Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIS2_LEIMA

TriTrypDb:

LmjF.07.0220 , LMJLV39_070008100 , LMJSD75_070008300

Length:

635

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QIS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIS2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.552
CLV_NRD_NRD_1	122	124	PF00675	0.507
CLV_NRD_NRD_1	138	140	PF00675	0.408
CLV_NRD_NRD_1	304	306	PF00675	0.468
CLV_NRD_NRD_1	582	584	PF00675	0.393
CLV_PCSK_KEX2_1	138	140	PF00082	0.443
CLV_PCSK_KEX2_1	582	584	PF00082	0.393
CLV_PCSK_SKI1_1	231	235	PF00082	0.514
CLV_PCSK_SKI1_1	245	249	PF00082	0.459
CLV_PCSK_SKI1_1	436	440	PF00082	0.409
CLV_PCSK_SKI1_1	594	598	PF00082	0.448
CLV_PCSK_SKI1_1	622	626	PF00082	0.665
CLV_Separin_Metazoa	402	406	PF03568	0.461
DEG_APCC_DBOX_1	20	28	PF00400	0.533
DEG_SCF_FBW7_1	81	86	PF00400	0.508
DEG_SPOP_SBC_1	199	203	PF00917	0.557
DEG_SPOP_SBC_1	624	628	PF00917	0.581
DOC_CDC14_PxL_1	422	430	PF14671	0.370
DOC_CYCLIN_RxL_1	433	441	PF00134	0.387
DOC_CYCLIN_RxL_1	505	513	PF00134	0.454
DOC_MAPK_gen_1	228	236	PF00069	0.602
DOC_MAPK_gen_1	525	533	PF00069	0.460
DOC_MAPK_gen_1	9	19	PF00069	0.598
DOC_MAPK_MEF2A_6	11	19	PF00069	0.563
DOC_MAPK_MEF2A_6	228	236	PF00069	0.511
DOC_MAPK_MEF2A_6	495	503	PF00069	0.455
DOC_PP1_SILK_1	301	306	PF00149	0.263
DOC_PP2B_LxvP_1	375	378	PF13499	0.482
DOC_PP2B_LxvP_1	496	499	PF13499	0.465
DOC_PP4_FxxP_1	453	456	PF00568	0.488
DOC_USP7_MATH_1	414	418	PF00917	0.393
DOC_USP7_MATH_1	468	472	PF00917	0.602
DOC_USP7_MATH_1	595	599	PF00917	0.622
DOC_USP7_MATH_1	624	628	PF00917	0.629
DOC_USP7_UBL2_3	124	128	PF12436	0.517
DOC_USP7_UBL2_3	71	75	PF12436	0.705
DOC_WW_Pin1_4	142	147	PF00397	0.420
DOC_WW_Pin1_4	240	245	PF00397	0.616
DOC_WW_Pin1_4	404	409	PF00397	0.421
DOC_WW_Pin1_4	617	622	PF00397	0.665
DOC_WW_Pin1_4	79	84	PF00397	0.707
LIG_14-3-3_CanoR_1	139	149	PF00244	0.442
LIG_14-3-3_CanoR_1	552	559	PF00244	0.407
LIG_14-3-3_CanoR_1	594	600	PF00244	0.478
LIG_14-3-3_CterR_2	631	635	PF00244	0.623
LIG_APCC_ABBA_1	385	390	PF00400	0.406
LIG_BIR_III_4	84	88	PF00653	0.506
LIG_deltaCOP1_diTrp_1	568	575	PF00928	0.378
LIG_eIF4E_1	388	394	PF01652	0.407
LIG_FHA_1	246	252	PF00498	0.491
LIG_FHA_1	314	320	PF00498	0.351
LIG_FHA_1	347	353	PF00498	0.453
LIG_FHA_1	405	411	PF00498	0.405
