Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIS3_LEIMA

TriTrypDb:

LmjF.07.0210 , LMJLV39_070007900 , LMJSD75_070008100

Length:

254

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QIS3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIS3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	94	98	PF00656	0.632
CLV_NRD_NRD_1	160	162	PF00675	0.610
CLV_NRD_NRD_1	23	25	PF00675	0.668
CLV_PCSK_KEX2_1	160	162	PF00082	0.610
CLV_PCSK_KEX2_1	23	25	PF00082	0.709
DEG_SCF_FBW7_1	223	228	PF00400	0.558
DEG_SCF_FBW7_1	84	91	PF00400	0.742
DEG_SPOP_SBC_1	71	75	PF00917	0.505
DOC_CKS1_1	222	227	PF01111	0.564
DOC_CKS1_1	85	90	PF01111	0.742
DOC_MAPK_MEF2A_6	138	146	PF00069	0.558
DOC_PP2B_LxvP_1	186	189	PF13499	0.662
DOC_PP4_FxxP_1	4	7	PF00568	0.801
DOC_USP7_MATH_1	130	134	PF00917	0.659
DOC_USP7_MATH_1	199	203	PF00917	0.699
DOC_USP7_MATH_1	241	245	PF00917	0.612
DOC_USP7_MATH_1	71	75	PF00917	0.541
DOC_USP7_MATH_1	78	82	PF00917	0.621
DOC_USP7_MATH_1	88	92	PF00917	0.654
DOC_WW_Pin1_4	10	15	PF00397	0.716
DOC_WW_Pin1_4	136	141	PF00397	0.621
DOC_WW_Pin1_4	201	206	PF00397	0.724
DOC_WW_Pin1_4	214	219	PF00397	0.633
DOC_WW_Pin1_4	221	226	PF00397	0.584
DOC_WW_Pin1_4	72	77	PF00397	0.703
DOC_WW_Pin1_4	84	89	PF00397	0.816
LIG_14-3-3_CanoR_1	177	183	PF00244	0.585
LIG_14-3-3_CanoR_1	36	43	PF00244	0.567
LIG_14-3-3_CanoR_1	57	65	PF00244	0.419
LIG_APCC_ABBA_1	115	120	PF00400	0.644
LIG_FHA_1	103	109	PF00498	0.503
LIG_FHA_1	137	143	PF00498	0.649
LIG_FHA_2	11	17	PF00498	0.739
LIG_FHA_2	36	42	PF00498	0.587
LIG_LIR_Apic_2	220	225	PF02991	0.747
LIG_LIR_Gen_1	113	123	PF02991	0.667
LIG_LIR_Gen_1	49	59	PF02991	0.588
LIG_LIR_Nem_3	113	119	PF02991	0.634
LIG_LIR_Nem_3	224	230	PF02991	0.784
LIG_LIR_Nem_3	49	54	PF02991	0.585
LIG_PAM2_1	49	61	PF00658	0.430
LIG_PCNA_yPIPBox_3	177	186	PF02747	0.533
LIG_PDZ_Class_1	249	254	PF00595	0.705
LIG_Pex14_1	151	155	PF04695	0.411
LIG_Pex14_2	54	58	PF04695	0.594
LIG_SH2_CRK	60	64	PF00017	0.410
LIG_SH2_NCK_1	162	166	PF00017	0.650
LIG_SH2_NCK_1	60	64	PF00017	0.410
LIG_SH2_STAP1	162	166	PF00017	0.549
LIG_SH2_STAP1	242	246	PF00017	0.604
LIG_SH2_STAP1	60	64	PF00017	0.464
LIG_SH2_STAT5	155	158	PF00017	0.467
LIG_SH2_STAT5	60	63	PF00017	0.416
LIG_SH3_3	11	17	PF00018	0.712
LIG_SH3_3	82	88	PF00018	0.690
LIG_TRAF2_1	39	42	PF00917	0.588
MOD_CK1_1	217	223	PF00069	0.720
MOD_CK2_1	10	16	PF00069	0.701
MOD_CK2_1	161	167	PF00069	0.550
MOD_CK2_1	35	41	PF00069	0.661
MOD_CK2_1	88	94	PF00069	0.828
MOD_GlcNHglycan	100	103	PF01048	0.703
MOD_GlcNHglycan	163	166	PF01048	0.660
MOD_GlcNHglycan	208	211	PF01048	0.668
MOD_GlcNHglycan	226	230	PF01048	0.661
MOD_GlcNHglycan	80	83	PF01048	0.711
MOD_GSK3_1	106	113	PF00069	0.555
MOD_GSK3_1	213	220	PF00069	0.689
MOD_GSK3_1	221	228	PF00069	0.548
MOD_GSK3_1	49	56	PF00069	0.564
MOD_GSK3_1	84	91	PF00069	0.740
MOD_GSK3_1	98	105	PF00069	0.786
MOD_LATS_1	211	217	PF00433	0.697
MOD_N-GLC_1	178	183	PF02516	0.579
MOD_N-GLC_1	214	219	PF02516	0.759
MOD_NEK2_1	106	111	PF00069	0.551
MOD_NEK2_1	180	185	PF00069	0.619
MOD_NEK2_1	249	254	PF00069	0.640
MOD_NEK2_1	53	58	PF00069	0.575
MOD_PIKK_1	180	186	PF00454	0.396
MOD_PKA_2	35	41	PF00069	0.559
MOD_Plk_1	106	112	PF00069	0.558
MOD_Plk_1	178	184	PF00069	0.578
MOD_Plk_1	199	205	PF00069	0.687
MOD_Plk_1	231	237	PF00069	0.718
MOD_Plk_4	110	116	PF00069	0.516
MOD_Plk_4	218	224	PF00069	0.634
MOD_Plk_4	241	247	PF00069	0.547
MOD_ProDKin_1	10	16	PF00069	0.716
MOD_ProDKin_1	136	142	PF00069	0.610
MOD_ProDKin_1	201	207	PF00069	0.725
MOD_ProDKin_1	214	220	PF00069	0.633
MOD_ProDKin_1	221	227	PF00069	0.585
MOD_ProDKin_1	72	78	PF00069	0.711
MOD_ProDKin_1	84	90	PF00069	0.816
MOD_SUMO_rev_2	133	140	PF00179	0.657
TRG_DiLeu_BaLyEn_6	137	142	PF01217	0.598
TRG_ENDOCYTIC_2	242	245	PF00928	0.584
TRG_ENDOCYTIC_2	60	63	PF00928	0.416
TRG_ER_diArg_1	160	162	PF00400	0.610

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I988	Leptomonas seymouri	37%	100%
A0A3S5H5W6	Leishmania donovani	89%	100%
A4H4W5	Leishmania braziliensis	60%	100%
A4HT39	Leishmania infantum	88%	100%
E9AL31	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%