649
DEG_APCC_DBOX_1 190 198 PF00400 0.578
DEG_APCC_DBOX_1 583 591 PF00400 0.582
DEG_APCC_DBOX_1 713 721 PF00400 0.502
DEG_SPOP_SBC_1 265 269 PF00917 0.742
DOC_CYCLIN_RxL_1 521 534 PF00134 0.559
DOC_CYCLIN_yCln2_LP_2 122 128 PF00134 0.571
DOC_MAPK_FxFP_2 507 510 PF00069 0.503
DOC_MAPK_gen_1 191 197 PF00069 0.556
DOC_MAPK_gen_1 299 306 PF00069 0.548
DOC_MAPK_gen_1 453 460 PF00069 0.567
DOC_MAPK_MEF2A_6 175 183 PF00069 0.466
DOC_MAPK_MEF2A_6 739 746 PF00069 0.611
DOC_PP1_RVXF_1 164 170 PF00149 0.580
DOC_PP1_RVXF_1 615 622 PF00149 0.564
DOC_PP2B_LxvP_1 293 296 PF13499 0.631
DOC_PP4_FxxP_1 507 510 PF00568 0.503
DOC_USP7_MATH_1 113 117 PF00917 0.573
DOC_USP7_MATH_1 139 143 PF00917 0.535
DOC_USP7_MATH_1 222 226 PF00917 0.760
DOC_USP7_MATH_1 271 275 PF00917 0.716
DOC_USP7_MATH_1 400 404 PF00917 0.723
DOC_USP7_MATH_1 411 415 PF00917 0.736
DOC_USP7_MATH_1 437 441 PF00917 0.751
DOC_USP7_MATH_1 44 48 PF00917 0.680
DOC_USP7_MATH_1 670 674 PF00917 0.574
DOC_USP7_MATH_1 681 685 PF00917 0.486
DOC_USP7_MATH_1 69 73 PF00917 0.732
DOC_USP7_MATH_2 670 676 PF00917 0.570
DOC_WW_Pin1_4 223 228 PF00397 0.716
DOC_WW_Pin1_4 383 388 PF00397 0.781
DOC_WW_Pin1_4 398 403 PF00397 0.677
DOC_WW_Pin1_4 40 45 PF00397 0.686
DOC_WW_Pin1_4 418 423 PF00397 0.759
DOC_WW_Pin1_4 432 437 PF00397 0.605
DOC_WW_Pin1_4 445 450 PF00397 0.661
DOC_WW_Pin1_4 540 545 PF00397 0.499
DOC_WW_Pin1_4 639 644 PF00397 0.748
LIG_14-3-3_CanoR_1 141 146 PF00244 0.501
LIG_14-3-3_CanoR_1 360 364 PF00244 0.552
LIG_14-3-3_CanoR_1 531 540 PF00244 0.507
LIG_14-3-3_CanoR_1 70 76 PF00244 0.686
LIG_Actin_WH2_2 592 609 PF00022 0.595
LIG_APCC_ABBA_1 19 24 PF00400 0.587
LIG_APCC_ABBAyCdc20_2 516 522 PF00400 0.521
LIG_BIR_III_4 78 82 PF00653 0.507
LIG_BRCT_BRCA1_1 155 159 PF00533 0.535
LIG_deltaCOP1_diTrp_1 500 507 PF00928 0.575
LIG_EH1_1 176 184 PF00400 0.529
LIG_FHA_1 116 122 PF00498 0.572
LIG_FHA_1 16 22 PF00498 0.334
LIG_FHA_1 178 184 PF00498 0.550
LIG_FHA_1 208 214 PF00498 0.723
LIG_FHA_1 350 356 PF00498 0.589
LIG_FHA_1 437 443 PF00498 0.746
LIG_FHA_1 558 564 PF00498 0.534
LIG_FHA_1 565 571 PF00498 0.495
LIG_FHA_2 197 203 PF00498 0.569
LIG_FHA_2 331 337 PF00498 0.546
LIG_FHA_2 532 538 PF00498 0.567
LIG_FHA_2 702 708 PF00498 0.584
LIG_LIR_Apic_2 505 510 PF02991 0.507
LIG_LIR_Gen_1 127 137 PF02991 0.499
LIG_LIR_Gen_1 18 25 PF02991 0.567
LIG_LIR_Gen_1 184 190 PF02991 0.550
LIG_LIR_Gen_1 288 297 PF02991 0.567
LIG_LIR_Gen_1 336 346 PF02991 0.508
LIG_LIR_Gen_1 502 512 PF02991 0.522
LIG_LIR_Gen_1 543 553 PF02991 0.503
LIG_LIR_Nem_3 127 132 PF02991 0.497
LIG_LIR_Nem_3 18 22 PF02991 0.351
LIG_LIR_Nem_3 288 293 PF02991 0.578
LIG_LIR_Nem_3 336 341 PF02991 0.497
LIG_LIR_Nem_3 498 504 PF02991 0.547
LIG_LIR_Nem_3 506 512 PF02991 0.460
