Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIS0_LEIMA

TriTrypDb:

LmjF.07.0240 , LMJLV39_070008300 , LMJSD75_070008500

Length:

607

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	5
GO:0016020	membrane	2	3

Expansion

Sequence features

Q4QIS0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIS0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	243	247	PF00656	0.398
CLV_C14_Caspase3-7	543	547	PF00656	0.381
CLV_NRD_NRD_1	231	233	PF00675	0.701
CLV_NRD_NRD_1	236	238	PF00675	0.671
CLV_NRD_NRD_1	271	273	PF00675	0.604
CLV_NRD_NRD_1	290	292	PF00675	0.599
CLV_NRD_NRD_1	303	305	PF00675	0.627
CLV_NRD_NRD_1	315	317	PF00675	0.535
CLV_NRD_NRD_1	33	35	PF00675	0.443
CLV_NRD_NRD_1	365	367	PF00675	0.707
CLV_NRD_NRD_1	40	42	PF00675	0.432
CLV_NRD_NRD_1	427	429	PF00675	0.823
CLV_PCSK_FUR_1	301	305	PF00082	0.718
CLV_PCSK_KEX2_1	231	233	PF00082	0.704
CLV_PCSK_KEX2_1	236	238	PF00082	0.675
CLV_PCSK_KEX2_1	271	273	PF00082	0.604
CLV_PCSK_KEX2_1	290	292	PF00082	0.599
CLV_PCSK_KEX2_1	303	305	PF00082	0.627
CLV_PCSK_KEX2_1	315	317	PF00082	0.550
CLV_PCSK_KEX2_1	33	35	PF00082	0.437
CLV_PCSK_KEX2_1	364	366	PF00082	0.703
CLV_PCSK_KEX2_1	39	41	PF00082	0.445
CLV_PCSK_KEX2_1	427	429	PF00082	0.823
CLV_PCSK_PC7_1	232	238	PF00082	0.685
CLV_PCSK_SKI1_1	271	275	PF00082	0.610
CLV_PCSK_SKI1_1	455	459	PF00082	0.766
CLV_PCSK_SKI1_1	46	50	PF00082	0.521
CLV_PCSK_SKI1_1	503	507	PF00082	0.708
DEG_Kelch_Keap1_1	400	405	PF01344	0.492
DEG_Nend_Nbox_1	1	3	PF02207	0.708
DOC_CKS1_1	178	183	PF01111	0.551
DOC_CYCLIN_RxL_1	268	277	PF00134	0.411
DOC_CYCLIN_yCln2_LP_2	321	327	PF00134	0.441
DOC_MAPK_gen_1	236	242	PF00069	0.421
DOC_MAPK_gen_1	364	372	PF00069	0.437
DOC_MAPK_gen_1	424	434	PF00069	0.590
DOC_MAPK_MEF2A_6	132	140	PF00069	0.367
DOC_MAPK_RevD_3	352	366	PF00069	0.467
DOC_PP2B_LxvP_1	79	82	PF13499	0.511
DOC_PP4_FxxP_1	125	128	PF00568	0.414
DOC_PP4_FxxP_1	178	181	PF00568	0.473
DOC_PP4_FxxP_1	327	330	PF00568	0.516
DOC_USP7_MATH_1	170	174	PF00917	0.624
DOC_USP7_MATH_1	376	380	PF00917	0.542
DOC_USP7_MATH_1	459	463	PF00917	0.571
DOC_USP7_MATH_1	572	576	PF00917	0.514
DOC_USP7_MATH_1	581	585	PF00917	0.392
DOC_WW_Pin1_4	168	173	PF00397	0.574
DOC_WW_Pin1_4	17	22	PF00397	0.693
DOC_WW_Pin1_4	177	182	PF00397	0.584
DOC_WW_Pin1_4	210	215	PF00397	0.545
DOC_WW_Pin1_4	274	279	PF00397	0.432
DOC_WW_Pin1_4	295	300	PF00397	0.440
LIG_14-3-3_CanoR_1	132	140	PF00244	0.367
LIG_14-3-3_CanoR_1	271	277	PF00244	0.381
LIG_14-3-3_CanoR_1	331	339	PF00244	0.470
LIG_14-3-3_CanoR_1	427	433	PF00244	0.524
LIG_14-3-3_CanoR_1	476	484	PF00244	0.517
LIG_Actin_WH2_2	116	134	PF00022	0.393
LIG_Actin_WH2_2	524	539	PF00022	0.570
LIG_APCC_ABBA_1	354	359	PF00400	0.386
LIG_BRCT_BRCA1_1	188	192	PF00533	0.562
LIG_BRCT_BRCA1_1	26	30	PF00533	0.662
LIG_DLG_GKlike_1	40	47	PF00625	0.619
LIG_eIF4E_1	61	67	PF01652	0.402
LIG_FHA_1	107	113	PF00498	0.421
LIG_FHA_1	213	219	PF00498	0.492
LIG_FHA_1	24	30	PF00498	0.590
LIG_FHA_1	261	267	PF00498	0.424
LIG_FHA_1	3	9	PF00498	0.754
LIG_FHA_1	342	348	PF00498	0.474
LIG_FHA_1	459	465	PF00498	0.633
LIG_FHA_1	62	68	PF00498	0.389
LIG_FHA_2	246	252	PF00498	0.480
LIG_FHA_2	417	423	PF00498	0.537
LIG_FHA_2	541	547	PF00498	0.377
LIG_FHA_2	85	91	PF00498	0.420
LIG_LIR_Apic_2	124	128	PF02991	0.372
LIG_LIR_Apic_2	176	181	PF02991	0.455
LIG_LIR_Gen_1	248	255	PF02991	0.467
LIG_LIR_Gen_1	355	363	PF02991	0.387
LIG_LIR_Gen_1	487	494	PF02991	0.464
LIG_LIR_LC3C_4	64	68	PF02991	0.375
LIG_LIR_Nem_3	248	253	PF02991	0.472
LIG_LIR_Nem_3	355	360	PF02991	0.385
LIG_LIR_Nem_3	43	47	PF02991	0.598
LIG_LIR_Nem_3	436	442	PF02991	0.481
LIG_LIR_Nem_3	487	491	PF02991	0.461
LIG_LIR_Nem_3	89	94	PF02991	0.441
LIG_MYND_1	96	100	PF01753	0.421
LIG_PCNA_PIPBox_1	73	82	PF02747	0.428
LIG_PCNA_yPIPBox_3	69	80	PF02747	0.418
LIG_Pex14_2	121	125	PF04695	0.399
LIG_PTB_Apo_2	244	251	PF02174	0.424
LIG_PTB_Phospho_1	244	250	PF10480	0.418
LIG_REV1ctd_RIR_1	123	127	PF16727	0.403
LIG_SH2_NCK_1	133	137	PF00017	0.365
LIG_SH2_NCK_1	250	254	PF00017	0.430
LIG_SH2_SRC	435	438	PF00017	0.509
LIG_SH2_SRC	556	559	PF00017	0.501
LIG_SH2_STAP1	133	137	PF00017	0.365
LIG_SH2_STAP1	435	439	PF00017	0.513
LIG_SH2_STAT3	550	553	PF00017	0.426
LIG_SH2_STAT5	286	289	PF00017	0.383
LIG_SH2_STAT5	61	64	PF00017	0.362
LIG_SH2_STAT5	86	89	PF00017	0.459
LIG_SH3_1	368	374	PF00018	0.500
LIG_SH3_1	453	459	PF00018	0.564
LIG_SH3_3	136	142	PF00018	0.377
LIG_SH3_3	15	21	PF00018	0.778
LIG_SH3_3	208	214	PF00018	0.546
LIG_SH3_3	368	374	PF00018	0.516
LIG_SH3_3	408	414	PF00018	0.600
LIG_SH3_3	453	459	PF00018	0.564
LIG_SH3_5	82	86	PF00018	0.560
LIG_SUMO_SIM_anti_2	102	107	PF11976	0.382
LIG_SUMO_SIM_anti_2	134	140	PF11976	0.366
LIG_SUMO_SIM_par_1	272	277	PF11976	0.428
LIG_TRAF2_1	603	606	PF00917	0.615
LIG_TYR_ITIM	131	136	PF00017	0.444
LIG_TYR_ITSM	246	253	PF00017	0.400
LIG_ULM_U2AF65_1	364	370	PF00076	0.629
LIG_WRC_WIRS_1	122	127	PF05994	0.499
MOD_CDC14_SPxK_1	171	174	PF00782	0.711
MOD_CDK_SPxK_1	168	174	PF00069	0.711
MOD_CDK_SPxK_1	295	301	PF00069	0.541
MOD_CDK_SPxxK_3	17	24	PF00069	0.662
MOD_CDK_SPxxK_3	177	184	PF00069	0.702
MOD_CK1_1	173	179	PF00069	0.692
MOD_CK1_1	560	566	PF00069	0.489
MOD_CK2_1	345	351	PF00069	0.475
MOD_CK2_1	399	405	PF00069	0.798
MOD_CK2_1	459	465	PF00069	0.711
MOD_Cter_Amidation	313	316	PF01082	0.529
MOD_GlcNHglycan	14	17	PF01048	0.628
MOD_GlcNHglycan	175	178	PF01048	0.773
MOD_GlcNHglycan	200	203	PF01048	0.760
MOD_GlcNHglycan	278	281	PF01048	0.652
MOD_GlcNHglycan	378	381	PF01048	0.697
MOD_GlcNHglycan	399	402	PF01048	0.846
MOD_GSK3_1	106	113	PF00069	0.483
MOD_GSK3_1	173	180	PF00069	0.757
MOD_GSK3_1	272	279	PF00069	0.591
MOD_GSK3_1	341	348	PF00069	0.633
MOD_GSK3_1	381	388	PF00069	0.776
MOD_GSK3_1	556	563	PF00069	0.611
MOD_N-GLC_1	186	191	PF02516	0.601
MOD_N-GLC_1	257	262	PF02516	0.647
MOD_N-GLC_1	581	586	PF02516	0.528
MOD_NEK2_1	106	111	PF00069	0.485
MOD_NEK2_1	121	126	PF00069	0.488
MOD_NEK2_1	131	136	PF00069	0.547
MOD_NEK2_1	2	7	PF00069	0.612
MOD_NEK2_1	317	322	PF00069	0.543
MOD_NEK2_1	477	482	PF00069	0.681
MOD_PIKK_1	331	337	PF00454	0.576
MOD_PK_1	272	278	PF00069	0.565
MOD_PKA_1	40	46	PF00069	0.414
MOD_PKA_2	106	112	PF00069	0.447
MOD_PKA_2	131	137	PF00069	0.442
MOD_PKA_2	193	199	PF00069	0.711
MOD_PKA_2	2	8	PF00069	0.609
MOD_PKA_2	40	46	PF00069	0.513
MOD_PKA_2	426	432	PF00069	0.767
MOD_PKA_2	477	483	PF00069	0.681
MOD_PKB_1	184	192	PF00069	0.646
MOD_Plk_1	317	323	PF00069	0.641
MOD_Plk_1	459	465	PF00069	0.711
MOD_Plk_1	581	587	PF00069	0.533
MOD_Plk_1	84	90	PF00069	0.590
MOD_Plk_2-3	193	199	PF00069	0.556
MOD_Plk_4	121	127	PF00069	0.555
MOD_Plk_4	317	323	PF00069	0.539
MOD_Plk_4	459	465	PF00069	0.711
MOD_Plk_4	46	52	PF00069	0.358
MOD_Plk_4	572	578	PF00069	0.637
MOD_ProDKin_1	168	174	PF00069	0.733
MOD_ProDKin_1	17	23	PF00069	0.616
MOD_ProDKin_1	177	183	PF00069	0.736
MOD_ProDKin_1	210	216	PF00069	0.684
MOD_ProDKin_1	274	280	PF00069	0.533
MOD_ProDKin_1	295	301	PF00069	0.541
MOD_SUMO_rev_2	85	94	PF00179	0.606
TRG_DiLeu_BaLyEn_6	269	274	PF01217	0.601
TRG_DiLeu_BaLyEn_6	453	458	PF01217	0.817
TRG_ENDOCYTIC_2	133	136	PF00928	0.439
TRG_ENDOCYTIC_2	250	253	PF00928	0.595
TRG_ENDOCYTIC_2	284	287	PF00928	0.483
TRG_ENDOCYTIC_2	357	360	PF00928	0.467
TRG_ENDOCYTIC_2	439	442	PF00928	0.671
TRG_ER_diArg_1	183	186	PF00400	0.730
TRG_ER_diArg_1	231	233	PF00400	0.637
TRG_ER_diArg_1	235	237	PF00400	0.629
TRG_ER_diArg_1	271	273	PF00400	0.492
TRG_ER_diArg_1	289	291	PF00400	0.477
TRG_ER_diArg_1	303	305	PF00400	0.511
TRG_ER_diArg_1	315	317	PF00400	0.459
TRG_ER_diArg_1	33	35	PF00400	0.547
TRG_ER_diArg_1	363	366	PF00400	0.610
TRG_ER_diArg_1	38	41	PF00400	0.525
TRG_ER_diArg_1	427	430	PF00400	0.727
TRG_ER_diArg_1	475	478	PF00400	0.674
TRG_ER_diArg_1	481	484	PF00400	0.647
TRG_Pf-PMV_PEXEL_1	186	190	PF00026	0.642
TRG_Pf-PMV_PEXEL_1	455	460	PF00026	0.822
TRG_Pf-PMV_PEXEL_1	503	508	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	6	10	PF00026	0.590
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE68	Leptomonas seymouri	53%	100%
A0A3S5H5W8	Leishmania donovani	94%	100%
A4H4W9	Leishmania braziliensis	78%	100%
A4HT42	Leishmania infantum	94%	100%
E9AL34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%