LIG_FHA_1	507	513	PF00498	0.587
LIG_FHA_1	552	558	PF00498	0.380
LIG_FHA_1	595	601	PF00498	0.444
LIG_FHA_1	609	615	PF00498	0.434
LIG_FHA_2	84	90	PF00498	0.770
LIG_FHA_2	97	103	PF00498	0.417
LIG_GBD_Chelix_1	536	544	PF00786	0.381
LIG_LIR_Gen_1	290	299	PF02991	0.493
LIG_LIR_Gen_1	318	329	PF02991	0.396
LIG_LIR_Gen_1	366	375	PF02991	0.567
LIG_LIR_Gen_1	398	409	PF02991	0.455
LIG_LIR_Nem_3	290	294	PF02991	0.513
LIG_LIR_Nem_3	298	303	PF02991	0.354
LIG_LIR_Nem_3	318	324	PF02991	0.426
LIG_LIR_Nem_3	366	371	PF02991	0.589
LIG_LIR_Nem_3	398	404	PF02991	0.437
LIG_LYPXL_yS_3	425	428	PF13949	0.424
LIG_NRBOX	427	433	PF00104	0.402
LIG_PCNA_yPIPBox_3	582	591	PF02747	0.453
LIG_Pex14_1	160	164	PF04695	0.506
LIG_PTB_Apo_2	421	428	PF02174	0.275
LIG_PTB_Phospho_1	421	427	PF10480	0.279
LIG_SH2_CRK	291	295	PF00017	0.482
LIG_SH2_CRK	300	304	PF00017	0.399
LIG_SH2_CRK	321	325	PF00017	0.428
LIG_SH2_GRB2like	291	294	PF00017	0.301
LIG_SH2_SRC	291	294	PF00017	0.463
LIG_SH2_STAP1	321	325	PF00017	0.405
LIG_SH2_STAP1	388	392	PF00017	0.409
LIG_SH2_STAT5	164	167	PF00017	0.506
LIG_SH2_STAT5	246	249	PF00017	0.516
LIG_SH2_STAT5	351	354	PF00017	0.463
LIG_SH2_STAT5	427	430	PF00017	0.396
LIG_SH2_STAT5	437	440	PF00017	0.365
LIG_SH2_STAT5	539	542	PF00017	0.357
LIG_SH3_3	350	356	PF00018	0.456
LIG_SUMO_SIM_anti_2	13	19	PF11976	0.553
LIG_SUMO_SIM_par_1	508	513	PF11976	0.431
LIG_TRAF2_1	445	448	PF00917	0.451
LIG_TYR_ITIM	319	324	PF00017	0.434
LIG_TYR_ITIM	423	428	PF00017	0.425
LIG_TYR_ITSM	296	303	PF00017	0.408
LIG_UBA3_1	517	525	PF00899	0.491
LIG_WRC_WIRS_1	368	373	PF05994	0.600
MOD_CDK_SPK_2	240	245	PF00069	0.533
MOD_CDK_SPK_2	617	622	PF00069	0.585
MOD_CK1_1	163	169	PF00069	0.504
MOD_CK1_1	203	209	PF00069	0.724
MOD_CK1_1	217	223	PF00069	0.714
MOD_CK1_1	369	375	PF00069	0.608
MOD_CK1_1	42	48	PF00069	0.709
MOD_CK1_1	66	72	PF00069	0.712
MOD_CK2_1	152	158	PF00069	0.534
MOD_CK2_1	367	373	PF00069	0.583
MOD_CK2_1	442	448	PF00069	0.419
MOD_CK2_1	624	630	PF00069	0.610
MOD_CK2_1	83	89	PF00069	0.727
MOD_CK2_1	96	102	PF00069	0.424
MOD_GlcNHglycan	154	157	PF01048	0.488
MOD_GlcNHglycan	184	187	PF01048	0.563
MOD_GlcNHglycan	202	205	PF01048	0.603
MOD_GlcNHglycan	283	286	PF01048	0.500
MOD_GlcNHglycan	300	303	PF01048	0.325
MOD_GlcNHglycan	40	44	PF01048	0.710
MOD_GlcNHglycan	465	468	PF01048	0.583
MOD_GlcNHglycan	52	55	PF01048	0.648
MOD_GlcNHglycan	578	581	PF01048	0.392
MOD_GSK3_1	166	173	PF00069	0.555
MOD_GSK3_1	174	181	PF00069	0.690
MOD_GSK3_1	182	189	PF00069	0.400
MOD_GSK3_1	199	206	PF00069	0.757
MOD_GSK3_1	213	220	PF00069	0.675
MOD_GSK3_1	277	284	PF00069	0.539
MOD_GSK3_1	309	316	PF00069	0.440
MOD_GSK3_1	438	445	PF00069	0.404
MOD_GSK3_1	483	490	PF00069	0.554
MOD_GSK3_1	590	597	PF00069	0.513
MOD_GSK3_1	79	86	PF00069	0.716
MOD_N-GLC_1	432	437	PF02516	0.387
MOD_N-GLC_1	442	447	PF02516	0.413
MOD_N-GLC_1	607	612	PF02516	0.612
MOD_N-GLC_1	617	622	PF02516	0.677
MOD_NEK2_1	182	187	PF00069	0.521
MOD_NEK2_1	295	300	PF00069	0.404
MOD_NEK2_1	313	318	PF00069	0.362
MOD_NEK2_1	367	372	PF00069	0.563
MOD_NEK2_1	379	384	PF00069	0.470
MOD_NEK2_1	432	437	PF00069	0.405
MOD_NEK2_1	438	443	PF00069	0.392
MOD_NEK2_1	463	468	PF00069	0.745
MOD_NEK2_1	532	537	PF00069	0.402
MOD_NEK2_1	616	621	PF00069	0.548
MOD_NEK2_2	315	320	PF00069	0.391
MOD_PIKK_1	456	462	PF00454	0.461
MOD_PK_1	516	522	PF00069	0.324
MOD_PKA_2	199	205	PF00069	0.734
MOD_PKA_2	551	557	PF00069	0.386
MOD_PKB_1	198	206	PF00069	0.530
MOD_Plk_1	88	94	PF00069	0.562
MOD_Plk_4	160	166	PF00069	0.531
MOD_Plk_4	379	385	PF00069	0.424
MOD_Plk_4	516	522	PF00069	0.396
MOD_Plk_4	595	601	PF00069	0.576
MOD_ProDKin_1	142	148	PF00069	0.421
MOD_ProDKin_1	240	246	PF00069	0.607
MOD_ProDKin_1	404	410	PF00069	0.429
MOD_ProDKin_1	617	623	PF00069	0.670
MOD_ProDKin_1	79	85	PF00069	0.704
MOD_SUMO_rev_2	254	264	PF00179	0.456
TRG_DiLeu_BaLyEn_6	453	458	PF01217	0.430
TRG_ENDOCYTIC_2	291	294	PF00928	0.498
TRG_ENDOCYTIC_2	300	303	PF00928	0.448
TRG_ENDOCYTIC_2	321	324	PF00928	0.442
TRG_ENDOCYTIC_2	425	428	PF00928	0.456
TRG_ER_diArg_1	137	139	PF00400	0.434
TRG_ER_diArg_1	21	24	PF00400	0.637
TRG_ER_diArg_1	581	583	PF00400	0.454
TRG_ER_diArg_1	8	11	PF00400	0.605
TRG_NES_CRM1_1	26	38	PF08389	0.566
TRG_NES_CRM1_1	366	381	PF08389	0.457
TRG_Pf-PMV_PEXEL_1	391	395	PF00026	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7J6	Leptomonas seymouri	61%	99%
A0A3S5H5W7	Leishmania donovani	94%	100%
A4H4W6	Leishmania braziliensis	73%	100%
A4HT40	Leishmania infantum	94%	100%
C9ZUU8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AL32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5B8V4	Trypanosoma cruzi	33%	100%