LIG_LIR_Nem_3 593 599 PF02991 0.507
LIG_NRBOX 716 722 PF00104 0.506
LIG_OCRL_FandH_1 313 325 PF00620 0.536
LIG_PALB2_WD40_1 346 354 PF16756 0.525
LIG_PCNA_PIPBox_1 98 107 PF02747 0.531
LIG_PCNA_yPIPBox_3 337 351 PF02747 0.505
LIG_PCNA_yPIPBox_3 91 105 PF02747 0.641
LIG_PDZ_Class_3 750 755 PF00595 0.622
LIG_Pex14_1 290 294 PF04695 0.588
LIG_SH2_CRK 284 288 PF00017 0.563
LIG_SH2_CRK 338 342 PF00017 0.462
LIG_SH2_CRK 603 607 PF00017 0.587
LIG_SH2_CRK 689 693 PF00017 0.538
LIG_SH2_GRB2like 284 287 PF00017 0.561
LIG_SH2_GRB2like 545 548 PF00017 0.505
LIG_SH2_SRC 284 287 PF00017 0.561
LIG_SH2_SRC 7 10 PF00017 0.333
LIG_SH2_STAP1 504 508 PF00017 0.554
LIG_SH2_STAT5 149 152 PF00017 0.506
LIG_SH2_STAT5 330 333 PF00017 0.515
LIG_SH2_STAT5 545 548 PF00017 0.510
LIG_SH2_STAT5 562 565 PF00017 0.490
LIG_SH2_STAT5 589 592 PF00017 0.511
LIG_SH2_STAT5 598 601 PF00017 0.524
LIG_SH2_STAT5 678 681 PF00017 0.508
LIG_SH2_STAT5 7 10 PF00017 0.399
LIG_SH3_3 431 437 PF00018 0.710
LIG_SUMO_SIM_anti_2 178 184 PF11976 0.524
LIG_SUMO_SIM_anti_2 455 461 PF11976 0.536
LIG_SUMO_SIM_par_1 178 184 PF11976 0.565
LIG_SUMO_SIM_par_1 193 199 PF11976 0.605
LIG_TYR_ITIM 5 10 PF00017 0.406
LIG_TYR_ITIM 587 592 PF00017 0.534
LIG_WRC_WIRS_1 101 106 PF05994 0.521
LIG_WRC_WIRS_1 504 509 PF05994 0.552
MOD_CDC14_SPxK_1 421 424 PF00782 0.657
MOD_CDK_SPxK_1 383 389 PF00069 0.795
MOD_CDK_SPxK_1 418 424 PF00069 0.666
MOD_CDK_SPxxK_3 383 390 PF00069 0.642
MOD_CDK_SPxxK_3 639 646 PF00069 0.683
MOD_CK1_1 196 202 PF00069 0.617
MOD_CK1_1 209 215 PF00069 0.612
MOD_CK1_1 223 229 PF00069 0.743
MOD_CK1_1 231 237 PF00069 0.763
MOD_CK1_1 263 269 PF00069 0.770
MOD_CK1_1 398 404 PF00069 0.749
MOD_CK1_1 440 446 PF00069 0.734
MOD_CK1_1 469 475 PF00069 0.557
MOD_CK1_1 47 53 PF00069 0.736
MOD_CK1_1 569 575 PF00069 0.524
MOD_CK2_1 196 202 PF00069 0.591
MOD_CK2_1 411 417 PF00069 0.715
MOD_CK2_1 440 446 PF00069 0.707
MOD_CK2_1 530 536 PF00069 0.573
MOD_CK2_1 77 83 PF00069 0.633
MOD_Cter_Amidation 629 632 PF01082 0.410
MOD_DYRK1A_RPxSP_1 432 436 PF00069 0.729
MOD_GlcNHglycan 145 148 PF01048 0.306
MOD_GlcNHglycan 222 225 PF01048 0.567
MOD_GlcNHglycan 263 266 PF01048 0.577
MOD_GlcNHglycan 397 400 PF01048 0.522
MOD_GlcNHglycan 413 416 PF01048 0.416
MOD_GlcNHglycan 46 49 PF01048 0.497
MOD_GlcNHglycan 674 677 PF01048 0.346
MOD_GlcNHglycan 78 82 PF01048 0.463
MOD_GSK3_1 139 146 PF00069 0.528
MOD_GSK3_1 222 229 PF00069 0.809
MOD_GSK3_1 230 237 PF00069 0.769
MOD_GSK3_1 256 263 PF00069 0.804
MOD_GSK3_1 394 401 PF00069 0.739
MOD_GSK3_1 40 47 PF00069 0.690
MOD_GSK3_1 407 414 PF00069 0.709
MOD_GSK3_1 428 435 PF00069 0.757
MOD_GSK3_1 436 443 PF00069 0.675
MOD_GSK3_1 495 502 PF00069 0.516
MOD_GSK3_1 721 728 PF00069 0.530
MOD_LATS_1 610 616 PF00433 0.522
MOD_N-GLC_1 256 261 PF02516 0.448
MOD_N-GLC_1 324 329 PF02516 0.284
MOD_N-GLC_1 411 416 PF02516 0.545
MOD_NEK2_1 177 182 PF00069 0.564
MOD_NEK2_1 235 240 PF00069 0.811
MOD_NEK2_1 354 359 PF00069 0.540
MOD_NEK2_1 393 398 PF00069 0.734
MOD_NEK2_1 530 535 PF00069 0.553
MOD_NEK2_1 548 553 PF00069 0.453
MOD_NEK2_1 557 562 PF00069 0.539
MOD_NEK2_1 592 597 PF00069 0.539
MOD_NEK2_1 701 706 PF00069 0.505
MOD_NEK2_1 709 714 PF00069 0.507
MOD_NEK2_1 721 726 PF00069 0.412
MOD_NEK2_1 732 737 PF00069 0.664
MOD_NEK2_2 688 693 PF00069 0.511
MOD_PIKK_1 349 355 PF00454 0.543
MOD_PIKK_1 440 446 PF00454 0.744
MOD_PK_1 175 181 PF00069 0.462
MOD_PK_1 612 618 PF00069 0.580
MOD_PKA_2 316 322 PF00069 0.536
MOD_PKA_2 359 365 PF00069 0.542
MOD_PKA_2 452 458 PF00069 0.594
MOD_PKA_2 530 536 PF00069 0.573
MOD_PKA_2 69 75 PF00069 0.690
MOD_PKA_2 709 715 PF00069 0.573
MOD_Plk_1 499 505 PF00069 0.542
MOD_Plk_1 592 598 PF00069 0.543
MOD_Plk_1 612 618 PF00069 0.580
MOD_Plk_4 196 202 PF00069 0.591
MOD_Plk_4 236 242 PF00069 0.755
MOD_Plk_4 316 322 PF00069 0.496
MOD_Plk_4 437 443 PF00069 0.756
MOD_Plk_4 503 509 PF00069 0.492
MOD_Plk_4 520 526 PF00069 0.488
MOD_Plk_4 548 554 PF00069 0.571
MOD_Plk_4 558 564 PF00069 0.571
MOD_Plk_4 84 90 PF00069 0.564
MOD_ProDKin_1 223 229 PF00069 0.717
MOD_ProDKin_1 383 389 PF00069 0.781
MOD_ProDKin_1 398 404 PF00069 0.677
MOD_ProDKin_1 40 46 PF00069 0.690
MOD_ProDKin_1 418 424 PF00069 0.759
MOD_ProDKin_1 432 438 PF00069 0.608
MOD_ProDKin_1 445 451 PF00069 0.655
MOD_ProDKin_1 540 546 PF00069 0.501
MOD_ProDKin_1 639 645 PF00069 0.751
MOD_SUMO_rev_2 127 134 PF00179 0.463
MOD_SUMO_rev_2 184 194 PF00179 0.603
TRG_DiLeu_BaEn_1 716 721 PF01217 0.499
TRG_DiLeu_BaEn_2 535 541 PF01217 0.560
TRG_DiLeu_BaEn_2 696 702 PF01217 0.496
TRG_DiLeu_BaEn_2 99 105 PF01217 0.528
TRG_ENDOCYTIC_2 129 132 PF00928 0.535
TRG_ENDOCYTIC_2 185 188 PF00928 0.546
TRG_ENDOCYTIC_2 338 341 PF00928 0.486
TRG_ENDOCYTIC_2 504 507 PF00928 0.556
TRG_ENDOCYTIC_2 545 548 PF00928 0.515
TRG_ENDOCYTIC_2 589 592 PF00928 0.508
TRG_ENDOCYTIC_2 597 600 PF00928 0.509
TRG_ENDOCYTIC_2 603 606 PF00928 0.522
TRG_ENDOCYTIC_2 689 692 PF00928 0.539
TRG_ENDOCYTIC_2 7 10 PF00928 0.361
TRG_ER_diArg_1 166 169 PF00400 0.599
TRG_ER_diArg_1 277 280 PF00400 0.584
TRG_ER_diArg_1 491 493 PF00400 0.596
TRG_ER_diArg_1 606 608 PF00400 0.586
TRG_NES_CRM1_1 715 729 PF08389 0.526
TRG_Pf-PMV_PEXEL_1 198 202 PF00026 0.335

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1ILX1 Leptomonas seymouri 62% 100%
A0A0S4JQL9 Bodo saltans 37% 100%
A0A3R7KSA0 Trypanosoma rangeli 40% 100%
A0A3S5H5W5 Leishmania donovani 92% 100%
A4H4W4 Leishmania braziliensis 78% 100%
A4HT38 Leishmania infantum 92% 100%
E9AL30 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS